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Resilience in supply systems -What the food industry can learn from energy sector

Journal of Safety Science and Resilience 2022年第1期3卷 39-47页

作者： Fabian Ossevorth Paul Seidel Sebastian Krahmer joachim seifert Peter Schegner Peter Lochmann Lukas Oehm Marc Mauermann Technische Universität Dresden Professur für ElektroenergieversorgungDresden 01069Germany Technische Universität Dresden Professur für Gebäudeenergietechnik und WärmeversorgungDresden 01069Germany Technische Universität Dresden Professur für Verarbeitungsmaschinen/VerarbeitungstechnikDresden 01069Germany Fraunhofer-Institut for Process Engineering and Packaging IVV Division Processing Technology Dresden01069Germany

Drastic events such as pandemics,earthquakes or other disasters not only threaten the immediate living conditions of people but also indirect circumstances such as energy supply,infrastructure and food *** ensure that damage and failures in these areas do not lead to a disaster,special requirements are placed on this critical *** this context resilience,which is defined as the resistance of a system to external effects,is required.A field that is indeed part of the critical infrastructure,but which has not been considered as intensively as the energy sector,is food *** investigation focuses on how fundamental principles of thermodynamics,system theory and reliability theory can be applied to the modelling of food production processes to obtain a measure of *** known state and process variables from thermodynamics and electrical power engineering,analogous variables are derived for the food *** variables serve as an evaluation standard for a quality measure𝑄.In addi-tion to system-theoretical considerations,it is investigated how existing evaluation criteria of power engineering,such as System Average Interruption Duration Index(SAIDI)and Customer Average Interruption Duration Index(CAIDI),can be transferred to food ***:The investigation focuses on how fundamental principles of thermodynamics,system theory and reliability theory can be applied to the modelling of food production processes to obtain a measure of *** known state and process variables from thermodynamics and electrical power engineering,analogous variables are derived for the food ***:Drastic events such as pandemics,earthquakes or other disasters not only threaten the immediate living conditions of people but also indirect circumstances such as energy supply,infrastructure and food *** ensure that damage and failures in these areas do not lead to a disaster,special requirements are placed on t

关键词： Resilience Food industry Energy Sector System Theory

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Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans

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World Journal of Gastroenterology 2006年第42期12卷 6812-6817页

作者： Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann joachim seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor Department of General and Abdominal Surgery University hospital Mainz Germany Institute for Pathology University hospital Mainz Germany Institute for Neurosurgical Pathophysiology University hospital Mainz Germany Department of Pharmacy Pharmaceutical Biology Saarland University Germany

AIM： To evaluate the protective effects of preconditioning by α-lipoic acid （LA） in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS： Twenty-four patients undergoing liver resection for various reasons either received 600 mg LA or NaCI 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge biopsy samples were obtained after opening of the abdomen immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS： Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histomorphological features of oncosis. We observed TUNEL-positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenuated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION： This is the first report on the potential for LA reducing ischemia/reperfusion injury （IRI） of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans.

关键词： Liver ischemia Pringle manoeuvre Pharmacological pre-treatment Liver preconditioning Apoptosis Adenosine triphosphate

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