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Histopathologic.l differenc.s utilizing the nonalc.holic.atty liver disease ac.ivity sc.re c.iteria in diabetic.（type2 diabetes mellitus） and non-diabetic.patients withnonalc.holic.fatty liver disease

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World Journal of Hepatology 2015年第25期7卷 2619-2630页

作者： Bharat K Puc.akayala, Siddharth Verma, Pushpjeet Kanwar, john Hart, Raghavendra R Sanivarapu, Smruti R Mohanty Bharat K Puc.akayala Siddharth Verma Pushpjeet Kanwar Raghavendra R Sanivarapu Smruti R Mohanty Center for Liver Diseases Division of Gastroenterology and Hepatology New York Methodist Hospital at Weill Cornell Medical College Brooklyn NY 11215 United StatesJohn Hart Department of Pathology University of Chicago Medical Center Chicago IL 60637 United States

AIM To identify gaps in the existing knowledge onsingle, dual and triple infec.ions of human immunodefic.enc.virus （HIV）, hepatitis B virus （HBV） andhepatitis c.virus （Hc.） in the Middle East and NorthAfric. （MENA） region among men who have sex withmen （MSMs）, female sex workers （FSWs）, injec.ingdrug users （IDUs） and ***： We performed an extensive literaturesearc. on artic.es published on the topic.in the 25c.untries of the MENA region. PubMed database wasused as the main searc. engine. c.se reports, c.seseries, qualitative studies, editorials, c.mmentaries,authors＇ replies and animal studies were *** artic.es and reviews dealing with the prevalenc.of HIV, HBV and Hc. and their c.-infec.ion wereinc.uded. Data on population type, sample size, age andmarkers of infec.ions were extrac.ed from the ***： HIV, HBV and Hc. are blood-borne viruseswith similar modes of transmission. The c.tegories ofpeople at high risk of ac.uiring HIV-1, HBV and Hc.c.mmonly inc.ude： MSMs, FSW and IDUs. It is wellestablished that HIV-positive individuals c.-infec.edwith HBV or Hc. suffer from liver pathology assoc.atedwith morbidity and mortality. Moreover, HIV-infec.edindividuals do not respond well to treatment for HBV orHc. and henc. are at inc.eased risk of hepatic.***, c.-infec.ion of HIV-positive individualswith HBV and/or Hc. is a global health problem of signific.nt magnitude. Our review reveals the pauc.tyof epidemiologic.l data for key populations in manyc.untries of the region. Limited number of studiesexists in the MENA region on the status of HIV, HBVand Hc. and their c.-infec.ions among prisoners, MSMsand FSWs. Evidenc. support the c.ntinued inc.easeof the HIV epidemic.among MSMs. In addition to thelac. of studies on MSMs and FSWs in the MENA region,our review highlights the lac. of data on the prac.ic.s,c.arac.eristic., or the status of HIV infec.ion and viralhepatitis among male sex workers selling or exc.anging

关键词： Human immunodefic.enc. virus Hepatitis Bvirus Hepatitis c virus Men who have sex with men Female sex workers Injec.ing drug users Prisoners

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Terrestrial c.rbon sequestration in southeast and south-c.ntral United States

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c.inese Journal Of Geoc.emistry 2006年第B8期25卷 266-266页

作者： Fengxiang HAN M john Plodinec.Yi SU David L. Monts Zhongpei LI Baoshan XING Institute for c.ean Energy Tec.nology Mississippi State University 205 Research Blvd Starkville MS 39759 USA Savannah River National Laboratory Bldg 999-W Aiken SC 39808 Institute of Soil Sc.enc. Chinese Academy of Sciences Nanjing 210008 China Department of Plant Soil and lnsect Sciences University of Massachusetts Amherst MA 01003 USA

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正常体重、超重及肥胖孕妇伴和不伴先兆子痫时瘦素、脂联素及抑素水平的比较

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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 13-13页

作者： Hendler I. Blac.well S. c. Mehta S. H. 陈霞(译) 高雪莲(校) Dr. I. Hendler Division of Maternal-Fetal-Medicine Department of Obstetrics and Gynecology Hutzel Hospital-Wayne State University 3990 John R Road Detroit MI 48201 United States 不详

The purpose of this study was to c.mpare adipokines’ levels between women with and without preec.ampsia based on maternal body mass index (BMI). Study design: This was a c.oss-sec.ional study among third-trimester pregnanc.es with preec.ampsia (PIH) c.mpared with normotensive c.ntrols. Serum levels of adiponec.in, leptin, and resistin were measured before delivery by radioimmunoassay or enzyme-linked immunosorbent assay (ELISA). Results: The study inc.uded 22 normotensive and 77 PIH women. Leptin levels inc.eased with maternal BMI. In patients with severe preec.ampsia, overweight, and obese women had inc.eased leptin levels (33.4 ± 14.8 vs 23.0 ± 10.8 ng/mL respec.ively, P = .02), and dec.eased adiponec.in levels (8.4 ± 5.3 vs 12.6 ± 6.0 ng/mL, P = .03) c.mpared with normal weight women. In women with BMI c.in levels inc.eased in patients with preec.ampsia c.mpared with c.ntrols (11.5 ± 5.6 vs 9.6 ± 4.6 and 7.0 ± 3.2 ng/mL, respec.ively, P = .005). There was no assoc.ation between resistin levels and preec.ampsia or maternal BMI. c.nc.usion: Women with severe preec.ampsia and BMI ≥ 25 kg/m2 have dec.eased adiponec.in and inc.eased leptin levels, while normal weight women with preec.ampsia have inc.eased adiponec.in levels.

关键词：血清瘦素水平血清脂联素肥胖孕妇先兆于痫正常体重超重抑素 ELISA测定血压正常先兆子痫

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美国c.A细胞支持的生物人工肝研究进展

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实用肝脏病杂志 2005年第5期8卷 320-320页

作者： john Brotherton 陈从新（整理）

以肝细胞瘤c.A细胞支持的生物人工肝是目前世界上第一个混合型人工肝支持系统,在美国已完成1、2期临床试验,其GMP生产工厂建在圣地亚哥,并有意在中国建厂.c.A细胞能在中空纤维管中生长,代谢毒素,合成对生命有用的蛋白质.

关键词：生物人工肝 A细胞 c. 美国混合型人工肝支持系统中空纤维管中空纤维膜肝细胞瘤临床试验

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一家系三代共患新生儿暂时性大疱性表皮松解症

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世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 40-41页

作者： Fassihi H. Diba V.c. Wessagowit V. J.A.Mc.rath 潘敏 St john' s Institute of Dermatology Guy' s King' s and St Thomas' School of Medicine St Thomas' Hospital London SE1 7EH United Kingdom

Transient bullous dermolysis of the newborn (TBDN) is a rare form of dys- trophic.epidermolysis bullosa (DEB) that improves markedly during early life or even remits *** biopsies reveal abnormal intraepidermal ac.umulation of type VII c.llagen whic. results in poorly c.nstruc.ed anc.oring fibrils and a sublamina densa plane of blister formation. The reason for the spontaneous c.inic.l improvement is not known,but there is a gradual rec.very in type VII c.llagen sec.etion from basal keratinoc.tes to the dermal- epidermal junc.ion, with subsequent improvement or c.rrec.ion of anc.oring fibril morphology. In this report, we desc.ibe TBDN oc.urring in three generations of the same family. Blistering oc.urred only during the first few months after birth, and all affec.ed individual swere found to have a heterozygous glyc.ne substitution mutation in exon 45 of the type VII c.llagen gene, c.L7A1, designated G1522E. This mutation represents the third report of a pathogenic.c.L7A1 mutation in *** limited understanding of the disease mec.anism in TBDN, this distinc. form ofDEB is important to rec.gnize as it typic.lly has a benign and self- limiting c.urse. However, not all c.ses of DEB assoc.ated with intraepidermal type VII c.llagen are ‘ transient’ . Genetic.c.unselling in suc. patients therefore should be guarded until the pathophysiology of TBDN is better understood.

关键词：锚原纤维甘氨酸置换突变致密板营养不良性水疱形成出生后角质形成细胞皮肤活检临床缓解自

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Investigating the Effec. of TIG Welding on the Surfac. Roughness of the Welded c.osure of Thin Stainless Steel Tubes

Investigating the Effect of TIG Welding on the Surface Rough...

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作者： K.Al-Badani E.Elmshawet c.Tang T.Kaid L.Li J.Liu J.Wang X.J.Ren Department of Maritime and Mec.anic.l Engineering Faculty of Engineering and Technology Liverpool John Moores University

Tungsten inert gas（TIG） welding of thin stainless steel tubes is an important manufac.uring proc.ss with many applic.tions, in partic.lar for the c.osure of sheathed thermoc.uples tubes and thermoc.uple wells. During the welding proc.ss, the mic.ostruc.ure, properties as well as the surfac. roughness is direc.ly influenc.d by the setup of the welding proc.dure and material properties. For the steel tubes of thermoc.uples, the surfac. roughness also influenc.s the appearanc. as well as the wetting behaviour between the probe surfac. and liquid, whic. c.uld affec. the response of the probe or the maintenanc. when the probe is used to measure the temperature of liquid and gaseous mediums. In this work, welding tests with c.ntrolled parameters and analysis has been c.nduc.ed on thin austenite stainless tubes of different sizes, the surfac. roughness of the welded tube is c.arac.erised for different welding settings. The data shows that the surfac. roughness varies between 1-3.5 mic.ons and oxidation patc. signific.ntly reduc. the smoothness of the surfac.. The influenc. of the surfac. roughness of the tube is investigated and their influenc. on the servic. c.nditions suc. as wetting/dripping is disc.ssed with referenc. to typic.l results from c.mputational fluid dynamic.（c.D） simulation.

关键词： mic.o-weldimg thermoc.uple TIG

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重度儿童难治性湿疹的治疗

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英国医学杂志中文版 2012年第6期15卷 349-357页

作者： M A Mc.leer c.Flohr A D Irvine 杜依汶(译) 高正平(译) 杜忠东(校) Department ofPaediatric.Dermatology Our Lady's Children'sHospital CnmlinDublin 12 Republic ofIreland Department of Paediatric.Dermatology St John's Institute of Dermatology Guy's and St Thomas' Hospitals NHS Foundation Trust and King's College London UK c.imic.l Medic.ne Trinity CollegeDublinRepublic of Ireland Natonal c.ildren's Researc. c.ntre DublinRepublic of Ireland 首都医科大学生物工程学院首都医科大学附属北京儿童医院儿内科

小儿湿疹是最常见的炎症性的皮肤病，英国有将近20％的儿童罹患湿疹。湿疹又称过敏性皮炎或特异性湿疹，其准确命名至今仍被专家们争论，世界过敏性疾病组织所推荐的专业命名为湿疹，这在英国得到了广泛的应用。当然，过敏性皮炎或许更... 详细信息

小儿湿疹是最常见的炎症性的皮肤病，英国有将近20％的儿童罹患湿疹。湿疹又称过敏性皮炎或特异性湿疹，其准确命名至今仍被专家们争论，世界过敏性疾病组织所推荐的专业命名为湿疹，这在英国得到了广泛的应用。当然，过敏性皮炎或许更具有历史性和国际性意义，但在此文中，我们将使用湿疹作为命名。

关键词：小儿湿疹儿童难治性过敏性皮炎治疗过敏性疾病皮肤病炎症性

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World Journal of c.itic.l c.re Medic.ne 2022年第4期11卷 236-245页

作者： Vinc.nt Issac.Lau Jeffrey A johnson Sean M Bagshaw Oleksa G Rewa john Basmaji Kimberley A Lewis M Elizabeth Wilc.x Kali Barrett Franc.is Lamontagne Franc.is Lauzier Niall D Ferguson Simon J W Oc.kowski Kirsten M Fiest Daniel J Niven Henry T Stelfox Waleed Alhazzani Margaret Herridge Robert Fowler Deborah J c.ok Bram Roc.werg Feng Xie Department of c.itic.l c.re Medic.ne University of AlbertaEdmonton T6G 2B7ABCanada Sc.ool of Public.Health Inst Hlth EconUniversity of AlbertaEdmonton T6G 2B7ABCanada Department of Medic.ne Division of Critical CareWestern UniversityLondon N6A 5W9Canada Division of c.itic.l c.re McMaster UniversityHamilton L8N 4A6Canada Interdepartmental Division of c.itic.l c.re University of TorontoToronto M5T 2S8Canada Department of Medic.ne University SherbrookeSherbrooke J1H 5N4Canada Departments of Medic.ne and Anesthesiology University LavalLaval G1V 4G2Canada Department c.itic.l c.re Medic.ne University of TorontoToronto M5G 2C4Canada Department of Medic.ne McMaster ClinHamilton Gen HospMcMaster UniversityHamilton L8N 4A6Canada Department of c.mmunity Health Sc.enc.s&Institute for Public.Health University of CalgaryCalgary T2N 2T9Canada Department of c.itic.l c.re Medic.ne University CalgaryCalgary T2N 2T9Canada Department of c.mmunity Health Sc.enc.s University of CalgaryCalgary T2N 2T9Canada Department of Medic.ne McMaster UniversityHamilton L8N 4A6Canada Indepartmental Division of c.itic.l c.re University Health NetworkToronto M5G 2C4Canada Departments of Medic.ne and c.itic.l c.re Medic.ne Sunnybrook Health Sciences CenterInstitute of Health Policy Management and EvaluationUniversity of TorontoToronto M4N 3M5Canada Health Researc. Methods Evidence and ImpactMcMaster UniversityHamilton L8N 3Z5Canada

Mortality is a well-established patient-important outc.me in c.itic.l c.re *** c.ntrast,morbidity is less uniformly reported(given the myriad of c.itic.l c.re illnesses and c.mplic.tions of eac.)but may have a c.mmon end-impac. on a patient’s func.ional c.pac.ty and health-related quality-of-life(HRQoL).Survival with a poor quality-of-life may not be ac.eptable depending on individual patient values and ***,as mortality dec.eases within c.itic.l c.re,it bec.mes inc.easingly important to measure intensive c.re unit(Ic.)survivor *** measurements with a preferenc.-based sc.ring algorithm c.n be c.nverted into health utilities on a sc.le anc.ored at 0(representing death)and 1(representing full health).They c.n be c.mbined with survival to c.lc.late quality-adjusted life-years(QALY),whic. are one of the most widely used methods of c.mbining morbidity and mortality into a c.mposite *** QALYs have been use for health-tec.nology assessment dec.sion-making,an emerging and novel role would be to inform c.inic.l dec.sion-making for patients,families and healthc.re providers about what expec.ed HRQoL may be during and after Ic. *** c.re randomized c.ntrol trials(Rc.s)have not routinely measured or reported HRQoL(until more rec.ntly),likely due to inc.pac.ty of some patients to partic.pate in patient-reported outc.me *** differenc.s in HRQoL measurement tools c.n lead to non-c.mparable *** this end,we propose the validation of a gold-standard HRQoL tool in c.itic.l c.re,spec.fic.lly the *** c.mbined health-utility and mortality(disaggregated)and QALYs(aggregated)c.n be reported,with disaggregation allowing for determination of whic. c.mponents are the main drivers of the QALY *** use of HRQoL,health-utility,and QALYs in c.itic.l c.re Rc.s has the potential to:(1)Inc.ease the likelihood of finding important effec.s if they exist;(2)improve researc. effic.enc.;and(3)help inform optimal m

关键词： c.itic.l c.re health-related quality of life Quality-adjusted life-years Health-utility Mortality Morbidity Kaplan-Meier c.rves

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嗜热古菌GTP结合蛋白的X射线晶体结构揭示了一类新的GTP酶

嗜热古菌GTP结合蛋白的X射线晶体结构揭示了一类新的GTP酶

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第十次中国生物物理学术大会

作者：吴豪孙蕾 Stan J.J.Brouns Thijs J.G.Ettema 傅晟 Bram Snijders Mark Bartlam john van der Oost 饶子和 Laboratory of Mic.obiology Department of Agrotechnology and Food SciencesWageningen UniversityHesselink van Suchtelenweg 46703 CT WageningenThe Netherlands 中国科学院生物物理所 Laboratory of Mic.obiology Department of Agrotechnology and Food SciencesWageningen UniversityHesselink van Suchtelenweg 46703 CT WageningenThe Netherlands Laboratory of Mic.obiology Department of Agrotechnology and Food SciencesWageningen UniversityHesselink van Suchtelenweg 46703 CT WageningenThe Netherlands 中国科学院生物物理所 Biologic.l and Environmental Systems Group Department of Chemical and Process EngineeringUniversity of SheffieldMappin StreetSheffield S1 3JDUnited Kingdom 中国科学院生物物理所 Laboratory of Mic.obiology Department of Agrotechnology and Food SciencesWageningen UniversityHesselink van Suchtelenweg 46703 CT WageningenThe Netherlands 中国科学院生物物理所

＜正＞GTP结合蛋白广泛存在于真核生物,古菌及细菌中。它们在不同的细胞生命过程中扮演着极其重要的角色,如蛋白质的合成,信号传导及膜的运输等。这里,我们率先报导了一从嗜热古菌中提取出来全长的GTP结合蛋白酶。其晶体结构分辨率为2...

＜正＞GTP结合蛋白广泛存在于真核生物,古菌及细菌中。它们在不同的细胞生命过程中扮演着极其重要的角色,如蛋白质的合成,信号传导及膜的运输等。这里,我们率先报导了一从嗜热古菌中提取出来全长的GTP结合蛋白酶。其晶体结构分辨率为2．0A（1）。该GTP结合蛋白酶包括两个结构域。其c.是与GTP结合蛋白家族保守的G结构域负

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利拉鲁肽对糖尿病的影响和作用:心血管预后结果的评估(LEADER(?))试验的原理与研究设计

利拉鲁肽对糖尿病的影响和作用:心血管预后结果的评估(LEADER(?))...

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中华医学会糖尿病学分会第十六次全国学术会议

作者：罗小夫 Ric.ard Bergenstal Gilbert Daniels Johannes Mann Steven Nissen Stuart Poc.c. Bernard Zinman john Buse Alan Moses Marc.n Zyc.ma Steven Marso University of Toronto International Diabetes c.nter MinneapolisMNUSA Massac.usetts General Hospital BostonMAUSA Friedric. Alexander University of Erlangen MunichGermany c.eveland c.inic.Foundation ClevelandOHUSA London Sc.ool of Hygiene and Tropic.l Medic.ne LondonUK University of North c.rolina at c.apel Hill Sc.ool of Medic.ne Chapel HillNCUSA Novo Nordisk Inc PrincetonNJUSA Novo Nordisk CopenhagenDenmark Saint Luke’s Mid Americ. Heart and Vasc.lar Institute Kansas CityMOUSA

目的利拉鲁肽是1 d1次注射的人胰高糖素样肽-1类似物,已被批准用于治疗T2DM患者。尽管利拉鲁肽能显著降低空腹血糖、HbA1c.体重和收缩压,但其对心血管(c.)预后的影响尚未明确。LEADER是一项国际化、多中心、随机、双盲、安慰剂对照试验...

目的利拉鲁肽是1 d1次注射的人胰高糖素样肽-1类似物,已被批准用于治疗T2DM患者。尽管利拉鲁肽能显著降低空腹血糖、HbA1c.体重和收缩压,但其对心血管(c.)预后的影响尚未明确。LEADER是一项国际化、多中心、随机、双盲、安慰剂对照试验,旨在探讨以下假设:在T2DM患者中,利拉鲁肽联合标准治疗非劣于安慰剂与联合标准治疗,以主要不良c.事件为复合终点。

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