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Contact tracing-Old models and new challenges

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Infectious Disease modelling 2021年第1期6卷 222-231页

作者： johannes müller mirjam Kretzschmar mathematical Institute Technical University of MunichBoltzmannstr.385748GarchingGermany Institute for Computational Biology Helmholtz Center Munich85764NeuherbergGermany Julius Center for Health Sciences and Primary Care University Medical Center UtrechtUtrecht UniversityHeidelberglaan 1003584CXUtrechtthe Netherlands

Contact tracing is an effective method to control emerging infectious *** the 1980’s,modellers are developing a consistent theory for contact tracing,with the aim to find effective and efficient implementations,and to assess the effects of contact tracing on the spread of an infectious *** the progress made in the area,there remain important open *** addition,technological developments,especially in the field of molecular biology(genetic sequencing of pathogens)and modern communication(digital contact tracing),have posed new challenges for the modelling *** the present paper,we discuss modelling approaches for contact tracing and identify some of the current challenges for the field.

关键词： Contact tracing mathematical models

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Si掺杂HfO_2薄膜的铁电和反铁电性质

物理学报 2014年第11期63卷 286-290页

作者：周大雨徐进 johannes müller Uwe Schroder 大连理工大学材料科学与工程学院大连116024 大连东软信息学院电子工程系大连116023 德国弗劳恩霍夫光学微系统研究所纳米电子技术中心德累斯顿01109 德国德累斯顿工业大学纳米电子材料研究所德累斯顿01187

通过改变Si掺杂量制备出了具有显著铁电和反铁电特征的HfO2纳米薄膜,对其电滞回线、电容-电压和漏电流-电压特性以及物相温度稳定性进行了对比研究.反铁电薄膜的介电系数大于铁电薄膜,在电场加载和减载过程中发生的可逆反铁电-铁电相变... 详细信息

通过改变Si掺杂量制备出了具有显著铁电和反铁电特征的HfO2纳米薄膜,对其电滞回线、电容-电压和漏电流-电压特性以及物相温度稳定性进行了对比研究.反铁电薄膜的介电系数大于铁电薄膜,在电场加载和减载过程中发生的可逆反铁电-铁电相变导致了双电滞回线的出现,在室温至185℃的测试温度范围内未出现反铁电→顺电相变.在电流-电压特性测量时观察到的负微分电阻效应归因于极化弛豫等慢响应机理的贡献.

关键词： HfO2薄膜铁电反铁电相变

Changes in myocardial collagen content before and after left ventricular assist device application in dilated cardiomyopathy

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Chinese medical Journal 2004年第3期117卷 401-407页

作者：梁红 johannes müller 翁渝国 Gerd Wallukat 付平林汉生 Sabina Bartel Christoph Knosalla Reinhard Pregla Roland Hetzer Department of Cardiovascular and Thoracic Surgery Medical College of Jinan University Deutsches Herzzentrum Berlin max-Delbrück Centre for molecular medicine Department of Cardiovascular Surgery Institute of Cardiovascular Diseases Tongji Medical University Department of medical Statistics Medical College of Jinan University

BACKGROUND: The purposes of this study were to confirm the changes in myocardial collagen level after left ventricular assist device (LVAD) support in dilated cardiomyopathy (DCm), find the relation between these changes and prognosis, and test a practical method to assess the level of myocardial collagen. mETHODS: Left ventricular samples were collected from DCm patients with different prognosis (transplanted group n = 8, weaning group n = 10) at the time when the LVADs were implanted and again during cardiac transplantation (n = 8). The level of neutral salt soluble collagen (NSC) and acid soluble collagen (ASC) was measured by Sircol collagen assay, and that of total collagen and insoluble collagen (ISC) by quantification of hydroxyproline (Hyp). Serum samples were collected from a portion of these patients (transplanted group, n = 6; weaning group n = 7) at the time the LVADs were implanted, 1 month after implantation and on explantation. Circulating concentration of carboxy-terminal propeptide of type I procollagen (P I CP), amino-terminal propeptide of type I procollagen (P I NP), amino-terminal propeptide of type III procollagen (P III NP) and type I collagen telopeptide (I CTP) were measured by the equilibrium type radioimmunoassay. RESULTS: Before LVAD implantation the level of NSC and ISC in the weaning group was higher but ASC in the transplanted group was lower than in the controls (P

关键词： Heart-Assist Devices Adult Cardiomyopathy, Dilated Collagen Comparative Study Female Heart Transplantation Humans Hydroxyproline male middle Aged myocardium Procollagen Prognosis

Wear dependent virtual flow rate sensor for progressing cavity pumps with deformable stator

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Petroleum Science 2024年第2期21卷 1346-1353页

作者： Jens müller Sebastian Leonow johannes Schulz Christian Hansen martin monnigmann Ruhr-Universitat Bochum Universit atsstraûe 150Bochum44801Germany SEEPEX GmbH Scharnh olzstraûe 344Bottrop46240Germany

This contribution presents a novel wear dependent virtual flow rate sensor for single stage single lobe progressing cavity pumps. We study the wear-induced material loss of the pump components and the impact of this material loss on the volumetric efficiency. The results are combined with an established backflow model to implement a backflow calculation procedure that is adaptive to wear. We use a laboratory test setup with a highly abrasive fluid and operate a pump from new to worn condition to validate our approach. The obtained measurement data show that the presented virtual sensor is capable of calculating the flow rate of a pump being subject to wear during its regular operation.

关键词： Backflow Progressing cavity pump Virtual sensor Wear

movement analysis in the diagnosis and management of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 485-486页

作者： johannes Burtscher Nicolas Bourdillon Jules mJanssen Daalen Aurélien Patoz Julien FBally martin Kopp Davide malatesta Bastiaan RBloem Institute of Sport Sciences University of LausanneLausanneSwitzerland Radboud University medical Center Department of NeurologyDonders Institute for BrainCognition and BehaviorCenter of Expertise for Parkinson and Movement DisordersNijmegenThe Netherlands Radboud University medical Center Department of Medical BioSciencesNijmegenThe Netherlands Research and Development Department Volodalen Swiss Sport LabAigleSwitzerland Service of Neurology Department of Clinical NeurosciencesLausanne University Hospital(CHUV)and University of Lausanne(UNIL)LausanneSwitzerland Department of Sport Science University of InnsbruckInnsbruckAustria

Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall ***,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses *** biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024).

关键词： diagnosis Clinical eventually

Using machine learning models to explore the solution space of large nonlinear systems underlying flowsheet simulations with constraints

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Frontiers of Chemical Science and Engineering 2022年第2期16卷 183-197页

作者： Patrick Otto Ludl Raoul Heese johannes Höller Norbert Asprion michael Bortz Fraunhofer ITWm Optimization Department Kaiserslautern 67663Germany Chemical and Process Engineering BASF SE Ludwigshafen 67056Germany

Flowsheet simulations of chemical processes on an industrial scale require the solution of large systems of nonlinear equations,so that solvability becomes a practical *** constraints from technical,economic,environmental,and safety considerations may further limit the feasible solution space beyond the convergence requirement.A priori,the design variable domains for which a simulation converges and fulfills the imposed constraints are usually unknown and it can become very time-consuming to distinguish feasible from infeasible design variable choices by simply running the simulation for each *** support the exploration of the design variable space for such scenarios,an adaptive sampling technique based on machine learning models has recently been ***,that approach only considers the exploration of the convergent domain and ignores additional *** this paper,we present an improvement which particularly takes the fulfillment of constraints into *** successfully apply the proposed algorithm to a toy example in up to 20 dimensions and to an industrially relevant flowsheet simulation.

关键词： machine learning flowsheet simulations constraints exploration

Immunosuppression for in vivo research： state-of-the-at protocols and experimental approaches

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Cellular & molecular Immunology 2017年第2期14卷 146-179页

作者： Rita Diehl Fabienne Ferrara Claudia müller Antje Y Dreyer Damian D mcLeod Stephan Fricke johannes Boltze Fraunhofer-lnstitute for Cell Therapy and Immunology Leipzig 04103 Germany Institute of Vegetative Physiology Charite University Medicine and Center for Cardiovascular Research Berlin 10115 Germany University of Newcastle Callaghan NSW 2308 Australia Fraunhofer Research Institution for marine Biotechnolegy and Institute for medical and marine Bietechnolegy University of LObeck LObeck 23562 Germany These authors contributed equally to this work

Almost every experimental treatment strategy using non-autologous cell, tissue or organ transplantation is tested in small and large animal models before clinical translation. Because these strategies require immunosuppression in most cases, immunosuppressive protocols are a key element in transplantation experiments. However, standard immunosuppressive protocols are often applied without detailed knowledge regarding their efficacy within the particular experimental setting and in the chosen model species. Optimization of such protocols is pertinent to the translation of experimental results to human patients and thus warrants further investigation. This review summarizes current knowledge regarding immunosuppressive drug classes as well as their dosages and application regimens with consideration of species-specific drug metabolization and side effects. It also summarizes contemporary knowledge of novel immunomodulatory strategies, such as the use of mesenchymal stem cells or antibodies. Thus, this review is intended to serve as a state-of-the-art compendium for researchers to refine applied experimental immunosuppression and immunomodulation strategies to enhance the predictive value of preclinical transplantation studies.

关键词： animal models immunomodulation immunosuppression transplantation translational research

Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis

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World Journal of Gastroenterology 2014年第47期20卷 17839-17850页

作者： Yvette Simon Sonja m Kessler Katja Gemperlein Rainer m Bohle Rolf müller johannes Haybaeck Alexandra K Kiemer Department of Pharmacy Pharmaceutical BiologySaarland University66123 SaarbrückenGermany medical University of Graz Institute of PathologyGraz 8036Austria Department of Pharmacy Pharmaceutical BiotechnologySaarland University and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)Helmholtz Centre for Infection Research (HZI)66123 SaarbrückenGermany Saarland University Department of Pathology66421 HomburgGermany

AIm: To characterize how insulin-like growth factor 2 (IGF2) mRNA binding protein p62/ImP2-2 promotes steatohepatitis in the absence of dietary cholesterol.

关键词： Insulin-like growth factor 2 mRNA binding protein 2-2 methionine/choline deficient Non-alcoholic fatty liver disease Filipin Iron

Abundance of insects and aerial insectivorous birds in relation to pesticide and fertilizer use

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Avian Research 2021年第3期12卷 412-420页

作者： Anders Pape møller Dorota Czeszczewik Einar Flensted-Jensen johannes Erritzøe Indrikis Krams Karsten Laursen Wei Liang Wiesław Walankiewicz Ecologie Systématique Evolution UniversitéParis-SudCNRSAgroParisTechUniversitéParis-Saclay91405 Orsay CedexFrance ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijing 100875China Faculty of Exact and Natural Sciences Institute of Biological SciencesSiedlce University of Natural Sciences and Humanitiesul.B.Prusa 1408-110 SiedlcePoland Cypresvej 1 9700 BrønderslevDenmark House of Bird Research Taps6070 ChristiansfeldDenmark Department of Biotechnology Daugavpils UniversityDaugavpils 5401Latvia Department of Bioscience Aarhus UniversityGrenåvej 148410 RøndeDenmark ministry of Education Key Laboratory for Ecology of Tropical Islands Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikou 571158China

Background:The abundance of insects has decreased considerably during recent decades,resulting in current abundance showing 70-80%reductions in more than 15 studies across temperate climate *** reduc-tions in the abundance of insects are likely to have consequences for other taxa at higher trophic levels such as preda-tors and ***,fertilizers and agricultural land use are likely candidates accounting for such reductions in the abundance of ***:Here we surveyed the abundance of flying insects,and the reduction in the abundance of insects as a consequence of intensive reduction in agricultural practice linked to fertilizer use and pesticide *** we dem-onstrated consistency in abundance of birds among study ***:We demonstrated that the use of fertilizers and pesticides had reduced the abundance of insects,with consequences for the abundance of insectivorous bird species such as Barn Swallows(Hirundo rustica),House martins(Delichon urbicum)and Swifts(Apus apus).Juvenile Barn Swallows were negatively affected by the reduced abundance of insects and hence the reproductive success of insectivorous bird *** effects imply that the abundance of insects could be reduced by the availability of insect ***:These effects of intensive agriculture on insect food abundance are likely to have negative impacts on populations of insects and their avian *** hypothesis was validated by a reduction in the abundance of insects,linked to an increase in the abundance of fertilizers and a general change in farming practice.

关键词： Aerial insectivores Fecundity of insects Insect abundance Insectivores,Insects