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有机小分子纳米粒子的光学诊疗应用

高等学校化学学报 2020年第11期41卷 2356-2382页

作者：邵伟 lee jiyoung 李方园凌代舜浙江大学药学院药物制剂研究所杭州310058

癌症严重威胁着人类健康,因此,急需开发高效的诊断和治疗方法.基于光敏剂和近红外激光的光学诊疗将诊断和治疗集于一体,与传统的手术治疗和化学治疗相比,光学诊疗显示出无创性和高空间选择性的优点.有机小分子染料具有确定且易于修饰的... 详细信息

癌症严重威胁着人类健康,因此,急需开发高效的诊断和治疗方法.基于光敏剂和近红外激光的光学诊疗将诊断和治疗集于一体,与传统的手术治疗和化学治疗相比,光学诊疗显示出无创性和高空间选择性的优点.有机小分子染料具有确定且易于修饰的化学结构、良好的重现性和优异的生物相容性,与无机和聚合物材料相比,它是一类具有前景的可用于光学诊疗的光敏剂.本文总结了基于传统小分子染料、给体-受体(D-A)共轭小分子和聚集诱导发光(AIE)分子等有机小分子的纳米粒子在光学诊疗中的应用.此外,对于光学诊疗用有机小分子染料纳米粒子未来的挑战和前景也进行了展望.

关键词：有机小分子纳米粒子光声成像荧光成像光热治疗光动力学治疗

A K~+-sensitive AND-gate dual-mode probe for simultaneous tumor imaging and malignancy identification

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National Science Review 2022年第7期9卷 127-136页

作者： Qiyue Wang Fangyuan Li Zeyu Liang Hongwei Liao Bo Zhang Peihua Lin Xun Liu Shen Hu jiyoung lee Daishun Ling Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical Sciences Zhejiang University World Laureates Association (WLA) Laboratories Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational Medicine Shanghai Jiao Tong University Department of Obstetrics The Second Affiliated Hospital of Zhejiang University School of Medicine

Although molecular imaging probes have the potential to non-invasively diagnose a tumor,imaging probes that can detect a tumor and simultaneously identify tumor malignancy remain ***,we demonstrate a potassium ion(K+) sensitive dual-mode nanoprobe(KDMN) for non-invasive tumor imaging and malignancy identification,which operates via a cascaded ’AND’ logic gate controlled by inputs of magnetic resonance imaging(MRI) and fluorescence imaging(FI) *** encapsulate commercial K~+ indicators into the hollow cavities of magnetic mesoporous silica nanoparticles,which are subsequently coated with a K+-selective membrane that exclusively permits the passage of K+while excluding other *** KDMN can readily accumulate in tumors and enhance the MRI contrast after systemic *** information of the tumor lesion is thus accessible via MRI and forms the first layer of the ’AND’ ***,the KDMN selectively captures K+and prevents interference from other cations,triggering a K~+-activated FI signal as the second layer of the ’AND’ gate in the case of a malignant tumor with a high extracellular K~+*** dual-mode imaging approach effectively eliminates false positive or negative diagnostic results and allows for non-invasive imaging of tumor malignancy with high sensitivity and accuracy.

关键词： dual-mode imaging probe fluorescence imaging MRI tumor malignancy identification potassium ion

SIZ1-Mediated SUMOylation of TPR1 Suppresses Plant Immunity in Arabidopsis

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Molecular Plant 2019年第2期12卷 215-228页

作者： De Niu Xiao-Li Lin Xiangxiong Kong Gao-Ping Qu Bin Cai jiyoung lee Jing Bo Jin Key Laboratory of Plant Molecular Physiology Institute of Botany Chinese Academy of Sciences Beijing 100093 China University of Chinese Academy of Sciences Beijing 100049 China Biological Resource Center Korea Research In stitute of Bioscie nee and Biotech no logy Jeon geup 56212 South Korea

Plant immune responses are tightly regulated to ensure their appropriate deployment. Overexpression of TOPLESS-RELATED 1 (TPR1), a SUPPRESSOR OF npr1-1, CONSTITUTIVE 1 (SNC1)-interacting protein, results in autoimmunity that reduces plant growth and development. However, how TPR1 activity is regulated remains unknown. Loss of function of SIZ1, a (SUMO) E3 ligase, induces an autoimmune response, partially due to elevated SNC1 levels. Here we show that SNC1 expression is upregulated in Arabidopsis thaliana siz1-2 due to positive-feedback regulation by salicylic acid. SIZ1 physically interacts with TPR1 and facilitates its SUMO modification. The K282 and K721 residues in TPR1 serve as critical SUMO attachment sites. Simultaneous introduction of K282R and K721R substitutions in TPR1 blocked its SUMOylation, enhaneed its transcriptional co-repressor activity, and increased its association with HISTONE DEACETYLASE 19 (HDA19), suggesting that SUMOylation of TPR1 represses its transcriptional co-repressor activity and inhibits its interaction with HDA19. In agreement with this finding, the simultaneous introduction of K282R and K721R substitutions enhanced TPR1 mediated immunity, and the tpr1 mutation partially suppressed autoimmunity in siz1-2. These results demonstrate that SIZ1-mediated SUMOylation of TPR1 represses plant immunity, which at least partly contributes to the suppression of autoimmunity under nonpathogenic conditions to ensure proper plant development.

关键词： immune response SIZ1 SUMO E3 ligase SUMO modification TOPLESS

A Sub-Nanostructural Transformable Nanozyme for Tumor Photocatalytic Therapy

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Nano-Micro Letters 2022年第6期14卷 282-293页

作者： Xi Hu Nan Wang Xia Guo Zeyu Liang Heng Sun Hongwei Liao Fan Xia Yunan Guan jiyoung lee Daishun Ling Fangyuan Li Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058People’s Republic of China Frontiers Science Center for Transformative Molecules State Key Laboratory of Oncogenes and Related GenesSchool of Chemistry and Chemical EngineeringNational Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Department of Clinical Pharmacy The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003People’s Republic of China WLA Laboratories Shanghai 201203People’s Republic of China Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roWonmi-guBucheon-SiGyeonggi-do 14662Republic of Korea

The structural change-mediated catalytic activity regulation plays a significant role in the biological functions of natural ***,there is virtually no artificial nanozyme reported that can achieve natural enzyme-like stringent spatiotemporal structure-based catalytic activity ***,we report a subnanostructural transformable gold@ceria(STGC-PEG)nanozyme that performs tunable catalytic activities via near-infrared(NIR)light-mediated sub-nanostructural *** gold core in STGC-PEG can generate energetic hot electrons upon NIR irradiation,wherein an internal sub-nanostructural transformation is initiated by the conversion between CeO;and electron-rich state of CeO;-x,and active oxygen vacancies generation via the hot-electron ***,the sub-nanostructural transformation of STGC-PEG enhances peroxidase-like activity and unprecedentedly activates plasmon-promoted oxidase-like activity,allowing highly efficient low-power NIR light(50 m W cm;)-activated photocatalytic therapy of *** atomic-level design and fabrication provide a platform to precisely regulate the catalytic activities of nanozymes via a light-mediated sub-nanostructural transformation,approaching natural enzyme-like activity control in complex living systems.

关键词： Nanozymes Sub-nanostructural transformation Catalytic activity Reactive oxygen species Photocatalytic therapy

Nanotechnology enabled metal-ion-based disease diagnostics

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Science Bulletin 2020年第19期65卷 1587-1589页

作者： Peihua Lin jiyoung lee Ying Chen Fangyuan Li Daishun Ling Institute of Pharmaceutics and Hangzhou Institute of Innovative Medicine College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Biomedical Engineering of Ministry of Education College of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhou 310058China

Potassium ion(K^+)is one of the most essential ingredients of life that plays a vital regulatory role in numerous cellular processes,whose dyshomeostasis is featured in the occurrence and development of various diseases including neurodegenerative diseases and cancers[1].Consequently,in situ real-time imaging of K^+ dynamic changes is an excellent option to visualize the progress of ***,it is very challenging to achieve such a goal due to the following limitations of conventional imaging sensors[2].

关键词：疾病诊断纳米科技 limitations

Comparison of Bacterial Profiles of Fish between Storage Conditions at Retails Using DGGE and Banding Pattern Analysis: Consumer’s Perspective

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Food and Nutrition Sciences 2012年第2期3卷 190-200页

作者： Chongtao Ge Chang Soo lee Zhongtang Yu jiyoung lee College of Public Health Division of Environmental Health Sciences The Ohio State University Columbus USA Department of Animal Sciences The Ohio State University Columbus USA. Department of Food Science & Technology The Ohio State University Columbus USA Department of Food Science & Technology The Ohio State University Columbus USA 2College of Public Health Division of Environmental Health Sciences The Ohio State University Columbus USA

Bacterial profiles between storage conditions (frozen vs fresh) were compared using PCR-DGGE and banding pattern analysis. Salmon and tuna were collected and the bacteria cells were separated from fish cells using a somatic cell re-leasing agent. The results demonstrated that some were indigenous waterborne bacteria. However, the majority were identified as spoilage bacteria, pathogens and potential fecal contamination bacteria. Banding pattern analysis showed that the storage conditions were a significant factor in clustering bacteria. Frozen fish showed a smaller number of bac-terial species than fresh samples. Freezing seemed to play a role as a selective pressure by inactivating some microor-ganisms while favoring resistant ones to low temperature. The bacterial profiles seemed to be more influenced by afterharvest practices than the original environmental contamination. These findings provide consumers insight into fish quality, potential health risks of raw fish consumption, and the impact of storage conditions on bacterial group of raw fish.

关键词： Fish PCR-DGGE Bacterial Profiles Storage

The Impact of Inoculum-Substrate Ratios on Microbial Levels during Psychrophilic Anaerobic Digestion

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Journal of Environmental Science and Engineering(A) 2013年第10期2卷 625-636页

作者： James Rosenblum Juan Castano jiyoung lee Jay Martin Michael Bisesi Division of Environmental Health Sciences College of Public Health The Ohio State University Columbus Ohio 43210 USA Department of Food Agriculture and Biological Engineering The Ohio State University Columbus Ohio 43210 USA Universidad Tecnologica de Pereira ApartadoAereo 097 Pereira Colombia Department of Food Science and Technology the Ohio State University Columbus Ohio 43210 USA

The study evaluated impact of psychrophilic anaerobic digestion on levels of viable populations of fecal indicator bacteria using various inoculum-to-substrate ratios （I：S）. Laboratory-scale batch reactors were maintained at 10 ℃ and 20 ℃ for 25 days with dairy manure substrate. Five treatments included inoculum （control inoculum; inoculum only [CI]）, manure （control manure; substrate only [CM]）, and 3I：1S, II：IS, and 1I：3S. E. coli decreased in all treatments, while Enterococci decreased in only a few treatments. Treatment 1 I： 1S achieved highest E. coli decrease at 20 ℃ （3.11 log）; CM showed highest E. coli decrease at 10 ℃ （2.33 log）. The 1I：3 Streatment showed highest decrease of Enterococci at 20 ℃ （1.82 log）, whereas CM had highest, but less substantial, decrease at 10 ℃ （0.49 log）. These decreases may be the result of environmental conditions, namely substrate limitation for E. coli, and, increased VFA （volatile fatty acid） levels for Enterococci. Lower I：S showed higher levels of indicator organisms; less stable conditions with more acidic pH, higher VFAs, and lower biogas production. Results suggest II：IS is ideal for starting a digester at 20 ℃, whereas 3I：1S appears optimal for 10 ℃, Overall, I：S influenced chemical parameters and fecal indicators during batch psychrophilic anaerobic digestion of manure.

关键词： Biogas psychrophilic anaerobic digestion fecal indicators inoculum-to-substrate ratio.

Methane Emission from Rice Fields:Necessity for Molecular Approach for Mitigation

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Rice science 2024年第2期31卷 159-178页

作者： Sujeevan RAJENDRAN Hyeonseo PARK jiyoung KIM Soon Ju PARK Dongjin SHIN Jong-Hee lee Young Hun SONG Nam-Chon PAEK Chul Min KIM Department of Horticulture Industry Wonkwang UniversityIksan 54538Korea Plant Molecular Biology and Biotechnology Research Center Gyeongsang National UniversityJinju 52828Korea Department of Southern Area Crop Science National Institute of Crop ScienceMiryang 50424Korea Department of Agricultural Biotechnology Seoul National UniversitySeoul 08826Korea Department of Plant Science Plant Genomics and Breeding InstituteResearch Institute of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Korea

Anthropogenic methane emissions are a leading cause of the increase in global averagetemperatures,often referred to as global *** soils play a significant role in methaneproduction,where the anaerobic conditions promote the production of methane by *** fields contribute a considerable portion of agricultural methane emissions,as riceplants provide both factors that enhance and limit methane *** plants harbor both methaneproducingand methane-oxidizing *** from rice roots provide source for methaneproduction,while oxygen delivered from the root aerenchyma enhances methane *** haveshown that the diversity of these microorganisms depends on rice cultivars with some genes characterizedas harboring specific groups of microorganisms related to methane ***,there is still aneed for research to determine the balance between methane production and oxidation,as rice plantspossess the ability to regulate net methane *** agronomical practices,such as fertilizerand water management,have been employed to mitigate methane ***,studiescorrelating agronomic and chemical management of methane with productivity are ***,evidences for breeding low-methane-emitting rice varieties are scattered largely due to the absence ofcoordinated breeding *** has indicated that phenotypic characteristics,such as rootbiomass,shoot architecture,and aerenchyma,are highly correlated with methane *** reviewdiscusses available studies that involve the correlation between plant characteristics and *** emphasizes the necessity and importance of breeding low-methane-emitting rice varieties inaddition to existing agronomic,biological,and chemical *** review also delves into the idealphenotypic and physiological characteristics of low-methane-emitting rice and potential breeding techniques,drawing from studies conducted

关键词： methane emission rice breeding aerenchyma greenhouse gas radial oxygen loss

Increased atherosclerotic lesion area in apoprotein E deficient mice superimposed by experimental renal hypertension

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Increased atherosclerotic lesion area in apoprotein E defici...