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socioecological drivers facilitating biodiversity conservation in traditional farming landscapes

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Ecosystem Health and sustainability 2015年第9期1卷 8-17页

作者： Ine Dorresteijn Jacqueline Loos Jan Hanspach joern Fischer Faculty of sustainability Leuphana University LuneburgScharnhorststraße 121335 LuneburgGermany

Traditional farming landscapes have evolved as tightly coupled socioecological systems that support high ***,land-use change severely threatens the high biodiversity of these *** nature conservation in such landscapes requires a thorough understanding of the key drivers underpinning *** empirical research on mammals,birds,butterflies,and plants in a traditional cultural landscape in Romania,we revealed seven hypothesized drivers facilitating biodiversity *** proportions of three main land-use types support the landscape species pool,most likely through habitat connectivity and frequent spillover between land-use *** complementation and supplementation provide additional habitat for species outside their core *** of woody vegetation cover and gradients in land-cover heterogeneity provide mosaic landscapes with wide ranges of *** land-use practices underpin landscape heterogeneity,traditional land-use elements such as wood pastures,and human-carnivore ***-down predator control may limit herbivore ***,cultural ties between humans and nature have a central influence on people’s values and sustainable use of natural *** approaches should aim to maintain or restore these socioecological drivers by targeting the heterogeneous character of the forest-farmland mosaic at large scales through"broad and shallow"conservation *** large-scale measures should be complemented with"deep and narrow"conservation measures addressing specific land-use types,threats,or *** both cases,conservation measures should integrate the entire socioecological system,by recognizing and strengthening important links between people and the environment.

关键词： countryside biogeography coupled human and natural systems cultural landscapes human–environment systems landscape ecology resilience Romania special Feature:Ecosystem Management in Transition in Central and Eastern Europe Transylvania

The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes

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Cellular & Molecular Immunology 2021年第5期18卷 1211-1221页

作者： Carolin Wiechers Mangge Zou Eric Galvez Michael Beckstette Maria Ebel Till strowig Jochen Huehn joern Pezoldt Department Experimental Immunology Helmholtz Centre for Infection ResearchBraunschweigGermany Department Microbial Immune Regulation Helmholtz Centre for Infection ResearchBraunschweigGermany Department of Computational Biology for Individualised Medicine Centre for Individualised Infection MedicineHelmholtz Centre for Infection Research and Hannover Medical SchoolHannoverGermany Cluster of Excellence REsIsT(EXC 2155) Hannover Medical SchoolHannoverGermany Laboratory of systems Biology and Genetics École Polytechnique Fédérale de LausanneLausanneSwitzerland

Intestinal Foxp3+regulatory T cell(Treg)subsets are crucial players in tolerance to microbiota-derived and food-borne antigens,and compelling evidence suggests that the intestinal microbiota modulates their generation,functional specialization,and *** bacterial species and microbiota-derived metabolites,such as short-chain fatty acids(sCFAs),have been reported to promote Treg homeostasis in the intestinal lamina ***,gut-draining mesenteric lymph nodes(mLNs)are particularly efficient sites for the generation of peripherally induced Tregs(pTregs).Despite this knowledge,the direct role of the microbiota and their metabolites in the early stages of pTreg induction within mLNs is not fully ***,using an adoptive transfer-based pTreg induction system,we demonstrate that neither transfer of a dysbiotic microbiota nor dietary sCFA supplementation modulated the pTreg induction capacity of *** mice housed under germ-free(GF)conditions displayed equivalent pTreg induction within *** molecular characterization of these de novo induced pTregs from mLNs by dissection of their transcriptomes and accessible chromatin regions revealed that the microbiota indeed has a limited impact and does not contribute to the initialization of the Treg-specific epigenetic ***,our data suggest that the microbiota is dispensable for the early stages of pTreg induction within mLNs.

关键词： Peripheral regulatory T cells Microbiota Tolerance

Integrated Assessment of Natural Hazards, Including Climate Change’s Influences, for Cultural Heritage sites: The Case of the Historic Centre of Rethymno in Greece

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International Journal of Disaster Risk science 2019年第3期10卷 343-361页

作者： Mohammad Ravankhah Rosmarie de Wit Athanasios V.Argyriou Angelos Chliaoutakis Maria Joao Revez joern Birkmann Maja Zuvela-Aloise Apostolos sarris Anastasia Tzigounaki Kostas Giapitsoglou Institute of spatial and Regional Planning(IREUs-Institut fur Raumordnung und Entwicklungsplanung) University of Stuttgart70174 StuttgartGermany Central Institution for Meteorology and Geodynamics(ZAMG-Zentralanstalt fur Meteorologie und Geodynamik) 1190 ViennaAustria Geosat ReseArch Lab IMS-ORTH(Geophysical-SatelliteRemote Sensing and Archaeoenvironment LabInstitute for Mediterranean Studies-Foundation for Research and TechnologyHellas)74100 RethymnoGreece Nova Conservacao S.A.1200-872LisbonPortugal The Archaeological Research Unit Department of Historyand ArchaeologyUniversity of Cyprus1678 NicosiaCyprus Ephorate of Antiquities of Rethymno 74100 RethymnoGreece

Within the framework of disaster risk management, this article proposes an interdisciplinary method for the analysis of multiple natural hazards, including climate change’s influences, in the context of cultural heritage. A taxonomy of natural hazards applicable to cultural heritage was developed based on the existing theoretical and conceptual frameworks. sudden-onset hazards, such as earthquakes and floods, and slow-onset hazards, such as wetting–drying cycles and biological contamination, were incorporated into the hazard assessment procedure. Future alteration of conditions due to climate change, such as change in heat waves’ duration, was also taken into account. The proposed hazard assessment framework was applied to the case of the Historic Centre of Rethymno, a city on the northern coast of the island of Crete in Greece,to identify, analyze, and prioritize the hazards that have the potential to cause damage to the center’s historic structures. The assessment procedure includes climate model projections, GIs spatial modeling and mapping, and finally a hazard analysis matrix to enable the sharing of a better understanding of multiple hazards with the *** results can facilitate decision making by providing the vulnerability and risk analysis with the nature and spatial distribution of the significant hazards within the study area and its setting.

关键词： Climate change analysis Crete Cultural heritage protection Greece Hazard assessment Historic centre of Rethymno Risk assessment

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组织工程化人工神经实验研究

中国创伤骨科杂志 2000年第4期2卷 290-292页

作者：沈尊理 BERGER Alfred HIERNER Robert LOHMEYER joern ALLMELING Christina WALTER F.Gerhard 上海市第一人民医院整形外科上海市200080 德国汉诺威医学院整形手重建外科德国汉诺威医学院神经病理研究所

目的研究组织工程化人工神经修复大鼠2.5cm长坐骨神经缺损的效果。方法 21只2月龄Lewis lw雌性大鼠随机分成三个神经移植组,每组7只。A组:种植同源雪旺细胞并具有内部支架结构的胶原神经管,即组织工程化人工神经。B组:无雪旺细胞但具... 详细信息

目的研究组织工程化人工神经修复大鼠2.5cm长坐骨神经缺损的效果。方法 21只2月龄Lewis lw雌性大鼠随机分成三个神经移植组,每组7只。A组:种植同源雪旺细胞并具有内部支架结构的胶原神经管,即组织工程化人工神经。B组:无雪旺细胞但具有内部支架结构的胶原神经管。C组:自体神经移植组。术后六个月,进行系列神经电生理监测,神经肌肉组织学观察,s-100和神经微丝蛋白(Neurofilament)免疫组化染色,轴突计数等检查。结果在A组和C组移植神经上均能诱发出波幅明显的神经肌肉复合动作电位(CMAP),再生轴突已通过移植神经全长,远端肌肉轻度萎缩。而B组中没有或仅记录到极小波幅的CMAP,移植神经远端结缔纤维组织增生,再生轴突罕见,所支配肌肉明显萎缩。结论初步结果显示:组织工程化人工神经可用来修复大鼠长段神经缺损。

关键词：组织工程神经移植雪旺氏细胞培养神经管

组织工程化人工神经修复长段神经缺损实验的初步报告

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中华手外科杂志 2001年第2期17卷 112-115页

作者：沈尊理 Berger Alfred Hierner Robert Lohmeyer joern Allmeling Christina Walter F.Gerhard 上海市第一人民医院整形外科 200080 Clinic of Plastic Hand and Reconstructive SurgeryHannover MedicalSchool Institute of europathology

目的　研究组织工程化人工神经修复大鼠 2 .5cm长坐骨神经缺损的效果。方法　 90只 2个月月龄的Lewis 1W雌性大鼠 ,按手术先后顺序随机分成 3个神经移植组 ,每组 3 0只。A组 :用种植同源雪旺细胞并具有内部支架结构的胶原神经管桥接 ,... 详细信息

目的　研究组织工程化人工神经修复大鼠 2 .5cm长坐骨神经缺损的效果。方法　 90只 2个月月龄的Lewis 1W雌性大鼠 ,按手术先后顺序随机分成 3个神经移植组 ,每组 3 0只。A组 :用种植同源雪旺细胞并具有内部支架结构的胶原神经管桥接 ,即组织工程化人工神经组。B组 :用无雪旺细胞但具有内部支架结构的胶原神经管桥接 ,即对照组。C组 :自体神经移植组。术后 6个月 ,进行神经电生理监测 ,神经肌肉组织学观察 ;用s 10 0和神经微丝蛋白免疫组化染色后 ,行轴突计数等检测。结果　完成对 2 1只大鼠 (每组 7只 )的实验评估。从A组和C组的胫前肌中均能诱发出波幅明显的神经肌肉复合动作电位 (CMAP) ,再生轴突已通过移植段神经全长 ,远端肌肉轻度萎缩。B组中则没有或仅记录到波幅很低的CMAP ,移植神经远端结缔纤维组织增生 ,再生轴突罕见 ,所支配肌肉明显萎缩。结论　组织工程化人工神经可用来修复大鼠长段神经缺损。

关键词：神经移植许旺氏细胞细胞培养组织工程

Observatory science with eXTP

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science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 97-138页

作者： Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria sala Giulia stratta Thomas M.Tauris joern wil.s XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni sudip Bhattacharyya stefano Bianchi Anna Bilous Pere Blay Joao Braga sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del santo Valerio D'Elia Tiziana Di salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle s.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.Osborne Luigi Pacciani stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig sRON Netherlands Institute for space Research Department of Astronomy University of Geneva Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences school of Astronomy and space science Nanjing University INAF-IAsF Bologna AsI Via del Politecnico snc INAF-Istituto di Astrofisica e Planetologie spaziali Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen NAsA Goddard space Flight Center ICREA&Institute of space sciences(IEEC-CsIC) Campus UABCarrer de Can Magrans CsPAR SPA University of Alabama in Huntsville Department of Physics Texas Tech University INAF Osservatorio Astronomico di Capodimonte Leiden Observatory Leiden University Anton Pannekoek Institute University of Amsterdam AsTRON Netherlands Institute for Radio Astronomy Universitat Politecnica de Catalunya(UPC-IEEC) Universitádegli studi di Urbino‘Carlo Bo’ Max-Planck-Institut für Radioastronomie Dr.Karl-Remeis-sternwarte and Erlangen Centre for Astroparticle Physics(ECAP) Friedrich Alexander Universit?t Erlangen-Nurnberg Purple Mountain Observatory Chinese Academy of Sciences Instituto de Astrofysíca de Andalucia-CsIC Department of Physics and Astronomy University of Southampton IRAP Universitéde ToulouseCNRSUPSCNES Mathematical sciences and sTAG Research Centre University of Southampton New York University Abu Dhabi Center for Relativistic Astrophysics School of PhysicsGeorgia Institute of Technology Physics Department Middle East Technical University Department of Physics Technion-Israel Institute of Technology INAF Osservatorio Astronomico di Brera Tata Institute of Fundamental Research Dipartimento di Matematica e Fisica Universitàdegli Studi Roma Tre Instituto de Astrofísica de Canarias Instituto Nacional de Pesquisas Espaciais-INPE National space Institute Technical University of Denmark(DTU Space) Department of Physics and Astronomy Michigan State University INAF Osservatorio Astrofisico di Arcetri Dipartimento di Fisica Universitádegli Studi di Cagliari Department of Physics and A

In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of science, the eXTP mission is expected to be launched in the mid 2020s.

关键词： space research in struments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar winds cataclysmic binaries X-ray binaries supernova remnants active galactic nuclei X-ray bursts gamma-ray bursts gravitational waves