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Structural Optimization of Metal and Polymer Ore Conveyor Belt Rollers

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Computer Modeling in Engineering & Sciences 2022年第12期133卷 601-618页

作者： joao pedro Ceniz Rodrigo de Sá Martins Marco Antonio Luersen Tiago Cousseau Department of Mechanical Engineering Federal University of Technology-Parana(UTFPR)Curitiba81280-340Brazil

Ore conveyor belt rollers operate in harsh environments,making them prone to premature *** service lives are highly dependent on the stress field and bearing misalignment angle,for which limit values are defined in a *** this work,an optimization methodology using metamodels based on radial basis functions is implemented to reduce themass of twomodels of *** a structural point of view,one of the rollers ismade completely of metal,while the other also has some components made of polymeric *** objective of this study is to develop and apply a parametric structural optimization methodology to minimize the mass of the two models of *** represent the mechanical behavior of the rollers,simulations were performed using the finite element *** the numerical optimization process,the variable parameters were the dimensions of the shaft and external *** geometric configuration that corresponded at the same time to the lowest mass and acceptable ranges for the stress and bearingmisalignment angle was *** the proposed methodology,a 32.3% reduction in mass was obtained for a metal roller design and an 18.9% reduction for a polymer *** both cases,the constraints were not *** the all-metal roller,the safety factors for the maximum stress and bearingmisalignment angle were 1.44 and 1.75,respectively,while for the polymer roller the corresponding figures were 1.50 and *** work describes a low-computational-cost optimization methodology for roller designs that have been little studied in the ***,the methodology could be adapted for use with other types of rollers and rollers made of different materials.

关键词： Conveyor belt rollers structural optimization surrogate models radial basis functions

A fuzzy cognitive map-based algorithm for predicting water consumption in Spanish healthcare centres

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Building Simulation 2023年第11期16卷 2193-2205页

作者： Gonzalo Sánchez-Barroso Jaime González-Domínguez joao Paulo Almeida-fernandes Justo García-Sanz-Calcedo Engineering Projects Area University of ExtremaduraAv.Elvas06006BadajozSpain Department of Paisagem Ambiente e OrdenamentoUniversity of EvoraR.Romão Ramalho7000-650ÉvoraPortugal

The management of water consumption in healthcare centres can have positive impacts on both the environmental performance and profitability of health *** tools assist in the decision-making process of managing the operation and maintenance of healthcare *** research aimed to integrate the empirical knowledge of experts in Healthcare Engineering and the historical data from 66 healthcare centres in a Fuzzy Cognitive *** outputs of the predictive model included water consumption,water cost,and CO_(2) emissions in healthcare facilities,along with eleven variables to discover the causes and consequences of water consumption in healthcare centres.A healthcare centre with about 12350 users,located in a city that experiences an average of 1100 heating degree days,whose facilities be moderately energy-efficient contributing over 50%with renewable energies is expected to consume 8.4 dam^(3) of water with 32.1 k€of cost,and contribute realising 30.8 ton CO_(2)eq *** use of Fuzzy Cognitive Maps for prediction can provide a high level of effectiveness in identifying the factors that contribute to water consumption and in designing key performance indicators to manage the environmental performance of healthcare *** tool is extremely effective in enhancing the performance of the management division of health systems.

关键词： water consumption Fuzzy Cognitive Maps healthcare centres Healthcare Engineering water management

Immunological mechanisms of fecal microbiota transplantation in recurrent Clostridioides difficile infection

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World Journal of Gastroenterology 2022年第33期28卷 4762-4772页

作者： Lucas F Soveral Gabriela G Korczaguin pedro S Schmidt Isabel S Nunes Camilo fernandes Carlos R Zarate-Blades Laboratory of Immunoregulation Department of MicrobiologyImmunologyand ParasitologyCenter for Dysbiosis ControlFederal University of Santa CatarinaFlorianopolis 88037-000Brazil Division of Infectious Diseases Hospital Nereu RamosFlorianopolis 88025-301Brazil

Fecal microbiota transplantation(FMT)is a successful method for treating recurrent Clostridioides difficile(***)infection(rCDI)with around 90%*** to the relative simplicity of this approach,it is being widely used and currently,thousands of patients have been treated with FMT ***,the mechanisms underlying its effects are just beginning to be *** indicate that FMT effectiveness is due to a combination of microbiological direct mechanisms against ***,but also through indirect mechanisms including the production of microbiota-derived metabolites as secondary bile acids and short chain fatty ***,the modulation of the strong inflammatory response triggered by *** after FMT seems to rely on a pivotal role of regulatory T cells,which would be responsible for the reduction of several cells and soluble inflammatory mediators,ensuing normalization of the intestinal mucosal immune *** this minireview,we analyze recent advances in these immunological aspects associated with the efficacy of FMT.

关键词： Fecal microbiota transplantation Immunity Mechanism Dysbiosis Pseudomembranous colitis Clostridioides difficile

Quantification of theophylline or paracetamol in milk matrices by high-performance liquid chromatography

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Journal of Pharmaceutical Analysis 2017年第6期7卷 401-405页

作者： Tania A.P.fernandes joao P.Aguiara Ana I.fernandes joao F.Pinto CiiEM-Centro de Investigacao Interdisciplinar Egas Moniz Instituto Superior de Cinncias da Saude Egas MonizCampus Universitario-Quinta da GranjaMonte de Caparica2829-511 CaparicaPortugal iMed.UL-Dep.Tecnologia Farmaceutica Faeuldade de FarmdciaUniversidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal

A simple, accurate and sensitive high-performance liquid chromatography （HPLC） method was developed, validated and applied to the determination of either theophylline or paracetamol in milk-based samples. The method allowed drug quantification in fresh and powdered milk with a relatively short run time of analysis and it was also successfully applied to the quantification of the drugs in solid dosage forms intended for pediatric use. Moreover, the main significant advantages over other published works are the simplicity of the sample preparation, reduced assay time and sample loss. The method meets the International Conference on Harmonization guideline for analytical methods validation regarding specificity, linearity, accuracy, precision, specificity and robustness as required by health authorities and applied by industry while designing and marketing new drug products. The technique encompasses the separation of the analytes with a reverse phase C18 column under isocrafic conditions and UV detection at 272 nm and 243 nm, respectively, for theophylline and paraeetamol. The lower limit of quantification for both drugs was determined as 0.2 μg/mL and the between-batch accuracy was 99.7%. This HPLC method allows quantification of theophylline and paracetamol in milk matrices and it can be applied in the design, development and production of milk-based pediatric dosage forms.

关键词： Liquid chromatography Fresh milk Powdered milk Paracetamol Theophylline

Influence of bed elevation discordance on flow patterns and head losses in an open-channel confluence

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Water Science and Engineering 2019年第3期12卷 235-243页

作者： pedro Xavier Ramos Laurent Schindfessel joao pedro Pego Tom De Mulder Department of Civil Engineering Ghent University Ghent 9000 Belgium Faculty of Engineering University of Porto Porto 4200-465 Portugal

Confluences play a major role in the dynamics of networks of natural and man-made open channels, and field measurements on river confluences reveal that discordance in bed elevation is *** of schematized confluences with a step at the interface between the tributary and the main channel bed reveal that bed elevation discordance is an important additional control for the confluence *** study aimed to improve understanding of the influence of bed elevation discordance on the flow patterns and head losses in a right-angled confluence of an open channel with rectangular cross-sections.A large eddy simulation (LES)-based numerical model was set up and validated with experiments by *** configurations with different bed discordance ratios were *** results confirm that, with increasing bed elevation discordance, the tributary streamlines at the confluence interface deviate less from the geometrical confluence angle, the extent of the recirculation zone (RZ) gets smaller, the ratio of the water depth upstream to that downstream of the confluence decreases, and the water level depression *** bed elevation discordance also leads to the development of a large-scale structure in the lee of the *** the appearance of the large-scale structure, the reduced extent of the RZ and associated changes in flow deflection/contraction reduce total head losses experienced by the main channel with an increase of the bed discordance *** turns out that bed elevation discordance converts the lateral momentum from the tributary to streamwise momentum in the main channel more efficiently.

关键词： Open channel confluence Bed elevation discordance Three-dimensional numerical modelling Large eddy simulation Recirculation zone

Boosting energy-storage capability in carbon-based supercapacitors using low-temperature water-in-salt electrolytes

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Journal of Energy Chemistry 2022年第7期31卷 521-530,I0013页

作者： joao pedro A.Santos Manuel J.Pinzón érick A.Santos Rafael Vicentini Cesar J.B.Pagan Leonardo M.Da Silva Hudson Zanin Brazilian Renewable Energies Center for Innovation on New EnergiesSchool of Electrical and Computer EngineeringUniversity of CampinasSao Paulo 13083-852Brazil Department of Semiconductors Instruments and PhotonicsSchool of Electrical and Computer EngineeringUniversity of CampinasSao Paulo 13083-852Brazil Laboratory of Fundamental and Applied Electrochemistry Department of ChemistryFederal University of Jequitinhonha e Mucuri’s ValleyMinas Gerais 39100-000Brazil

Supercapacitors(SCs) are high-power energy storage devices with ultra-fast charge/discharge *** using concentrated aqueous-based electrolytes can work at low temperatures due to their intrinsic properties, such as higher freezing point depression(FPD) and robustness. Besides the traditional organic-and aqueous-based(salt-in-water) electrolytes used in SCs, water-in-salt(WISE) sodium perchlorate electrolytes offer high FPD, non-flammability, and low-toxicity conditions, allowing the fabrication of safer, environmentally friendly, and more robust devices. For the first time, this work reports a comprehensive study regarding WISE system’s charge-storage capabilities and physicochemical properties under low-temperature conditions(T < 0 ℃) using mesoporous carbon-based electrodes. The effect of temperature reduction on the electrolyte viscosity and electrical properties was investigated using different techniques and the in-situ(or operando) Raman spectroscopy under dynamic polarization *** cell voltage, equivalent series resistance, and specific capacitance were investigated as a function of the temperature. The cell voltage(U) increased ~ 50%, while the specific capacitance decreased ~20%when the temperature was reduced from 25 ℃ to -10 ℃. As a result, the maximum specific energy(E = CU^(2)/2) increased ~ 100%. Therefore, low-temperature WISEs are promising candidates to improve the energy-storage characteristics in SCs.

关键词： Carbon supercapacitors Water-in-salt electrolytes Low-temperature charge-storage Specific energy improvement at low temperatures

Peripheral nerve regeneration with conduits:use of vein tubes

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Neural Regeneration Research 2015年第4期10卷 529-533页

作者： Rodrigo Guerra Sabongi Marcela fernandes joao Baptista Gomes dos Santos Department of Orthopedics and Traumatology Escola Paulista de MedicinaFederal University of Sao Paulo Division of Hand Surgery Department of Orthopedics and TraumatologyEscola Paulista de MedicinaFederal University of Sao Paulo

Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the com-plexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made to develop an alternative to the au-tologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous experimental and clinical trials. The use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit.

关键词： peripheral nerve injury nerve graft nerve conduit Wallerian degeneration neurotrophic factors veins autografts nerve regeneration

Ecophysiology and multivariate analysis for production of Tachigali vulgaris in Brazil:Influence of rainfall seasonality and fertilization

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林业研究:英文版 2023年第5期34卷 1289-1305页

作者： pedro Henrique Oliveira Simoes Candido Ferreira de Oliveira Neto Manoel Tavares de Paula Dênmora Gomes de Araújo Rodrigo Silva do Vale joao Olegário Pereira de Carvalho Universidade Federal de Mato Grosso Campus Universitario de SinopSinop 78550728Mato GrossoBrazil Universidade Federal Rural da Amazonia Campus BelemBelem 66077830ParaBrazil Universidade do Estado do Para Centro de Ciencias Naturais e TecnologiaBelem 66095015ParaBrazil Universidade Federal Rural da Amazonia Campus Capitao-PocoCapitao Poco 68650000ParaBrazil

Studies on fertilization management of species native to the Amazon for energy plantations contribute to the diversity of species use and reduce biological risk due to the excessive use of clones or hybrids of *** study evaluates the effect of precipitation seasonality and phosphorus and potassium fertilization on gas exchange in a Tachigali vulgaris *** levels of P(zero,65.2,130.4 kg ha^(-1))and three of K(zero,100.0,200.0 kg ha^(-1))were applied in a 3×3 factorial randomized block *** exchange measurements were conducted in April and November *** low rainfall,high irradiance period,photo synthetic rates were up to four times higher than in the high rainfall period,reaching 20.3μmol m^(-2)s^(-1)in the treatment with 130.4 g kg^(-1)of P and 100.0 g kg^(-1)of *** analysis and principal component analysis reduced the initial eight gas exchange variables to two and three principal components in periods of high and low rainfall,*** multivariate method used in this study readily identified variations in the variables as a function of rainfall,with high reliability in explaining the data set.

关键词： Photosynthesis rate Stomatal conductance Principal component analysis Factor analysis Tachigali vulgaris

Exosomal glypican-1 is elevated in pancreatic cancer precursors and can signal genetic predisposition in the absence of endoscopic ultrasound abnormalities

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World Journal of Gastroenterology 2022年第31期28卷 4310-4327页

作者： pedro Moutinho-Ribeiro Ines A Batista Sofia T Quintas Bárbara Adem Marco Silva Rui Morais Armando peixoto Rosa Coelho pedro Costa-Moreira Renato Medas Susana Lopes Filipe Vilas-Boas Manuela Baptista Diogo Dias-Silva Ana L Esteves Filipa Martins Joanne Lopes Helena Barroca Fátima Carneiro Guilherme Macedo Sonia A Melo Serviço de Gastrenterologia Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Faculty of Medicine University of PortoPorto 4200Portugal Instituto de Investigacao e Inovacao em Saúde(i3S) Universidade do PortoPorto 4200Portugal IPATIMUP-Institute of Molecular Pathology and Immunology University of PortoPorto 4200Portugal Instituto de Ciencias Biomédicas Abel Salazar(ICBAS) University of PortoPorto 4050Portugal Servico de Cirurgia Geral Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Unidade de Saúde Familiar Serpa Pinto ACeS Porto OcidentalPorto 4250Portugal Serviço de Anatomia Patológica Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal

BACKGROUND Individuals within specific risk groups for pancreatic ductal adenocarcinoma(PDAC)[mucinous cystic lesions(MCLs),hereditary risk(HR),and new-late onset diabetes mellitus(NLOD)]represent an opportunity for early cancer *** ultrasound(EUS)is a premium image modality for PDAC screening and precursor lesion *** no specific biomarker is currently clinically available for this purpose,glypican-1(GPC1)is overexpressed in the circulating exosomes(crExos)of patients with PDAC compared with healthy subjects or those harboring benign pancreatic *** To evaluate the capacity of GPC1+crExos to identify individuals at higher risk within these specific groups,all characterized by *** This cross-sectional study with a prospective unicentric cohort included 88 subjects:40 patients with MCL,20 individuals with HR,and 20 patients with NLOD.A control group(CG)was submitted to EUS for other reasons than pancreatic pathology,with normal pancreas and absence of hereditary risk factors(n=8).The inclusion period was between October 2016 and January 2019,and the study was approved by the Ethics Committee of Centro Hospitalar Universitário de São João,Porto,*** patients provided written informed *** and blood tests for quantification of GPC1+crExos by flow cytometry and carbohydrate antigen 19-9(CA 19-9)levels by ELISA were performed in all ***-guided tissue acquisition was done whenever *** statistical analysis,SPSS®27.0(IBM Corp.,Armonk,NY,United States)version was *** graphs were created using GraphPad Prism 7.00(GraphPad Software,San Diego,CA,United States).RESULTS Half of MCLs harbored worrisome features(WF)or high-risk stigmata(HRS).Pancreatic abnormalities were detected by EUS in 10.0%and 35.0%in HR and NLOD individuals,respectively,all considered non-malignant and“harmless.”Median levels of GPC1+crExos were statistically different:MCL[99.4%,interquartile range(IQR):94.9%-99.8%],HR(8

关键词： Glypican-1 Circulating exosomes Endoscopic ultrasound Pancreatic cancer risk groups Pancreatic cancer precursor lesions Genetic predisposition