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Cancer Communications 2022年第7期42卷 673-676页

作者： Johannes Diers Laura Acar johanna C.Wagner Philip Baum Mohammed Hankir Sven Flemming Carolin kastner Christoph-Thomas Germer Helmut L’hoest Ursula Marschall Johan Friso Lock Armin Wiegering Department of General VisceralTransplantationVascular and Pediatric SurgeryUniversity HospitalUniversity of WuerzburgWuerzburg 97080Germany Department Medizin und Versorgungsforschung Institut fuer GesundheitssystemforschungBarmerWuppertal 42275Germany Department of Biochemistry and Molecular Biology University ofWuerzburgWuerzburg 97074Germany Comprehensive Cancer Centre Mainfranken University of Wuerzburg Medical CentreWuerzburg 97080Germany

Dear Editor,The coronavirus disease of 2019(COVID-19)pandemic has necessitated that semi-urgent and elective medical cases,including cancer screenings,are postponed in hospitals worldwide to accommodate the increasing number of patients with severe COVID-19 symptoms[1-4].Consequently,several reports from the first COVID-19 wave in spring 2020 showed a significant decrease in new cancer diagnoses as well as cancer therapy and screenings[5,6].

关键词： diagnosis cancer Cancer

Modelling growing space of four valuable broadleaved tree species in southern China

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Forestry Studies in China 2013年第3期15卷 167-178页

作者： johanna SCHULER Josephine CUENI Heinrich SPIECkER Wen-Fu GUO Faculty of Environment and Natural Resources Albert-Ludwigs-Universitt Sci-Tech Division of the Experimental Centre for Tropical Forestry Chinese Academy of Forestry

We present management tools for growing four valuable broadleaved tree species, indigenous to *** southern China. Crown diameter （CD） of the species studied can be predicted very well by using a model that is so e y a near funct on of d ameter at breast he ght （DBH）. The add t on of tree age （AGE） and yield class （YC） to this-nodel did not significantly improve its predictive capacity. We used species-specific crown diameter models to calcu- ate the amount of growing space and subsequently stand density that each species needs to achieve desired stem ＂adial growth rates. Furthermore we used this information to calculate a ＂distance factor＂, a rule of thumb that roughly ~stimates the distance between two neighboring trees needed to achieve a desired future target diameter. These tools ＇acilitate the planning of thinning regimes by using crown diameter models combined with annual radial growth rates to ;alculate the number of crop trees per hectare required to reach a desired target stem diameter.

关键词： crown diameter diameter growth growth model valuable timber management tool

Proteomics reveals differential adsorption of angiogenic platelet lysate proteins on calcium phosphate bone substitute materials

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Regenerative Biomaterials 2022年第1期9卷 636-649页

作者： Richard da Costa Marques johanna Simon Cyril d’Arros katharina Landfester kerstin Jurk Volker Mailänder Dermatology Clinic University Medical Center of the Johannes Gutenberg-University Mainz55131 MainzGermany Max Planck Institute for Polymer Research 55128 MainzGermany INSERM UMR 1229Regenerative Medicine and SkeletonONIRISUniversitéde Nantes44042 NantesFrance Biomatlante—Advanced Medical Solutions Group Plc 44360 Vigneux-de-BretagneFrance Center for Thrombosis and Hemostasis(CTH) University Medical Center of the Johannes Gutenberg-University Mainz55131 MainzGermany

Protein adsorption on biomaterials for bone substitution,such as calcium phosphates(CaP),evokes biological responses and shapes the interactions of biomaterials with the surrounding biological *** adsorb when CaP materials are combined with growth factor-rich hemoderivatives prior to implantation to achieve enhanced angiogenesis and stimulate new bone ***,the identification of the adsorbed proteins and their angiogenic effect on bone homeostasis remain incompletely *** this study,we analyzed the adsorbed complex protein composition on CaP surfaces when using the hemoderivatives plasma,platelet lysate in plasma(PL),and washed platelet lysate proteins(wPL).We detected highly abundant,non-regenerative proteins and anti-angiogenic proteins adsorbed on CaP surfaces after incubation with PL and wPL by liquid chromatography and mass spectrometry(LC–MS)***,we measured a decreased amount of adsorbed pro-angiogenic growth *** formation assays with human umbilical endothelial cells demonstrated that the CaP surfaces only stimulate an angiogenic response when kept in the hemoderivative medium but not after washing with *** results highlight the necessity to correlate biomaterial surfaces with complex adsorbed protein compositions to tailor the biomaterial surface toward an enrichment of pro-angiogenic factors.

关键词： protein adsorption calcium phosphates proteomics angiogenesis platelet lysate

Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps

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World Journal of Gastroenterology 2012年第41期18卷 5905-5911页

作者： johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad Department of Medicine Duke University Medical CenterDurham NC 27705 United States Duke Clinical Research Institute DurhamNC 27705 United States Department of Pathology Duke UniversityMedical Center Durham NC 27705 United States Durham VA Medical Center Durham NC 27705United States

AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white ***:This is a single-center comparative effectiveness pilot ***(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy *** were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous *** determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous *** diagnosis was the gold standard ***:One hundred and three small polyps,detected from forty-three patients,were included in the *** average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include "lymphoid aggregates","non-specific colitis," and "no pathologic diagnosis." Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging *** endoscopist demonstrated a significant learning effect with i-SCAN during the *** endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B de

关键词：数字高清晰度结肠镜白光病理组织学诊断肉效益特征平均风险

高原鼠兔(Ochotona curzoniae)及对其种群的人工控制对高寒草原鸟类群落结构的影响

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Journal of Resources and Ecology 2023年第1期14卷 46-56页

作者： JOSEPH P.LAMBERT johanna V.HARTMANN 时坤 PHILIP RIORDAN 北京林业大学生态与自然保护学院野生动物研究所北京100083 南安普顿大学生物学院英国南安普顿SO171BJ Marwell Wildlife 英国温切斯特罕布什尔SO211JH 陆桥生态中心北京100083

中国的青藏高原地区是鸟类保护的重要区域,也是许多特有种和濒危物种赖以繁衍、栖息的家园。在全球范围内,群居穴居哺乳动物的存在对生活在干旱草原生态系统中的鸟类的种群结构都有着至关重要的影响。高原鼠兔(Ochotona curzoniae)便是... 详细信息

中国的青藏高原地区是鸟类保护的重要区域,也是许多特有种和濒危物种赖以繁衍、栖息的家园。在全球范围内,群居穴居哺乳动物的存在对生活在干旱草原生态系统中的鸟类的种群结构都有着至关重要的影响。高原鼠兔(Ochotona curzoniae)便是其中的代表物种之一,其集群筑巢的行为为青藏高原地区的许多鸟类提供了丰富的生存资源。然而,鼠兔被当地牧民视作有害物种,并被列为人工灭杀的目标物种之一,鼠兔种群的急剧下降可能对当地鸟类群落造成显著影响。本研究在甘肃盐池湾国家级自然保护区开展了鸟类群落调查,旨在研究鸟类群落结构的差异与鼠兔洞穴群存在与否的关系。为此,本研究将调查点按照鼠兔洞穴的有(群落中)无(群落外),以及鼠兔群落是否已被灭杀进行分类。综合运用非度量多维标定法(NMDS)、置换多元方差分析(PERMANOVA),以及秩和检验(Wilcoxon rank-sum tests)进行分析,结果显示,分布在鼠兔群落已被灭杀和未被灭杀的调查点的鸟类群落在结构上不存在显著差异。另一方面,本研究在“群落中”和“群落外”观测到的鸟类群落结构则存在显著的差异,且此差异具有统计学意义。在有鼠兔集群的调查点中观测到了10个物种,而只有角百灵(Eremophila alpestris)被持续观测到出现在“群落外”。有6个物种在“群落中”的物种多度显著高于“群落外”。虽然本研究结果无法证实盐池湾地区开展的鼠兔种群控制行动直接改变了当地鸟类群落的结构,但鼠兔群落的存在无疑为鸟类提供了不可或缺的生存资源。

关键词：鸟类群落生态学生态系统工程师高原鼠兔青藏高原

Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: Effect of H pylori treatment

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World Journal of Gastroenterology 2003年第12期9卷 2706-2710页

作者： johanna M.Mkinen Seppo Niemel Tuomo kerola Juhani Lehtola Tuomo J.karttunen Department of Pathology University of OuluOuluFinland Department of Internal Medicine Oulu University HospitalOuluFinland Department of Pathology Lnsi-Pohja Central HospitalKemiFinland

AIM: Lymphocytic gastritis is commonly ass ociated with Helicobacter pylori infection. The presence of glandular atrophy and foveolar hyperplasia in lymphocytic gastritis suggests abnormalities in cell proliferation and differentiation,forming a potential link with the suspected association with gastric cancer. Our aim was to compare epithelial cell proliferation and morphology in H pylori associated lymphocytic gastritis and H pylori gastritis without features of lymphocytic gastritis,and to evaluate the effect of H pylori ***: We studied 14 lymphocytic gastritis patients with H pylori infection. For controls, we selected 14 matched dyspeptic patients participating in another treatment trial whose H pylori infection had successfully been *** groups were treated with a triple therapy and followed up with biopsies for 6-18 months (patients) or 3 months (controls). Blinded evaluation for histopathological features was carried out. To determine the cell proliferation index,the sections were labeled with ki-67 ***: Before treatment, lymphocytic gastritis was characterized by foveolar hyperplasia (P=0.001) and glandular atrophy in the body (P=0.008), and increased proliferation in both the body (P=0.001) and antrum (P=0.002). Proliferation correlated with foveolar hyperplasia and inflammation activity. After eradication therapy, the number of intraepithelial lymphocytes decreased in the body (P=0.004)and antrum (P=0.065), remaining higher than in controls (P＜0.001). Simultaneously, the proliferation index decreased in the body from 0.38 to 0.15 (P=0.043), and in the antrum from 0.34 to 0.20 (P=0.069), the antral index still being higher in lymphocytic gastritis than in controls (P=0.010).Foveolar hyperplasia and glandular atrophy in the body improved (P=0.021), reaching the non-LG ***: In lymphocytic gastritis, excessive epithelial cell proliferation is predominantly present in the body, where it associates with foveola

关键词：上皮细胞细胞增殖淋巴细胞胃炎幽门螺杆菌腺性萎缩

Suspicious brush cytology is an indication for liver transplantation evaluation in primary sclerosing cholangitis

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World Journal of Gastroenterology 2017年第33期23卷 6147-6154页

作者： Sonja Boyd Marko Vannas kalle Jokelainen Helena Isoniemi Heikki Makisalo Martti A Farkkila johanna Arola Department of Pathology University of Helsinki and Helsinki University Hospital Transplantation and Liver Surgery Clinic University of Helsinki and Helsinki University Hospital Clinic of Gastroenterology University of Helsinki and Helsinki University Hospital

AIM To investigate markers for high-grade dysplasia for the optimal timing of liver transplantation in patients with primary sclerosing cholangitis(PSC).METHODS Earlier data support a dysplasia-carcinoma sequence,even low-to high-grade dysplasia,in PSC-associated cholangiocarcinoma(CCA). Surveillance using endoscopic retrograde cholangiography(ERC) and brush cytology aims to detect cases of biliary dysplasia,and liver transplantation is an option in cases with suspicion of malignancy in brushing. This study investigated markers to identify patients with highgrade biliary dysplasia for optimal timing in early liver transplantation. Patients undergoing surveillance using ERC and brush cytology during 2008-2014 and who were diagnosed with biliary dysplasia in explanted liver or CCA until February 2016 were included in the study. Demographic data,cholangiography findings,laboratory values,cytological morphology and DNA ploidy were *** Thirty PSC patients had biliary neoplasia in the explanted liver during the study period. Sixteen of these patients had low-grade dysplasia,10 patients had high-grade dysplasia,and 4 patients had CCA. Fifteen PSC patients diagnosed with CCA were not transplanted. Patients with low-grade dysplasia were younger. Alkaline phosphatase or carcinoembryonic antigen values did not differ between groups during surveillance,but carbohydrate antigen 19-9 was higher in CCA patients. No difference in PSC duration,ERC scores,suspicious cytology,or ploidy analysis was found between groups. No difference was observed between fibrosis stage in explanted livers. Low-and high-grade dysplasia could not be differentiated before liver transplantation based on liver enzymes,tumour markers,ERC scores,brush cytology or DNA *** Repeated suspicion of neoplasia in brush cytology should be an indication for evaluations of liver transplantation prior to the development of CCA.

关键词： Endoscopic retrograde cholangiography Brush cytology Cholangiocarcinoma Biliary dysplasia

阅读目标和阅读任务对读者眼动的影响(中文)

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心理与行为研究 2011年第1期9卷 24-34页

作者： Jukka Hyn johanna k.kaakinen University of Turku

We review two studies examining task effects on eye guidance during reading. The first study investigated effects of reading perspective on eye behavior in reading. It demonstrated that both the initial encoding of words as well as the later integration stage of wrapping up the sentence meaning are influenced by the reading perspective. Early effects of reading perspective were observed both in saccadic programming and in fixation times and were primarily seen when reading a text of familiar content. In the second study, effects of reading task were examined by comparing eye movements between proofreading and reading for comprehension. Task effects appeared very early in the processing time line; both temporal and spatial aspects of eye movements were affected. Taking together, the two studies demonstrate that readers make a global adjustment to eye behavior on the basis of reading task or goal.

关键词：心理学行为研究理论

Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing

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Bone Research 2022年第3期10卷 469-481页

作者： Mubashir Ahmad Benjamin Thilo krüger Torsten kroll Sabine Vettorazzi Ann-kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen kumar Tangudu David Carro Vázquez johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann Institute of Comparative Molecular Endocrinology(CME) Ulm UniversityHelmholtzstrasse 8/189081 UlmGermany Institute of Orthopedic Research and Biomechanics Ulm UniversityHelmholtzstrasse 1489081 UlmGermany Leibniz Institute on Aging–Fritz Lipmann Institute(FLI) Beutenbergstrasse 11D-07745 JenaGermany Praxisklinik für Orthopädie Unfall-und Neurochirurgie Prof.Bischoff/Dr.Spies/Dr.Mengele89231 Neu-UlmGermany Paracelsus Medizinische Privatuniverstät Institute of PharmacyStrubergasse 215020 SalzburgAustria Department of Endocrinology Ludwig Maximilians University MunichMunich 80336Germany Present address:Institute of Orthopedic Research and Biomechanics Ulm UniversityHelmholtzstrasse 1489081 UlmGermany Present address:UPMC Hillman Cancer Center Department of Pharmacology and Chemical BiologyUniversity of Pittsburgh5115 Center Avenue15232 PittsburghPAUSA Present address:TAmiRNA GmbH Leberstrasse 201110 ViennaAustria

Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPk pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing.

关键词： Cdk5 healing expression

Effects of undigested protein-rich ingredients on polarised small intestinal organoid monolayers

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Journal of Animal Science and Biotechnology 2020年第4期11卷 1026-1032页

作者： Soumya k.kar Bart van der Hee Linda M.P.Loonen Nico Taverne johanna J.Taverne-Thiele Dirkjan Schokker Mari A.Smits Alfons J.M.Jansman Jerry M.Wells Host Microbe Interactomics Group Wageningen University&ResearchDe Elst 16708 WD WageningenThe Netherlands Laboratory of Microbiology Wageningen University&ResearchStippeneng 46708 WE WageningenThe Netherlands Wageningen Livestock Research Wageningen University&ResearchDe Elst 16708 WD WageningenThe Netherlands

Here, we describe the use of monolayers of intestinal epithelial cells derived from intestinal organoids and transcriptomics to investigate the direct effects of dietary protein sources on epithelial function. Mechanically dissociated 3 D organoids of mouse duodenum were used to generate a polarized epithelium containing all cell types found in the tissue of origin. The organoid-derived cell monolayers were exposed to 4%(w/v) of ‘undigested(non-hydrolysed)-soluble' fraction of protein sources used as feed ingredients [soybean meal(SBM) and casein], or alternative protein sources(spray dried plasma protein, and yellow meal worm), or controls for 6 h prior to RNA isolation and transcriptomics. All protein sources altered expression of unique biological processes in the epithelial cells. Exposure of intestinal organoids to SBM downregulated expression of retinol and retinoid metabolic processes as well as cholesterol and lipid biosynthetic pathways, consistent with the reported hypotriglyceridaemic effect of soy protein in vivo. These findings support the use of intestinal organoids as models to evaluate complex interactions between dietary ingredients and the intestinal epithelium and highlights some unique host effects of alternative protein sources in animal feed and potentially human food.

关键词： Alternative protein sources Casein Intestinal organoids Organoids Soybean meal Spray dried plasma protein Transcriptomics Yellow meal worm