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Real Estate Politik:Democracy and the Financialization of Social Networks

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Journal of Social Computing 2021年第4期2卷 323-336页

作者： joanne Cheung the Haas School of Business University of CaliforniaBerkeleyCA 94720USA

The power of social network platforms to amplify the scale,speed,and significance of everyday communication is increasingly weaponized against *** of social networks predominantly focus on design and its effects on *** article shifts the debate to their business *** as platform businesses,social networks are privately owned public spaces with structurally limited democratic *** from the history,theory,and practice of land use,I develop an analogy between the financialization of land by commercial real estate development and the financialization of attention by platform *** policies,such as incentive zoning and exclusionary zoning,shed light on how platform businesses use systems of measurement and valuation to conflate users’roles,tokenize the incentives that drive behavior,and defer the ethical responsibilities businesses have to the *** the real estate framing reveals social networks’structural flaws and colonial roots,lessons from urban planning,community land trusts,and Indigenous land stewardship can inform their regulation and *** on the broader effort to embed ethics in the development of technology,I describe possibilities to steward social networks in the public interest.

关键词： social networks social media platform studies financialization urban planning land use

Renal drug transporters and their significance in drug–drug interactions

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Acta Pharmaceutica Sinica B 2016年第5期6卷 363-373,518页

作者： Jia Yin joanne Wang Department of Pharmaceutics University of Washington

The kidney is a vital organ for the elimination of therapeutic drugs and their *** drug transporters,which are primarily located in the renal proximal tubules,play an important role in tubular secretion and reabsorption of drug molecules in the *** secretion is characterized by high clearance capacities,broad substrate specificities,and distinct charge selectivity for organic cations and *** the past two decades,substantial progress has been made in understanding the roles of transporters in drug disposition,efficacy,toxicity and drug–drug interactions(DDIs).In the kidney,several transporters are involved in renal handling of organic cation(OC) and organic anion(OA) *** transporters are increasingly recognized as the target for clinically significant *** review focuses on the functional characteristics of major human renal drug transporters and their involvement in clinically significant DDIs.

关键词： Renal drug transporters Drug–drug interactions Organic cations Organic anions Nephrotoxicity

RAID 4SMR:RAID Array with Shingled Magnetic Recording Disk for Mass Storage Systems

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Journal of Computer Science & Technology 2019年第4期34卷 854-868页

作者： Quoc Le Ahmed Amer joanne Holliday Department of Computer Engineering School of EngineeringSanta Clara UniversitySanta ClaraCA 95053U.S.A.

One way to increase storage density is using a shingled magnetic recording(SMR)*** propose a novel use of SMR disks with RAID(redundant array of independent disks)arrays,specifically building upon and compared with a basic RAID 4 *** proposed scheme(called RAID 4SMR)has the potential to improve the performance of a traditional RAID 4 array with SMR *** evaluation shows that compared with the standard RAID 4,when using update in-place in RAID arrays,RAID 4SMR with garbage collection not just can allow the adoption of SMR disks with a reduced performance penalty,but offers a performance improvement of up to 56%.

关键词： disk array redundant array of independent disks(RAID) shingled magnetic recording(SMR) shingled write

Electrochemical Fabrication and Electrocatalytic Properties of Nanostructured Mesoporous Platinum Microelectrodes

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Journal of Materials Science & Technology 2005年第6期21卷 863-865页

作者： Mengyan NIE joanne M.Elliott School of Chemistry The University of Reading Reading RG6 6AD UK

Electrodeposition from a lyotropic liquid crystal template medium was used to produce nanostructured platinum microelectrodes with high specific surface area and high mass transport efficiency. Compared to polished and conventional platinized microelectrodes, well-ordered nanostructured platinum microelectrodes exhibited enhanced electrocatalytic properties for oxygen and ascorbic acid, whilst well-ordered nanostructured platinum microelectrodes offered improved electrocatalytic properties for oxygen reduction compared to disordered nanostructured platinum microelectrodes.

关键词： Liquid crystal template Mesoporous Microelectrode Electrocatalysis

Joint Loading Estimation Method for Horse Forelimb High Jerk Locomotion:Jumping

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Journal of Bionic Engineering 2019年第4期16卷 674-685页

作者： joanne Becker Mermoz Emmanuel Linares Jean-Marc Airbus Helicopters Aeroport de Marseille ProvenceMarignane 13700France Aix Marseille Univ CNRSISMInst Movement SciMarseille 13009France

Maximal local loads in animal joints are necessary to design bio-inspired mechanical *** studies presented methods to determine joint reaction forces in humans and ***,many of these methods are invasive,and no work has been published yet about the joint reaction forces in the horse forelimb during ***-invasive methods to measure the kinematics and ground reaction force of a horse forelimb were used in this work.A musculoskeletal model of horse forelimb was built with mechanical methods for the estimation of joint reaction *** entire forelimb was reconstructed by scanning real bones geometry with a 3D optical scanner and modeling all the muscles on a Computer Assisted Design(CAD)*** model dynamics were simulated with OpenSim in order to estimate the joint *** study allows knowing an order of magnitude of the loads at the joints at jumping in order to determine latter the maximal joint contact loading values that will be a key at designing bio-inspired joints for mechanical assemblies.

关键词： joint loading jumping kinematics modelling OpenSim

SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1174-1185页

作者： Sumit Bhattacharyya joanne K.Tobacman Jesse Brown VA Medical Center and University of Illinois at Chicago ChicagoIL 60612USA

Immunostaining in lungs of patients who died with CovID-19 infection showed increased intensity and distribution of chondroitin sulfate and decline in N-acetylgalactostamine-4-sulfatase(Arylsulfatase B;ARSB).To explain these findings,human small airway epithelial cells were exposed to the SARS-CoV-2 spike protein receptor binding domain(SPRBD)and transcriptional mechanisms were ***-p38 MAPK and phospho-SMAD3 increased following exposure to the SPRBD,and their inhibition suppressed the promoter activation of the carbohydrate sulfotransferases CHST15 and CHST11,which contributed to chondroitin sulfate *** in ARSB was mediated by phospho-38 MAPK-induced N-terminal Rb phosphorylation and an associated increase in Rb-E2F1 binding and decline in E2F1 binding to the ARSB *** increases in chondroitin sulfotransferases were inhibited when treated with phospho-p38-MAPK inhibitors,SMAD3(SIS3)inhibitors,as well as antihistamine desloratadine and antibiotic *** the mouse model of carrageenan-induced systemic inflammation,increases in phosphop38 MAPK and expression of CHST15 and CHST11 and declines in DNA-E2F binding and ARSB expression occurred in the lung,similar to theobserved effects in this SPRBD model of COVID-19 *** accumulation of chondroitin sulfates is associated with fibrotic lung conditions and diffuse alveolar damage,increased attention to p38-MAPK inhibition may be beneficial in amelioratingCovid-19infections.

关键词： ACE2 lung inhibited

The Influences of Business and Decision Makers’ Characteristics on Disaster Preparedness—A Study on the 1989 Loma Prieta Earthquake

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International Journal of Disaster Risk Science 2011年第4期2卷 22-31页

作者： Ziqiang Han joanne Nigg Disaster Research Center University of Delaware Newark DE 19716 USA

Disaster preparedness is very important for business continuity, but the determinants of disaster preparedness in business organizations have not been explored much in existing research. Therefore, in this article we undertake to analyze the influences of organizational and decision makers’ characteristics on business disaster preparedness. In 1997, eight years after the Loma Prieta earthquake, the Disaster Research Center at University of Delaware conducted a large-scale mail questionnaire survey in Santa Cruz County, California, which was hard-hit by the 1989 earthquake. A total of 933 completed surveys from business organizations were obtained. Our analysis is based on this historical dataset. The results revealed that larger companies are more likely to engage in disaster preparedness activities, which is consistent with previous studies. Companies in finance, insurance, and real estate sectors tend to prepare more for disasters compared with wholesale and retail trade firms. Disaster experience has a significant and positive impact on business disaster preparedness, and the degree of lifeline loss can be a reasonable indicator of the disaster experiences of business organizations. One interesting finding is that the better a company’s financial condition is, the less it will engage in preparing for disasters. Finally, the risk perception of business owners or decision makers has a statistically significant and consistent positive effect on business disaster preparedness activities.

关键词： disaster Loma finance

给新生儿补充维生素A对其早期死亡率的影响:印度南部社区的群体随机试验

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英国医学杂志中文版 2004年第2期7卷 126-126页

作者： Lakshmi Rahmathullah James M Tielsch R D Thulasiraj joanne katz Christian Coles Sheela Devi Rajeesh John Karthik Prakash A V Sadanand N Edwin C Kamaraj 吕小东

目的:评定给新生儿补充维生素A对其6个月大时死亡率的影响。设计:群体、随机、双盲、安慰剂对照试验。地点:印度南部2个农村社区。

关键词：新生儿维生素A补充早期死亡率印度南部试验

Dendritic cells license regulatory B cells to produce IL-10 and mediate suppression of antigen-specific CD8 T cells

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Cellular & Molecular Immunology 2020年第8期17卷 843-855页

作者： joanne Boldison Larissa Camargo Da Rosa joanne Davies Li Wen F.Susan Wong Division of Infection and Immunity Cardiff University School of MedicineCardiffCF144XNUK Section of Endocrinology School of MedicineYale UniversityYaleCT06520USA

Regulatory B cells(Bregs)suppress and reduce autoimmune ***,given the variety of Breg subsets,the role of Bregs in the pathogenesis of type 1 diabetes is still ***,we dissect this fundamental *** show that natural protection from type 1 diabetes in nonobese diabetic(NOD)mice is associated with increased numbers of IL-10-producing B cells,while development of type 1 diabetes in NOD mice occurs in animals with compromised IL-10 production by B ***,B cells from diabetic mice regain IL-10 function if activated by the innate immune receptor TLR4 and can suppress insulin-specific CD8 T cells in a dendritic cell(DC)-dependent,IL-10-mediated *** of CD8 T cells is reliant on B-cell contact with *** cell contact results in deactivation of DCs,inducing a tolerogenic state,which in turn can regulate pathogenic CD8 T *** findings emphasize the importance of DC–Breg interactions during the development of type 1 diabetes.

关键词： Regulatory B cells type 1 diabetes IL-10 Dendritic cells