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The innate immune system in Parkinson's disease:a novel target promoting endogenous neuroregeneration

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Neural Regeneration Research 2015年第5期10卷 704-706页

作者： johannes CM Schlachetzki Jürgen Winkler Department of Molecular Neurology Friedrich-AlexanderUniversity (FAU) Erlangen-Nürnberg University Hospital Erlangen

Parkinson＇s disease （PD） is a slowly progressing neuro- degenerative disorder clinically defined by key symptoms like bradykinesia, rigidity, resting tremor, and postural instability. Reduction of dopaminergic terminals in the caudate nucleus and putamen, i.e., the striatum, accom- panied by decreased striatal levels of dopamine, and most likely consecutive degeneration of dopaminergic neurons in the substantia nigra pars compacta （SNpc） are tightly linked to the onset of the motor symptoms. With the etiology of PD largely not yet well defined, there is accu- mulating evidence for increased immune activation in PD. The majority of studies favor a detrimental effect of microglia, the resident innate immune cells of the brain, on PD pathogenesis. In the presence of alpha-synuclein, inflammatory responses elicited by microglia may be initiated by pattern recognition receptors, e.g.,

关键词： SVZ GFAP PD

Evaluation of Transmission Losses of Various Battery Electric Vehicles

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Automotive Innovation 2022年第4期5卷 388-399页

作者： johannes Hengst Matthias Werra Ferit KüÇükay Institute of Automotive Engineering TU BraunschweigBraunschweigGermany

Transmission losses in battery electric vehicles have compared to internal combustion engine powertrains a larger share in the total energy consumption and play therefore a major ***,the power flows not only during propulsion through the transmissions,but also during recuperation,whereby efficiency improvements have a double *** investigation of transmission losses of electric vehicles thus plays a major *** this paper,three simulation models of the Institute of Automotive Engineering(the lossmap-based simulation model,the modular simulation model,and the 3D simulation model)are *** lossmap-based simulation model calculates transmission losses for electric and hybrid transmissions,where three spur gear transmission concepts for battery electric vehicles are *** transmission concepts include a single-speed transmission as a reference and two two-speed ***,the transmission lossmaps are integrated into the modular simulation model(backward simulation)and in the 3D simulation model(forward simulation),which improves the simulation *** modular simulation model calculates the optimal operation of the transmission concepts and the 3D simulation model represents the more realistic behavior of the transmission *** different transmission concepts are investigated in Worldwide Harmonized Light Vehicle Test Cycle and evaluated in terms of transmission losses as well as the total energy *** map-based simulation model allows the transmission losses to be broken down into the individual component losses,thus allowing transmission concepts to be examined and evaluated in terms of their efficiency in the early development stage to develop optimum powertrains for electric axle *** considering transmission losses in detail with a high degree of accuracy,less efficient concepts can be eliminated at an early development *** a result,only relevant concepts are built as prototypes,which reduce

关键词： Battery electric vehicle(BEV) Transmission losses Efficiency analysis WLTC Backward simulation Forward simulation Energy consumption

A Sub-element Adaptive Shock Capturing Approach for Discontinuous Galerkin Methods

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Communications on Applied Mathematics and Computation 2023年第2期5卷 679-721页

作者： johannes Markert Gregor Gassner Stefanie Walch Department for Mathematics and Computer Science University of CologneWeyertal 86-9050931 CologneGermany Department for Mathematics and Computer Science Center for Data and Simulation ScienceUniversity of CologneWeyertal 86-9050931 CologneGermany I.Physikalisches Institut Center for Data and Simulation ScienceUniversity of CologneZülpicher Str.7750937 CologneGermany

In this paper,a new strategy for a sub-element-based shock capturing for discontinuous Galerkin(DG)approximations is *** idea is to interpret a DG element as a col-lection of data and construct a hierarchy of low-to-high-order discretizations on this set of data,including a first-order finite volume scheme up to the full-order DG *** dif-ferent DG discretizations are then blended according to sub-element troubled cell indicators,resulting in a final discretization that adaptively blends from low to high order within a single DG *** goal is to retain as much high-order accuracy as possible,even in simula-tions with very strong shocks,as,e.g.,presented in the Sedov *** framework retains the locality of the standard DG scheme and is hence well suited for a combination with adaptive mesh refinement and parallel *** numerical tests demonstrate the sub-element adaptive behavior of the new shock capturing approach and its high accuracy.

关键词： High-order methods Discontinuous Galerkin spectral element method Finite volume method Shock capturing Astrophysics Stellar physics

Semi-stable Extensions Over 1-dimensional Bases

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Acta Mathematica Sinica,English Series 2018年第1期34卷 103-113页

作者： Janos KOLLAR johannes NICAISE Chen Yang XU Department of Mathematics Princeton University Department of Mathematics Imperial CollegeSouth Kensington Campus Beijing International Center of Mathematics Research

Given a family of Calabi-Yau varieties over the punctured disc or over the field of Laurentseries, we show that, after a finite base change, the family can be extended across the origin while keeping the canonical class trivial. More generally, we prove similar extension results for families whose log-canonical class is semi-ample. We use these to show that the Berkovich and essential skeleta agree for smooth varieties over C（（t）） with semi-ample canonical class.

关键词： Semi-stable extension Laurent series essential skeleton

Model of an iron ore sinter plant with selective waste gas recirculation

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Carbon Resources Conversion 2022年第1期5卷 71-83页

作者： johannes Niel Bernd Weiss Walter Wukovits TU Wien Institute of ChemicalEnvironmental and Bioscience EngineeringGetreidemarkt 9/1661060 ViennaAustria Primetals Primetals Technologies Austria GmbHLinzAustria

The use of sinter influences hot metal production substantially and significantly affects an integrated steel mill’s total emissions. Sintering of iron ores is an enormousenergy-intensive and resources consuming process. Introducing a selective waste gas recirculation (SWGR) to the sintering process reduces the energy consumption,stack gas volume flow, and sulfur dioxide emissions of an iron sinter production. Simulating this complex process in flowsheet simulations of integrated iron andsteelworks is a fast and cost-effective opportunity to validate new operation settings. The implementation of a sinter plant in gPROMS ModelBuilder®characterizesthe sintering processes by three main sub-models. A burner model describes the gas combustion, a black-box model consider the main sintering processes, and a windbox model divides the total off-gas into a recycle gas and a stack gas. A specific temperature polynomial represents the temperature distribution across the wind boxesto allow detailed investigations on SWGR in complex flowsheet simulations. Implementing SWGR to the sintering process, the model shows a reduction of cokeconsumption, stack gas flow rate, and sulfur dioxide emissions by 11%, 27%, and 27%, respectively. In the SWGR scenario, the utilization rate of carbon monoxideincreases and less coke is consumed. The chlorine emissions of the sintering process differ with and without SWGR insignificantly.

关键词： dioxide monoxide consuming

Energy Disaggregation of Industrial Machinery Utilizing Artificial Neural Networks for Non-intrusive Load Monitoring

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Energy and AI

Energy and AI 2024年第3期17卷 342-356页

作者： Philipp Pelger johannes Steinleitner Alexander Sauer Fraunhofer Institute for Manufacturing Engineering and Automation IPA Stuttgart 70569Germany Institute for Energy Efficiency in Production(EEP) University of StuttgartStuttgart 70569Germany

This paper explores the application of non-intrusive load monitoring techniques in the industrial sector for disaggregating the energy consumption of machinery in manufacturing processes. With an increasing focus on energy efficiency and decarbonization measures, achieving energy transparency in production becomes crucial. Utilizing non-intrusive load monitoring, energy data analysis and processing can provide valuable insights for informed decision-making on energy efficiency improvements and emission reductions. While non-intrusive load monitoring has been extensively researched in the building and residential sectors, the application in the industrial manufacturing domain needs to be further explored. This paper addresses this research gap by adapting established non-intrusive load monitoring techniques to an industrial dataset. By employing artificial neural networks for energy disaggregation, the determination of energy consumption of industrial machinery is made possible. Therefore, a generally applicable cross-energy carrier method to disaggregate the energy consumption of machinery in manufacturing processes is developed using a design science research approach and validated through a practical case study utilizing a compressed air demonstrator. The results show that the utilization of artificial neural networks is well-suited for energy disaggregation of industrial data, effectively identifying on and off states, multi-level states and continuously variable states. Non-intrusive load monitoring should be further considered in the research of emerging artificial intelligence technologies in energy consumption evaluation. It can be a viable alternative for intrusive load monitoring and is a prerequisite to installing energy meters for every machine.

关键词： Non-intrusive load monitoring Energy transparency Energy consumption evaluation Industrial manufacturing Artificial neural networks

Implications of fine water mist environment on the post-detonation processes of a PE4 explosive charge in a semi-confined blast chamber

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Defence Technology（防务技术） 2018年第5期14卷 366-372页

作者： Zetu Jiba Tleyane Jonas Sono Frederik johannes Mostert Council for Scientific and Industrial Research (CSIR) Defence Peace Safety and Security

The effects of a fine water mist environment in a semi-confined blast chamber on the chemical and thermodynamic processes following detonation of a 20 g PE4 explosive charge have been *** effects were quantified by the analysis of pressure profiles recorded where several parameters including arrival time of the shock at the sensors, peak overpressures, specific impulse of the positive phase, period of the negative phase and the specific impulse of the multiple reflections were *** effect of the fine water mist on the arrival time, peak pressures and the specific impulse of the positive phase agrees with previous findings in literature. In this paper, the focus is on the implications of the fine water mist on the negative phase and the impulse of multiple pressure reflections. The period of the negative phase was found to have increased by 40% and with higher negative peak pressure in the mist condition compared to the atmospheric condition. The activities of the multiple pressure reflections were found to have decreased considerably, both in number and in amplitude leading to lower impulses(by about 60%) for the water mist conditions.

关键词： Fine water mist Blast mitigation Semi-confined blast chamber Negative phase pressure Multiple pressure reflections

Contribution of Fluid Dynamics to Woodwind Instruments Investigations of Timbre and Pitch of Bassoon Bocals

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Journal of Thermal Science 2005年第3期14卷 264-266页

作者： Roger GRUNDMANN johannes BAUMGART Andreas RICHTER Hans KRüGER Technische Universitt Dresden Institute for Aerospace Engineering D-01062 Dresden Germany ProfessorTechnische Universitt Dresden Institute for Aerospace Engineering D-01062 Dresden GermanyTechnische Universitt Dresden Institute for Aerospace Engineering D-01062 Dresden GermanyTechnische Universit?t Dresden Institute for Aerospace Engineering D-01062 Dresden Germany

The discussed topic of isolating certain parameters which describe the timbre in connection with bocals of bassoons is of major interest for manufacturers and artist likewise since a reduction in the overall shear stress of these kinds of technical diffusors is very helpful but not sufficient. The timbre seen from the side of the musician has to be the same. Up to now two criteria have been isolated which have a deep influence on the easier blowing of the bassoon and on the comparable timbre due to geometrical reasons. If the geometrical outer contour is designed carefully, it is possible to modify the shape and preserve the timbre.

关键词： musical instrument bocal bassoon timbre principal component analysis

Four-dimensional light shaping: manipulating ultrafast spatiotemporal foci in space and time

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Light(Science & Applications) 2017年第1期6卷 293-299页

作者： Bangshan Sun Patrick S Salter Clemens Roider Alexander Jesacher johannes Strauss johannes Heberle Michael Schmidt Martin J Booth Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK Institute of Photonic Technologies Friedrich-Alexander-University Erlangen-NurembergKonrad-Zuse-Strasse 3/5Erlangen 91052Germany Division of Biomedical Physics Innsbruck Medical UniversityMullerstrasse 44Innsbruck 6020Austria Graduate School in Advanced Optical Technologies(SAOT) Friedrich-Alexander University Erlangen-NurembergPaul-Gordan-Strasse 6Erlangen 91052Germany Centre for Neural Circuits and Behaviour University of OxfordMansfield RoadOxford OX13SRUK

The spectral dispersion of ultrashort pulses allows the simultaneous focusing of light in both space and time,which creates socalled spatiotemporal *** space–time coupling may be combined with the existing holographic techniques to give a further dimension of control when generating focal light *** the present study,it is shown that a phase-only hologram placed in the pupil plane of an objective and illuminated by a spatially chirped ultrashort pulse can be used to generate threedimensional arrays of spatio-temporally focused *** exploiting the pulse front tilt generated at focus when applying simultaneous spatial and temporal focusing(SSTF),it is possible to overlap neighboring foci in time to create a smooth intensity *** resulting light field displays a high level of axial confinement,with experimental demonstrations given through two-photon microscopy and the non-linear laser fabrication of glass.

关键词： laser material processing light shaping spatiotemporal focusing ultrafast lasers