检索结果-南通市图书馆

Current Zoology 2022年第6期68卷 708-715页

作者： Robert PATCHETT Patrick STYLES Joanna ROBINS KING Alexander NGKIRSCHEL Will CRESSWELL Centre for Biological Diversity University of St AndrewsSt AndrewsKY169THUK Department of Biological Sciences University of CyprusNicosia1678Cyprus

One possible hypothesis for the function of post-fledging dispersal is to locate a suitable future breeding area.This post-fledging period may be particularly important in migratory species because they have a limited period to gather information prior to autumn migration,and in protandrous species,males must quickly acquire a territory after returning from spring migration to maximize their fitness.Here we use color-ring resightings to investigate how the post-fledging dispersal movements of the Cyprus wheatear Oenanthe cypriaca,a small migratory passerine,relate to their first breeding territory the following year when they return from migration.We found that males established first breeding territories that were significantly closer to their post-fledging location than to their natal sites or to post-fledging locations of other conspecifics,but these patterns were not apparent in females.Our findings suggest that familiarity with potential breeding sites may be important for juveniles of migratory species,particularly for the sex that acquires and advertises breeding territories.Exploratory dispersal prior to a migrant’s first autumn migration may contribute toward its breeding success the following year,further highlighting the importance of early seasonal breeding on fitness and population dynamics more generally.

关键词： dispersal migratory bird juvenile territory selection

Bioactive injectable composites based on insulin-functionalized silica particles reinforced polymeric hydrogels for potential applications in bone tissue engineering

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第10期105卷 153-163页

作者： Aleksandra Krajcer joanna Klara Wojciech Horak joanna Lewandowska-Łańcucka Faculty of Chemistry Jagiellonian UniversityGronostajowa 2Kraków 30-387Poland AGH University of Science and Technology Faculty of Mechanical Engineering and RoboticsDepartment of Machine Design and TechnologyAl.Mickiewicza 30Kraków 30-059Poland

Novel bioactive injectable composites based on biopolymeric hydrogels reinforced with insulin-functionalized silica particles were synthesized.The insulin(INS)was immobilized on the surface of amine-modifed silica particles employing covalent attachment by EDC/NHS chemistry and via electrostatic interaction.The resulting formulations were examined for the morphology(SEM),chemical composition(FTIR,XPS)as well as protein content.To facilitate the injectability and support the bone regeneration,developed particles were dispersed in biopolymeric sol composed of collagen,chitosan and lysinemodifed hyaluronic acid and crosslinked with genipin.By means of rheological study,the sol-gel in situ transition of obtained systems was verifed.It was found in vitro study that MG-63 cells cultured on the developed composites exhibit signifcantly higher alkaline phosphatase(ALP)activity,compared to the pristine hydrogel.Furthermore,the biomineralization ability in the simulated body fluid(SBF)model was also demonstrated.Our fndings suggest that proposed herein novel hydrogel-based composites might be the promising formulation for regeneration of bone defects,especially as a less-cost effective support/alternative for BMP-2 systems.

关键词： Injectable composites Biopolymers Insulin-functionalized silica particles Bone tissue engineering

K^(+)/Cl^(−) co-transporter-2 upmodulation: a multi-modal therapy to treat spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第9期17卷 1984-1986页

作者： Shane V.Hegarty joanna Stanicka AXONIS Therapeutics Inc.LabCentralCambridgeMAUSA

Herein,the rationale and supporting evidence for the promise of developing K+/Cl−co-transporter-2(KCC2)neuromodulatory therapies for spinal cord injury(SCI)is discussed.SCI is commonly a life-changing,unforeseen neuro t rauma that has devastating consequences for the injured person,their families and society as a whole.Because less than 1%of patients have a complete recovery,the vast majority of people after SCI have significant disabilities and can be entirely dependent upon others for assistance in their activities of daily living.The socioeconomic costs are a significant global burden,with SCI often occurring in adults during their peak earning years.Currently,there are no approved drugs that improve functional outcomes for people with SCI.Therefore,SCI commonly leads to a lifetime of disability,and new therapeutic approaches are urgently needed.

关键词： injury modal consequences

Closed-Form Formulae for European Options Under Three-Factor Models

在线全文

学校读者我要写书评

暂无评论

Communications in Mathematics and Statistics 2020年第4期8卷 379-408页

作者： joanna Goard University of Wollongong WollongongNSWAustrali

In this paper,we derive new closed-form valuations to European options under three-factor hybrid models that include stochastic interest rates and stochastic volatility and incorporate a nonzero covariance structure between factors.We make novel use of the empirically proven 3/2 stochastic volatility model with a time-dependent drift inwhich we are free to choose the moving reversion target.Thismodel has been shown bymany authors to empirically outperform other volatility models in maximising model fit.We also improve the valuation of European options under the Heston volatility and Cox,Ingersoll,Ross interest rate model,recently published in the literature,by replacing open-form infinite series with closed-form analytic expressions.For completeness,we also add a fuller covariance structure in this setting and detail closed-form valuations for options.The inclusion of nonzero covariances amongst the factors can significantly improve option pricing by allowing for a wider variety of market behaviour.The solutions are derived by firstly formulating the price of a European call option in terms of the corresponding characteristic function of the underlying price and then determining a partial differential equation for the characteristic function.By including empirically proven models into our analysis,the options formulae could provide more realistic prices for investors and practitioners.

关键词： European optionvaluation Stochastic volatility Stochastic interest rates Heston model 3/2 model

Spatially variable soils affecting geotechnical strip foundation design

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2022年第3期14卷 886-895页

作者： joanna Pieczyńska-Kozowska Giovanna Vessia Department of Civil Engineering Wrocław University of Science and TechnologyWrocław50-370Poland Department of Engineering and Geology Universitàdegli Studi G.d’Annunzio Chieti-PescaraChieti66100Italy

Natural soil variability is a well-known issue in geotechnical design,although not frequently managed in practice.When subsoil must be characterized in terms of mechanical properties for infrastructure design,random finite element method(RFEM)can be effectively adopted for shallow foundation design to gain a twofold purpose:(1)understanding how much the bearing capacity is affected by the spatial variability structure of soils,and(2)optimisation of the foundation dimension(i.***.width B).The present study focuses on calculating the bearing capacity of shallow foundations by RFEM in terms of undrained and drained conditions.The spatial variability structure of soil is characterized by the autocorrelation function and the scale of fluctuation(δ).The latter has been derived by geostatistical tools such as the ordinary Kriging(OK)approach based on 182 cone penetration tests(CPTs)performed in the alluvial plain in Bologna Province,Italy.Results show that the increase of the B/δratio not only reduces the bearing capacity uncertainty but also increases its mean value under drained conditions.Conversely,under the undrained condition,the autocorrelation function strongly affects the mean values of bearing capacity.Therefore,the authors advise caution when selecting the autocorrelation function model for describing the soil spatial variability structure and point out that undrained conditions are more affected by soil variability compared to the drained ones.

关键词： Bearing capacity Shallow foundation Random finite element method(RFEM) Ordinary kriging(OK) Soil property variability structure Reliability-based design

A-kinase anchoring protein-mediated compartmentalization of pro-survival signaling in the retina

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 479-480页

作者： joanna Mackiewicz Tomasz Boczek Department of Molecular Neurochemistry Medical University of LodzLodzPoland

The retina plays a fundamental role in the process of vision,serving as the primary interface between external visual stimuli and the central nervous system.Because the retina is exposed to a variety of environmental stresses and deleterious insults,it is susceptible to a spectrum of pathological conditions that can detrimentally affect vision.This often leads to irreversible vision loss due to the injury of specific cell types.For instance,inherited retinal degeneration and age-related macular degeneration can lead to the death of photoreceptors,while conditions like glaucoma and optic nerve injury can result in the loss of ganglion cells.The precise pathological mechanisms driving retinal degeneration remain largely elusive,although research utilizing mouse models suggests that disruptions in intracellular signal transduction pathways may play a pivotal role.Signaling pathways within the retina orchestrate various aspects of retinal physiology,including phototransduction,synaptic transmission,and neuronal survival.

关键词： degeneration utilizing irreversible

Long-term changes and periodicity of ice phenomena in the high mountain Lake Morskie Oko(Tatra Mountains,Western Carpathians)

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2022年第11期19卷 3063-3075页

作者： POCIASK-KARTECZKA joanna NIECKARZ Zenon CHOIŃSKI Adam Institute of Geography and Spatial Management Jagiellonian UniversityKraków 30387Poland Marian Smoluchowski Institute of Physics Jagiellonian UniversityKraków 30348Poland Institute of Physical Geography and Environmental Planning Adam Mickiewicz University in PoznańPoznań61680Poland

High montain lakes are regarded as sensitive indicators of environmental changes in local and global scales.In recent years,climate change has considerablely influenced the timing of ice phenomena in these lakes.The objective of the paper is an investigation of long-term changes and periodicity of ice phenomena in high mountain Lake Morskie Oko(1392.8 m a.s.l.)located in the Tatra Mts.in the period 1971-2020.The study employed the Lomb-Scargle periodogram,linear regression modelling for temporal trends,correlation analysis,parameters of variability,and flashiness index.Periodicity of the duration of ice phenomena(~5.4 y)and ice cover on the lake(~13.5 y)was observed,although both are statistically insignificant.Ice cover duration has been interrupted several times by winter thaws after 1996 whereas no such events had been reported earlier.The trend towards a delayed appearance of ice phenomena reaches 4.0 d·decade^(-1)(p<0.001).The observed trend towards an earlier ice phenomena disappearance reaches 5.1 d·decade^(-1)(p<0.001).It results in a decline of the number of days with ice phenomena on Lake Morskie Oko at a rate of 9.0 d·decade^(-1)(p<0.001).The duration of ice cover on Lake Morskie Oko has been decreasing at a rate of 10.4 d·decade^(-1).It is attributed to later freezeup(3.9 d·decade^(-1),p<0.001)and earlier ice break-up(5.6 d·decade^(-1),p<0.001).An increasing trend of average annual air temperature(0.4°C·decade^(-1),p<0.001)in the period 1971-2020 is observed.A statistically significant correlation is recorded between ice phenomena and ice cover(beginning,end,duration),average annual air temperature,average air temperature of three summer months(June,July,August),and average air temperature of the six months period from June to November.Higher air temperature induces growing heat resources accumulated in the lake water in the summer and autumn seasons,potentially causing later initiation of ice phenomena in the lake.There is no statistically significant relationship between maximum ice thickness and an

关键词： Ice phenomena Lakes High mountains Climate warming East-Central Europe

Chimeric Antigen Receptors and Regulatory T Cells:The Potential for HLA-Specific Immunosuppression in Transplantation

在线全文

学校读者我要写书评

暂无评论

Engineering 2022年第3期8卷 30-43页

作者： Sabrina Wright Conor Hennessy joanna Hester Fadi Issa Nuffield Department of Surgical Sciences University of OxfordOxford OX39DUUK

Chimeric antigen receptors(CARs)are a breakthrough in genetic engineering that have revolutio nized the field of adoptive cellular therapy(ACT).Cells expressing these receptors are rerouted to a predefined target by the inclusion of an antigen-specific binding region within the synthetic CAR construct.The advantage of cells with programmed specificity has been demonstrated clinically in the field of oncology,and it is clear that such cells have greater accuracy,potency,and reduced off-target therapeutic effects compared with their unmodified counterparts.In contrast to conventional T cells(Tconvs),regulatory T cells(Tregs)play a major role in suppressing immune activation and regulating the host immune response.CAR expression within Tregs has been proposed as a therapy for autoimmune and inflammatory diseases,graft-versus-host disease(GVHD),and organ transplant rejectio n.In the latter,they hold immense potential as mediators of immune tolerance for recipients of allotransplants.However,current research into CAR-Treg engineering is extremely limited,and there is uncertainty regarding optimal design for therapeutic use.This review examines the rationale behind the development of CAR-Tregs,their significance for human transplantation,potential designs,safety considerations,and comparisons of CAR-Tregs in transplantation models to date.

关键词： Chimeric antigen receptors T cell Treg Alloimmunity Bioengineering Transplant Autoimmunity

Transcription tipping points for T follicular helper cell and T-helper 1 cell fate commitment

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第3期18卷 528-538页

作者： Amania A.Sheikh joanna R.Groom Divisions of Immunology and Molecular Immunology Walter and Eliza Hall Institute of Medical ResearchParkvilleVIC 3052Australia Department of Medical Biology University of MelbourneParkvilleVIC 3010Australia

During viral infection,immune cells coordinate the induction of inflammatory responses that clear infection and humoral responses that promote protection.CD4^(+)T-cell differentiation sits at the center of this axis.Differentiation toward T-helper 1(Th1)cells mediates inflammation and pathogen clearance,while T follicular helper(Tfh)cells facilitate germinal center(GC)reactions for the generation of high-affinity antibodies and immune memory.While Th1 and Tfh differentiation occurs in parallel,these CD4^(+)T-cell identities are mutually exclusive,and progression toward these ends is determined via the upregulation of T-bet and Bcl6,respectively.These lineage-defining transcription factors act in concert with multiple networks of transcriptional regulators that tip the T-bet and Bd6 axis in CD4^(+)T-cell progenitors to either a Th1 or Tfh fate.It is now clear that these transcriptional networks are guided by cytokine cues that are not only varied between distinct viral infections but also dynamically altered throughout the duration of infection.Thus,multiple intrinsic and extrinsic factors combine to specify the fate,plasticity,and function of Th1 and Tfh cells during infection.Here,we review the current information on the mode of action of the lineage-defining transcription factors Bcl6 and T-bet and how they act individually and in complex to govern CD4^(+)T-cell ontogeny.Furthermore,we outline the multifaceted transcriptional regulatory networks that act upstream and downstream of Bcl6 and T-bet to tip the differentiation equilibrium toward either a Tfh or Th1 fate and how these are impacted by dynamic inflammatory cues.

关键词： Cytokines Infection T follicular helper cells T-helper 1 cells Transcription factors

Multitasking guardian of mitochondrial quality:Parkin function and Parkinson’s disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2021年第1期10卷 40-57页

作者： Iryna Kamienieva Jerzy Duszynski joanna Szczepanowska Nencki Institute of Experimental Biology Polish Academy of Science02-093 WarsawPoland

The familial form of Parkinson's disease(PD)is linked to mutations in specific genes.The mutations in parkin are one of the most common causes of early-onset PD.Mitochondrial dysfunction is an emerging active player in the pathology of neurodegenerative diseases,because mitochondria are highly dynamic structures integrated with many cellular functions.Herein,we overview and discuss the role of the parkin protein product,Parkin E3 ubiquitin ligase,in the cellular processes related to mitochondrial function,and how parkin mutations can result in pathology in vitro and in vivo.

关键词： Mitochondria Parkinson's disease Parkin PINK1 Mitophagy Parkin mutations