检索结果-南通市图书馆

Journal of Materials Science & Technology 2021年第24期83卷 248-255页

作者： L.T.Zhang Y.J.Duan T.Wada H.Kato J.M.pelletier D.Crespo E.Pineda J.C.Qiao School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710072China Institute for Materials Research Tohoku UniversitySendai980-8577Japan Universitéde Lyon MATEISUMR CNRS5510Bat.B.PascalINSA-LyonF-69621Villeurbanne CedexFrance Department of Physics Barcelona Research Center in Multiscale Science and TechnologyInstitute of Energy TechnologiesUniversitat Politècnica de Catalunya08019BarcelonaSpain

Non-equiatomic high entropy bulk metallic glasses were reported recently and show unique mechanical and physical *** mechanical relaxation behavior of Zr_(35)Hf_(17.5)Ti_(5.5)Al_(12.5)Co_(7.5)Ni_(12)Cu_(10)high entropy bulk metallic glass was investigated by dynamic mechanical analysis(DMA)and the mechanical spectra could be well described by the quasi-point defects(QPD)*** to typical metallic glasses,the intensity of theβrelaxation of Zr_(35)Hf_(17.5)Ti_(5.5)Al_(12.5)Co_(7.5)Ni_(12)Cu_(10)high entropy bulk metallic glass is lower due to the sluggish *** the same time,the correlation factor is higher than that of conventional metallic glasses and this is ascribed to the high configuration *** parallel,physical aging below the glass transition temperature leads to a decrease of atomic mobility,caused by a decrease of the concentration of defects.

关键词： High entropy bulk metallic glass Mechanical relaxation Quasi-point defects Physical aging

Adalimumab and pharmacokinetics:Impact on the clinical prescription for inflammatory bowel disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Pharmacology 2016年第1期5卷 44-50页

作者： Anne-Laure pelletier Pascale Nicaise-Roland Department of Hepato-gastroenterology H?pital Bichat-Claude Bernard Department of Immunology Autoimmunité et Hypersensibilités H?pital Bichat-Claude Bernard

Anti-tumor necrosis factor(TNF) drugs are widely prescribed for inflammatory disease. A loss of response to adalimumab is frequent and the pharmacokinetics of anti-TNF therapy have important implications for patient management. Individual factors such as albumin, body weight, and disease severity based on the C-reactive protein level influence drug metabolism. Adalimumab trough levels are associated with clinical remission. On the other hand, the detection of antibodies is associated with clinical relapse. Immunosuppressive therapy could reduce antibody formation although the clinical impact is not proven. New algorithms are available to provide personalized treatment and adapt the dosage. More data are needed on dose de-escalation.

关键词： Pharmacokinetics Adalimumab Crohn's disease

Analysis of the anelastic deformation of high-entropy Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20) metallic glass under stress relaxation and recovery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第12期107卷 82-91页

作者： Y.J.Duan L.T.Zhang T.Wada H.Kato E.Pineda D.Crespo J.M.pelletier J.C.Qiao School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an 710072China Department of Physics Institute of Energy TechnologiesUniversitat Politècnica de CatalunyaBarcelona 08019Spain Institute for Materials Research Tohoku UniversitySendai 980-8577Japan Universitéde Lyon MATEISUMR CNRS5510Bat.B.PascalINSA-LyonF-69621 Villeurbanne CedexFrance

The anelastic deformation behavior of Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20) high-entropy metallic glass was probed by monitoring the stress relaxation and recovery processes. The stress relaxation under consecutive strain steps can be described by the Kohlrausch-Williams-Watts(KWW) function. In addition, considering a hierarchy of relaxation processes related to the structural heterogeneity, a constitutive model is proposed in order to describe the whole process of stress relaxation and determine the contribution of different time scales. Moreover, a crossover from stochastic activation to percolation of flow defects with the ultimate strain can be observed during stress relaxation process. The anelastic recovery process after a strain step is studied as a function of the initial strain level and characterized by means of a direct spectrum analysis. The peaks in the recovery time-spectra revealed the evolution of flow defects in Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20) high-entropy metallic glass. The understanding of the atomic free-volume zones effect and the anelastic deformation provides important insight into how atomic structural features affect the deformation behavior of high-entropy metallic glasses, and may provide a new avenue into the improvement of their mechanical properties.

关键词： High-entropy metallic glass Stress relaxation Anelastic deformation Flow defects Free-volume zones

若干非天然产C_(19)-二萜生物碱的结构及其核磁共振谱的研究

在线全文

学校读者我要写书评

暂无评论

华西药学杂志 1989年第4期4卷 193-200页

作者：王锋鹏 pelletier S W 华西医科大学药学院天然药物化学教研室 Institute for Natural Products Research The University of Georgia Athens GA 30602 U. S. A.

根据光谱分析确定了16个非天然产二萜生物碱1-16的结构。指定了化合物1-9、12-16的氢谱和1-10、12-14的碳谱。有趣的是N-氧化物8在乙酰氯(-5℃,2日)作用下生成去氮乙基化合物15。讨论了化合物12-16形成的可能反应机理。

关键词：二萜生物碱结构核磁共振谱

Reliability and sensitivity to change of IW-TSE versus DESS magnetic resonance imaging sequences in the assessment of bone marrow lesions in knee osteoarthritis patients: Longitudinal data from the Osteoarthritis Initiative (OAI) cohort

在线全文

学校读者我要写书评

暂无评论

Journal of Biomedical Science and Engineering 2013年第3期6卷 337-345页

作者： Jean-Pierre Raynauld Lukas Martin Wildi Francois Abram Thomas Moser Jean-Pierre pelletier Johanne Martel-pelletier Osteoarthritis Research Unit University of Montreal Hospital Research Center(CRCHUM)MontrealCanada Department of Rheumatology University Hospital of ZurichZurichSwitzerland Imaging Research&Development ArthroLab Inc.MontrealCanada Department of Radiology University of Montreal Hospital Centre(CHUM)MontrealCanada

Background: Bone marrow lesions (BMLs) are associated with osteoarthritis (OA). We assessed the performance of two commonly used MRI sequences, IW-TSE and DESS, for reliability in the detection of BMLs and sensitivity to estimate change over time. We suggested that the IW-TSE would demonstrate higher sensitivity to change than DESS in the assessment of BML prevalence and change over time. This study was performed using a subset of the Osteoarthritis Initiative (OAI) cohort. Methods: A sub-group of 144 patients was selected from the OAI progression cohort who all had IW-TSE and DESS MRI acquisitions at baseline and 24 months. BMLs were assessed using a semi-quantitative scale in the global knee, medial and lateral compartments, and subregions. Intra-reader reliability was assessed on a subset of 51 patients. Results: Intra-reader reliability was substantial for the global knee ≥ 0.64, medial ≥ 0.70, and lateral ≥ 0.63 compartments for IW-TSE and DESS. The prevalence of BML detected at baseline was only slightly greater for IW-TSE compared to DESS. The mean BML score at baseline was significantly higher (p ≤ 0.006) for the IW-TSE than the DESS. However, mean change at 24 months was similar for both sequences for all regions except the medial compartment (p = 0.034) and medial femur (p = 0.015) where they were significantly higher for DESS than IW-TSE. Moreover, the prevalence of BML change at 24 months was similar in all regions except the global knee (p = 0.047) and the lateral tibial plateau (p = 0.031). Conclusion: This study does not suggest superior sensitivity to change of one sequence over the other for almost all the regions. The only difference is a higher BML mean change over time detected by the DESS sequence in the medial compartment and femur. These data bring into perspective that both sequences seem equivalent regarding their use for the assessment of BML in clinical trials.

关键词： Osteoarthritis Magnetic Resonance Imaging Bone Marrow Lesions

TWO COMPLEXES BETWEEN ELECTRON TRANSFER PARTNERS,CYTOCHROME C PEROXIDASE AND CYTOCHROME

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

TWO COMPLEXES BETWEEN ELECTRON TRANSFER PARTNERS,CYTOCHROME ...

Low phospholipid-associated cholelithiasis syndrome:A rare cause of acute pancreatitis that should not be neglected

Sixteenth Congress of the International Union of Crystallography

作者： C.H.pelletier Department of Chemistry University of California/San DiegoLa JollaCalifornia

＜正＞The crystal structure of a 1:1 complex between yeast cytochrome c peroxidase and yeast iso-1-cytochrome c has been determined at 2.3 A resolution and refined to a crystallographic R-factor of 17.2%. This structure reveals a possible electron transfer pathway unlike any previously proposed for this extensively studied redox *** one of the closest interprotein contacts the exposed heme methyl

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Hepatology 2020年第6期12卷 312-322页

作者： Nicolas Gille Pascale Karila-Cohen Gaël Goujon Dimitrios Konstantinou Samia Rekik Hakim Bécheur Anne-Laure pelletier Department of Hepato-Gastroenterology and Digestive Oncology AP-HP Bichat University HospitalParis 75018France Department of Radiology AP-HP Bichat University HospitalParis 75018France

BACKGROUND Low phospholipid-associated cholelithiasis(LPAC)syndrome is a very particular form of biliary lithiasis with no excess of cholesterol secretion into bile,but a decrease in phosphatidylcholine secretion,which is responsible for stones forming not only in the gallbladder,but also in the *** syndrome may be underreported due to a lack of testing resulting from insufficient awareness among *** To describe the clinical and radiological characteristics of patients with LPAC syndrome to better identify and diagnose the *** We prospectively evaluated all patients aged over 18 years old who were consulted or hospitalized in two hospitals in Paris,France(Bichat University Hospital and Croix-Saint-Simon Hospital)between January 1,2017 and August 31,*** patients whose profiles led to a clinical suspicion of LPAC syndrome underwent a liver ultrasound examination performed by an experienced radiologist to confirm the diagnosis of LPAC ***-four patients were *** about the patients’general characteristics,their medical history,their symptoms,and their blood tests results were collected during both their initial hospitalization and *** and cholestasis were expressed compared to the normal values(N)of serum aspartate and alanine transaminase activities,and to the normal value of alkaline phosphatase level,*** subjects were systematically reevaluated and asked about their symptoms 6 mo after inclusion in the study through an in-person medical appointment or phone *** testing was not performed systematically,but according to the decision of each *** Most patients were young(median age of 37 years),male(58%),and not overweight(median body mass index was 24).Many had a personal history of acute pancreatitis(54%)or cholecystectomy(42%),and a family history of gallstones in first-degree relatives(30%).LPAC syndrome was identified primarily in patients with recurring bilia

关键词： Low phospholipid-associated cholelithiasis syndrome Acute pancreatitis Cholelithiasis Echography Ursodeoxycholic acid

Performances of a Bitumen Fume and Condensate Generation System for Sampling Method Development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Protection 2016年第7期7卷 973-984页

作者： Benjamin Sutter Eric pelletier Christel Ravera Eddy Langlois Pollutants Metrology Institut National de Recherche et Sécurité Vandoeuvre-Les-Nancy France

A laboratory system was designed to generate bitumen fumes and expose tested samplers in a homogenised chamber. The system was also designed to condense the fumes in the form of oil that could be used as a standard for further analytical method development. The laboratory system was evaluated in terms of stability, repeatability, aging, and ranges, focusing on the quality and quantity of the fumes and their physical characteristics. The fumes generated with the laboratory system were also compared to fumes emitted at workplaces to evaluate their similarity. The results demonstrated that laboratory fume generation was stable and repeatable. Humidity ranged from 20% to 80% RH and the total fume concentration ranged from 0.01 to 9.36 mg.m-3, covering the conditions encountered for road paving worksites. The fumes generated in the laboratory were found to be similar to those of workplaces, with slight differences in light compounds equivalent to C12 and below n-alkanes. Thus, the system designed in this study is considered capable of generating bitumen fumes used to develop sampling and analysis methods.

关键词： Bitumen Fumes Laboratory Generation Condensate Generation Road Paving

Investigation into a practical approach and application of cotton fiber elongation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cotton Research 2023年第1期6卷 13-24页

作者： DELHOM Christopher D. WANJURA John D. pelletier Mathew G. HOLT Gregory A. HEQUET Eric F. USDA-ARS New OrleansLA 70124USA USDA-ARS LubbockTX 79403USA Texas Tech University LubbockTX 79409USA

Background The strength of cotton fiber has been extensively studied and significantly improved through selec-tive breeding,but fiber elongation has largely been ignored,even though elongation contributes to determining the energy needed to break *** developments to calibrate the high volume instrument(HVI)for elongation has renewed interest in ***,it is not understood how best to utilize yet another fiber property which has the potential to add to the complexity of fiber *** explore a practical approach to applying elongation,cot-ton samples were tested using single fiber methods,the Stelometer,and the *** of strength,elongation,and combined properties such as modulus were *** HVI testing was shown to be sensitive enough to characterize elongation differences but unlike single fiber testing it was unable to capture within-sample *** bundle testing,like Stelometer and HVI was shown to reduce bias due to fiber *** The use of secant modulus,an intrinsic material property,allowed for one value to represent both strength and *** modulus was shown to contain more useful information than either elongation or ***-to-break was shown to be more influenced by a specific value of breaking force or elongation rather than the intrinsic behavior of the sample being *** the influence of genetics and environment on elongation,and its interaction with other fiber properties,requires additional *** modulus,by combining strength and elongation into one value,shows the potential to incorporate elongation values into fiber characteriza-tion without increasing the complexity of current fiber selection processes.

关键词： Cotton Elongation Tenacity Work-to-break ModulusBackground

Advanced non-alcoholic steatohepatitis cirrhosis: A high-risk population for pre-liver transplant portal vein thrombosis

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2017年第3期9卷 139-146页

作者： Jonathan G Stine Curtis K Argo Shawn J pelletier Daniel G Maluf Stephen H Caldwell Patrick G Northup Division of Gastroenterology and Hepatology Department of Medicine Center for the Study of Coagulation Disorders in Liver Disease University of Virginia Division of Transplant Department of Surgery University of Virginia

AIMTo examine if liver transplant recipients with high-risk non-alcoholic steatohepatitis (NASH) are at increased risk for pre-transplant portal venous thrombosis. METHODSData on all liver transplants in the United States from February 2002 through September 2014 were analyzed. Recipients were sorted into three distinct groups: High-risk (age > 60, body mass index > 30 kg/m2, hypertension and diabetes), low-risk and non-NASH cirrhosis. Multivariable logistic regression models were constructed. RESULTSThirty-five thousand and seventy-two candidates underwent liver transplantation and of those organ recipients, 465 were transplanted for high-risk and 2775 for low-risk NASH. Two thousand six hundred and twenty-six (7.5%) recipients had pre-transplant portal vein thrombosis; 66 (14.2%) of the high-risk NASH group had portal vein thrombosis vs 328 (11.8%) of the low-risk NASH group. In general, all NASH recipients were less likely to be male or African American and more likely to be obese. In adjusted multivariable regression analyses, high-risk recipients had the greatest risk of pre-transplant portal vein thrombosis with OR = 2.11 (95%CI: 1.60-2.76, P CONCLUSIONLiver transplant candidates with high-risk NASH are at the greatest risk for portal vein thrombosis development prior to transplantation. These candidates may benefit from interventions to decrease their likelihood of clot formation and resultant downstream hepatic decompensating events. Prospective study is needed.

关键词： Liver transplantation Non-alcoholic fatty liver disease Portal hypertension Hepatology Coagulopathy