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Peritoneal interposition flap reduces symptomatic lymphocele following transperitoneal robot-assisted radical prostatectomy and pelvic lymph node dissection:An updated meta-analysis

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Current Urology 2024年第3期18卷 167-176页

作者： joão henrique Sendrete de Pinho Lorrane Vieira Siqueira Riscado joão Padua Manzano Faculty of Medicine of the Federal University of Juiz de Fora Minas GeraisBrazil Faculty of Medicine of the Federal University of São Paulo São PauloBrazil

Background Robot-assisted radical prostatectomy with intraoperative pelvic lymph node dissection is the criterion standard for surgical treatment of nonmetastatic intermediate-and high-risk prostate ***,this method is associated with symptomatic lymphocele(SLC),which is an important morbidity *** overcome this complication,several modifications of the technique have been developed,including the peritoneal interposition flap(PIF).We performed an updated systematic review and meta-analysis to investigate the efficacy and safety of this technique for preventing SLC and lymphocele(LC)*** and methods Searches were performed using databases and references from included studies and previous systematic *** randomized controlled trials and nonrandomized cohorts were *** outcomes were the incidence of SLC and LC formation,and safety outcomes were defined as operation time,estimated blood loss,length of hospital stay,and urinary *** assessment was performed using the Newcastle-ottawa Scale and Cochrane Collaboration's *** treatment effects were estimated using odds ratios with 95%confidence intervals(CIs)for binary *** was examined using Cochran's Q test and I2 statistics;p values25%were considered significant for *** used Mantel-Haenszel fixed-effect models in the analyses with low ***,the DerSimonian and Laird random-effects model was *** The initial search yielded 510 *** the removal of duplicate records and application of the exclusion criterion,9 studies were fully reviewed for *** randomized controlled trials and 5 retrospective cohorts met all the inclusion criteria,comprising 2261 patients,of whom 1073(47.4%)underwent *** studies reported a significant reduction in SLC in the PIF group,and 3 of the 4 studies reported LC formation yielded significant results in preventing this complication.

关键词： Robot-assisted radical prostatectomy Lymphocele Peritoneal reapproximation Peritoneal interpolated flap Meta-analysis

Histological Assessment of Bone Regeneration in the Maxilla with Homologous Bone Graft:A Feasible option for Maxillary Bone Reconstruction

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journal of Renewable Materials 2024年第1期12卷 131-148页

作者： Sergio henrique Gonçalves Motta Ana Paula Ramos Soares Juliana campos Hasse Fernandes Gustavo Vicentis oliveira Fernandes Graduate Center of Faculdade Redentor CLIVORio de JaneiroBrazil Periodontics and oral Medicine Department University of Michigan School of DentistryAnn ArborMI48109USA Centre for Interdisciplinary Research in Health(CIIS) Universidade Católica PortuguesaViseu3504-505Portugal

Bone biomaterials have been increasingly used to reconstruct maxillary atrophic ***,the aim of this study was to evaluate bone reconstruction in the maxilla using a homologous cortico-cancellous FFB(lyophilized)graft and verify its *** individuals were included from 2014 to *** first surgery was performed to install homologous bone blocks in the *** period of the second intervention varied between 5 months and 15 days to 11 months(≈7.93 months).The biopsies were taken from the central region of the matured graft during the surgery for implant *** patients presented clinical and radiographic conditions for the installation of dental *** was a 100%of survival *** histological assessment showed that the homologous block bone graft was an osteoconductive biomaterial,with connective tissue present,and newly formed bone juxtaposed on its *** were bone trabeculae with osteocytes and active osteoblasts with connective tissue in the mineralization process;the remodeling process can be found through the reverse lines.A limited focus of necrosis with fibrosis was detected,with small resorption and areas of inflammatory infiltrate,but without clinical *** homologous block bone graft can be considered a feasible option to substitute the autogenous bone graft(gold standard),with predictable clinical and favorable histological *** patients had a shorter surgical period,low morbidity,and an unlimited amount of biomaterial available at an accessible cost.

关键词： Regeneration bone graft histology homologous allogenous autogenous

What is the effect of Tribulus terrestris on testicular morphology and sperm production?An experimental study in the rat model

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Asian journal of Andrology 2024年第1期26卷 67-70页

作者： Marcello henrique Araujo Da Silva Gabriela Faria Buys-Goncalves joao henrique Duque Reis Estrada Francisco jose Barcellos Sampaio Diogo Benchimol de Souza Urogenital Research Unit Rio de Janeiro State UniversityRio de Janeiro 20551-030RJBrazil

The objective of this study was to investigate whether treatment with Tribulus terrestris(Tt)has any impact on the testicular morphology and function in a rodent *** male rats were divided into a control group and a group receiving 100 mg kg^(-1) body weight of Tt *** 4o days of experiment,the animals were submitted to euthanasia;epididymal tail spermatozoa were collected;and spermatozoa concentration,motility,and viability were *** addition,testicles were collected and processed for histomorphometrical *** were compared using the Student's t-test and considered significant when Poncentration,motility,and viability showed no difference between the ***,testicular weight and volume,seminiferous tubule diameter,tunica propria surface density,seminiferous epithelium surface density,and intertubular compartment surface density were statistically similar between the ***,seminiferous epithelium height and tubular lumen surface density were augmented in animals treated with *** with Tt does not cause a major impact on testicular morphology,promoting only subtle *** difference on spermatozoa parameters was observed.

关键词： morphometry testicle Tribulus terrestris

In-Hospital outcomes in Minimally Invasive Mitral Valve Surgery: First Results in a Brazilian Single Center

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open journal of Thoracic Surgery 2024年第1期14卷 17-28页

作者： Daniel de Magalhães Freitas joão Alberto Pansani Max Weyler Nery Stanlley de oliveira Loyola Maurício Lopes Prudente Giulliano Gardenghi Artur henrique de Souza Department of Cardiovascular Surgery Encore Hospital Aparecida de Goiania Brazil Anesthesia Clinic (Clianest) Goiania Brazil

Introduction: Treatments for cardiovascular diseases have increasingly evolved with the tendency to offer minimally invasive or transcatheter procedures instead of conventional sternotomy surgery. In this context, we highlight minimally invasive mitral valve surgery (MIMVS), which has been shown to be an increasingly solid option with some superior results when compared to the conventional technique: better pain control, shorter hospital stays, shorter recovery time, shorter readmission rate in the first postoperative year, better aesthetic results, and lower overall cost. Aim: This study aims to evaluate the stages of MIMVS, by primary mitral valve consultation, in our service and compare these results with data from the literature. Methods: All electronic medical records of patients who underwent MIMVS for primary mitral valve injury in the Encore Hospital from January 2020 to February 2023 were analyzed. Tabulation and statistical analysis were performed using the Microsoft Excel® program. Quantitative variables were presented as means, standard deviations. Results: 46 patients were enrolled in our study (Age: 59.1 ± 12.4 years old;60.8% Female, BMI: 26 ± 4.4 Kg/m2, Low risk STS score: 82.6%). The observed 30-day mortality was 2.1%, plastic rate of 23.9%, blood transfusion rate of 41.3%, length of stay in an intensive care bed (ICB) of 3.3 ± 3.3 days and hospital stay of 6.4 ± 5.1 days. Conclusions: We noticed that the MIMVS results carried out in our service agree with data from national and international literature with approximately 1.3 days more hospitalization in ICB.

关键词： Minimally Invasive Surgical Procedures Mitral Valve outcome Assessment Health Care

Supercritical fluid technology as a sustainable alternative method for textile dyeing:An approach on waste,energy,and Co_(2)emission reduction

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journal of Environmental Sciences 2024年第6期140卷 123-145页

作者： Carlos Rafael Silva de oliveira Patrícia Viera de oliveira Leandro Pellenz Catia Rosana Lange de Aguiar Afonso henrique da Silva Júnior Federal University of Santa Catarina Textile Engineering Department2514 João Pessoa St.BlumenauSC89036-004Brazil Federal University of Santa Catarina Chemical Engineering DepartmentS/n Biotério Central St.FlorianópolisSC88040-900Brazil

The clothing industry is considered one of the most polluting industries on the planet due to the high consumption of water,energy,chemicals/dyes,and high generation of solid waste and *** with environmental concerns,the textile ennoblement sector is the most critical of the textile production chain,especially the traditional dyeing *** an alternative to current problems,dyeing with supercritical Co_(2)(scCo_(2))has been presented as a clean and efficient process for a sustainable textile *** fluid dyeing(SFD)has shown a growing interest due to its significant impact on environmental preservation and social,economic,and financial *** main SFD benefits include economy and reuse of non-adsorbed dyes;reduction of process time and energy expenditure;capture of atmospheric Co_(2)(greenhouse gas);use and recycling of Co_(2)in SFD;generation of carbon credits;water-free process;effluent-free process;reduction of Co_(2)emission and auxiliary *** being still a non-scalable and evolving technology,SFD is the future of *** review presented a comprehensive overview of the environmental impacts caused by traditional processes and confronted the advantages of *** SFD technique was introduced,along with its latest advances and future *** and environmental gains were also discussed.

关键词： Textile industry Supercritical dyeing Sustainable processes Water free dyeing Energy saving Cleaner production

The aryl hydrocarbon receptor and the gut–brain axis

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Cellular & Molecular Immunology 2021年第2期18卷 259-268页

作者： Andreia Barroso joão Vitor Mahler Pedro henrique Fonseca-Castro Francisco J.Quintana Ann Romney Center for Neurologic Diseases Brigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Faculdade de Medicina FMUSP Universidade de São PauloSão PauloSPBrazil Broad Institute of MIT and Harvard CambridgeMAUSA

The aryl hydrocarbon receptor(AHR)is a ligand-activated transcription factor initially identified as the receptor for *** half a century after its discovery,AHR is now recognized as a receptor for multiple physiological ligands,with important roles in health and *** this review,we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases.

关键词： Aryl hydrocarbon receptor Autoimmune diseases Infectious diseases cancer

Faujasite zeolite decorated with cobalt ferrite nanoparticles for improving removal and reuse in Pb^2+ions adsorption

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Chinese journal of Chemical Engineering 2020年第7期28卷 1884-1890页

作者： Elaine C.Paris joão o.D.Malafatti henrique C.Musetti Alexandra Manzoli Alessandra Zenatti Márcia T.Escote Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoXV de Novembro St.145213560-970 São CarlosSPBrazil Department of Chemistry Federal University of São CarlosRod.Washington Luizkm 23513565-905 São CarlosSPBrazil Regional Integrated University of High Uruguay and Missions(URI) Sete de Setembro Ave.162199709-910ErechimRSBrazil Federal University of ABC(UFABC) Avenida dos Estados5001Santo AndréSPBrazil

Water pollution caused by heavy metals ions has been gaining attention in recent years,increasing the interest in the development of methodologies for their efficient removal focusing on the adsorption process for these *** current challenge faced by adsorption processes is the adequate adsorbent immobilization for removal and ***,the present work aimed at producing a faujasite zeolite nanocomposite decorated with cobalt ferrite nanoparticles for Pb^2+ions adsorption in an aqueous medium improving magnetic removal and *** a result,a high surface area(434.4 m^2·g^-1)for the nanocomposite and an 18.93 emu·g^-1 saturation magnetization value were obtained,indicating magnetic removal in a promising material for adsorption *** nanocomposite regeneration capacity evaluated by magnetic recovery after 24 h suspension presented a high Pb^2+ion adsorptive capacity(98.4%)in the first *** 98%of the Pb^2+ions were adsorbed in the second *** this way,the synthesized faujasite:cobalt ferrite nanocomposite reveals itself as a promising alternative in adsorption processes,aiming at a synergic effect of FAU zeolite high adsorptive activity and the cobalt ferrite nanoparticles magnetic activity,allowing for adsorbent recovery from the aqueous medium via magnetic force and successive adsorptive cycles.

关键词： Faujasite zeolite Adsorption Cobalt ferrite Nanoparticles Magnetic nanocomposite

Trace metal dynamics in an industrialized Brazilian river:A combined application of Zn isotopes,geochemical partitioning,and multivariate statistics

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journal of Environmental Sciences 2021年第3期33卷 313-325页

作者： Myller S.Tonhá Daniel F.Araújo Rafael Araújo Bruno C.A.Cunha Wilson Machado joelma F.Portela joão PR Souza Hikari K.Carvalho Elton L.Dantas henrique L.Roig Patrick Seyler Jeremie Garnier Universidade de Brasília Instituto de GeociênciasCampus Darcy RibeiroL2Asa Norte70910900 BrasíliaDistrito FederalBrazil Laboratoire de Biogéochimie des Contaminants Métalliques IfremerCentre AtlantiqueF44311 Nantes Cedex 3France Institute of Geosciences University of São PauloRua do Lago562São Paulo 05508-080Brazil Universidade Federal Fluminense Programa de GeoquímicaCampus do ValonguinhoNiteróiRio de JaneiroBrazil Analytical and Environmental Chemistry Laboratory Instituto de QuímicaUniversity of BrasiliaBrasiliaFederal District 70919-970Brazil Laboratoire Mixte International“observatoire des Changements Environnementaux”(LMI oCE) Institut de Recherche pour le Développement/University of BrasiliaCampus Darcy RibeiroBrasiliaBrazil Hydrosciences Montpellier Universitéde MontpellierInstitut de Recherche pour le développementCentre National de la Recherche ScientifiqueMontpellierFrance

The Paraiba do Sul(PSR)and Guandu Rivers(GR)water diversion system(120 km long)is located in the main industrial pole of Brazil and supplies drinking water for 9.4 million people in the metropolitan region of Rio de *** study aims to discern the trace metals dynamics in this complex aquatic *** used a combined approach of geochemical tools such as geochemical partitioning,Zn isotopes signatures,and multivariate *** and Pb concentrations in Suspended Particulate Matter(SPM)and sediments were considerably higher in some *** sediment partition of As,Cr,and Cu revealed the residual fraction(F4)as the main fraction for these elements,indicating low *** and Pb were mostly associated with the exchangeable/carbonate(F1)and the reducible(F2)fractions,respectively,implying a higher susceptibility of these elements to being released from *** isotopic compositions of sediments and SPM fell in a binary mixing source process between lithogenic(δ^(66/64)Zn_(JMC)≈+0.30‰)and anthropogenic(δ^(66/64)Zn_(JMC)≈+0.15‰)end *** lighterδ^(66/64)Zn_(JMC)values accompanied by high Zn concentrations in exchangeable/carbonate fraction(ZnF1)enable the tracking of Zn anthropogenic sources in the studied ***,the results indicated that Hg,Pb,and Zn had a dominant anthropogenic origin linked to the industrial activities,while As,Cr,and Cu were mainly associated with lithogenic *** work demonstrates how integrating geochemical tools is valuable for assessing geochemical processes and mixing source effects in anthropized river watersheds.

关键词： Metal pollution Isotope tracer Sequential extraction Anthropogenic activity

Trans-10,cis-12 conjugated linoleic acid reduces neutral lipid content and may affect cryotolerance of in vitro-produced crossbred bovine embryos

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journal of Animal Science and Biotechnology 2014年第4期5卷 391-398页

作者： Ribrio Ivan Tavares Pereira Batista Nadia Rezende Barbosa Raposo Paulo henrique Almeida campos-Junior Michele Munk Pereira Luiz Sergio Almeida Camargo Bruno campos Carvalho Marco Antonio Sundfeld Gama joao henrique Moreira Viana Federal University of Juiz de Fora Juiz de ForaMG 36036-900Brazil Embrapa Dairy Cattle Research Center Juiz de ForaMG 36038-330Brazil Federal University of Minas Gerais Belo HorizonteMG 31270-901Brazil

Background：Due to high neutral lipids accumulation in the cytoplasm,in vitro-produced embryos from Bos primigenius indicus and their crosses are more sensitive to chilling and cryopreservation than those from Bos primigenius *** objective of the present study was to evaluate the effects of trans-10,cis-12 conjugated linoleic acid（CLA） on the development and cryotolerance of crossbred Bos primigenius taurus x Bos primigenius indicus embryos produced in vitro,and cultured in the presence of fetal calf *** zygotes（n = 1,692）were randomly assigned to one of the following treatment groups：1） Control,zygotes cultured in Charles Rosenkrans 2 amino acid（CR2aa） medium（n = 815） or 2） CLA,zygotes cultured in CR2 aa medium supplemented with 100 μmol/L of trans-10,cis-12 CLA（n =877）.Embryo development（cleavage and blastocyst rates evaluated at days 3 and 8 of culture,respectively）,lipid content at morula stage（day 5） and blastocyst cryotolerance（re-expansion and hatching rates,evaluated 24 and 72 h post-thawing,respectively） were compared between ***,selected mRNA transcripts were measured by Real-Time PCR in blastocyst ***：The CLA treatment had no effect on cleavage and blastocyst rates,or on mRNA levels for genes related to cellular stress and *** the other hand,abundance of mRNA for the 1-acylglycerol-3-phosphate0-acyltransferase-encoding gene（AGPAT）,which is involved in triglycerides synthesis,and consequently neutral lipid content,were reduced by CLA treatment.A significant increase was observed in the re-expansion rate of embryos cultured with trans-10,cis-12 CLA when compared to control（56.3 vs.34.4%,respectively,P = 0.002）.However,this difference was not observed in the hatching rate（16.5 vs.14.0%,respectively,P=0.62）.Conclusions：The supplementation with trans-10,ds-12 CLA isomer in culture medium reduced the lipid content of in vitro produced bovine embryos by reducing the gene expression of 1-acylglycerol 3-phosphate 0

关键词： Blastocysts CLA Crossbred cattle Cryopreservation Lipid content