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Mechanical design of an ultra-light vertex detector prototype for CEPC

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Radiation Detection Technology and Methods 2022年第2期6卷 159-169页

作者： Jinyu Fu Zhijun Liang Hao Zeng Gang Li Mingyi Dong Huamin Qu joao Guimaraes da costa Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Particle Detection and Electronics.Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Background The Circular Electron Positron Collider(CEPC)is a large international scientific facility proposed to study the Higgs boson in great *** requires state-of-the-art detectors,including extremely precise vertexing and tracking devices,such as a silicon vertex *** Silicon vertex detector with the precision required by the CEPC has never been built before and needs extensive research and *** paper describes the mechanical design of a vertex detector prototype being built to explore the required technologies and the major *** The exceptional high spatial resolution of the CEPC vertex detector is achievable only with a detector of extremely low mass to limit particle *** paper proposes a mechanical design for the vertex detector prototype,highlighting the choice of low-mass materials,the analysis of support structures,the solution of detector cooling issues,and the drafts of procedures for detector *** The ultra-light support of the ladder(a structural unit of the CEPC vertex detector prototype),which is mainly made of carbon fiber reinforced polymer composite,has been *** fabrication process has also been *** supporting and cooling method of the vertex detector prototype has been designed and chosen with results from finite element analysis and computational fluid dynamics *** assembly and installation schemes for the prototype have been developed,and the respective tooling has also been *** performance of the vertex detector prototype,using this low-mass mechanical structure,was demonstrated with fast simulation to closely meet the CEPC physics requirement.

关键词： CEPC Silicon detector Mechanical design Carbon fiber reinforced polymer

Comparison between Google Earth KML Data and RTK Data on a Flight Planning Simulated to the Unmanned Aerial Vehicle Microdrone MD4-1000

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Journal of Earth Science and Engineering 2012年第10期2卷 613-616页

作者： Antoninho joao Pegoraro Marcelo costa Napoleao Jurgen Wilhelm Philips University of Santa Catarina Joao David Ferreira Lima Chancellor University Campus Florian6polis City Santa CatarinaState CEP 88040-9 Brazil

The UAVs （unmanned aerial vehicles） and the use of graphical data files of extension KML （keyhole markup language） have become popular nowadays. The KML files are associated to the Google Earth applications. Developed by Microdrone company for planning, overflight simulation and data flight analysis, the program mdCockpit was used in this experiment. The UAV Microdrone＇s flight path was programmed in two ways： using geo referenced images from Google Earth and entering points coordinates into the program. These points have had their geographical decimal coordinates collected by GPS （global positioning system）（RTK （real time kinematic）） method. The aim here is to describe a way of evaluating the difference between the alternatives of flight planning. A flight path, defined a route with 22 points, was also simulated in the program mdCockpit. The points were collected and saved, while the images captured by the program went automatically forming a georeferenced mosaic. A comparison between the differences of coordinates to each point was made by choosing on the images and also by a RTK positioning. The result was up to 14.20 m to a 100 m flight height. There is a significant change of position and this can result in unwanted over flights in locations or even jeopardizing the safety of air activity.

关键词： Simulation of flight path MD4-1000 KML data RTK data.

Intraoperative Glycaemia Following Paracetamol with and without Glucose: A Randomized-Controlled Trial

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International Journal of Clinical Medicine 2013年第9期4卷 409-416页

作者： Ricardo Mota Pereira Fatima Goncalves joao costa Filomena Couto Carolina Sa Isabel Neves Lucindo Ormonde Department of Anaesthesiology Santa Maria University HospitalLisbonPortugal Laboratory of Clinical Pharmacology and Therapeutics Faculty of MedicineUniversity of LisbonLisbonPortugal Evidence-Based Medicine Centre Faculty of MedicineUniversity of LisbonLisbonPortugal Instituto de Medicina Molecular(IMM) Faculty of MedicineUniversity of LisbonLisbonPortugal Department of Gynaecology Santa Maria University HospitalLisbonPortugal

Background: Hyperglycaemia is conversely a risk factor for perioperative complications. We are currently using a generic 3.3 g glucose containing formula of intravenous 1000 mg paracetamol for perioperative analgesia. Our main goal was to compare the trends of glycaemic values after administration of a generic 3.3 g glucose containing formula with a non-glucose containing branded formula of intravenous 1000 mg paracetamol. Methods: A exploratory proof-of-concept randomized clinical trial was conducted with 150 patients scheduled for elective gynaecologic. Patients were randomly assigned into three groups: control group (saline);active-control group: intraoperative administration of a branded non-glucose containing 1000 mg paracetamol formula;experimental group: intraoperative administration of a generic 3.3 g glucose containing 1000 mg paracetamol formula. The primary outcome was mean change from baseline in glaucoma. In case significant differences were found, the following secondary outcomes were explored: the proportion of patients with high glycaemia values (>150 mg/dL) and the proportion of patients with negative glycaemic variation. Results: Mean glycaemia change was higher after generic 3.3 g glucose containing paracetamol formula both in comparison to placebo (16.3 mg/dL [95% CI: 6.1 to 26.6]) and active-control (19.1 mg/dL [8.2 to 30.0] groups. Similar results were found in the intention-to-treat analysis. In only the experimental group, patients had high glycaemic values (11.3%). Conclusions: This study showed that in non-diabetic, under non-cardiac surgery, administration of a generic glucose-containing formula of intravenous 1000 mg paracetamol was associated with poorer glycaemic control. These results raise the question of a possible increased risk among these patients. Further studies using diabetic patients are recommended.

关键词： Paracetamol Hyperglycaemia Gyneacologic Surgical Procedures Randomized Controlled Trial

Effects of voluntary imipramine intake via food and water in paradigms of anxiety and depression in naive mice

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Translational Neuroscience and Clinics 2016年第3期2卷 172-182,149页

作者： joao Pedro costa-Nunes Anastassia Bakhmet Margarida Araújo-Correia Andreia Barbosa Valenca Tatyana Strekalova Harry W.M.Steinbusch School for Mental Health and Neuroscience Maastricht University Center for Neuroscience and Cell Biology Universidade de CoimbraFaculdade de MedicinaRua Larga Centro de Biologia Ambiental Faculdade de Ciências da Universidade de Lisboa Department of Human Anatomy Moscow State Medical University Centro de Estudos de Doencas Crónicas(CEDOC) Edifício CEDOCⅡRua Camara Pestana Centro Interdisciplinar de Investigacao em Saúde Animal(CIISA) Faculdade de Medicina VeterináriaAlameda da Universidade Técnica

Objective: We sought to investigate the efficacy of oral dosing in mice with imipramine(7mg/kg/day) via water or in food pellets, and to compare its effects in the paradigms of learned helplessness, locomotion, hedonic state, and anxiety. Methods: Water and food consumption were measured to determine daily imipramine dosage in C57BL/6N mice. Next, baseline scores for O-maze, dark/light box, and sucrose tests were measured. Mice were then subjected to a 4-week treatment of voluntary ingestion of drinking water or food pellets containing imipramine. Lastly, all groups were subjected to novel cage, open field, O-maze, dark/light box, sucrose test, and forced swim test to assess the effects of the treatment. Results: In na?ve mice, imipramine delivered via food, induced a reduction of total floating and increased latency in the forced swim test, i.e., antidepressant-like effects. No other significant effects were found. Dosing with water did not change behavior in the forced swim, sucrose preference test, anxiety, or locomotor paradigms, but increased exploration in the novel cage. Conclusions: Voluntary ingestion is an effective method of chronic dosing with imipramine in na?ve mice. Delivery of imipramine with food pellets elicits antidepressant-like effects in the forced swim test, with no effects on anxiety, locomotion, or preference behaviors. In contrast, no such effects were observed with treatment via drinking water, suggesting that a higher dose may be required. Our work argues for a broader use of oral delivery using food-treated pellets, in small rodent models of pre-clinical depression. It may substantially improve animal welfare and overcome potential confounds in translational research, which are frequently associated with adverse chronic invasive pharmacotherapies.

关键词： pre-clinical models depression anxiety oral dosing animal welfare

Complete Achilles Tenotomy:A New Improved Experimental Surgical Technique in Rats

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Open Journal of Animal Sciences 2018年第1期8卷 1-11页

作者： Kelly Biancardini Gomes Barbato Guilherme de Almeida joao da costa Libardo Rodriguez Clara Raposo Hanna Dias Renata Paiva Liszt Palmeira de Oliveira Jorge Carvalho Clinical and Experimental Pathophysiology Postgraduate Program School of MedicineState University of Rio de JaneiroRio de JaneiroBrazil Department of Surgical Specialties School of MedicineState University of Rio de JaneiroRio de JaneiroBrazil School of Medicine State University of Rio de JaneiroRio de JaneiroBrazil Department of Histology and Embriology Roberto Alcantara Gomes Institute of BiologyState University of Rio de JaneiroRio de JaneiroBrazil

Rupture of the Achilles tendon is one of the most frequent tendon injuries in humans. However, there is no standard surgical technique thus far to reproduce complete rupture of this tendon in rats. Surgical procedures were performed in Wistar rats under light microscopy, with posterior longitudinal incision and preservation of the plantaris tendon. The animals were sacrificed on 2nd and 8th postoperative week and we used hematoxilin and eosin, picrosirius-red and Weigert’s resorcin-fuchsin to observe general tendon healing. The mean operative time was one minute and 24 seconds. Histological studies showed cellular proliferation and fibrillogenesis at two weeks, with decreased amounts of cellularity and elastic fibers at the 8th week, besides changes in structural organization of collagen fibers. The complete Achilles tenotomy in rats, was improved under light microscopy and sparing the plantaris tendon. This surgical technique was simple and quick, showed signs of normal healing process, could be easily reproducible, and triggered translational researches in this area.

关键词： Achilles Tendon Rupture Animal Experimentation Wound Healing Collagen Elastic Tissue

Benefits of the Combined Use of NSAID and Early Exercise on Tendon Healing in a Murine Model

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Open Journal of Animal Sciences 2018年第4期8卷 357-369页

作者： Kelly Biancardini Gomes Barbato Clara Raposo Hanna Dias Renata Paiva joao da costa Libardo Rodriguez Guilherme de Almeida Oscar Rocha-Barbosa Liszt Palmeira de Oliveira Jorge Carvalho School of Medicine State University of Rio de JaneiroRio de JaneiroBrazil Department of Surgical Specialties School of MedicineState University of Rio de JaneiroRio de JaneiroBrazil Department of Zoology Roberto Alcantara Gomes Institute of BiologyState University of Rio de JaneiroRio de JaneiroBrazil Department of Histology and Embriology Roberto Alcantara Gomes Institute of BiologyState University of Rio de JaneiroRio de JaneiroBrazil

Achilles tendon rupture is one of the most frequent tendon injuries. The aim of this experimental study was to evaluate the effect of a non-steroidal anti-inflammatory drug (NSAID) and of aerobic exercise, in an isolated fashion and combined, on cell proliferation and on the biomechanical aspects of the Achilles tendon during healing process after a complete tenotomy in 156 male Wistar rats. Half of the animals received an intra-muscular injection of tenoxicam for 7 days and exercise was initiated on the 8th day for half the animals of each group. Animals were sacrificed at 1, 2, 4 and 8 weeks after the tenotomy and cell proliferation was evaluated by immunohistochemistry for PCNA, biomechanical evaluation was performed with ultimate load and gait cycle analysis was also carried out. Animals were divided into four treatment groups: A) no NSAID and no exercise (control group);B) NSAID plus exercise;C) no NSAID, with exercise;D) NSAID and no exercise. We used the test of two-way analysis of variance with equal cells number, Kruskal-Wallis test and also, Bonferroni method, in the R Project program 3.5.0. The highest intensity of PCNA immunostaining was found at 2 weeks in all groups except for group A (control) that had the highest intensity at 1 week. Animals submitted to exercise had significantly higher (P = 0.02) ultimate loads when compared to animals that were not submitted to exercise at 8 weeks after injury. The animals that received NSAID presented with a more stable gait cycle than the animals that did not receive NSAID. Aerobic exercise, initiated early after a complete Achilles tendon tenotomy, was beneficial to the biomechanical aspects of the tendon that occur during tendon regeneration and the combined use of NSAID improved the gait’s characteristics which could be protective against re-ruptures.

关键词： Achilles Tendon Rupture Experimental Study Non-Steroidal Anti-Inflammatory Drug Aerobic Exercise PCNA Biomechanics

Improved dark ambient degradation of organic pollutants by cerium strontium cobalt perovskite

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Journal of Environmental Sciences 2020年第4期32卷 110-118页

作者： Huihuang Chen Julius Motuzas Wayde Martens joao C.Diniz da costa The University of Queensland FIM^2 Lab-Functional Interfacial Materials and Membranes LaboratorySchool of Chemical EngineeringBrisbaneQld 4072Australia Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaAnhui 230026China Science and Engineering Faculty Queensland University of TechnologyBrisbaneQld 4000Australia LAQV-REQUIMTE (Bio)Chemical Process EngineeringDepartment of ChemistryFaculty of Science and TechnologyUniversidade NOVA de LisboaCaparica 2829-516Portugal

This work investigates the effect of cerium substation into strontium cobalt perovskites(CeSrCoO)for the oxidative degradation of OrangeⅡ(OII)in dark ambient conditions without the aid of any external stimulants such as light,heating or chemical *** OII degradation rate by CeSrCoO reached 65%in the first hour,whilst for the blank sample without cerium(SrCoO)took over 2 hr to reach the same level of OII ***,the cerium substitution improved the catalytic activity of the perovskite material,mainly associated with the Ce0.1Sr0.9CoO3 perovskite *** contacting CeSrCoO,the-N=Nazo bonds of the OII molecules broke down resulting in electron donation and the formation of *** electrons are injected into the CeSrCoO and resulted in a redox pair of Co3+/Co2+,establishing a bridge for the electron transfer between OII and the ***,the electrons also formed reactive species(·OH)responsible for OII degradation as evidenced by radical trapping *** species were formed via the reaction between 02 and donated electrons from OII with the aid of cobalt redox *** the prepared materials dispensed with the need for light irradiation and additional oxidants,it opens a window of environmental applications for treating contaminated wastewaters.

关键词： Dark catalysis Acid orange degradation Cerium substituted perovskite Catalytic activity

Computational fluid dynamics applied to high temperature hydrogen separation membranes

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Frontiers of Chemical Science and Engineering 2012年第1期6卷 3-12页

作者： Guozhao JI Guoxiong WANG Kamel HOOMAN Suresh BHATIA joao C. DINIZ da costa School of Chemical Engineering the University of Queensland Brisbane 4072 Australia School of Mechanical and Mining Engineering the University of Queensland Brisbane 4072 Australia

This work reviews the development of computational fluid dynamics （CFD） modeling for hydrogen separation, with a focus on high temperature membranes to address industrial requirements in terms of membrane systems as contactors, or in membrane reactor arrange- ments. CFD modeling of membrane,.s attracts interesting challenges as the membrane provides a discontinuity of flow, and therefore cannot be solved by the Navier-Stokes equations. To address this problem, tile concept of source has been introduced to understand gas flows on both sides or domains （feed and permeate） of the membrane. This is an important solution, as the gas flow and concentrations in the permeate domain are intrinsically affected by the gas flow and concentrations in the feed domain and vice-versa. In turn, the source term will depend on the membrane used, as different membrane materials comply with different transport mechanisms, in addition to varying gas selectiv- ity and fluxes. This work also addresses concentration polarization, a common effect in membrane systems, though its significance is dependent upon the performance of the membrane coupled with the operating conditions. Finally, CFD modeling is shifting from simplified single gas simulation to industrial gas mixtures, when the mathematical treatment becomes more complex.

关键词： membrane gas separat:ion computationalfluid dynamics concentration polarization hydrogen

Precision Higgs physics at the CEPC

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Chinese Physics C 2019年第4期43卷 5-44页

作者： Fenfen An Yu Bai Chunhui Chen Xin Chen Zhenxing Chen joao Guimaraes da costa Zhenwei Cui Yaquan Fang Chengdong Fu Jun Gao Yanyan Gao Yuanning Gao Shaofeng Ge Jiayin Gu Fangyi Guo Jun Guo Tao Han Shuang Han Hongjian He Xianke He Xiaogang He Jifeng Hu Shih-Chieh Hsu Shan Jin Maoqiang Jing Susmita Jyotishmati Ryuta Kiuchi Chia-Ming Kuo Peizhu Lai Boyang Li Congqiao Li Gang Li Haifeng Li Liang Li Shu Li Tong Li Qiang Li Hao Liang Zhijun Liang Libo Liao Bo Liu Jianbei Liu Tao Liu Zhen Liu Xinchou Lou Lianliang Ma Bruce Mellado Xin Mo Mila Pandurovic Jianming Qian Zhuoni Qian Nikolaos Rompotis Manqi Ruan Alex Schuy Lianyou Shan Jingyuan Shi Xin Shi Shufang Su Dayong Wang Jin Wang Liantao Wang Yifang Wang Yuqian Wei Yue Xu Haijun Yang Ying Yang Weiming Yao Dan Yu Kaili Zhang Zhaoru Zhang Mingrui Zhao Xianghu Zhao Ning Zhou Institute of High Energy Physics Department of Physics and Astronomy Iowa State University Department of Physics Southeast University Department of Engineering Physics Physics Department Tsinghua University School of Physics Peking University University of Chinese Academy of Science (UCAS) Physical Science Laboratory Huairou National Comprehensive Science Center School of Physics and Astronomy Shanghai Jiao Tong University KLPPAC-MoE SKLPPC Department of Physics University of Liverpool Kavli IPMU (WPI) UTIAS The University of Tokyo Department of Physics University of California PRISMA Cluster of Excellence & Mainz Institute of Theoretical Physics Johannes Gutenberg-Universit?t Mainz Department of Modern Physics University of Science and Technology of China Department of Physics & Astronomy University of Pittsburgh Tsung-Dao Lee Institute Department of Physics National Taiwan University Department of Physics University of Washington Department of Physics Nanjing University School of Nuclear Science and Technology University of South China Department of Physics University of Texas at Dallas Department of Physics and Center for High Energy and High Field Physics National Central University Institute of Frontier and Interdisciplinary Science and Key Laboratory of Particle Physics and Particle Irradiation (MOE) Shandong University Department of Physics Hong Kong University of Science and Technology Theoretical Physics Department Fermi National Accelerator Laboratory Maryland Center for Fundamental Physics Department of Physics University of Maryland School of Physics and Institute for Collider Particle Physics University of the Witwatersrand iThemba LABS National Research Foundation Vinca Institute of Nuclear Sciences University of Belgrade Department of Physics University of Michigan Center for Theoretical Physics of the Universe Institute of Basic Science Department of Physics University of Arizona Department of Physics University of Chicago Lawrence Berkeley National Laboratory Chi

The discovery of the Higgs boson with its mass around 125 GeV by the ATLAS and CMS Collaborations marked the beginning of a new era in high energy *** Higgs boson will be the subject of extensive studies of the ongoing LHC *** the same time,lepton collider based Higgs factories have been proposed as a possible next step beyond the LHC,with its main goal to precisely measure the properties of the Higgs boson and probe potential new physics associated with the Higgs *** Circular Electron Positron Collider(CEPC)is one of such proposed Higgs *** CEPC is an e^+e^- circular collider proposed by and to be hosted in *** in a tunnel of approximately 100 km in circumference,it will operate at a center-of-mass energy of 240 GeV as the Higgs *** this paper,we present the first estimates on the precision of the Higgs boson property measurements achievable at the CEPC and discuss implications of these measurements.

关键词： CEPC Higgs bos on Higgs boson properties Higgs boson couplings Higgs factory effective field theory,EFT