Immunological mechanisms of fecal microbiota transplantation in recurrent Clostridioides difficile infection

作     者：Lucas F Soveral Gabriela G Korczaguin Pedro S Schmidt Isabel S Nunes Camilo Fernandes Carlos R Zarate-Blades 

作者机构：Laboratory of ImmunoregulationDepartment of MicrobiologyImmunologyand ParasitologyCenter for Dysbiosis ControlFederal University of Santa CatarinaFlorianopolis 88037-000Brazil Division of Infectious DiseasesHospital Nereu RamosFlorianopolis 88025-301Brazil 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第33期

页      面：4762-4772页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the grant“Programa de ciencia tecnologia e inovacao aos grupos de pesquisa da Universidade Federal de Santa Catarina”,FAPESC(2021TR000301) Soveral LF is a graduate student fellow of Fundação de AmparoàPesquisa e Inovação do Estado de Santa Catarina,FAPESC(3003/2021) Schmidt PS is student fellow of Programa Institucional de Iniciacao Cientifica e Tecnologica,PIBIC of the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico,CNPq(2021/949248) Nunes IS is a graduate student fellow of Coordenacao de Aperfeiçoamento de Pessoal de Nivel Superior,CAPES(202003075) 

主　　题：Fecal microbiota transplantation Immunity Mechanism Dysbiosis Pseudomembranous colitis Clostridioides difficile 

摘      要：Fecal microbiota transplantation(FMT)is a successful method for treating recurrent Clostridioides difficile(***)infection(rCDI)with around 90%*** to the relative simplicity of this approach,it is being widely used and currently,thousands of patients have been treated with FMT ***,the mechanisms underlying its effects are just beginning to be *** indicate that FMT effectiveness is due to a combination of microbiological direct mechanisms against ***,but also through indirect mechanisms including the production of microbiota-derived metabolites as secondary bile acids and short chain fatty ***,the modulation of the strong inflammatory response triggered by *** after FMT seems to rely on a pivotal role of regulatory T cells,which would be responsible for the reduction of several cells and soluble inflammatory mediators,ensuing normalization of the intestinal mucosal immune *** this minireview,we analyze recent advances in these immunological aspects associated with the efficacy of FMT.