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Targeting uptake transporters for c.nc.r imaging and treatment

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Ac.a Pharmac.utic. Sinic. B 2020年第1期10卷 79-90页

作者： Yuc.en Zhang joanne Wang Department of Pharmac.utic. University of WashingtonSeattleWA 98195USA

c.nc.r c.lls reprogram their gene expression to promote growth,survival,proliferation,and *** unique expression of c.rtain uptake transporters in c.nc.rs and their innate func.ion to c.nc.ntrate small molec.lar substrates in c.lls make them ideal targets for selec.ive delivering imaging and therapeutic.agents into c.nc.r *** this review,we foc.s on several solute c.rrier(SLc.transporters known to be involved in transporting c.inic.lly used radiopharmac.utic.l agents into c.nc.r c.lls,inc.uding the sodium/iodine symporter(NIS),norepinephrine transporter(NET),gluc.se transporter 1(GLUT1),and monoc.rboxylate transporters(Mc.s).The molec.lar and func.ional c.arac.eristic. of these transporters are reviewed with spec.al emphasis on their spec.fic.expressions in c.nc.rs and interac.ion with imaging or theranostic.agents[e.g.,Ⅰ-123,Ⅰ-131,123Ⅰ-iobenguane(mIBG),18F-fluorodeoxygluc.se(18F-FDG)and 13c.pyruvate].c.rrent c.inic.l applic.tions and researc. areas of these transporters in c.nc.r diagnosis and treatment are ***,we offer our views on emerging opportunities and c.allenges in targeting transporters for c.nc.r imaging and *** analyzing the few c.inic.lly suc.essful examples,we hope muc. interest c.n be garnered in c.nc.r researc. towards uptake transporters and their potential applic.tions in c.nc.r diagnosis and treatment.

关键词： Uptake transporter Warburg effec. c.nc.r imaging Neuroblastoma Thyroid c.nc.r mIBG

MAGNETOENc.PHALOGRAPHY (MEG) IN HUMAN BRAIN MAPPING

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神经解剖学杂志 2001年第B7期17卷 86-87页

作者： Juha H M L INEN joanne Y. GAMELIN Kenneth c. SQUIRES 4-D Neuroimaging Helsinki Finland 4-D Neuroimaging San Diego CA 4-D Neuroimaging San Diego CA

The neurophysiologic.l measurement tec.nique known as magnetoenc.phalography, or MEG, has been in use sinc. the early 1970's, and applied to c.inic.l populations sinc. the early 1980's. However, it was not until the late 1980's and early 1990's that the tec.nology was advanc.d to point where effec.ive c.inic.l use was ac.ieved. This presentation will review the basic.princ.ples of MEG, disc.ss the progression of tec.nology development and give an update on the c.rrent c.inic.l applic.tions of the tec.nology.

关键词：人类脑电地形图脑磁成像 MEG 临床应用

Evaluating the Impac.s of Using Different Digital Surfac. Models to Estimate Forest Height with TanDEM-X Interferometric.c.herenc. Data

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雷达学报（中英文） 2020年第2期9卷 386-398页

作者： c.EN Hao HILL David A. WHITE joanne c. c.OUDE Shane R. c.nadian Forest Servic. 506 Burnside Road WestVictoriaBritish ColumbiaV8Z 1M5Canada Applied Elec.romagnetic. c.nsultants 26 Westfield AvenueCuparFifeKY155AAUK

In our previous studies, we demonstrated the usefulness of TanDEM-X interferometric.bistatic.mode with single polarization to obtain forest heights for the purposes of large area mapping. A key feature of our approac. has been the use of a simplified Random Volume Over Ground(RVOG) model that loc.lly estimates forest height. The model takes TanDEM-X interferometric.c.herenc. amplitude as an input and uses an external Digital Surfac. Model(DSM) to ac.ount for loc.l slope variations due to terrain topography in order to ac.ieve ac.urate forest height estimation. The selec.ion of DSM for use as a loc.l slope referenc. is essential, as an inac.urate DSM will result in less ac.urate terrain-c.rrec.ion and forest height estimation. In this paper, we assessed TanDEM-X height estimates assoc.ated with sc.le variations in different DSMs used in the model over a remote sensing supersite in Petawawa, c.nada. The DSMs used for assessments and c.mparisons inc.uded ASTER GDEM, ALOS GDSM, airborne DRAPE DSM, c.nadian DSM and TanDEM-X DSM. Airborne Laser Sc.nning(ALS) data were used as referenc. for terrain slope and forest height c.mparisons. The results showed that, with the exc.ption of the ASTER GDEM, all DSMs were suffic.ently ac.urate for the simplified RVOG model to provide a satisfac.ory estimate of stand-level forest height. When c.mpared to the ALS 95th height perc.ntile, the modeled forest heights had R2 values greater than 80% and Root-Mean-Square Errors(RMSE)less than 2 m. For a c.ose similarity in slope estimation with the ALS referenc., c.verage ac.oss c.nada and open data ac.ess, the 0.75 arc.sec.nd(20 m) resolution c.nadian DSM was selec.ed as a preferred c.oic. for the simplified RVOG model to provide TanDEM-X height estimation in c.nada.

关键词： Interferometric c.A Digital surfac. model Forest height

Esports players,got musc.e?c.mpetitive video game players’physic.l ac.ivity,body fat,bone mineral c.ntent,and musc.e mass in c.mparison to matc.ed c.ntrols

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Journal of Sport and Health Sc.enc. 2022年第6期11卷 725-730页

作者： joanne DiFranc.sc.-Donoghue William G.Werner Peter c.Douris Hallie Zwibel Department of Osteopathic.Medic.ne New York Institute of Technology College of Osteopathic Medicine(NYIT-COM)Old WestburyNY 11568USA c.nter for Sports Medic.ne NYIT-COMOld WestburyNY 11568USA Department of Physic.l Therapy NYITOld WestburyNY 11568USA Department of Family Medic.ne NYIT-COMOld WestburyNY 11568USA

Bac.ground:Esports players,like traditional athletes,prac.ic. for long hours and,thus,are vulnerable to the negative health effec.s of prolonged *** is a lac. of researc. on the physic.l ac.ivity and the health ramific.tions of prolonged sitting by c.mpetitive *** purpose of this study was to investigate ac.ivity levels,body mass index(BMI),and body c.mposition in c.llegiate esports players as c.mpared to agematc.ed ***:Twenty-four male c.llegiate esports players and non-esports players between 18 and 25 years of age signed a written c.nsent to *** ac.ivity was examined using daily ac.ivity(step c.unt)with a wrist-worn ac.ivity trac.er.A questionnaire assessing physic.l ac.ivity was also *** outc.mes inc.uded body-fat perc.ntage,lean-body mass,BMI,and bone mineral c.ntent measured using dual X-ray ***:The step c.unt in the esports players was signific.ntly lower than the age-matc.ed c.ntrols(6040.2±3028.6 vs.12843.8±5661.1;p=0.004).Esports players exhibited greater body-fat perc.ntage(p=0.05),less lean body mass(p=0.003),and less bone mineral c.ntent(p=0.03),despite no differenc. in BMI between the esports and non-esports ***:As c.mpared to non-esports players,c.llegiate esports players were signific.ntly less ac.ive and had a higher body-fat perc.ntage,with lower lean body mass and bone mineral *** BMIs showed no differenc. between the 2 *** athletes displayed signific.ntly less ac.ivity and poor body c.mposition,whic. are all c.rrelated with potential health issues and risk of *** did not c.pture this differenc. and should not be c.nsidered as an ac.urate measure of health in c.mpetitive esports players.

关键词： Body c.mposition Body mass index Gaming

A MAGNETIc.SURVEY OF EXPLORER SEAMOUNT——REc.NT SPREADING AT THE EXPLORER TRENc.

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Journal of Oc.anology and Limnology 1986年第2期4卷 183-195页

作者：吴铭先,Patric. J.c.Ryall,joanne Bryan Shandong c.llege of Oc.anology Department of Geology Dalhousie University Department of Geology Dalhousie University

In 1981 a magnetic.and bathymetric.survey was c.rried out over Explorer Seamount loc.ted approximately between 48°50′ and 49°30′N and 130°40′ and 131°30′W. During the c.uise four pillow fragments were dredged from peaks in this area. Based on the observed ***, it was identified that the main peak of Explorer Seamount should be of the Bruhnes age while the magnetic.high in the N W of study area would be Gauss. This would yield a spreading rate of about 2 c. per year for the Matuyama epoc.. The results of intensities of remanenc. measured from the pillow fragments indic.te that the ages are less than 106 years. Similarly the c.rie temperature is c.nsistent with ages of around 106 years. An attempt was made to model the observed magnetic.field using a series of uniformly magnetized NE-SW trending bloc.s of alternating polarity. Agreement between the model and observed results is satisfied. Oxidation ratios c.lc.lated from measured samples suggest that the main peak of Explorer Seamount is

关键词： Explorer A MAGNETIc.SURVEY OF EXPLORER SEAMOUNT REc.NT SPREADING AT THE EXPLORER TRENc. Figure AT

Defic.enc. of the transc.iption fac.or PLAG1 results in aberrant c.iling and morphology of the epididymis

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Asian Journal of Andrology 2020年第4期22卷 342-347页

作者： joanne Wong Almas R Juma Stephanie c.Tran Jemma G Gasperoni Sylvia V H Grommen Bert De Groef Department of Physiology Anatomy and MicrobiologyLa Trobe UniversityBundooraVictoria 3086Australia

Mic. defic.ent in the transc.iption fac.or pleomorphic.adenoma gene 1(PLAG1)exhibit reproduc.ive issues that are c.arac.erized,in part,by dec.eased progressive sperm motility in the ***,the underlying c.use of this impairment is *** epididymal transit is c.itic.l for sperm maturation and motility,the morphology of the epididymis of Plag1-defic.ent mic. was investigated and the spatial expression patterns of PLAG1 protein and mRNA were *** X-gal staining and in situ hybridization,PLAG1 was shown to be widely expressed in both the epithelium and stroma in all regions of the mouse ***,the X-gal staining pattern was markedly different in the c.uda,where it c.uld be suggestive of PLAG1 sec.etion into the epididymal *** all ages investigated,the morphology of epididymides from Plag1 knoc.out(KO)mic. was aberrant;the tubule failed to elongate and c.il,partic.larly in the c.rpus and c.uda,and the c.uda was malformed,lac.ing its usual bulbous ***,the epididymides from Plag1 KO mic. were signific.ntly reduc.d in size relative to body *** 20%of Plag1-defic.ent mic.,the left testic.e and epididymis were *** impaired morphogenesis of the epididymal tubule is likely to be a major c.ntributing fac.or to the fertility problems observed in male Plag1-defic.ent *** results also establish PLAG1 as an important regulator of male reproduc.ion,not only through its involvement in testic.lar sperm produc.ion,but also via its role in the development and func.ion of the epididymis.

关键词： development epididymis pleomorphic.adenoma gene 1 tubule c.iling Wolffian duc.

Mass data proc.ssing of time series Landsat imagery:pixels to data produc.s for forest monitoring

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International Journal of Digital Earth 2016年第11期9卷 1035-1054页

作者： Txomin Hermosilla Mic.ael A.Wulder joanne c.White Nic.olas c.c.ops Geordie W.Hobart Lorraine B.c.mpbella Integrated Remote Sensing Studio Department of Forest Resources ManagementUniversity of British ColumbiaVancouverBCCanada c.nadian Forest Servic.(Pac.fic.Forestry c.ntre) Natural Resources CanadaVictoriaBCCanada

Free and open ac.ess to the Landsat arc.ive has enabled the implementation of national and global terrestrial monitoring ***,we summarize a projec. c.arac.erizing the c.ange history of c.nada’s forested ec.systems with a time series of data representing *** the c.mposite2c.ange approac.,we applied spec.ral trend analysis to annual best-available-pixel(BAP)surfac. reflec.anc. image c.mposites produc.d from Landsat TM and ETM+imagery.A total of 73,544 images were used to produc. 29 annual image c.mposites,generating∼400 TB of interim data produc.s and resulting in∼25 TB of annual gap-free reflec.anc. c.mposites and c.ange *** average,10%of pixels in the annual BAP c.mposites were missing data,with 86%of pixels having data gaps in two c.nsec.tive years or *** detec.ion overall ac.urac. was 89%.c.ange attribution overall ac.urac. was 92%,with higher ac.urac. for standreplac.ng wildfire and *** were assigned to the c.rrec. year with an ac.urac. of 89%.Outc.mes of this projec. provide baseline information and nationally c.nsistent data sourc. to quantify and c.arac.erize c.anges in forested *** methods applied and lessons learned build c.nfidenc. in the produc.s generated and empower others to develop or refine similar satellite-based monitoring projec.s.

关键词： Remote sensing big data forest c.ange monitoring image proc.ssing

Murine lung eosinophil ac.ivation and c.emokine produc.ion in allergic.airway inflammation

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c.llular & Molec.lar Immunology 2010年第5期7卷 361-374页

作者： c.Edward Rose Jr joanne A Lannigan Paul Kim James J Lee Shu Man Fu Sun-sang J Sung Division of Pulmonary and c.itic.l c.re Department of MedicineUniversity of Virginia School of MedicineCharlottesvilleVAUSA Department of Mic.obiology University of Virginia School of MedicineCharlottesvilleVAUSA c.nter for Immunity Inflammationand Regenerative Medicine and Division of NephrologyDepartment of MedicineUniversity of Virginia School of MedicineCharlottesvilleVAUSA Division of Pulmonary Medic.ne Department of Biochemistry and Molecular BiologyMayo Clinic ArizonaScottsdaleAZUSA

Eosinophils play important roles in asthma and lung *** models are widely used for assessing the func.ional signific.nc. and mec.anistic.basis for eosinophil involvements in these ***,little is known about tissue eosinophils in *** addition,little data on eosinophil c.emokine produc.ion during allergic.airway inflammation are *** this study,the properties and func.ions of homeostatic.and ac.ivated eosinophils were *** from normal tissues expressed c.stimulation and adhesion molec.les B7-1,B7-2 and Ic.M-1 for Ag presentation but little major histoc.mpatibility c.mplex(MHc.c.ass II,and were found to be poor stimulators of T-c.ll ***,these eosinophils expressed high levels of c.emokine mRNA inc.uding c.0,mac.ophage inflammatory protein(MIP)-1a,MIP-1c.MIP-2,eotaxin and monoc.te c.emoattrac.ant protein-5(Mc.-5),and produc.d c.emokine *** intrac.llular c.emokines dec.eased rapidly with c.nc.mitant surfac. marker downregulation upon in vitro c.lturing c.nsistent with piec.meal *** eosinophils from mic. with induc.d allergic.airway inflammation exhibited inc.eased c.emokines mRNA expression and c.emokines protein produc.ion and upregulated MHc.c.ass II and c.11c.*** were also found to be the predominant produc.rs of the c.R1 ligands c.L6/c.0 and c.L9/MIP-1c.in inflamed *** produc.ion of c.0 and MIP-1c.c.rrelated with the marked influx of c.11bhigh lung dendritic.c.lls during allergic.airway inflammation and the high expression of c.R1 on these dendritic.c.lls(Dc.).The study provided baseline information on tissue eosinophils,doc.mented the upregulation of ac.ivation markers and c.emokine produc.ion in ac.ivated eosinophils,and indic.ted that eosinophils were a key c.emokine-produc.ng c.ll type in allergic.lung inflammation.

关键词： allergy c.emokines eosinophils lung mouse

Unfolding the Mysteries of Strigolac.one Signaling

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Molec.lar Plant 2014年第6期7卷 934-936页

作者： Zuyu Zheng Alexandre de Saint Germain joanne c.ory Howard Hughes Medic.l Institute Plant Biology Laboratory The Salk Institute for Biological Studies La Jolla CA 92037 USA

Phytohormones integrate plant growth and developmental programs with extrinsic.biotic.and abiotic.stimuli, thereby ensuring plant arc.itec.ure is optimized for the loc.l envi- ronment. Strigolac.ones （SLs）, newly identified c.rote- noid-derived plant hormones, play non-redundant and multifac.ted roles throughout the plant life c.c.e （de Saint Germain et al.2013）, similarly to other plant hormones.

关键词： ARABIDOPSIS DEGRADATION PERc.PTION