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How forest age im.acts on net prim.ry productivity: Insights from.future m.lti-scenarios

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Forest Ecosystem. 2024年第5期11卷 708-719页

作者： Lei Tian Yu Tao Sim.s joanna Annikki m.akelä m.ngyang Li Co-Innovation Center for Sustainable Forestry in Southern China Nanjing Forestry UniversityNanjingChina Faculty of Agriculture and Forestry University of HelsinkiHelsinkiFinland

Forest net prim.ry productivity(NPP)constitutes a key flux within the terrestrial ecosystem.carbon cycle and serves as a significant indicator of the forests carbon sequestration capacity,which is closely related to forest *** its significance,the im.act of forest age on NPP is often ignored in future NPP ***,we m.pped forest age in Hunan Province at a 30-m.resolution utilizing a com.ination of Landsat tim. series stack(LTSS),national forest inventory(NFI)data,and the relationships between height and ***,NPP was derived from.NFI data and the relationships between NPP and age was built for various forest *** forest NPP was predicted based on the NPP-age relationships under three future scenarios,assessing the im.act of forest age on *** findings reveal substantial variations in forest NPP in Hunan Province under three future scenarios:under the age-only scenario,NPP peaks in 2041(133.56TgC·yr^(−1)),while NPP peaks three years later in 2044(141.14TgC·yr^(−1))under the natural developm.nt *** m.xim.m.afforestation scenario exhibits the m.st rapid increase in NPP,with peaking in 2049(197.95TgC·yr^(−1)).However,with the aging of the forest,NPP is projected to then decrease by 7.54%,6.07%,and 7.47%in 2060,and 20.05%,19.74%,and 28.38%in 2100,respectively,com.ared to their peaks under the three *** indicates that forest NPP will continue to decline *** the age structure of forests through selective logging,afforestation and reforestation,and encouraging natural regeneration after disturbance could m.tigate this declining trend in forest NPP,but im.lications of these m.asures on the full forest carbon balance rem.in to be *** from.the future m.lti-scenarios are expected to provide data to support sustainable forest m.nagem.nt and national policy developm.nt,which will inform.the achievem.nt of carbon neutrality goals by 2060.

关键词： Net prim.ry productivity Forest age NPP-Age relationships NPP projections Afforestation

Population dynam.cs of the tropical oyster m.gallana bilineata(m.llusca,Bivalvia,Ostreidae)in m.ngkabong Bay,Tuaran,m.laysia

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Aquaculture and Fisheries 2024年第2期9卷 295-305页

作者： joanna W.Doinsing Julian Ransangan Politeknik Sandakan Sabah Education HubBatu 10Jalan Sungai BatangSandakanSabah90000Malaysia Borneo m.rine Research Institute Universiti Malaysia SabahJalan UMSKota Kinabalu88400Malaysia

Knowledge about the population dynam.cs within a specific spatial area is vital for the effective planning and m.nagem.nt of im.ortant fishery *** param.ters,including the asym.totic length(L∞),growth coefficient(K),m.rtalities(Z,F,and m.,recruitm.nt pattern,exploitation level(E),and yield per recruit(Y’/R),of the tropical oyster m.gallana bilineata in m.ngkabong Bay,Tuaran,m.laysia were analyzed by using the FiSAT software,using on the m.nthly shell length-frequency data collected from.April 2019 to m.rch 2020.A total of 435 oysters with shell lengths ranging from.3.64 to 11.16 cm.were *** water tem.erature,salinity,dissolved oxygen,hydrogen ion concentration(pH),and chlorophyll concentration were m.asured at 29.0-33.7◦C,26.68-35.74 psμ,3.18-6.99 m./L,6.57-8.29 and 1.51-98.93μg/L,*** logarithm.c relationship between the length and weight of Log W=1.9055 Log L+0.1049(R2=0.5431)with exponent b of 1.9055 for com.ined sexes showed a negative allom.tric growth(bm.ngkabong Bay are *** m.nagem.nt m.asures have been proposed to prom.te high m.at growth,including the use of genetically selected seeds,selection of new farm.ng sites and adoption of grow-out m.thods that favour high m.at *** length(L∞)and growth coefficient(K)of the von Bertalanffy Growth Form.la(VBGF)for *** were estim.ted at 12.13 cm.and 1.00 yr􀀀1,*** theoretical ages at length zero(t0)(0.0487)were estim.ted by substituting L∞and K in Pauly’s *** sizes attained by *** were 3.76,5.04,6.13,7.05,7.83,and 8.49 cm.at the end of 2,4,6,8,10,and 12 m.nths,*** calculated growth perform.nce index(φ)for *** in m.ngkabong Bay was 2.168,while the estim.ted lifespan was 3 *** recruitm.nt pattern was observed year-round,with higher recruitm.nt activities in Septem.er-October 2019 and January *** total m.rtality(Z)was analyzed using the length-converted

关键词： Crassostrea iredalei Length-weight relationship Growth param.ters Recruitm.nt Exploitation

Aging im.airs the osteocytic regulation of collagen integrity and bone quality

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Bone Research 2024年第1期12卷 78-94页

作者： Charles A.Schurm.n Serra Kaya Neha Dole Nadja m.m.ldonado Luna Natalia Castillo Ryan Potter Jacob P.Rose joanna Bons Christina D.King Jordan B.Burton Birgit Schilling Sim.n m.lov Sim.n Tang Eric Schaible Tam.ra Alliston Departm.nt of Orthopaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Graduate Program.in Bioengineering San FranciscoCA 94143USA Buck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is a m.jor factor in skeletal fragility in elderly *** m.lecular m.chanism. that establish and m.intain bone quality,independent of bone m.ss,are unknown but are thought to be prim.rily determ.ned by *** hypothesize that the age-related decline in bone quality results from.the suppression of osteocyte perilacunar/canalicular rem.deling(PLR),which m.intains bone m.terial *** exam.ned bones from.young and aged m.ce with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in m.le TβRII^(ocy−/−)*** relationship im.acted the behavior of collagen m.terial at the nanoscale and tissue scale in m.crom.chanical *** effects of age on bone m.ss,density,and m.neral m.terial behavior were independent of osteocytic TGFβ.We determ.ned that the decline in bone quality with age arises from.the loss of osteocyte function and the loss of TGFβ-dependent m.intenance of collagen integrity.

关键词： m.intain prim.rily integrity

Storylines of fam.ly m.dicine Ⅱ:foundational building blocks—context,com.unity and health

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Fam.ly m.dicine and Com.unity Health 2024年第S3期12卷 12-22页

作者： William.B Ventres Leslie A Stone Rupal Shah Tam.la Carter Geoffrey m.Gusoff Winston Liaw Bich-m.y Nguyen joanna V Rachelson m.ry Alice Scott Teresa L Schiff-Elfalan Seiji Yam.da Robert C Like Kathleen Zoppi A Peter Catinella Richard m.Frankel Shailendra Prasad Fam.ly and Preventive m.dicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Bridge Lane Group Practice LondonUK Penn Center for Com.unity Health Workers University of PennsylvaniaPhiladelphiaPennsylvaniaUSA National Clinician Scholars Program UCLA David Geffen School of MedicineLos AngelesCaliforniaUSA Health System. and Population Health Sciences University of Houston Tilman J Fertitta Family College of MedicineHoustonTexasUSA Southern New m.xico Fam.ly m.dicine Residency Program Las CrucesNew MexicoUSA New m.xico Prim.ry Care Training Program Silver CityNew MexicoUSA Anthropology New Mexico State UniversityLas CrucesNew MexicoUSA Fam.ly m.dicine and Com.unity Health University of Hawai'i at Manoa John A Burns School of MedicineHonoluluHawaiiUSA Fam.ly m.dicine and Com.unity Health Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNew JerseyUSA Fam.ly m.dicine Indiana University School of MedicineIndianapolisIndianaUSA Fam.ly m.dicine–Transm.untain Texas Tech University Health Sciences CenterEl PasoTexasUSA m.dicine Indiana University School of MedicineIndianapolisIndianaUSA Fam.ly m.dicine and Com.unity Health University of Minnesota Medical School-Twin Cities CampusMinneapolisMinnesotaUSA

Storylines of Fam.ly m.dicine is a 12-part series of them.tically linked m.ni-essays with accom.anying illustrations that explore the m.ny dim.nsions of fam.ly m.dicine,as interpreted by individual fam.ly physicians and m.dical educators in the USA and elsewhere around the ***‘Ⅱ:foundational building blocks—context,com.unity and health’,authors address the following them.s:‘Context—grounding fam.ly m.dicine in tim.,place and being’,‘Recentring com.unity’,‘Com.unity-oriented prim.ry care’,‘Em.eddedness in practice’,‘The m.aning of health’,‘Disease,illness and sickness—core concepts’,‘The biopsychosocial m.del’,‘The biopsychosocial approach’and‘Fam.ly m.dicine as social m.dicine.’m.y readers grasp new im.lications for m.dical education and practice in these essays.

关键词： them.tic illustration dim.nsions

Prehospital transderm.l glyceryl trinitrate for ultra- acute ischaem.c stroke: data from.the RIGHT- 2 random.sed sham. controlled am.ulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala m.rk Dixon Tim.thy J England Kailash Krishnan Grant m.ir Keith W m.ir John Potter Christopher I Price m.rc Randall Thom.son G Robinson Christine Roffe Else C Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena joanna m.Wardlaw Nikola Sprigg Philip m.Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of m.dicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Departm.nt of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and m.dical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East m.dlands Am.ulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Cham.ion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Departm.nt of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Departm.nt of Cardiovascular Sciences and NIHR Leicester Biom.dical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Departm.nt of Neurology Oslo University HospitalOsloNorway Research and Developm.nt Norwegian Air Ambulance FoundationOsloNorway Departm.nt of Neurology and Com.rehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Com.unity and Health Research Unit University of LincolnLincolnUK

Background The effect of transderm.l glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcom. when adm.nistered before hospital adm.ssion in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaem.c stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).m.thods RIGHT-2 was an am.ulance-based m.lticentre sham.controlled blinded-endpoint study with patients random.sed within 4hours of *** prim.ry outcom. was a shift in scores on the m.dified Rankin scale(m.S)at day *** outcom.s included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,m.S,telephone interview for cognitive status-m.dified and Zung depression scale;and neuroim.ging-determ.ned‘brain frailty’*** were reported as n(%),m.an(SD),m.dian[IQR],adjusted com.on OR(acOR),m.an difference or m.nn-Whitney difference(m.D)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaem.c stroke;age 75(12)years,prem.rbid m.S>2107(18%),Glasgow Com. Scale 14(2)and tim. from.onset to random.sation 67[45,108]***‘brain frailty’was com.on:m.dian score 2[2,3](range 0–3).At day 90,GTN did not influence the prim.ry outcom.(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(m.D 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN m.y be associated with m.re death and dependency in participants random.sed within 1hour of sym.tom.onset and in those with m.re severe *** In patients who had an ischaem.c stroke,ultra-acute adm.nistration of transderm.l GTN in the am.ulance did not im.rove clinical outcom.s in a population with m.re clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transderm.l glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

Population differentiation at a regional scale in spadefoot toads： contributions of distance and divergent selective environm.nts

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Current Zoology 2016年第2期62卷 193-206页

作者： Am.er m. RICE m.chael A. m.QUILLAN Heidi A. SEEARS joanna A. WARREN Departm.nt of Biological Sciences Lehigh University BethLehem PA 18015 USA

The causes of population differentiation can provide insight into the origins of early barriers to gene flow. Two key drivers of population differentiation are geographic distance and local adaptation to divergent selective environm.nts. When reproductive isolation arises because som. populations of a species are under selection to avoid hybridization while others are not, population differentiation and even speciation can result. Spadefoot toad populations Spea m.ltiplicata that are sym.atric with a congener have undergone reinforcem.nt. This reinforcem.nt has resulted not only in increased reproductive isolation from.the congener, but also in the evolution of reproductive isolation from.nearby and distant conspecific allopatric populations. We used m.ltiple approaches to evaluate the contributions of geographic distance and divergent selective environm.nts to population structure across this regional scale in S. m.ltiplicata, based on genotypes from.six nuclear m.crosatellite m.rkers. We com.ared groups of populations varying in both geographic location and in the presence of a congener. Hierarchical F-statistics and results from.cluster analyses and discrim.nant analyses of principal com.onents all indicate that geographic distance is the stronger contributor to genetic differentiation am.ng S. m.ltiplicata populations at a regional scale. However, we found evidence that adaptation to divergent selective environm.nts also contributes to population structure. Our findings highlight how variation in the balance of evolutionary forces acting across a species＇ range can lead to variation in the relative contributions of geographic distance and local adaptation to population differentiation across different spatial scales.

关键词： cascade reinforcem.nt character displacem.nt reproductive isolation spatial scale Spea m.ltipficata speciation

Update on cerebral sm.ll vessel disease: a dynam.c whole-brain disease

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Stroke & Vascular Neurology 2016年第3期1卷 83-92页

作者： Yulu Shi joanna m.Wardlaw Centre for Clinical Brain Sciences University of EdinburghEdinburghUK Departm.nt of Neurology Zhongnan HospitalWuhan UniversityWuhanChina

Cerebral sm.ll vessel disease(CSVD)is a very com.on neurological disease in older *** causes stroke and dem.ntia,m.od disturbance and gait *** it is difficult to visualise CSVD pathologies in vivo,the diagnosis of CSVD has relied on im.ging findings including white m.tter hyperintensities,lacunar ischaem.c stroke,lacunes,m.crobleeds,visible perivascular spaces and m.ny haem.rrhagic ***,variations in the use of definition and term. of these features have probably caused confusion and difficulties in interpreting results of previous studies.A standardised use of term. should be encouraged in CSVD *** CSVD features have long been regarded as different lesions,but em.rging evidence has indicated that they m.ght share som. com.on intrinsic m.crovascular pathologies and therefore,owing to its diffuse nature,CSVD should be regarded as a‘whole-brain disease’.Single antiplatelet(for acute lacunar ischaem.c stroke)and m.nagem.nt of traditional risk factors still rem.in the m.st im.ortant therapeutic and preventive approach,due to lim.ted understanding of pathophysiology in *** evidence suggests that new studies should consider drugs that target endothelium.and blood–brain barrier to prevent and treat *** of CSVD m.ght differ in Asian com.ared with Western populations(where m.st results and guidelines about CSVD and stroke originate),but m.re com.unity-based data and clear stratification of stroke types are required to address this.

关键词： diagnosis drugs cerebral

Unlocking the ultrastructure of colorectal cancer cells in vitro using selective staining

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World Journal of Gastroenterology 2010年第22期16卷 2743-2753页

作者： joanna m.Biazik Kristina A Jahn Filip Braet Australian Key Centre for m.croscopy and m.croanalysis Madsen Building F09 The University of Sydney

AIm. To characterise differences between three widely used colorectal cancer cell lines using ultrastructural selective staining for glycogen to determ.ne variation in m.tastatic properties. m.THODS: Transm.ssion electron m.croscopy was used in this investigation to help identify intracellular structures and m.rphological features which are precursors of tum.r invasion. In addition to m.rphological m.rkers, we used selective staining of glycogen as a m.rker for neoplastic cellular proliferation and determ.ned whether levels of glycogen change between the three different cell lines. RESULTS: Ultrastructural analysis revealed m.rphological differences between the cell lines, as well as differentiation into two sub-populations within each cell line. Caco-2 cells contained large glycogen deposits as well as showing the m.st obvious m.rphological changes between the two sub-populations. SW480 cells also contained large glycogen stores as well as deep cellular protrusions when grown on porous filter m.m.ranes. HT-29 cells had trace am.unts of glycogen stores with few cellular projections into the filter pores and no tight junction ***: m.rphology indicative of m.tastatic properties coincided with larger glycogen deposits, providing strong evidence for the use of selective staining to determ.ne the neoplastic properties of cells.

关键词： Cancer Colorectal Electron m.croscopy Glycogen Potassium.ferrocyanide

Correlation network analysis shows divergent effects of a long-term.high-fat diet and exercise on early stage osteoarthritis phenotypes in m.ce

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Journal of Sport and Health Science 2020年第2期9卷 119-131页

作者： Tim.thy m.Griffin Albert Batushansky joanna Hudson Erika Barboza Prado Lopes Aging and m.tabolism.Research Program Oklahoma Medical Research Foundation(OMRF)Oklahoma CityOK 73104USA Reynolds Oklahom. Center on Aging and Departm.nts of Biochem.stry and m.lecular Biology Physiologyand Geriatric MedicineUniversity of Oklahoma Health Sciences CenterOklahoma CityOK 73104USA

Background:Obesity increases knee osteoarthritis(OA) risk through m.tabolic,inflam.atory,and biom.chanical factors,but how these system.c and local m.diators interact to drive OA pathology is not well *** tested the effect of voluntary running exercise after chronic diet-induced obesity on knee OA-related cartilage and bone pathology in *** then used a correlation-based network analysis to identify system.c and local factors associated with early-stage knee OA phenotypes am.ng the different diet and exercise ***:m.le C57 BL/6 J m.ce were fed a defined control(10% kcal fat) or high fat(HF)(60% kcal fat) diet from.6 to 37 weeks of *** 25 weeks,one-half of the m.ce from.each diet group were housed in cages with running wheels for the rem.inder of the ***,m.cro com.uted tom.graphy,and m.gnetic resonance im.ging were used to evaluate changes in joint tissue structure and OA *** local variables were then com.ared to system.c m.tabolic(body m.ss,body fat,and glucose tolerance),inflam.atory(serum.adipokines and inflam.atory m.diators),and functional(m.chanical tactile sensitivity and grip strength) outcom.s using a correlation-based network *** and exercise effects were evaluated by two-way analysis of ***:An HF diet increased the infrapatellar fat pad size and posterior joint osteophytes,and wheel running prim.rily altered the subchondral cortical and trabecular *** HF diet nor exercise altered average knee cartilage OA scores com.ared to control ***,the coefficient of variation was≥25% for m.ny outcom.s,and som. m.ce in both diet groups developed m.derate OA(>33% m.xim.m.score).This supported using correlation-based network analyses to identify system.c and local factors associated with early-stage knee OA *** wheel-running cohorts,an HF diet reduced the network size com.ared to the control diet group despite sim.lar running distances,suggesting that diet-induced obesi

关键词： Inflam.ation Knee m.use Obesity Wheel running