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How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1405-1406页

作者： Livia la Barbera Paraskevi Krashia Annalisa Nobili Department of Medicine and Surgery UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly Department of Experimental Neurosciences IRCCS Santa Lucia FoundationVia del Fosso di FioranoRomeItaly Department of Science and Technology for Sustainable Development and One Health UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly

Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc *** is cha racterized by featured histological alterations including amyloid-beta (AB) plaque deposition,accumulation of neurofibrillary to ngles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes.

关键词： Alzheimer alterations dopamine

Investigation of system parameters towards safer impact based shock-to-detonation transition in a novel laser driven flyer plate prototype

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Defence Technology（防务技术） 2024年第9期39卷 103-113页

作者： gonca Saglam Ozkasapoglu Selis Onel Institute of Science Hacettepe UniversityBeytepe06800Turkey TUBITAK SAGE Defense Industries Research and Development Institute Ankara06261Turkey Department of Chemical Engineering Hacettepe UniversityBeytepe06800AnkaraTurkey

laser driven flyer plate technology offers improved safety and reliability for detonation of explosives in industrial applications ranging from mining and stone quarrying to the aerospace and defense *** study is based on developing a safer laser driven flyer plate prototype comprised of a laser initiator and a flyer plate subsystem that can be used with secondary *** parameters were optimized to initiate the shock-to-detonation transition(SDT)of a secondary explosive based on the impact created by the flyer plate on the explosive *** of the flyer was investigated at the mechanically weakened region located on the interface of these subsystems,where the product gases from the deflagration of the explosive provide the required energy.A bilayer energetic material was used,where the first layer consisted of a pyrotechnic component,zirconium potassium perchlorate(ZPP),for sustaining the ignition by the laser beam and the second layer consisted of an insensitive explosive,cyclotetramethylene-tetranitramine(HMX),for deflagration.A plexiglass interface was used to enfold the energetic *** focal length of the laser beam from the diode was optimized to provide a homogeneous beam profile with maximum power at the surface of the *** bomb experiments were conducted in an internal volume of 10 cm^(3) for evaluation of *** of the laser driven flyer plate system output on confinement,explosive density,and laser beam power were *** using a high-speed camera resulted in a flyer velocity of 670±20 m/s that renders the prototype suitable as a laser detonator in applications,where controlled employment of explosives is critical.

关键词： laser driven flyer plate Shock to detonation transition Detonation Secondary explosives Pyrotechnic materials Confinement

Onset for the Electron Velocity Overshoot in Indium Nitride

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Chinese Physics Letters 2012年第12期29卷 177-180页

作者： Clóves G.Rodrigues Departamento de Matemática e Física Pontifícia Universidade Católica de Goiás CP 8674605-010 GoianiaGoiásBrazil

A theoretical study on the electron drift velocity and electron nonequilibrium temperature of indium nitride(InN)is *** is based on a nonlinear quantum kinetic theory which provides a description of the dissipative phenomena developing in the *** ultrafast time evolution of the electron drift velocity and electron nonequilibrium temperature is obtained,and overshoot effects are evidenced on both of *** overshoot onsets are shown to occur at 4 kV/cm,electric field intensity which is considerably smaller than those recently derived by resorting to Monte Carlo simulations.

关键词： nonequilibrium Electron considerably

Creeping fat and gut microbiota in Crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello Imbrizi Ellen CS De Oliveira Luiz C Di Stasi Ligia Y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease(CD).CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in CD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing CD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.

关键词： Creeping fat Mesenteric adipose tissue Gut microbiota Crohn’s disease Inflammatory bowel disease

Bird habitat preferences drive hemoparasite infection in the Neotropical region

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Integrative Zoology 2021年第5期16卷 755-768页

作者： Gabriel Massaccesi DE la TORRE Karla Magalhães CAMPIÃO Biological Interactions Departamento de ZoologiaUniversidade Federal do ParanáCuritibaBrazil Programa de Pós-graduação em Ecologia e Conservação Universidade Federal do ParanáCuritibaBrazil

The role that the environment plays in vector-borne parasite infection is one of the central factors for understanding disease *** assessed how Neotropical bird foraging strata and habitat preferences determine infection by parasites of the genera Haemoproteus,Plasmodium,Leucocytozoon,and Trypanosoma and filarioids,and tested for phylogenetic signal in these host-parasite *** performed extensive searches of the scientific literature and created a database of hemoparasite *** collected data on host body mass,foraging strata,habitat preference,and migratory status,and tested if host ecological traits predict each hemoparasite occurrence and prevalence using a phylogenetic Bayesian *** of Plasmodium tend to infect birds from tropical forests while birds from altitudinal environments are likely to be infected by species of *** probability of a bird being infected by filarioid or Trypanosoma is higher in lowland *** species that occur in anthropic environments and dry habitats of tropical latitudes are more susceptible to infection by species of *** foraging strata is also influential and bird species that forage in the mid-high and canopy strata are more prone to infection by species of Haemoproteus and *** also identified phylogenetic signal for host-parasite associations with the probability of infection of Neotropical birds by any hemoparasite being more similar among more closely related *** provided a useful framework to identify environments that correlate with hemoparasite infection,which is also helpful for detecting areas with potential suitability for hemoparasite infection due to land conversion and climate change.

关键词： habitat use haemosporidians host-parasite interaction migratory birds prevalence

A rare case： paratesticular leiomyosarcoma

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Asian Journal of Andrology 2013年第6期15卷 843-844页

作者： Orcun Celik gonca Unlu Kemalpasa State Hospital Department of Urology Izmir 35140 Turkey Bornova Turkan Ozilhan State Hospital Department of Pathology Bornova Izmir 35120 Turkey

Dear Editor, We would like to present a rare case of primary paratesticular leio-myosarcoma. Primary leiomyosarcoma of testis is a rare entity with few cases reported in literature. Most cases reported in the literature indicate that this may be an indolent tumor with a potential for cure if treated early. A 53-year-old man presented with a right scrotal swell- ing. A computarized tomography （CT） scan showed a heterogeneous enhancing 12 × 9 cm right scrotal mass. Radical orchiectomy with high ligation of the spermatic cord was performed. The mass was charac-terized as a grade 2 paratesticular leiomyosarcoma. Intensive follow-up including repeated CT scans was performed. No metastasis was found.

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The roles of anurans in antagonistic networks are explained by life-habit and body-size

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Integrative Zoology 2022年第4期17卷 530-542页

作者： Amanda Caroline DUDCZAK Gabriel Massaccesi DE la TORRE Lorena EUCLYDes Karla Magalhães CAMPIÃO Department of Zoology Federal University of ParanáCuritibaBrazil Postgraduate Program in Zoology Federal University of ParanáCuritibaBrazil Postgraduate Program in Ecology and Conservation Federal University of ParanáCuritibaBrazil

Interactions among living beings are the structuring basis of ecosystems,and studies of networks allow us to identify the patterns and consistency of such *** networks reflect the energy flow of communities,and identifying network structure and the biological aspects that influence its stability is crucial to understanding ecosystem *** used antagonistic anuran interactions-predator-prey and host-parasite-to assess structural patterns and to identify the key anuran species structuring these *** tested whether anuran body-size and life-habit are related to their roles in these *** collected individuals of 9 species of anurans from an area of the Atlantic Forest in Brazil and identified their prey and helminth *** used network(modularity,specialization,and nestedness)and centrality metrics(degree,closeness,and betweenness)to identify the role of anuran species in both *** then evaluated whether anuran body-size or life-habit were related to anuran centrality using generalized linear mixed *** networks formed specialized interactions in compartments composed by key species from different *** our networks,anurans with rheophilic and cryptozoic habit are central in predator-prey networks,and those with larger body size and arboreal and cryptozoic habit in the host-parasite *** study represents a step towards a better understanding of the influential factors that affect the structure of anuran antagonist networks,as well as to recognize the functioning roles of anuran species.

关键词： diet disease food web helminth infection network centrality

Nutritional and herbal supplements in the treatment of obsessive compulsive disorder

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General Psychiatry 2020年第2期33卷 101-106页

作者： Canan Kuygun Karci gonca Gul Celik Child and Adolescent Psychiatry Dr.Ekrem Tok Psychiatry HospitalAdanaTurkey Child and Adolescent Psychiatry Cukurova University Medical FacultyAdanaTurkey

Obsessive-compulsive disorder(OCD)is a neuropsychiatric disorder that is characterised by obsessions and *** recommended treatments for OCD are cognitive-behavioural therapy using exposure and response prevention and/or *** the other hand,some nutritional and herbal supplements may be effective in the treatment of *** and herbal supplements in OCD treatment will be reviewed in this ***(Medline),Cochrane Library and Google Scholar databases were reviewed for the *** are some supplements that have been researched in OCD treatment studies such as vitamin D,vitamin B12,folic acid,homocysteine,trace elements,N-acetyl cysteine,glycine,myoinositol,St John's wort,milk thistle,valerian root,curcumin and *** effectiveness of herbal and nutritional supplements in the treatment of OCD should be supported with more conclusive evidence.

关键词： vitamin prevention treatment Cochrane

Mercury in sediments and vegetation in a moderately contaminated salt marsh (Tagus estuary, Portugal)

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Journal of Environmental Sciences 2010年第8期22卷 1151-1157页

作者： joao Canário Carlos Vale laurier Poissant Marta Nogueira Martin Pilote Vasco Branco INRB I.P./IPIMAR Av. Brasília Environment Canada Science and Technology Branch

Depth variations of total mercury （Hg） and methylmercury （MeHg） concentrations were studied in cores from non-colonized sediments, sediments colonized by Halimione portulacoides, Sarcocornia fruticosa and Spartina maritima and belowground biomass, in a moderately contaminated salt marsh （Tagus estuary, Portugal）. Concentrations in belowground biomass exceeded up to 3 （Hg） and 15 （MeHg） times the levels in sediments, and up to 198 （Hg） and 308 （MeHg） times those found in aboveground parts. Methylmercury in colonized sediments reached 3% of the total Hg, 50 times above the maximum values found in non-colonized sediments. The absence of correlations between total Hg concentrations in sediments and the corresponding MeHg levels suggested that methylation was only dependent on the environmental and microbiological factors. The analysis of belowground biomass at high-depth resolution （2 cm） provided evidence that Hg and MeHg were actively absorbed from sediments, with higher enrichment factors at layers where higher microbial activity was probably occurring. The results obtained in this study indicated that the biotransformation of Hg to the toxic MeHg could increase the toxicity of plant-colonized sediments.

关键词： mercury methylmercury salt marshes Tagus estuary Portugal