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异黄酮辅剂对解冻精子特征的影响

Asian Journal of Andrology 2010年第3期12卷 431-441,I0012页

作者： Juan Carlos Martinez-Soto Juan de DiosHourcade Alfonso Gutierrez-Adan Jose Lorenzo Landeras joaquin Gadea Department of Physiology School of Veterinary Murcia University Murcia 30100 Spain IVI- MURCIA Murcia 30007 Spain Department of Animal Reproduction INIA Madrid 28040 Spain

In this study, we evaluated the effects of genistein supplementation of the thawing extender on frozen-thawed human semen parameters. We analyzed the effect of supplementation on sperm motility, capacitation （membrane lipid disorder）, reactive oxygen species （ROS） generation, chromatin condensation and DNA damage. Using this preliminary information, it maybe possible to improve the cryopreservation process and reduce the cellular damage. We have confirmed that the isoflavone genistein （10 μmol L-1） has antioxidant properties on the frozen-thawed spermatozoa. This results in a decreased ROS production that shows a slight improvement in the sperm motility, and decreases the membrane lipid disorder and DNA damage caused by cryopreservation. These results suggest an effect of genistein on sperm functionality that could be of interest for assisted reproduction treatments using frozen- thawed human spermatozoa, but further studies will be necessary to confirm our findings and to evaluate the possible clinical applications.

关键词： antioxidants cryopreservation DNA damage genistein isoflavones sperm motility

DYNAMICS OF EMERGENT AND RE-EMERGENT DISEASES INA GLOBAL VILLAGE

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DYNAMICS OF EMERGENT AND RE-EMERGENT DISEASES INA GLOBAL VIL...

Key genes and drug delivery systems to improve the efficiency of chemotherapy

第三世界生态高峰会

作者： Carlos Castillo-Chavez joaquin Bustoz Jr. Arizona State University Arizona State University

The control and prevention of a growing number of diseases will only be effective if local and national public health policies adopt a global *** role of mass transportation,immigration,tourism, demographic growth,tourism and bioterrorism are but some of the engines behind disease dynamics and disease *** using recent epidemic outbreaks will be used to highlight not only the importance of these epidemic drivers but also to advance the importance of health policy perspectives without borders.

关键词： INA DYNAMICS OF EMERGENT AND RE-EMERGENT DISEASES INA GLOBAL VILLAGE

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Cancer Drug Resistance 2021年第1期4卷 163-191页

作者： Zally Torres-Martinez Yamixa Delgado Yancy Ferrer-Acosta Ivette J Suarez-Arroyo Freisa M.joaquin-Ovalle Louis J.Delinois Kai Griebenow Chemistry Department University of Puerto Rico-Rio Piedras campusSan JuanPR 00936USA Biochemistry&Pharmacology Department San Juan Bautista School of MedicineCaguasPR 00726USA Neuroscience Department Universidad Central del CaribeBayamonPR 00956USA Biochemistry Department Universidad Central del CaribeBayamonPR 00956USA

Cancer cells can develop resistance to anticancer drugs,thereby becoming tolerant to treatment through different *** biological mechanisms leading to the generation of anticancer treatment resistance include alterations in transmembrane proteins,DNA damage and repair mechanisms,alterations in target molecules,and genetic responses,among *** most common anti-cancer drugs reported to develop resistance to cancer cells include cisplatin,doxorubicin,paclitaxel,and *** anticancer drugs have different mechanisms of action,and specific cancer types can be affected by different *** development of drug resistance is a cellular response which uses differential gene expression,to enable adaptation and survival of the cell to diverse threatening environmental *** this review,we briefly look at the key regulatory genes,their expression,as well as the responses and regulation of cancer cells when exposed to anticancer drugs,along with the incorporation of alternative nanocarriers as treatments to overcome anticancer drug resistance.

关键词： Cancer resistance drug delivery systems resistance genes

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青光眼手术并发症的预防与处理

眼科学报 1986年第3期2卷 161-163页

作者： joaquin Barraquer 伍绍铭陈智聪 Barcelona(Spain)

在闭角型青光眼,应早期施行YAG-激光虹膜切开术或传统的周边虹膜切除术。倘小梁已不可逆的损害,则应作小梁切除术。在开角型青光眼,用药物治疗或激光小梁成形术不能控制,则必需手术治疗,一般应选用小梁切除术。与传统的滤过手术相比较,... 详细信息

在闭角型青光眼,应早期施行YAG-激光虹膜切开术或传统的周边虹膜切除术。倘小梁已不可逆的损害,则应作小梁切除术。在开角型青光眼,用药物治疗或激光小梁成形术不能控制,则必需手术治疗,一般应选用小梁切除术。与传统的滤过手术相比较,小梁切除术较少发生前房塌陷,但有时也可发生。为了预防这种并发症,作者建议切开前房后立即注射透明质酸钠。倘所有预防措施都用过了,但手术后前房仍消失(由睫状体阻滞性青光眼或过度过滤伴脉络膜和睫状体的继发性脱离所致),约物治疗又无效,则必需再手术。值得选择注射透明质酸钠以再建前房。

关键词：青光眼手术房水透明质酸钠小梁切除术巩膜瓣睫状体葡萄膜并发症并发病疾病

绿色营销对消费者行为的影响研究：来自菲律宾卡加延德奥罗市的案例研究

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绿色营销对消费者行为的影响研究：来自菲律宾卡加延德奥罗市的案...

作者： Karl Lenin joaquin D. Tigulo 福建师范大学

学位级别：硕士

绿色营销型公司正试图通过提升环境的核心价值来超越传统营销型公司,他们寄希望消费者能将这些价值与他们的品牌绑定在一起。他们参与环境可持续活动,因为这些活动可以为新的目标市场创建新的产品线。对于全世界的人们而言,变得健康是... 详细信息

绿色营销型公司正试图通过提升环境的核心价值来超越传统营销型公司,他们寄希望消费者能将这些价值与他们的品牌绑定在一起。他们参与环境可持续活动,因为这些活动可以为新的目标市场创建新的产品线。对于全世界的人们而言,变得健康是新的箴言。为了与这些人统一战线,很多公司都试图主打环境友好的名片。这项研究的目的是调查绿色营销对菲律宾消费者购买和决策的影响。研究在菲律宾卡加延德奥罗市进行的,主要是调查消费者对绿色营销所创造的绿色价值的理解,及其对他们生态可持续产品的购买行为的影响。我使用的研究方法是以调查为研究工具的定量方法,着重于观察消费者的绿色意识和绿色营销传播的影响,以了解消费者如何被影响从而去购买绿色产品。研究表明,在支持环境友好的消费者群体,菲律宾市场仍有很大的绿色产品市场,但是绿色产品的市场营销传播并不广泛。这项研究将有助于菲律宾卡加延德奥罗市绿色营销和消费者行为理论的一体化进展。研究通过关注消费者对环境的行为,为国内和国际公司提供重要的发现,以促进绿色产品的发展。不仅如此,这项研究还提供了重要的指导方针,以提高社会对绿色营销的积极态度,并帮助公司制定有效的策略来推广其绿色产品。

关键词：环境意识绿色推广绿色购买行为绿色产品

Does Muller Cell Differentiation Occur Prior to the Emergence of Synapses in Embryonic Turtle Retina？

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Journal of Life Sciences 2012年第11期6卷 1200-1205页

作者： Yolanda Segovia Rosa Maria Perez Norberto Mauricio Grzywacz joaquin De Juan Departamento de Biotecnologia Universidad de Alicante Alicante 03080 Spain Departamento de Enfermeria Universidad de Alicante Alicante 03080 Spain Department of Biomedical Engineering University of Southern California Los Angeles CA 90089-111 USA

Müller cells are the main glial cells in the retina, and are related to plexiform layer activity. Recent studies have demonstrated that Müller cells are involved in the synaptic conservation, plasticity, development and metabolism of glutamate. During turtle retinal development, layers, cells and synapses appear at different times. The aim of this research is to study the emergence of Müller cells during embryonic development and their relationship with the synaptogenesis. The authors used retinas from embryos at stages S14, 18, 20, 23, and 26. Some retinas were processed with immunocytochemistry in order to detect the presence of glutamine synthetase in Müller cells, which was used as a marker of these cells. Other retinas from the same stages were processed for ultrastructural studies. Samples were observed in confocal and transmission electron microscopes, respectively. The present results show that glutamine synthetase expression in Müller cells occurs at S18, before the emergence of the retinal layers and the early synapses.

关键词：神经胶质细胞黄缘闭壳龟神经突触胚胎发育视网膜谷氨酰胺合成酶电子显微镜观察分化

Local Changes in Chromatin Accessibility and Transcriptional Networks Underlying the Nitrate Response in Arabidopsis Roots

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Molecular Plant 2019年第12期12卷 1545-1560页

作者： Jose M.Alvarez Tomas C.moyano Tao Zhang Diana E.Gras Francisco J.Herrera Viviana Araus Jose AQ'Brien Laura Carrillo joaquin Medina Jesus Vicente-Carbajosa Jiming Jiang Rodrigo A.Gutierrez Pontificia Universidad Catolica de Chile SantiagoChile Yangzhou University YangzhouChina Instituto de Agrobiotecnologia del Litoral CONICETSanta FeArgentina University of California BerkeleyCAUSA Trancura Biosciences Inc.San FranciscoCA 94158USA Centro de Biotecnología y Genómica de Plantas(CBGP UPM-INIA)Universidad Politecnica de Madrid(UPM)Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA)Campus de Montegancedo28223-Pozuelo de AlarcóMadridSpain Department of Horticulture University of Wisconsin-MadisonMadisonWI 53706USA Department of Plant Biology and Horticulture Michigan State UniversityMI 48824USA

Transcriptional regulation,determined by the chromatin structure and regulatory elements interacting at pro-moter regions,is a key step in plant responses to environmental ***(NO3-)is a nutrient signal that regulates the expression of hundreds of genes in Arabidopsis ***,we integrate mRNA sequencing,genome-wide RNA polymeraseⅡ(RNPⅡ),chromatin immunoprecipitation sequencing,and DNase Sequencing datasets to establish the relationship between RNPⅡoccupancy and chromatin accessibility in response to NO3-treatments in Arabidopsis *** footprinting allowed us to identify in vivo regula-tory elements controlling gene expression in response to ***3--modulated transcription factor(TF)footprints are important for a rapid increase in RNPⅡoccupancy and transcript accumulation over *** mapped key TF regulatory interactions and functionally validated the role of NAP,an NAC-domain containing TF,as a new regulatory factor in *** together,our study provides a comprehensive view of transcriptional networks in response to a nutrient signal in Arabidopsis roots.

关键词： nitrate transcriptional regulation footprinting RNA polymeraseⅡ regulatory networks

Complications of extrahepatic echinococcosis:Fistulization of an adrenal hydatid cyst into the intestine

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World Journal of Gastroenterology 2008年第9期14卷 1467-1469页

作者： Juan Francisco Ruiz-Rabelo Manuel Gomez-Alvarez joaquin Sanchez-Rodriguez Sebastian Rufian Pea Department of General Surgery Reina Sofia University Hospital Avda Menendez Pidal S/N Cordoba 14004 Spain

Echinococcal cysts are usually found in liver and lungs, but any other organ can potentially be involved. Extrahepatic disease due to hydatid cyst may develop in the abdominal and pelvic cavity, aside from in other less common locations, which may make both diagnosis and treatment more complex. We present a rare case of extrahepatic echinococcosis in a 70-year old patient with a 4-d history of dull abdominal pain, anemia within the transfusion range and fever. She underwent surgery for left renal hydatid cysts 30 years ago. After non operative treatment, imaging studies showed a calcified hydatid cyst in a retrogastric location communicating with a proximal jejunal loop. En-block resection of the mass together with the adrenal gland was performed including closure of the enteric fistula. Anatomic pathology confirmed the diagnosis of a calcified hydatid cyst of left adrenal origin. Surgery is the treatment of choice and most authors recommend removal of cyst and adrenal gland.

关键词：包虫病并发症肾上腺囊肿外科手术

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主要急性期蛋白是健康状况的生物标记物

中国畜牧杂志 2015年第10期51卷 47-50页

作者：张永刚 Matilde Pineiro joaquin Morales Carlos Pineiro 法国Animine公司上海200211 PigChamp Pro Europa

急性期蛋白（Acute Phase Proteins，APPs）是一种血蛋白，在组织受损、感染和应急的情况下这种蛋白在血液中的浓度会发生改变。APPs水平的改变是生理变化的一部分，发生在有机体应对外源入侵所做出的快速普遍反应过程中，

关键词：急性期蛋白生物标记物健康状况 Phase 生理变化 APPs 反应过程有机体