Low phospholipid-associated cholelithiasis syndrome:A rare cause of acute pancreatitis that should not be neglected

作     者：Nicolas Gille Pascale Karila-Cohen Gaël Goujon Dimitrios Konstantinou Samia Rekik Hakim Bécheur Anne-Laure Pelletier 

作者机构：Department of Hepato-Gastroenterology and Digestive OncologyAP-HP Bichat University HospitalParis 75018France Department of RadiologyAP-HP Bichat University HospitalParis 75018France 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2020年第12卷第6期

页      面：312-322页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Low phospholipid-associated cholelithiasis syndrome Acute pancreatitis Cholelithiasis Echography Ursodeoxycholic acid 

摘      要：BACKGROUND Low phospholipid-associated cholelithiasis(LPAC)syndrome is a very particular form of biliary lithiasis with no excess of cholesterol secretion into bile,but a decrease in phosphatidylcholine secretion,which is responsible for stones forming not only in the gallbladder,but also in the *** syndrome may be underreported due to a lack of testing resulting from insufficient awareness among *** To describe the clinical and radiological characteristics of patients with LPAC syndrome to better identify and diagnose the *** We prospectively evaluated all patients aged over 18 years old who were consulted or hospitalized in two hospitals in Paris,France(Bichat University Hospital and Croix-Saint-Simon Hospital)between January 1,2017 and August 31,*** patients whose profiles led to a clinical suspicion of LPAC syndrome underwent a liver ultrasound examination performed by an experienced radiologist to confirm the diagnosis of LPAC ***-four patients were *** about the patients’general characteristics,their medical history,their symptoms,and their blood tests results were collected during both their initial hospitalization and *** and cholestasis were expressed compared to the normal values(N)of serum aspartate and alanine transaminase activities,and to the normal value of alkaline phosphatase level,*** subjects were systematically reevaluated and asked about their symptoms 6 mo after inclusion in the study through an in-person medical appointment or phone *** testing was not performed systematically,but according to the decision of each *** Most patients were young(median age of 37 years),male(58%),and not overweight(median body mass index was 24).Many had a personal history of acute pancreatitis(54%)or cholecystectomy(42%),and a family history of gallstones in first-degree relatives(30%).LPAC syndrome was identified primarily in patients with recurring bilia