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chronic peripheral inflammation: a possible contributor to neurodegenerative diseases

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Neural Regeneration Research 2021年第9期16卷 1711-1714页

作者： Patrick Süβ Addison J.Lana johannes c.m.schlachetzki Department of molecular Neurology Friedrich-Alexander-University Erlangen-NürnbergUniversity Hospital ErlangenErlangenGermany Department of cellular and molecular medicine University of California San DiegoLa JollaCAUSA

The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question. Sustained activation of the peripheral innate and adaptive immune systems occurs in the context of a broad array of disorders ranging from chronic infectious diseases to autoimmune and metabolic diseases. In addition, progressive systemic inflammation is increasingly recognized during aging. Peripheral immune cells could potentially modulate the cellular brain environment via the secretion of soluble molecules. There is an ongoing debate whether peripheral immune cells have the potential to migrate into the brain under certain permissive circumstances. In this perspective, we discuss the possible contribution of chronic peripheral inflammation to the pathogenesis of age-related neurodegenerative diseases with a focus on microglia, the resident immune cells of the brain parenchyma.

关键词： aging Alzheimer's disease inflammation innate immune system microglia neurodegeneration Parkinson's disease

Summer Warming Limited Bud Output Drives a Decline in Daughter Shoot Biomass through Reduced Photosynthetis of Parent Shoots in Leymus chinensis Seedlings

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1667-1675页

作者： Song Gao Ruocheng Xu Lin Li Jiao Wang Nian Liu johannes m.H.Knops Junfeng Wang Graduate School Changchun UniversityChangchun130022China Key Laboratory of Vegetation Ecology Ministry of EducationInstitute of Grassland ScienceSchool of Life SciencesJilin Songnen Grassland Ecosystem National Observation and Research StationNortheast Normal UniversityChangchun130024China Jilin Agricultural Radio and Television School Changchun130599China Department of Health and Environmental Sciences Xi’an Jiaotong Liverpool UniversitySuzhou215000China

Understanding how summer warming inﬂuences the parent and daughter shoot production in a perennial clonal grass is vital for comprehending the response of grassland productivity to global ***,we conducted a simulated experiment using potted Leymus chinensis,to study the relationship between the photosynthetic activ-ity of parent shoots and the production of daughter shoots under a whole(90 days)summer warming scenario(+3°c).The results showed that the biomass of parents and buds decreased by 25.52%and 33.45%,respectively,under warming *** reduction in parent shoot biomass due to warming directly resulted from decreased leaf area(18.03%),chlorophyll a(18.27%),chlorophyll b(29.21%)content,as well as a reduction in net photosynthetic rate(7.32%)and the maximum quantum efﬁciency of photosystem II(PSII)photochemistry(4.29%).The decline in daughter shoot biomass was linked to a decrease in daughter shoot number(33.33%)by ***,the number of belowground buds increased by 46.43%.The results indicated that long-term summer warming reduces biomass accumulation in parent shoot by increasing both limitation of stoma and ***,the parent shoot allocates relatively more biomass to the belowground organs to maintain the survival and growth of ***,buds,as a potential aboveground population,could remedy for the cur-rent loss of parent shoot density by increasing the number of future daughter shoots if summer warming subsides.

关键词： Warming parent shoot bud bank photosynthesis chlorophyllﬂuorescence Leymus chinensis

Effect of Processing and cultivar on Thermo-chemical Properties of Australian-Grown Hemp Hurd(cannabis sativa L.)

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Journal of Renewable materials 2024年第8期12卷 1475-1493页

作者： johannes Fehrmann Benoit Belleville Barbara Ozarska maya Ismayati Wahyu Dwianto School of Agriculture Food and Ecosystem Sciences(SAFES)Faculty of ScienceThe University of MelbourneMelbourne3121Australia Research center for Biomass and Bioproducts National Research and Innovation Agency(BRIN)Jakarta16911Indonesia

This study explored the thermo-chemical properties of industrial hemp hurd with different provenances,maturity stages,and retting *** findings were then compared to hemp hurd used in the fabrication of citric acid-bonded ultra-low-density hemp hurd ***-gas chromatography-mass spectrometry(Py-Gc/mS),Fourier-transform infrared spectroscopy(FTIR),and thermogravimetric analysis(TGA)were employed to document the variability of the hurd and comprehend the potential impact on biobased composite *** choice of cultivar,maturity stage,and processing modality significantly influenced the chemical composition,presence of functional groups,and thermal stability of the ***-Gc/mS revealed substantial variations in the lignin-to-carbohydrate(L/c)ratio,along with the absence of fatty acids in certain *** FTIR signals confirmed consistent functional groups,differences in peak intensities were indicative of carbohydrate variations associated with maturity and retting duration,impacting the availability of hydroxyl groups for,i.e.,interparticle bonding in citric acid-based ***,it was observed that shorter retting durations initially enhanced the thermal resistance,but prolonged retting led to accelerated degradation,significantly reducing the hurd’s residual *** findings indicated notable differences among the samples,emphasizing the importance of investigating variables such as provenance/cultivar,maturity,and processing *** assessment is essential to ensure effective agronomic practices that align the raw material characteristics with the specific requirements of intended applications,such as the fabrication of biobased hemp hurd composites.

关键词： Hemp hurd material characterization chemical analysis thermal analysis

clinical-based phenotypes in children with pediatric post-cOVID-19 condition

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World Journal of Pediatrics 2024年第7期20卷 682-691页

作者： Lieke c.E.Noij Jelle m.Blankestijn coen R.Lap marlies A.van Houten Giske Biesbroek Anke-Hilse maitland-van der Zee mahmoud I.Abdel-Aziz johannes B.van Goudoever mattijs W.Alsem caroline L.H.Brackel Kim J.Oostrom Simone Hashimoto Suzanne W.J.Terheggen-Lagro Department of Pediatric Pulmonology and Allergy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands Department of Pulmonary medicine Amsterdam UMCAmsterdamThe Netherlands Department of Pediatrics Spaarne GasthuisHoofddorpThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands Department of Rehabilitation medicine Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands Department of Paediatric Pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands Department of child and Adolescent Psychiatry and Psychosocial care Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Background Pediatric post coronavirus disease 2019(cOVID-19)condition(PPcc)is a heterogeneous syndrome,which can significantly affect the daily lives of *** study aimed to identify clinically meaningful phenotypes in children with PPcc,to better characterize and treat this *** Participants were children with physician-diagnosed PPcc,referred to the academic hospital Amsterdam Umc in the Netherlands between November 2021 and march *** factors and information on post-cOVID symptoms,comorbidities,and impact on daily life were *** clusters were identified using an unsupervised and unbiased approach for mixed data *** Analysis of 111 patients(aged 3–18 years)revealed three distinct clusters within *** 1(n=62,median age=15 years)predominantly consisted of girls(74.2%).These patients suffered relatively more from exercise intolerance,dyspnea,and smell *** 2(n=33,median age=13 years)contained patients with an even gender distribution(51.5%girls).They suffered from relatively more sleep problems,memory loss,gastrointestinal symptoms,and *** 3(n=16,median age=11 years)had a higher proportion of boys(75.0%),suffered relatively more from fever,had significantly fewer symptoms(median of 5 symptoms compared to 8 and 10 for clusters 1 and 2 respectively),and experienced a lower impact on daily *** This study identified three distinct clinical PPcc phenotypes,with variations in sex,age,symptom patterns,and impact on daily *** findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-cOVID symptoms in children.

关键词： Adolescents clusters Long cOVID Pediatric Phenotypes Post-cOVID syndrome

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： carina Hromada Patrick Heimel markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier monforte johannes c.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGcs). However, the use of tNGcs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGc would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGcs and compared the various features of these improved silk^(+) tNGcs with the tubes without holes(silk^(–) tNGcs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGcs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGcs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGcs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGcs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Towards cr（VI）-free anodization of aluminum alloys for aerospace adhesive bonding applications： A review

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Frontiers of chemical Science and Engineering 2017年第3期11卷 465-482页

作者： Shoshan T. Abrahami John m.m. de Kok Herman Terryn johannes m.c. mol materials innovation institute (m2i) 2628 XG Delft The Netherlands Delft University of Technology Department of Materials Science and Engineering 2628 CD Delft The Netherlands Fokker Aerostructures BV 3351 LB Papendrecht The Netherlands Department of materials and chemistry Research Group Electrochemical and Surface Engineering (SURF) Vrije Universiteit Brussel 1050 Brussels Belgium

For more than six decades, chromic acid anodizing （cAA） has been the central process in the surface pre-treatment of aluminum for adhesively bonded aircraft structures. Unfortunately, this electrolyte contains hexavalent chromium （cr（VI））, a compound known for its toxicity and carcinogenic properties. To comply with the new strict international regulations, the cr（VI）-era will soon have to come to an end. Anodizing aluminum in acid electrolytes produces a self-ordered porous oxide layer. Although different acids can be used to create this type of structure, the excellent adhesion and corrosion resistance that is currently achieved by the complete cr（VI）-based process is not easily matched. This paper provides a critical overview and appraisal of proposed alternatives to cAA, including combinations of multiple anodizing steps, pre- and post anodizing treatments. The work is presented in terms of the modifications to the oxide properties, such as morphological features （e.g., pore size, barrier layer thickness） and surface chemistry, in order to evaluate the link between fundamental principles of adhesion and bond performance.

关键词： aluminum cr(VI)-free surface pre-treat- merits anodizing adhesive bonding

Long-term deterioration of lubricant-infused nanoporous anodic aluminium oxide surface immersed in Nacl solution

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Journal of materials Science & Technology 2021年第5期64卷 57-65页

作者： Dequan Wu Lingwei ma Bei Liu Dawei Zhang Badar minhas Hongchang Qian Herman A.Terryn johannes m.c.mol Beijing Advanced Innovation centre for materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Department of materials and chemistry Research Group Electrochemical and Surface EngineeringVrije Universiteit BrusselBrusselsBelgium Department of materials Science and Engineering Delft University of TechnologyDelftthe Netherlands

This study investigated the deterioration of a lubricant-infused anodic aluminium oxide surface in a 1m Nacl solution for~200 *** observation by cryo-SEm and quantitative analyses by UV spectroscopy and EIS revealed that the long-term deterioration of the lubricant-infused surface was divided into two stages:the surface-adhered lubricant layer gradually dissolved at a constant rate until the substrate was exposed;afterwards the lubricant infused in the nanochannels began to diffuse and was depleted after~200 *** EIS results also revealed that the defects reduced the corrosion resistance of the lubricant-infused surface considerably.

关键词： Lubricant-infused surface Anodic aluminium oxide Deterioration EIS

Disruption of colonic barrier function and induction of mediator release by strains of campylobacter jejuni that invade epithelial cells

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World Journal of Gastroenterology 2008年第48期14卷 7345-7352页

作者： johannes Beltinger Jo del Buono maeve m Skelly John Thornley Robin c Spiller William A Stack christopher J Hawkey Wolfson Digestive Diseases centre Nottingham University Hospital QMC Campus

AIm: To study the mechanisms by which campylobacter jejuni (c. jejuni) causes inflammation and diarrhea. In particular, direct interactions with intestinal epithelial cells and effects on barrier function are poorly under- stood. mETHODS: To model the initial pathogenic effects of c. jejuni on intestinal epithelium, polarized human colonic HcA-7 monolayers were grown on permeabilized filters and infected apically with clinical isolates of c. jejuni. Integrity of the monolayer was monitored by changes in monolayer resistance, release of lactate dehydrogenase, mannitol fluxes and electron microscopy. Invasion of HcA-7 cells was assessed by a modified gentamicin protection assay, translocation by counting colony forming units in the basal chamber, stimulation of mediator release by immunoassays and secretory responses in monolayers stimulated by bradykinin in an Ussing chamber. RESULTS: All strains translocated across monolayers but only a minority invaded HcA-7 cells. Strains that invaded HcA-7 cells destroyed monolayer resistance over 6 h, accompanied by increased release of lactate dehydrogenase, a four-fold increase in permeability to [3H] mannitol, and ultrastructural disruption of tight junctions, with rounding and lifting of cells off the filter membrane. Synthesis of interleukin (IL)-8 and prostaglandin E2 was increased with strains that invaded the monolayer but not with those that did not. cONcLUSION: These data demonstrate two distinct effects of c. jejuni on colonic epithelial cells and provide an informative model for further investigation of initial host cell responses to c. jejuni.

关键词： campylobacter jejuni cell invasion cellculture chloride secretion colonocyte HcA-7 cells membrane permeability monolayer mucosal barrier Ussing chamber

Noni juice is not hepatotoxic

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World Journal of Gastroenterology 2006年第22期12卷 3616-3619页

作者： Brett J West c Jarakae Jensen johannes Westendorf Research and Development Department Tahitian Noni International American ForkUtahUnited States University medical School of Hamburg Department of Toxicology HamburgGennany

Noni juice （morinda citrifolia） has been approved for use as a safe food within the European Union, following a review of safety. Since approval, three cases of acute hepatitis in Austrian noni juice consumers have been published, where a causal link is suggested between the liver dysfunction and ingestion of anthraquinones from the plant. measurements of liver function in a human clinical safety study of TAHITIAN NONI Juice, as well as subacute and subchronic animal toxicity tests revealed no evidence of adverse liver effects at doses many times higher than those reported in the case studies. Additionally, m. citrifolia anthraquinones occur in the fruit in quantities too small to be of any toxicological significance. Further, these do not have chemical structures capable of being reduced to reactive anthrone radicals, which were implicated in previous cases of herbal hepototoxicity. The available data reveals no evidence of liver toxicity.

关键词： Noni juice morinda citrifolia Novel food Human clinical safety study