Key genes and drug delivery systems to improve the efficiency of chemotherapy
作者机构：Chemistry DepartmentUniversity of Puerto Rico-Rio Piedras campusSan JuanPR 00936USA Biochemistry&Pharmacology DepartmentSan Juan Bautista School of MedicineCaguasPR 00726USA Neuroscience DepartmentUniversidad Central del CaribeBayamonPR 00956USA Biochemistry DepartmentUniversidad Central del CaribeBayamonPR 00956USA
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2021年第4卷第1期
页 面：163-191页
学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Institutes of Health,RISE program,grant(no 5R25GM061151-18) Torres-Martinez Z.Institutional Development Award(IDeA)from the NIGMS/NIH under grant(number P20 GM103475-17)to Suarez-Arroyo IJ
主 题：Cancer resistance drug delivery systems resistance genes
摘 要：Cancer cells can develop resistance to anticancer drugs,thereby becoming tolerant to treatment through different *** biological mechanisms leading to the generation of anticancer treatment resistance include alterations in transmembrane proteins,DNA damage and repair mechanisms,alterations in target molecules,and genetic responses,among *** most common anti-cancer drugs reported to develop resistance to cancer cells include cisplatin,doxorubicin,paclitaxel,and *** anticancer drugs have different mechanisms of action,and specific cancer types can be affected by different *** development of drug resistance is a cellular response which uses differential gene expression,to enable adaptation and survival of the cell to diverse threatening environmental *** this review,we briefly look at the key regulatory genes,their expression,as well as the responses and regulation of cancer cells when exposed to anticancer drugs,along with the incorporation of alternative nanocarriers as treatments to overcome anticancer drug resistance.
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