检索结果-南通市图书馆

Indirect printing of hierarchical patient-specific scaffolds for meniscus tissue engineering

Bio-Design and manufacturing 2019年第4期2卷 225-241页

作者： Joao BCosta Joana Silva-Correia Sandra Pina Alain da Silva morais Sílvia Vieira Hélder Pereira Joao Espregueira-mendes Rui LReis joaquim m.oliveira B′s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017 Barco GmrPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimaraesPortugal The Discoveries Centre for Regenerative and Precision medicine Headquarters at University of MinhoAvepark4805-017 BarcoGuimar'sPortugal Ripoll y De Prado Sports Clinic:murcia-madrid FIFA medical Centre of Excellence MurciaSpain Orthopedic Department Centro Hospitalar Póvoa de Varzim Vila do CondePortugal Clínica do Dragao Espregueira-Mendes Sports CentreFIFA Medical Centre of ExcellencePortoPortugal Dom Henrique Research Centre PortoPortugal Orthopedic Department University of MinhoBragaPortugal

The complex meniscus tissue plays a critical role in the knee. The high susceptibility to injury has led to an intense pursuit for better tissue engineering regenerative strategies, where scaffolds play a major role. In this study, indirect printed hierarchical multilayered sca ffolds composed by a silk fibroin (SF) upper layer and an 80/20 (w/w) ratio of SF/ionic-doped β-tricalcium phosphate (TCP) bottom layer were developed. Furthermore, a comparative analysis between two types of sca ffolds pro- duced using di fferent SF concentrations, i.e., 8% (w/v) (Hi8) and 16% (w/v) (Hi16) was performed. In terms of architecture and morphology, the produced sca ffolds presented homogeneous porosity in both layers and no di fferences were observed when comparing both sca ffolds. A decrease in terms of mechanical performance of the sca ffolds was observed when SF concentration decreased from 16 to 8% (w/v). Hi16 revealed a static compressive modulus of 0.66 ± 0.05 mPa and dynamical mechanical properties ranging from 2.17 ± 0.25 to 3.19 ± 0.38 mPa. By its turn, Hi8 presented a compressive modulus of 0.27 ± 0.08 mPa and dynamical mechanical properties ranging from 1.03 ± 0.08 mPa to 1.56 ± 0.13 mPa. In vitro bioactivity studies showed formation of apatite crystals onto the surface of Hi8 and Hi16 bottom layers. Human meniscus cells (hmCs) and human primary osteoblasts were cultured separately onto the top layer (SF8 and SF16) and bottom layer (SF8/TCP and SF16/TCP) of the hierarchical sca ffolds Hi8 and Hi16, respectively. Both cell types showed good adhesion and proliferation as denoted by the live/dead staining, Alamar Blue assay and DNA quanti fication analysis. Subcutaneous implantation in mice revealed weak in flammation and sca ffold’s integrity. The hierarchical indirect printed SF sca ffolds can be promising candidate for meniscus TE sca ffolding applications due their suitable mechanical properties, good biological performance and possibility of being applied in a patie

关键词： Patient-specific Indirect printing Hierarchical Silk fibroin Enzymatic-cross-linking meniscus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Properties of Collagen/Sodium Alginate Hydrogels for Bioprinting of Skin models

引用

Journal of Bionic Engineering 2023年第1期20卷 105-118页

作者： Tian Jiao Qin Lian Weilong Lian Yonghui Wang Dichen Li Rui L.Reis joaquim miguel oliveira State Key Laboratory for manufacturing System Engineering Xi’an Jiaotong UniversityXi’an710049China Shaanxi Ketao-Am Technology Co. Ltd.Xi’an710100China B’s Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoBarco4805-017GuimarãesPortugal ICVS/3B’s–PT Government Associate Laboratory Barco4805-017GuimarãesPortugal

3D printing technology has great potential for the reconstruction of human ***,the reconstructed skin has some differences from natural skin,largely because the hydrogel used does not have the appropriate biological and physical properties to allow healing and *** study examines the swelling,degradability,microstructure and biological properties of Collagen/Sodium Alginate(Col/SA)hydrogels of differing compositions for the purposes of skin *** the content of sodium alginate causes the hydrogel to exhibit stronger mechanical and swelling properties,a faster degradation ratio,smaller pore size,and less favorable biological *** optimal 1%collagen hydrogel was used to print bi-layer skin in which fibroblasts and keratinocytes showed improved spreading and proliferation as compared to other developed *** Col/SA hydrogels presented suitable tunability and properties to be used as a bioink for bioprinting of skin aiming at finding applications as 3D models for wound healing research.

关键词： Bioink Bioprinting-Collagen sodium alginate hydrogel-Skin Wound healing Bionic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of the regional distribution of the pediatric surgery workforce and surgical load in Brazil

引用

World Journal of Pediatric Surgery 2023年第2期6卷 85-91页

作者： joaquim Bustorff-Silva marcio Lopes miranda Amanda Rosendo Ayla Gerk Antonio Goncalves oliveira-filho Pediatric Surgery State University of Campinas Medical SchoolCampinasBrazilPediatric SurgeryState University of Campinas Medical SchoolCampinasBrazil medicine Pontificia Universidad Católica ArgentinaBuenos AiresArgentina

Objective The purpose of this study is to examine the regional distribution of the pediatric surgery workforce and the expected local demand for pediatric surgical procedures in *** We collected data on the pediatric surgical workforce,surgical volume,Gross Domestic Product per capita,and mortality for gastrointestinal tract malformations(mGITm)across the different regions of Brazil for *** Data from the Federal medical Council reported 1515 pediatric surgery registries in Brazil,corresponding to 1414 pediatric surgeons(some pediatric surgeons are registered in more than one state),or 2.4 pediatric surgeons per 100000 children 14 years of age and *** were 828 men and 586 *** mean age was 51.5±12.8 years,and the mean time from graduation was 3.4±5.7 *** is a higher concentration of pediatric surgeons in the wealthier Central-West,South,and Southeast *** surgical volume ranged from 88 to 245 operations/year(average 146 operations/year)depending on the *** these,only nine(6.1%)were high-complexity(including neonatal)*** tended to be higher in the poorer North and Northeast regions than in other regions of *** Our findings suggest significant disparities in the surgical workforce and workload across Brazil related to socioeconomic *** with an increased surgical workforce were associated with lower *** average number of complex operations performed annually by each pediatric surgeon was considerably *** investment and well-defined health policies are imperative to enhance the quality of surgical care in the different regions of Brazil.

关键词： pediatric operations distribution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering nanoparticles for targeting rheumatoid arthritis： Past, present, and future trends

引用

Nano Research 2018年第9期11卷 4489-4506页

作者： Isabel matos oliveira Cristiana Goncalves Rui Lufs Reis joaquim miguel oliveira B's Research Group - Biomatefials Biodegradables and Biomimetics Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark 4805-017 Barco Guimaraes Portugal ICVS/3B's-PTGovernment Associate Laboratory University of Minho Campus de Gualtar 4710-057 Braga Portugal The Discoveries Centre for Regenerative and Precision medicine Headquarters at University of Minho Avepark 4805-017 Barco Guimaraes Portugal

Rheumatoid arthritis （RA） is a chronic inflammatory disease characterized by synovial joint inflammation and cartilage and bone tissue destruction. Although there exist some treatment strategies for RA, they are not completely safe and effective. Therefore, it is important to develop and test new drugs for RA that specifically target inflamed/swollen joints and simultaneously attenuate other possible damages to healthy tissues. Nanotechnology can be a good alternative to consider when envisioning predse medication for treating RA. Through the use of nanopartides, it is possible to increase bioavailability and bioactivity of therapeutics and enable selective targeting to damaged joints. Herein, recent studies using nanoparticles for the treatment of RA, namely with liposomes, polymeric nanoparticles, dendrimers, and metallic nanoparticles, have been reviewed. These therapeutic strategies have shown great promise in improving the treatment over that by traditional drugs. The results of these studies confirm that feasibility of the use of nanopartides is mainly due to their biocompatibility, low toxicity, controlled release, and selective drug delivery to inflamed tissues in animal RA models. Therefore, it is possible to claim that nanotechnology will, in the near future, play a crucial role in advanced treatments and patient-specific therapies for human diseases such as RA.

关键词： nanoparticles liposomes dendrimers rheumatoid arthritis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current advances in solid free-form techniques for osteochondral tissue engineering

引用

Bio-Design and manufacturing 2018年第3期1卷 171-181页

作者： Joao Bebiano Costa Joana Silva-Correia Rui Luis Reis joaquim miguel oliveira B's Research Group I3Bs - Research Institute onBiomaterials Biodegradables and Biomimetics University ofMinho Headquarters of the European Institute of Excellenceon Tissue Engineering and Regenerative Medicine AveParkParque de Ciencia e Tecnologia Zona Industrial da Gandra4805-017 Barco Guimaraes Portugal ICVS/3B's-PT Government Associate Laboratory Braga Guimarfies Portugal The Discoveries Centre for Regenerative and Precisionmedicine Headquarters at University of MinhoAvepark 4805-017 Barco Guimaraes Portugal

Osteochondral (OC) lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments have increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds’ processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form (SFF) techniques. These techniques allow tuning different properties at the micro–macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.

关键词：软骨病变生物技术生物科学发展现状

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Formation and Evolution of Wakes in the Spacetime Generated by a Cosmic String in <i>f</i>(<i>R</i>) Theory of Gravity

引用

Journal of High Energy Physics, Gravitation and Cosmology 2022年第1期8卷 85-96页

作者： Gabriela Coutinho de Carvalho maria Emília Xavier Guimarães Pablo oliveira mesquita joaquim Lopes Neto Universidade Estadual do Rio de Janeiro Faculdade de Tecnologia Resende Brazil Instituto de Física Universidade Federal Fluminense Av. Litoranea S/N Niterói Brazil Instituto de Fsica Universidade Federal do Rio de Janeiro—UFRJ Av. Athos da Silveira Ramos Cidade Universitária Rio de Janeiro Brazil

The formation and evolution of cosmic string wakes in the framework of a f(R) theory of gravity are investigated in this work. We consider a simple model in which baryonic matter flows past a cosmic string. We treat this problem in the Zel’dovich approximation. We compare our results with previous results obtained in the context of General Relativity and Scalar-Theories of Gravity.

关键词： Topological Defects Alternative Theories of Gravity Structure Formation in the Universe

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Local Acceleration Due to Gravity as Determined with a Cart and Track

引用

Open Journal of Applied Sciences 2023年第9期13卷 1634-1639页

作者： joaquim Bocresion St. Paul’s School New Hampshire USA

The aim of this lab is to determine an experimental value for the local acceleration due to gravity. In order to do this, a cart was released down a track and allowed to pass through two photogates recording the entrance and exit times of the cart. These times along with the length of a light blocking strip on the cart, were used to calculate the acceleration of the cart down the track at various angles, and through linearization, the experimental value for the local acceleration due to gravity was determined to be 10.027 ± 0.312 m/s2. This value has a percent error of only 2.2% from the accepted value of 9.8 m/s2, which proves that this method of determining local acceleration due to gravity can be effective and accurate. Additionally, this experimental value shows how similar the approximation is to the accepted value.

关键词： Gravity Local Acceleration Due to Gravity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adaptable hydrogel with reversible linkages for regenerative medicine:Dynamic mechanical microenvironment for cells

引用

Bioactive materials 2021年第5期6卷 1375-1387页

作者： Zongrui Tong Lulu Jin joaquim miguel oliveira Rui LReis Qi Zhong Zhengwei mao Changyou Gao mOE Key Laboratory of macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017Barco GMRPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal The Discoveries Centre for Regenerative and Precision medicine Headquarters at University of MinhoAvepark4805-017BarcoGuimarãesPortugal Key Laboratory of Advanced Textile materials&manufacturing Technology Ministry of EducationNational Base for International Science and Technology Cooperation in Textiles and Consumer-Goods ChemistryZhejiang Sci-Tech University310018HangzhouChina

Hydrogels are three-dimensional platforms that serve as substitutes for native extracellular *** materials are starting to play important roles in regenerative medicine because of their similarities to native matrix in water content and *** would be very advantagoues for researchers to be able to regulate cell behavior and fate with specific hydrogels that have tunable mechanical properties as biophysical *** developments in dynamic chemistry have yielded designs of adaptable hydrogels that mimic dynamic nature of extracellular *** current review provides a comprehensive overview for adaptable hydrogel in regenerative medicine as ***,we outline strategies to design adaptable hydrogel network with reversible linkages according to previous findings in supramolecular chemistry and dynamic covalent ***,we describe the mechanism of dynamic mechanical microenvironment influence cell behaviors and fate,including how stress relaxation influences on cell behavior and how mechanosignals regulate matrix ***,we highlight techniques such as bioprinting which utilize adaptable hydrogel in regenerative *** conclude by discussing the limitations and challenges for adaptable hydrogel,and we present perspectives for future studies.

关键词： Adaptable hydrogel Dynamic mechanical microenvironment Supramolecular chemistry Dynamic covalent chemistry Yes-associated protein

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

金属间化合物和低孔隙率TiC烧结体在热压下界面的扩散、挤压和反应行为(英文)

引用

稀有金属材料与工程 2012年第2期41卷 203-207页

作者：巫红燕高明霞 oliveira Filipe J 朱丹潘颐 Vieira joaquim m 浙江大学硅材料国家重点实验室 University of Aveiro Aveiro3810-193Portugal

分别以Fe40Al、Ni3Al和TiAl(NbCr)金属间化合物为基体,在一定的压力和温度下,使其和低孔隙率TiC粉体烧结体有效结合。采用扫描电镜及能谱仪等对其界面的组织结构进行分析。结果表明,所有金属间化合物均与TiC烧结体形成了冶金结合的界面... 详细信息

分别以Fe40Al、Ni3Al和TiAl(NbCr)金属间化合物为基体,在一定的压力和温度下,使其和低孔隙率TiC粉体烧结体有效结合。采用扫描电镜及能谱仪等对其界面的组织结构进行分析。结果表明,所有金属间化合物均与TiC烧结体形成了冶金结合的界面。TiC烧结体在高温保压过程中有微量分解,扩散进入了Fe40Al和Ni3Al基体表层,降低了其熔点,从而使其成为可流动状态,被挤压进入TiC烧结体的孔隙。但TiAl(NbCr)合金未能进入TiC烧结体孔隙,而是在与TiC的界面处形成了一层Ti含量高于基体约10at%的反应层。

关键词：双结构材料连接微观结构金属间化合物 TiC

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

碟式离心机分离性能试验及数值模拟研究

引用

天津大学学报（自然科学与工程技术版） 2023年第6期56卷 579-587页

作者：朱国瑞郝泽基吴将天 Pinto Lopes maia Junior joaquim 谭蔚天津大学化工学院天津300350 天津大学浙江研究院宁波315201 浙江轻机实业有限公司杭州311401

碟式离心机作为高效分离机械广泛应用于食品、化工、制药等行业生产.为探究碟式离心机的内部流场及分离效率,进行了现场试验,并根据Σ理论建立了具有20层碟片的简化三维物理模型,利用FLUENT软件对转鼓内的流场及分离过程进行数值模拟.... 详细信息

碟式离心机作为高效分离机械广泛应用于食品、化工、制药等行业生产.为探究碟式离心机的内部流场及分离效率,进行了现场试验,并根据Σ理论建立了具有20层碟片的简化三维物理模型,利用FLUENT软件对转鼓内的流场及分离过程进行数值模拟.试验结果表明,转速和进料量对碟式离心机分离效率影响较大,提高转速、降低进料量均能提高离心机的分离效率,通过分析进出口物料的粒径发现,在试验工况下,粒径大于6μm的颗粒均能被有效分离,改变操作参数主要影响粒径为2~5μm的颗粒的分离.模拟结果表明:在碟片间隙内,物料对碟片的跟随性良好,压力与半径呈现出二次型正比关系,周向速度与半径成正比关系,在沉渣区域物料明显滞后于转鼓转动,这导致离心液压和周向速度均小于理论值,同时随着转速的提高,沉渣区域物料的滞后性更加明显;由于上升通道存在,在碟片间隙内局部位置存在明显轴向速度,从而对碟片内的流动产生干扰,导致碟片大端位置的周向速度和离心液压分布不均;在两相分离过程中,颗粒自液相中分离,沉积于上碟片的下表面,并滑落至转鼓沉渣区,固相颗粒在碟片间隙内主要堆积于定距条前侧,在相邻两个定距条之间,固相体积分数沿顺时针方向减少.研究方法与结果为碟式离心机分离性能模拟计算提供了参考,对碟式离心机的设计与结构优化提供了数据指导.

关键词：碟式离心机离心沉降数值模拟固液两相分离

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：