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Fluffy hybrid nanoadjuvants for reversing the imbalance of osteoclastic andosteogenic niches in osteoporosis

Bioactive Materials 2024年第9期39卷 354-374页

作者： Guoyang Zhang Yuhao Kang jizhao dong c Dingyi Shi Yu Xiang Haihan Gao Zhiqi Lin Xiaojuan Wei Ren Ding Beibei Fan Hongmei Zhang Tonghe Zhu Liren Wang Xiaoyu Yan Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine No.600 Yishan RoadShanghai200233China Shanghai Jiao Tong University School of Medicine No.227 South Chongqing RoadShanghai200025China Multidisciplinary centre for Advanced Materials Institute for Frontier Medical TechnologySchool of Chemistry and Chemical EngineeringShanghai University of Engineering ScienceNo.333 Longteng RoadShanghai201620China Shanghai Baoshan District Hospital of Integrated Traditional chinese and Western Medicine Department of OrthopedicsNo.181 Youyi RoadShanghai201900China Shanghai Baoshan District Hospital of Integrated Traditional chinese and Western Medicine Department of PharmacyNo.181 Youyi RoadShanghai201900China Regenerative Sports Medicine and Translational Youth Science and Technology Innovation Workroom Shanghai Jiao Tong University School of MedicineNo.227 South Chongqing RoadShanghai200025China Regenerative Sports Medicine Lab of the Institute of Microsurgery on Extremities Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.600 Yishan RoadShanghai200233China

Osteoporosis is majorly caused by an imbalance between osteoclastic and osteogenic niches. Despite thedevelopment of nationally recognized first-line anti-osteoporosis drugs, including alendronate (AL), their lowbioavailability, poor uptake rate, and dose-related side effects present significant challenges in treatment. Thiscalls for an urgent need for more effective bone-affinity drug delivery systems. In this study, we produced hybridstructures with bioactive components and stable fluffy topological morphology by cross-linking calcium andphosphorus precursors based on mesoporous silica to fabricate nanoadjuvants for AL delivery. The subsequentgrafting of -PEG-DAsp8 ensured superior biocompatibility and bone targeting capacity. RNA sequencing revealedthat these fluffy nanoadjuvants effectively activated adhesion pathways through cARD11 and cD34 molecularmechanisms, hence promoting cellular uptake and intracellular delivery of AL. Experiments showed that smalldoseAL nanoadjuvants effectively suppress osteoclast formation and potentially promote osteogenesis. In vivoresults restored the balance between osteogenic and osteoclastic niches against osteoporosis as well as theconsequent significant recovery of bone mass. Therefore, this study constructed a drug nanoadjuvant withpeculiar topological structures and high bone targeting capacities, efficient intracellular drug delivery as well asbone bioactivity. This provides a novel perspective on drug delivery for osteoporosis and treatment strategies forother bone diseases.

关键词： Osteoporosis nanoadjuvants topological morphology bone niches Adhesion

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Lipid levels and insulin resistance markers in patients with colorectal cancer:Propensity score matching analysis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 130-142页

作者： Ren-Hao Hu dong-Yi Yan Ke-Hui Zhang Di Zhang Xi-Mao cui Xiao-Hua Jiang Shun Zhang Department of Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200092China Department of Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BAcKGROUND colorectal cancer(cRc)is a prevalent malignant neoplasm characterized by subtle early *** To investigate the correlation among serum lipid profiles,the triglyceride-glucose(TyG)index,and the atherosclerotic index(AI)in patients with ***,it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of *** A retrospective analysis encompassed 277 patients with cRc and 1034 healthy *** Following propensity score matching,patients with cRc exhibited significantly reduced levels of serum triglyceride(TG),total cholesterol(Tc),high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol(LDL-c),as well as a diminished TyG ***,they displayed elevated AI levels compared to their healthy *** in advanced stages exhibited lower serum levels of TG,Tc,and LDL-c compared to those in early *** with positive lymph node metastasis demonstrated reduced levels of TG,LDL-c,and the TyG *** operating characteristic analysis revealed that the combination of the TyG index,carcinoembryonic antigen,and carbohydrate antigen 19-9 yielded the highest positive prediction rate for cRc at 75.3%.cONcLUSION Preoperative serum lipid profiles exhibit a robust association with patients with *** concurrent assessment of multiple serum lipids and cancer antigens effectively enhances the diagnostic accuracy for cRc.

关键词： colorectal cancer Serum lipids Triglyceride-glucose index Atherosclerotic index Diagnostic marker

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Aligned Ion conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑chang Sung Gwang‑Hee Lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and chemical Engineering center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

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A Flexible Smart Healthcare Platform conjugated with Artificial Epidermis Assembled by Three‑Dimensionally conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng chencheng Hu Long Yang Zitong Kan Biao dong Miae Won Hongwei Song Lin Xu Jong Seung Kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of chemistry Korea UniversitySeoul 02841Republic of Korea Theranochem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)c_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)c_(2)T_(x)@cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)c_(2)T_(x)@cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

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Enhanced solid-electrolyte interface efficiency for practically viable hydrogen-air fuel cell systems

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Journal of Energy chemistry 2025年第1期 356-368页

作者： Venkitesan Sakthivel dong Jin Yoo Graduate School Department of Energy Storage/Conversion Engineering (BK21 FOUR) Hydrogen and Fuel Cell Research Center Jeonbuk National University Jeonju Department of Life Science Jeonbuk National University

Proton exchange membrane fuel cells （PEMFcs） provide an appealing sustainable energy system,with the solid-electrolyte membrane playing a crucial role in its overall ***,sulfonated poly（1,4-phenylene ether-ether sulfone）(SPEES),an aromatic hydrocarbon polymer,has garnered considerable attention as an alternative to Nafion ***,the long-term durability and stability of SPEES present a significant *** this context,we introduce a potential solution in the form of an additive,specifically a core–shell-based amine-functionalized iron titanate （A–Fe2TiO5）,which holds promise for improving the lifetime,proton conductivity,and power density of SPEES in *** modified SPEES/A–Fe2TiO5composite membranes exhibited notable characteristics,including high water uptake,enhanced thermomechanical stability,and oxidative ***,the SPEES membrane loaded with 1.2 wt%of A–Fe2TiO5demonstrates a maximum proton conductivity of 155 mS cm-1,a twofold increase compared to the SPEES membrane,at 80°c under 100%relative humidity （RH）.Furthermore,the 1.2 wt%of A–Fe2TiO5/SPEES composite membranes exhibited a maximum power density of 397.37 mW cm-2and a current density of 1148 mA cm-2at 60°c under 100%RH,with an opencircuit voltage decay of 0.05 m V/h during 103 h of continuous *** study offers significant insights into the development and understanding of innovative SPEES nanocomposite membranes for PEMFc applications.

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基于钢结构BIM模型的结构分析数据转换和软件开发

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哈尔滨工业大学学报 2025年第1期57卷 161-169页

作者：赵诗华刘栋余香林石永久清华大学土木工程系北京100084

为解决当前在钢结构建筑信息模型(building information modeling,BIM)与结构分析模型之间进行数据转换时存在的关键技术问题,本文在分析工业基础类(industry foundation classes,IFc)标准表达方法的基础上,以ABAQUS为结构分析平台,开... 详细信息

为解决当前在钢结构建筑信息模型(building information modeling,BIM)与结构分析模型之间进行数据转换时存在的关键技术问题,本文在分析工业基础类(industry foundation classes,IFc)标准表达方法的基础上,以ABAQUS为结构分析平台,开发了钢结构BIM模型数据转换算法,运用c#语言和Xbim工具包,实现了结构构件信息提取、构件空间位置调整和分析数据自动添加,并形成了相应的转换软件;通过钢框架结构实例分析验证了该软件的可靠性和准确性,并将其应用于安阳市游客集散中心的BIM模型转换和结构分析。结果表明,所开发的算法和软件解决了生成的结构分析模型节点不连接和人工添加分析数据工作量大等问题,实现了BIM中的钢结构设计模型或深化设计模型向ABAQUS结构分析模型数据的准确转换。与传统的在ABAQUS中直接建立结构分析模型相比,本文提出的方法能大大提高复杂钢结构的结构分析建模速度和效率。

关键词：钢结构建筑信息模型(BIM) IFc标准模型转换结构分析

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of critical care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a c57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Effects of adenosine triphosphate concentration on motor force regulation during skeletal muscle contraction

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Acta Mechanica Sinica 2017年第2期33卷 243-249页

作者： J. Wei c. dong B. chen Department of Engineering Mechanics Zhejiang UniversityHangzhou 310058 China

We employ a mechanical model of sarcomere to quantitatively investigate how adenosine triphosphate (ATP) concentration affects motor force regulation during skeletal muscle contraction. Our simulation indicates that there can be negative cross-bridges resisting contraction within the sarcomere and higher ATP concentration would decrease the resistance force from negative cross-bridges by promoting their timely detachment. It is revealed that the motor force is well regulated only when ATP concentration is above a certain level. These predictions may provide insights into the role of ATP in regulating coordination among multiple motors.

关键词： Motor force regulation ATP Muscle contraction Myosin

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Insect herbivory immediately before the eclipse of the gymnosperms:The Dawangzhangzi plant assemblage of Northeastern china

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Insect Science 2022年第5期29卷 1483-1520页

作者： Lifang Xiao conrad c.Labandeira dong Ren college of Life Science and Academy for Multidisciplinary Studies Capital Normal UniversityBejingChina Smithsonian Institution National Museum of Natural HistoryWashingtonDCUSA Department of Entomology and Bees Program University of MarylandCollege ParkMDUSA

The Early cretaceous terrestrial revolution involved global shifts from gymnosperm-to angiosperm-dominated ***,responses of insect herbivores to these changes remain *** evaluated 2176 highly sampled plant specimens representing 62 species/morphotypes from the 126 Ma Dawangzhangzi plant assemblage of Northeastern *** study consisted of horsetails,ferns,ginkgoaleans,czekanowskialeans,conifers,and an *** herbivory was evaluated by the functional feeding groups of hole feeding,margin feeding,and surface feeding(ectophytic feeders);piercer and suckers,and ovipositing insects(ectoendophytic feeders);mining,galling,and borings(endophytic feeders);and pathogens,collectively constituting 65 damage types(DTs).The plant assemblage was assessed for herbivory richness by DT richness,component community structure,and DT specialization on plant hosts;for herbivory intensity,it was evaluated for DT frequency,herbivorized surface area,and feeding event *** feeding event occurrences,the data supported seven species/morphotypes as most intensely herbivorized:Liaoningocladus boii(76.6%),czekanowskia sp.1(8.4%),czekanowskia rigida(4.10%),Lindleycladus lanceolatus(3.5%),Ginkgoites sp.2(2.0%),Podozamites sp.1(1.1%),and Solenites sp.1(0.9%).The most herbivorized taxa were pinaleans(conifers),then czekanowskialeans,and lastly ginkgoaleans;the monodominant component community was the conifer Liaoningocladus *** host specialization levels were *** plant assemblage had an overall low 0.86%of foliage removed by herbivores,explained by physical and chemical antiherbivore defenses,and parasitoid *** Paleozoic,gymnosperm-dominated assemblages had greater herbivory,component community structure of the three most herbivorized taxa are more similar to modern bracken fern and willow than modern gymnosperm taxa.

关键词： broadleaved conifer cretaceous terrestrial revolution czekanowskia damage type herbivory index Liaoningocladus boit Mesozoic ovipositor Yixian Formation

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consistency of optimizing finite-time carnot engines with the low-dissipation model in the two-level atomic heat engine

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communications in Theoretical Physics 2021年第12期73卷 78-85页

作者： Yu-Han Ma c P Sun Hui dong Graduate School of china Academy of Engineering Physics Beijing 100193China Beijing computational Science Research center Beijing 100193China

The efficiency at the maximum power(EMP)for finite-time carnot engines established with the low-dissipation model,relies significantly on the assumption of the inverse proportion scaling of the irreversible entropy generationΔS^(ir)on the operation timeτ,i.e.ΔS^(ir)∝1/τ.The optimal operation time of the finite-time isothermal process for EMP has to be within the valid regime of the inverse proportion ***,such consistency was not tested due to the unknown coefficient of the 1/τ-*** this paper,we reveal that the optimization of the finite-time two-level atomic carnot engines with the low-dissipation model is consistent only in the regime ofη_(c)c)is the carnot efficiency,andδis the compression ratio in energy level difference of the heat engine *** the large-η_(c)regime,the operation time for EMP obtained with the low-dissipation model is not within the valid regime of the 1/τ-scaling,and the exact EMP of the engine is found to surpass the well-known boundη_(c)=η_(c)/(2-η_(c)).

关键词： finite-time thermodynamics low-dissipation model quantum heat engine efficiency at maximum power irreversible entropy generation

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