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CRISPR/Cas9-Targeted Knockout of Rice Susceptibility Genes OsDjA2 and OsERF104 Reveals Alternative Sources of Resistance to Pyricularia oryzae

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Rice science 2022年第6期29卷 535-544,I0023-I0030页

作者： Fabiano T.P.KTÁVORA Anne Cécile MEUNIER Aurore VERNET Murielle PORTEFAIX joëlle milazzo Henri ADREIT Didier THARREAU Octávio LFRANCO Angela MEHTA Department of Genetics and Biotechnology Federal University of Juiz de ForaJuiz de Fora-MG 36036330Brazil Embrapa Genetic Resources and Biotechnology Brasília-DF 70770-917Brazil Genetic Improvement and Adaptation of Mediterranean and Tropical Plants Agricultural Research Center for International Development(CIRAD)Montpellier 34398 CEDEX 5France CIRAD-INRAe-Agro Institute University of MontpellierMontpellier 34000France Plant Health Institute of Montpellier CIRADMontpellier 34398France University of Montpellier National Institute of Agronomic ResearchResearch Institute for DevelopmentMontpellier SupAgroMontpellier 34398France Department of Genomics Science and Biotechnology Proteomics Analysis CenterCatholic University of BrasíliaBrasília-DF 71966-900Brazil S-Inova Biotech Catholic University of Dom BoscoCampo Grande-MS 79117-900Brazil

Rice genes OsDjA2 and OsERF104,encoding a chaperone protein and an APETELA2/ethylene-responsive factor,respectively,are strongly induced in a compatible interaction with blast fungus,and also have function in plant susceptibility validated through gene ***,we reported the CRISPR/Cas9 knockout of OsDjA2 and OsERF104 genes resulting in considerable improvement of blast resistance.A total of 15 OsDjA2(62.5%)and 17 OsERF104(70.8%)T_(0)transformed lines were identified from 24 regenerated plants for each target and used in downstream *** of homozygous T1 mutant lines revealed not only a significant decrease in the number of blast lesions but also a reduction in the percentage of diseased leaf area,compared with the infected control *** results supported CRISPR/Cas9-mediated target mutation in rice susceptibility genes as a potential and alternative breeding strategy for building resistance to blast disease.

关键词： gene editing plant-pathogen interaction Magnaporthe pathosystem plant immunity blast resistance S-gene rice

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Health Democracy and Storytelling:A Synthesis of Knowledge

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Psycho-Oncologie 2024年第1期18卷 33-41页

作者： Rossi Silvia Sandrine de Montgolfier joëlle Kivits Aix Marseille Univ INSERMIRDSESSTIMChaire démocratie en santéet engagement des personnes concernées par le cancerMarseille13009France University of Lorraine UR4360 APEMACVandoeuvre-lès-Nancy54500France UniversitéParis-Est Créteil Val de Marne UniversitéParis 12Créteil94000France UniversitéParis Cité ECEVEUMR 1123InsermParis75010France

Aims:Health democracy requires tools and methodologies to involve non-scientific actors in the development and implementation of health *** could be one of the tools to make health democracy *** aim is to describe how storytelling is used in relation to health democracy,the aims of its use,the methodology adopted and the results ***:We conducted a narrative review of the *** search equation was composed by the keyword“narration”and its variations“récit de vie”,“histoire de vie”and“medécine narrative”and by the keyword“démocratie en santé”/“démocratie sanitaire”.Results:We obtained 135 results and included six articles,published between 2015 and *** interest of storytelling in a health democracy approach concerns six main themes:a)the plurality of experiences;b)empowerment;c)the recognition of different types of knowledge;d)the involvement of all care actors in care;storytelling as a lever for change;e)in the care pathway;f)in health ***:The limited number of articles included in this literature review raises questions about the diffusion of the concept of health democracy associated with that of *** can contribute to the dissemination and effectiveness of health democracy:it is a complementary tool to quantitative tools for understanding the experiences of users of the health care system,and its use is particularly relevant to chronic diseases such as cancer.

关键词： Health democracy storytelling narratives narrative medicine

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Pure Hydrocarbons:An Efficient Molecular Design Strategy for the Next Generation of Host Materials for Phosphorescent Organic Light-Emitting Diodes

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Accounts of Materials Research 2022年第3期3卷 379-390页

作者： Cyril Poriel joëlle Rault-Berthelot 不详 UniversitéRennes CNRSISCR-6226F-35000 RennesFrance

CONSPECTUS:Fantastic progresses have been made since the discovery of phosphorescent organic light-emitting diodes(PhOLEDs)in 1998(Nature 1998,395,151).In the emissive layer of a PhOLED,a heavy-metal complex(emitter)is dispersed as a guest in an organic semiconductor(host)in order to harvest both singlet and triplet *** host/guest technique is essential to reach highperformance ***,designing high-efficiency host materials for red,green,and blue phosphors has been the main driving force of the ***,the most efficient PhOLEDs report very high external quantum efficiency(EQE)above 27%for the three *** molecular design of these high-efficiency host materials is based on small functional units,which have a crucial role in the device *** functional units are constructed on the assembly of electron-rich and/or electron-poor molecular fragments(such as carbazole,phenylamine,phosphine oxide,oxadiazole,pyridine,sulfone,etc.),which allows to finely tune the molecular orbitals energy levels(HOMO and LUMO)and the mobility of the charge carriers(hole and electrons).However,these molecular fragments incorporate heteroatoms,which in turn increase the molecular design complexity and production cost of the target materials and also create potential instability in the ***,the fragile C−N,C−P,and C−S bonds of such heteroatom-based hosts are involved,in part,in the OLED *** the instability of OLEDs is one of the most important problem to address at the current stage of development,developing new generations of host materials,without heteroatoms,has appeared as an important challenge in the *** recent years,this new generation of host materials,called Pure HydroCarbons(PHC),only incorporating carbon and hydrogen atoms,has drawn the attention of the scientific *** host materials only contain benzene rings,one of the most robust and inert building unit,which are assemble with suitable linkages to a

关键词： Strategy Host Molecular

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Probiotic yeasts: Anti-inflammatory potential of various non-pathogenic strains in experimental colitis in mice

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World journal of Gastroenterology 2010年第17期16卷 2134-2145页

作者： Benot Foligné jo■lle Dewulf Pascal Vandekerckove Georges Pignède Bruno Pot Institut Pasteur of Lille Lactic acid Bacteria & Mucosal ImmunityCenter for Infection and Immunity of Lille1 rue du Pr CalmetteBP 245F-59019 LilleFrance University of Lille Nord de France F-59000 LilleFrance Centre National de la Recherche Scientifique UMR 8204F-59021 LilleFrance Institut National de la Santé et de la Recherche Médicale U1019F-59019 LilleFrance Lesaffre International Direction of Research and Developpement147 rue Gabriel PériBP 602759700 Marcq-en-BaroeulFrance

AIM: To evaluate the in vitro immunomodulation capacity of various non-pathogenic yeast strains and to investigate the ability of some of these food grade yeasts to prevent experimental colitis in ***: In vitro immunomodulation was assessed by measuring cytokines [interleukin (IL)-12p70,IL-10,tumor necrosis factor and interferon γ] released by human peripheral blood mononuclear cells after 24 h stimulation with 6 live yeast strains (Saccharomyces ssp.) and with bacterial reference strains.A murine model of acute 2-4-6-trinitrobenzene sulfonic acid (TNBS)-colitis was next used to evaluate the distinct prophylactic protective capacities of three yeast strains compared with the performance of prednisolone ***: The six yeast strains all showed similar non-discriminating anti-inflammatory potential when tested on immunocompetent cells in vitro .However,although they exhibited similar colonization patterns in vivo ,some yeast strains showed significant anti-inflammatory activities in the TNBS-induced colitis model,whereas others had weaker or no preventive effect at all,as evidenced by colitis markers (body-weight loss,macroscopic and histological scores,myeloperoxidase activities and blood inflammatory markers).CONCLUSION: A careful selection of strains is required among the biodiversity of yeasts for specific clinical studies,including applications in inflammatory bowel disease and other therapeutic uses.

关键词： Yeast Probiotics Strain specificity Experimental colitis 2-4-6-trinitrobenzene sulfonic acid

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Mettre en dialogue disciplines et personnes concernées par le cancer pour améliorer le parcours des soins en oncologie Dialogue between Disciplines and People Affected by Cancer to Improve the Path of Care in Oncology

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Psycho-Oncologie 2024年第2期18卷 95-100页

作者： joëlle Kivits Frédérique Claudot Sandrine de Montgolfier Silvia Rossi UniversitéParis Cité ECEVEUMR 1123InsermParis75010France Universitéde Lorraine UMR 1319INSPIIREInsermNancy54500France Aix Marseille Univ InsermIRDSESSTIMChaire démocratie en santéet Engagement des personnes concernées par le CancerMarseille13284France

Interdisciplinarity and participatory research have become the guiding principles of cancer *** what are the practical forms and methods?Based on the experience of 3 successive research projects aimed at improving cancer care pathways-PARCA1,PARCA2 and 4P-we present the encounters between researchers on the one hand,and between these same researchers and patients and health professionals on the ***,these meetings have led to the co-construction of projects and the shared conduct of *** motivations behind the participatory approach are highlighted,as well as the‘step-by-step’approach needed to familiarize the people involved with the research process,and the limits of the approach:while everyone’s position tends to be adjusted as the projects progress,there is still an imbalance between the researchers and the people involved.

关键词： Interdisciplinarity transdisciplinarity participatory research healthcare pathways

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.Groh Moein Yaqubi Qiao-Ling Cui jo Anne Stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Usage Scenarios for Byte-Addressable Persistent Memory inHigh-Performance and Data Intensive Computing

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journal of Computer Science & Technology 2021年第1期36卷 110-122页

作者： Michèle Weiland Bernhard Homölle EPCC The University of EdinburghEdinburgh EH89BTU.K. System Vertrieb Alexander GmbH Paderborn 33106Germany

Byte-addressable persistent memory(B-APM)presents a new opportunity to bridge the performance gap between main memory and *** this paper,we present the usage scenarios for this new technology,based on the capabilities of Intel’s *** outline some of the basic performance characteristics of DCPMM,and explain how it can be configured and used to address the needs of memory and I/O intensive applications in the HPC(high-performance computing)and data intensive *** decision trees are presented to advise on the configuration options for BAPM;their use is illustrated with two *** show that the flexibility of the technology has the potential to be truly disruptive,not only because of the performance improvements it can deliver,but also because it allows systems to cater for wider range of applications on homogeneous hardware.

关键词： byte-addressable data intensive memory intensive persistent

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Priorities for Social and Humanities Projects Based on Text Analysis

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journal of Data and Information Science 2020年第4期5卷 116-125页

作者： Ülle Must Archimedes Foundation Väike-Turu Street 8Tartu 51004Estonia

Purpose:Changes in the world show that the role,importance,and coherence of SSH(social sciences and the humanities)will increase significantly in the coming *** paper aims to monitor and analyze the evolution(or overlapping)of the SSH thematic pattern through three funding instruments since ***/methodology/approach:The goal of the paper is to check to what extent the EU Framework Program(FP)affects/does not affect research on national level,and to highlight hot topics from a given period with the help of text *** project titles and abstracts derived from the EU FP,Slovenian,and Estonian RIS were *** final analysis and comparisons between different datasets were made based on the 200 most frequent *** removing punctuation marks,numeric values,articles,prepositions,conjunctions,and auxiliary verbs,4,854 unique words in ETIS,4,421 unique words in the Slovenian Research Information System(SICRIS),and 3,950 unique words in FP were ***:Across all funding instruments,about a quarter of the top words constitute half of the word *** text analysis results show that in the majority of cases words do not overlap between FP and nationally funded *** some cases,it may be due to using different *** is more overlapping between words in the case of Slovenia(SL)and Estonia(EE)and less in the case of Estonia and EU Framework Programmes(FP).At the same time,overlapping words indicate a wider reach(culture,education,social,history,human,innovation,etc.).In nationally funded projects(bottom-up),it was relatively difficult to observe the change in thematic trends over *** specific results emerged from the comparison of the different programs throughout FP(top-down).Research limitations:Only projects with English titles and abstracts were *** implications:The specifics of SSH have to take into account—the one-to-one meaning of terms/words is not as important as,for example,in the e

关键词： Text analysis SSH Estonian Research Information System(ETIS) Slovenian Research Information System(SICRIS) Community Research and Development Information Service(CORDIS)

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ON THE NUMERICAL SOLUTION OF QUASILINEAR WAVE EQUATION WITH STRONG DISSIPATIVE TERM

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Applied Mathematics and Mechanics(English Edition) 2004年第7期25卷 806-811页

作者： Aytekin Gülle Department of Mathematics

The numerical solution for a type of quasilinear wave equation is *** three-level difference scheme for quasi-linear waver equation with strong dissipative term is constructed and the convergence is *** error of the d... 详细信息

关键词： periodical problem quasilinear wave equation difference scheme numerical solution

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A quaternion-based simulation of multirotor dynamics

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International journal of Modeling, Simulation, and Scientific Computing 2015年第1期6卷 145-162页

作者： Valeria Artale Cristina L.R.milazzo Angela Ricciardello Kore University of Enna Faculty of Engineering and Architecture Cittadella Universitaria 94100EnnaItaly

The main problem addressed in this paper is the quaternion-based trajectory control of a microcopter consisting of six rotors with three pairs of counter-rotating fixed-pitch blades,known as *** the hypothesis of rigid body condition is assumed,the Newton–Euler equations describe the translational and rotational motion of the *** standard Euler-angle parametrization of three-dimensional rotations contains singular points in the coordinate space that can cause failure of both dynamical model and *** order to avoid singularities,all the rotations of the microcopter are thus parametrized in terms of quaternions and an original proportional derivative(PD)regulator is proposed in order to control the dynamical *** simulations will be performed on symmetrical flight configuration,proving the reliability of the proposed PD control technique.

关键词： Newton-Euler equation quaternion UAV control

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