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SENEX-mediated CDK4/6 inhibition promotes senescence and confers apoptosis resistance in B-cell non-Hodgkin lymphoma

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BIOCELL 2024年第3期48卷 453-462页

作者： jiyu wang LIUYING YI KEKE HUANG YANGYANG wang HUIPING wang ZHIMIN ZHAI Department of Hematology The Second Affiliated Hospital of Anhui Medical UniversityHefei230601China Department of Hematology The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu322000China

Background:The primary cause of treatment failure in patients with refractory or relapsed B-cell non-Hodgkin lymphoma(r/r B-NHL)is resistance to current therapies,and therapy-induced senescence(TIS)stands out as a crucial mechanism contributing to tumor drug ***,we analyzed SENEX/Rho GTPase Activating Protein 18(ARHGAP18)expression and prognostic signiﬁcance in doxorubicin-induced B-NHL-TIS model and r/r B-NHL patients,investigating its target in B-NHL cell senescence and the effect of combining speciﬁc inhibitors on apoptosis resistance in B-NHL-TIS ***:Raji cells were transfected with the human SENEX shRNA recombinant lentiviral vector(Sh-SENEX)and the empty vector negative(NC)to construct a stable transfection cell line with knockdown of *** of SENEX-silencing on B-NHL-TIS formation,cell function and cell cycle-related pathways was *** doxorubicin(DOX)-inducible senescent B-NHL cells combined with the speciﬁc cyclin dependent kinase 4/6(CDK4/6)inhibitor Palbociclib to observe that blocking CDK4/6 effects on TIS *** expression of 21 B-NHL patients and 8 healthy controls were analyzed by qRT-PCR,and the correlation between its expression and clinical indicators were ***:The downregulation of SENEX expression promotes G1-S phase transition and apoptosis while inhibiting cell proliferation,collectively suppressing the formation of TIS in *** of CDK4/6 promotes the DOX-induced G1 phase arrest to enhance TIS formation in B-NHL cells which can reverse the regulatory effect of silencing SENEX on B-NHL cell cycle regulation and *** expression levels of SENEX were notably elevated in B-NHL patients compared to healthy controls,and Elevated expression levels of SENEX were associated with poor prognosis of B-NHL ***:SENEX enhances apoptosis resistance in B-NHL by inhibiting CDK4/6,thereby preventing G1-S phase transition and promoting TIS formation.

关键词： SENEX B-cell non-Hodgkin lymphoma CDK4/6 G1-S phase transition Therapy-induced senescence Apoptosis resistance

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Liquid-FEP-based U-tube triboelectric nanogenerator for harvesting water-wave energy

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Nano Research 2018年第8期11卷 4062-4073页

作者： Lun Pan jiyu wang Peihong wang Ruijie Gao Yi-Cheng wang Xiangwen Zhang Ji-Jun zou Zhong Lin wang School of Material Science and Engineering Georgia Institute of Technology Atlanta Georgia 30332 USA Key Laboratory for Green Chemical Technology of the Ministry of Education School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China 3Collaborative Innovative Center of Chemical Science and Engineering (Tianjin) Tianjin 300072 China 4Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 100083 China Lun Pan and jiyu wang contributed equally to this work.

Harvesting ambient mechanical energy is a key technology for realizing self-powered electronics. With advantages of stability and durabilid, a liquid-solid-based triboelectric nanogenerator （TENG） has recently drawn much attention. However, the impacts of liquid properties on the TENG performance and the related working principle are still unclear. We assembled herein a U-tube TENG based on the liquid-solid mode and applied 11 liquids to study the effects of liquid properties on the TENG output performance. The results confirmed that the key factors influencing the output are polarity, dielectric constant, and affinity to fluorinated ethylene propylene （FEP）. Among the 11 liquids, the pure water-based U-tube TENG exhibited the best output with an open-circuit voltage （Voc） of 81.7 V and a short-circuit current （Isc） of 0.26 μA for the shaking mode （0.5 Hz）, which can further increase to 93.0 V and 0.48 μA, respectively, for the horizontal shifting mode （1.25 Hz）. The U-tube TENG can be utilized as a self-powered concentration sensor （component concentration or metal ion concentration） for an aqueous solution with an accuracy higher than 92%. Finally, an upgraded sandwich-like water-FEP U-tube TENG was applied to harvest water-wave energy, showing a high output with Voc of 350 V, Isc of 1.75 μA, and power density of 2.04 W/m3. We successfully lighted up 60 LEDs and powered a temperature-humidity meter. Given its high output performance, the water-FEP U-tube TENG is a very promising approach for harvesting water-wave energy for self-powered electronics.

关键词： triboelectric nanogenerator FEP U tube liquid properties ionic aqueous solution water-wave energy

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Decreased CD10-positive granulocytes for the differential diagnosis of myelodysplastic syndrome

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BIOCELL 2020年第4期44卷 607-611页

作者： jiyu wang HUIPING wang YING PAN QIANSHAN TAO ZHIMIN ZHAI Department of Hematology The Second Hospital of Anhui Medical UniversityHefei230601China

Myelodysplastic syndromes(MDS)are highly heterogeneous myeloid neoplasms,and a large number of patients are difficult to diagnose and classify by blood and bone marrow *** a surface marker of granulocyte,studies have shown CD10 can be used to define the degree of granulocyte maturation in MDS ***,whether it can be used for differential diagnosis of MDS and other hematological diseases remains *** explore the value of CD10 for differential diagnosis of MDS,60 newly diagnosed MDS,20 aplastic anemia(AA)patients,and 35 iron-deficient anemia(IDA)patients were selected for this *** marrow(BM)specimens were processed for surface marker analysis and labeled with pre-conjugated monoclonal *** cells were detected by flow *** results indicated that CD10-positive granulocytes were significantly decreased in BM of MDS patients than AA and IDA patients,and the level of CD10-positive mature granulocytes was not associated with the clinical stages of *** operating characteristic(ROC)areas under the curve(AUC)of CD10-positive granulocytes was 0.86 and 0.85,respectively,in MDS patients than the IDA group and AA group with good specificity and ***,CD10-positive granulocytes were increased after effective *** conclusion,we found the decrease in CD10-positive granulocytes has a differential diagnostic value of MDS.

关键词： Myelodysplastic syndromes CD10 Granulocytes Flow cytometry Differential diagnosis

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Bronchoalveolar lavage fluid metagenomic next-generation sequencing assay for identifying pathogens in lung cancer patients

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BIOCELL 2024年第4期48卷 623-637页

作者： jiyu wang HUIXIA LI DEYUAN ZHOU LIHONG BAI KEJING TANG Division of Pulmonary and Critical Care Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Institute of Pulmonary Diseases Sun Yat-sen UniversityGuangzhouChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

Background:For patients with lung cancer,timely identiﬁcation of new lung lesions as infectious or non-infectious,and accurate identiﬁcation of pathogens is very important in improving OS of *** a new auxiliary examination,metagenomic next-generation sequencing(mNGS)is believed to be more accurate in diagnosing infectious diseases in patients without underlying diseases,compared with conventional microbial tests(CMTs).We designed this study toﬁnd out whether mNGS has better performance in distinguishing infectious and non-infectious diseases in lung cancer patients using bronchoalveolar lavageﬂuid(BALF).Materials and Methods:This study was a real-world retrospective review based on electronic medical records of lung cancer patients with bronchoalveolar lavage(BAL)and BALF commercial mNGS testing as part of clinical care from 1 April 2019 through 30 April 2022 at The First Afﬁliated Hospital of Sun Yat-sen University.164 patients were included in this *** were categorized into the pulmonary non-infectious disease(PNID)group(n=64)and the pulmonary infectious disease(PID)group(n=100)groups based onﬁnal ***:BALF mNGS increased the sensitivity rate by 60%compared to CMTs(81%vs.21%,p0.1).Among the patients with PID,bacteria were the most common cause of *** infections occurred in 32%of patients,and Pneumocystis Yersini was most *** with Tyrosine kinase inhibitors(TKIs)therapy possess longer overall survival(OS)than other anti-cancer agents,the difference between TKIs and immuno-checkpoint inhibitors(ICIs)was insigniﬁcant(median OS TKIs *** ***-angiogenic *** ***=76 vs.84 vs.61 vs.58 vs.60).Conclusions:our study indicates that BALF mNGS can add value by improving overall sensitivity in lung cancer patients with potential pulmonary infection,and was outstanding in identifying Pneumocystis *** could be able

关键词： Lung cancer Bronchoalveolar lavage fluid Metagenomic next-generation sequencing Infectious diseases

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SENEX gene promotes cell proliferation by activating RB/E2F pathway in diffuse large B-cell lymphoma cells

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BIOCELL 2021年第4期45卷 933-942页

作者： jiyu wang YING PAN YANG WAN ZHIXIANG WANYAN ZHITAO wang QIANSHAN TAO ZHIMIN ZHAI Department of Hematology The Second Hospital of Anhui Medical UniversityHefei230601China

The present study aimed to clarify the role of SENEX in malignant cell proliferation in diffuse large B-cell lymphoma(DLBCL).22 DLBCL patients(6 newly diagnosed cases,7 cases at complete remission,and 9 relapsed cases)were included in the *** results indicated that both SENEX gene and protein were significantly increased in peripheral blood mononuclear cells(PBMCs)and tumor cells of relapsed DLBCL patients,accompanied by overexpression of p21,p16,and phosphorylated retinoblastoma(Rb).Silencing the SENEX gene in a DLBCL cell line caused a significant decrease in cell proliferation and inhibited cell cycle progression in the G1 *** Rb and E2F1 were also decreased,and activation of the Rb/E2F1 pathway was obviously *** conclude,the SENEX gene promotes proliferation in PBMC and tumor cells of DLBCL patients by activating the Rb/E2F1 pathway,in a manner suggesting that increased SENEX expression affects the relapse of DLBCL and may serve as an important target for DLBCL therapy.

关键词： SENEX DLBCL Cell proliferation Rb E2F

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Sudden cardiac death after modified electroconvulsive therapy

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上海精神医学 2015年第5期27卷 315-318页

作者： Zhihui wang jiyu wang Shanxi Rongjun Jingshen Kangning Hospital Shanxi China

Summary: Sudden deaths associated with the use of electroconvulsive therapy are rare. In this case report a 58-year-old male with a 20-year history of bipolar disorder and no history or signs of cardiac illness died from cardiac arrest within one hour of receiving an initial session of modified electroconvulsive therapy (MECT) to treat a recurrent episode of non-psychotic mania. The patient regained consciousness and was medically stable immediately after the MECT session (which did not produce a convulsion) but deteriorated rapidly after transfer to the recovery room. It was not possible to conduct an autopsy, but the authors surmise that the most probable cause was that the use of haloperidol 17hours prior to MECT exacerbated the cardiac effects of nonconvulsive MECT. The case highlights the need for a thorough cardiac work-up on patients being considered for MECT (possibly including assessment of cardiac enzymes in older individuals) and careful consideration of the concurrent use of antipsychotic medications and MECT,

关键词：心脏病治疗休克猝死抽搐同时使用精神病哌啶醇

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CD34^(+)CD38^(-)subpopulation without CD123 and CD44 is responsible for LSC and correlated with imbalance of immune cell subsets in AML

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BIOCELL 2022年第1期46卷 159-169页

作者： QIANSHAN TAO QING ZHANG HUIPING wang HAO XIAO MEI ZHOU LINLIN LIU HUI QIN jiyu wang FURUN AN ZHIMIN ZHAI YI DONG Department of Hematology The Second Hospital of Anhui Medical UniversityHematology Research CenterAnhui Medical UniversityHefei230601China

Acute myeloid leukemia(AML)is regarded as a stem cell ***,no one unique marker is expressed on leukemia stem cells(LSC)but not on leukemic blasts nor normal hematopoietic stem cells(HSC).CD34^(+)CD38^(-)with or without CD123 or CD44 subpopulations are immunophenotypically defined as putative LSC fractions in ***,markers that can be effectively and simply held responsible for the intrinsical heterogeneity of LSC is still *** the present study,we examined the frequency of three different LSC subtypes(CD34^(+)CD38^(-),CD34^(+)CD38^(-)CD123^(+),CD34^(+)CD38^(-)CD44^(+))in AML at *** then validated their prognostic significance on the relevance of spectral features for diagnostic stratification,immune status,induction therapy response,treatment effect maintenance,and long^(-)term *** our findings,high proportions of the above three different LSC subtypes were all significantly characterized with low complete remission(CR)rate,high relapse/refractory rate,poor overall survival(OS),frequent FLT3^(-)ITD mutation,the high level of regulatory T cells(Treg)and monocytic myeloid^(-)derived suppressor cells(M^(-)MDSC).However,there was no significant statistical difference in all kinds of other clinical performance among the three different LSC *** was demonstrated that CD34^(+)CD38^(-)subpopulation without CD123 and CD44 might be held responsible for LSC and correlated with an imbalance of immune cell subsets in AML.

关键词： Acute myeloid leukemia Leukemia stem cells CD123 CD44 Immune cell subsets

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An allelic variation in the promoter of the LRR-RLK gene,qSS6.1,is associated with melon seed size

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Journal of Integrative Agriculture 2024年第10期23卷 3522-3536页

作者： Xiaoxue Liang jiyu wang Lei Cao Xuanyu Du Junhao Qiang Wenlong Li Panqiao wang Juan Hou Xiang Li Wenwen Mao Huayu Zhu Luming Yang Qiong Li Jianbin Hu College of Horticulture Henan Agricultural UniversityZhengzhou 450002China Henan Engineering Research Center for Cucurbit Germplasm Enhancement and Utilization Zhengzhou 450002China International Joint Laboratory of Henan Horticultural Crop Biology Zhengzhou 450002China

Seed size is an important agronomic trait in melons that directly affects seed germination and subsequent seedling ***,the genetic mechanism underlying seed size in melon remains *** the present study,we employed Bulked-Segregant Analysis sequencing(BSA-seq)to identify a candidate region(~1.35 Mb)on chromosome 6 that corresponds to seed *** interval was confirmed by QTL mapping of three seed size-related traits from an F2 population across three *** mapping region represented nine QTLs that shared an overlapping region on chromosome 6,collectively referred to as *** InDel markers were developed in the qSS6.1 region,narrowing it down to a 68.35 kb interval that contains eight annotated *** variation analysis of the eight genes identified a SNP with a C to T transition mutation in the promoter region of MELO3C014002,a leucine-rich repeat receptor-like kinase(LRR-RLK)*** mutation affected the promoter activity of the MELO3C014002 gene and was successfully used to differentiate the large-seeded accessions(C-allele)from the small-seeded accessions(T-allele).qRT-PCR revealed differential expression of MELO3C014002 between the two parental *** predicted protein has typical LRR-RLK family domains,and phylogenetic analyses reveled its similarity with the homologs in several plant ***,these findings suggest MELO3C014002 as the most likely candidate gene involved in melon seed size *** results will be helpful for better understanding the genetic mechanism regulating seed size in melons and for genetically improving this important trait through molecular breeding pathways.

关键词： melon QTL mapping seed size candidate gene allelic variation

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Economic Life Assessment of Power Transformers Using an Improved Model

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CSEE Journal of Power and Energy Systems 2015年第3期1卷 68-75页

作者： jiyu wang Ruijin Liao Yiyi Zhang Fanjin Meng State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqing 400044China Electrical Engineering College of Guangxi University Nanning 530004China Tangshan Power Supply Company Tangshan 063000China

The electric power enterprise devotes considerable attention to the reliability of power transformers particularly when it decides to either maintain these transformers or decommission them altogether from *** this process has reduced the risk of transformer faults,the attendant dilemma is of excessive maintenance of transformers,or retiring them prematurely,leading to high economic *** paper is inspired by real-time engineering applications,and proposes an improved model to assess the economic life of power *** new model offers a more efficient approach than previous methods of assessment,with a specific focus of using the annual net income as separate criteria for determining the economic indices of continuous operation,overhaul,and retirement strategies of *** economic life of power transformers is divided into three sections according to different strategies to better resolve the quantification problem in this field.A case study is provided to prove the feasibility and validity of the proposed economic life *** case study achieves the fine management goal when the electric power enterprise is required to make the maintenance and retirement strategy decision.

关键词： Economic life model maintenance and retirement strategy power transformer

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Identification of candidate genes that regulate the trade-off between seedling cold tolerance and fruit quality in melon (Cucumis melo L.)

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Horticulture Research 2023年第7期10卷 7-21页

作者： Lili Li Qiong Li Bin Chen jiyu wang Fei Ding Panqiao wang Xiuyue Zhang Juan Hou Renren Luo Xiang Li Jingwen Zheng Sen Yang Luming Yang Lei Zhu Shouru Sun Changsheng Ma Qin Li Ying Li Jianbin Hu College of Horticulture Henan Agricultural UniversityZhengzhou 450002China The Seed Management Station of Zhengzhou City Zhengzhou 450001China

Trade-offs between survival and growth are widely observed in *** is an annual,trailing herb that produces economically valuable fruits that are traditionally cultivated in early spring in *** seedlings are sensitive to low temperatures,and thus usually suffer from cold stress during the early growth ***,little is known about the mechanism behind the trade-offs between seedling cold tolerance and fruit quality in *** this study,a total of 31 primary metabolites were detected from the mature fruits of eight melon lines that differ with respect to seedling cold tolerance;these included 12 amino acids,10 organic acids,and 9 soluble *** results showed that concentrations of most of the primary metabolites in the cold-resistant melons were generally lower than in the cold-sensitive melons;the greatest difference in metabolite levels was observed between the cold-resistant line H581 and the moderately cold-resistant line *** metabolite and transcriptome data for these two lines were then subjected to weighted correlation network analysis,resulting in the identification of five key candidate genes underlying the balancing between seedling cold tolerance and fruit *** these genes,CmEAF7 might play multiple roles in regulating chloroplast development,photosynthesis,and the ABA ***,multi-method functional analysis showed that CmEAF7 can certainly improve both seedling cold tolerance and fruit quality in *** study identified an agriculturally important gene,CmEAF7,and provides a new insight into breeding methods to develop melon cultivars with seedling cold tolerance and high fruit quality.

关键词： seedling breeding cultivar

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