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Efficacy of acupuncture on cancer pain:A systematic review and meta-analysis

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journal of Integrative Medicine 2024年第3期22卷 235-244页

作者： Miguel Faria Mónica Teixeira Maria joão Pinto Paulo Sargento Núcleo de Investigação em Ciências e Tecnologias da Saúde Instituto Politécnico da Lusofonia1950-396 LisboaPortugal Clínica São joão de deus 1700-048 LisboaPortugal rEQUIMTE/LAQV(rede de Química e Tecnologia/Laboratório Associado para a Química Verde) Instituto Superior de EngenhariaInstituto Politécnico do Porto4051-401 PortoPortugal Hospital SoErAD 2560-312 Torres VedrasPortugal Centro de Estudos Avançados em Direito“Francisco Suarez ”1749-024 LisboaPortugal

Background:Pain associated with cancer is one of the greatest causes of reduced quality of life in patients.Acupuncture is one of the treatments used to address this issue,with the great advantage of having little or no side effects,especially when compared with pharmacological pain-killers.objective:The aim of this systematic review and meta-analysis was to evaluate the current evidence regarding the efficacy of acupuncture for cancer pain.Search strategy:Six electronic databases(PubMed,EBSCo,Cochrane Library,Scielo,b-on and Scopus)were searched for relevant articles about pain relief in cancer patients from their beginning until 2022using MeSH terms such as“acupuncture,”“electroacupuncture,”“ear acupuncture,”“acupuncture analgesia,”“oncological pain,”and“cancer pain.”Inclusion criteria:Studies included were randomized controlled trials(rCTs)where acupuncture was compared with no treatment,placebo acupuncture or usual care.Data extraction and analysis:Three independent reviewers participated in data extraction and evaluation of risk of bias,and a meta-analysis was conducted.The primary outcome was pain intensity,measured with the visual analog scale,numeric rating scale,or brief pain inventory.Secondary outcomes also assessed were quality of life,functionality,xerostomia,pain interference,and analgesic consumption.results were expressed as standardized mean difference(SMD)with 95%confidence interval(CI).results:Sixteen rCTs with a total of 1124 participants were included in the meta-analysis,with the majority of the studies presenting a low or unclear risk of bias.Acupuncture was more effective in reducing pain than no treatment(SMD=–0.90,95%CI[–1.68,–0.12]),sham acupuncture(SMD=–1.10,95%CI[–1.59,–0.61])or usual care(SMD=–1.16,95%CI[–1.38,–0.93]).Conclusion:The results of this study suggest that acupuncture may be an effective intervention to reduce pain associated with cancer.Despite some limitations due to the low quality and small sample size of some included studies,as well as the different types and stages

关键词： Acupuncture Cancer pain Meta-analysis Systematic review

Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves deus Dahan da Cunha Nascimento Nicholas rolnick rodrigo Vanerson Passos Neves Andrea Lucena reis Thais Branquinho de Araujo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinesio Silva Neto Claudio Avelino rodrigues Santos Paolo Lucas rodrigues-Silva Fernando Honorato Souza Vitoria Marra da Motta Vilalva Mestrinho rafael Lavarini dos Santos rosangela Vieira Andrade jonato Prestes Thiago dos Santos rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and renalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(HD) per se is a risk factor for thrombosis.Considering the growing body of evidence on blood-flow restriction(BFr) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training model.The aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(rE) with BFr on this molecule.Methods:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of rE+BFr session consisted of 50% arterial occlusion pressure during 50 min sessions of HD(intradialytic exercise).rE repetitions included concentric and eccentric lifting phases(each lasting 2 s) and were supervised by a strength and conditioning specialist.results:Several variables were associated with elevated levels of D-dimer,including higher blood glucose,citrate use,recent cardiovascular events,recent intercurrents,higher inflammatory status,catheter as vascular access,older patients(>70 years old),and HD vintage.Furthermore,rE+BFr significantly increases D-dimer after 4 h.Patients with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo rE+BFr.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during rE+BFr.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hemodialysis Vascular occlusion exercises

response to Commentary by Dr. Matthew J. Clarkson on "Concerns on the application of blood-flow restriction resistance exercise and thrombosis risk in hemodialysis patients"

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journal of Sport and Health Science 2024年第5期13卷 670-671页

作者： Hugo de Luca Corrêa Lysleine Alves deus Dahan da Cunha Nascimento Nicholas rolnick rodrigo Vanerson Passos Neves Andrea Lucena reis Thais Branquinho de Araújo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinésio Silva Neto Cláudio Avelino rodrigues Santos Paolo Lucas rodrigues-Silva Fernando Honorato Souza Vitória Marra da Motta Vilalva Mestrinho rafael Lavarini dos Santos rosangela Vieira Andrade jonato Prestes Thiago dos Santos rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and renalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic resources and Biotechnology Brasılia 70770-917Brazil g Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Dear editor:We sincerely thank Matthew J.Clarkson for his insightful commentary1 on our recent publication in the journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFr) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFr exercise among hemodialysis patients.

关键词： patients application flow

Biodegradable stent for the treatment of a colonic stricture in Crohn's disease

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World journal of Gastrointestinal Endoscopy 2013年第5期5卷 265-269页

作者： Catarina rodrigues Ana oliveira Liliana Santos Eduardo Pires joo deus Department of Gastroenterology Hospital Professor Doutor Fernando FonsecaIC 19 2720-276 AmadoraPortugal

Biodegradable polydioxanone stents were developed for the treatment of refractory benign esophageal strictures but have been suggested as a new therapeutic option for intestinal strictures.The primary advantage of biodegradable stents over self-expandable metallic stents is that removal is not required.There are,however,few data available on their use in the small or large bowel.We herein describe the case of a 33-yearold patient with long-standing Crohn's disease(CD) who developed a fibrotic stricture of the sigmoid too long to be amenable to balloon dilation.The use of a biodegradable polydioxanone stent was chosen to avoid surgery.Combined endoscopic and fluoroscopic placement of the stent was technically simple,safe and clinically successful,and no recurrence of obstructive symptoms occurred during a 16-mo follow-up.Further studies are needed to evaluate the long-term efficacy and safety of biodegradable stents in the treatment of intestinal strictures,particularly in the context of CD.

关键词： Crohn’s disease Fibrosis Intestinal obstruction Stents Polydioxanone

建构中的经济危机理论——马克思《资本论》草稿与关于1866年危机的笔记本

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政治经济学评论 2018年第5期9卷 206-217页

作者：利奥纳多.德乌斯若安.宝拉雨果.塞奎拉卡洛斯.苏佩瑞亚克武传鹏刘礼巴西米纳斯吉拉斯联邦大学经济科学学院清华大学马克思主义学院中央财经大学马克思主义学院

《1864—1865年经济学手稿》中,马克思开创了危机理论许多方面的研究先河。关于1866年危机的草稿和笔记本进一步呈现出马克思危机理论的主要轮廓。在编辑工作中,恩格斯意识到了客观事物本身发生的变化以及马克思19世纪60年代所作文本的... 详细信息

《1864—1865年经济学手稿》中,马克思开创了危机理论许多方面的研究先河。关于1866年危机的草稿和笔记本进一步呈现出马克思危机理论的主要轮廓。在编辑工作中,恩格斯意识到了客观事物本身发生的变化以及马克思19世纪60年代所作文本的后续结论。尽管留有遗憾,恩格斯仍然抓住了《资本论》把握资本主义生产方式更为普遍的特征之目的。

关键词：马克思恩格斯《资本论》草稿 1866年危机笔记本