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人工智能虚拟数字医师在钬激光前列腺剜除日间手术患教管理中的应用

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中华腔镜泌尿外科杂志(电子版) 2024年第4期18卷 318-322页

作者：莫林键杨舒博农卫赟程继文广西医科大学附属第一医院泌尿外科

日间钬激光前列腺剜除术（Ho LEP）逐渐推广，相关的患者教育管理重要性日益凸显，患教管理中引入人工智能虚拟数字医师是值得探索的创新途径。本文概括人工智能技术的演进历程，提出人工智能虚拟数字医师在患者教育管理中的应用与挑战... 详细信息

日间钬激光前列腺剜除术（Ho LEP）逐渐推广，相关的患者教育管理重要性日益凸显，患教管理中引入人工智能虚拟数字医师是值得探索的创新途径。本文概括人工智能技术的演进历程，提出人工智能虚拟数字医师在患者教育管理中的应用与挑战，特别介绍本团队与专业人工智能机构合作开发的虚拟数字医师在日间Ho LEP手术患教管理中实践的探索，该虚拟医师通过自然语言交互进行患者教育，通过对人工智能虚拟数字医师在日间Ho LEP患教管理效果进行评估，结果表明虚拟数字医师在缓解患者焦虑以及在医学知识科普方面具有积极作用。人工智能虚拟数字医师在患者教育管理中展现了显著的优势，有望为患者提供更加个性化医疗服务，提升医疗服务的效率和质量，同时有效减轻医疗专业人员的工作负担。

关键词：人工智能虚拟数字人钬激光前列腺剜除术日间手术患教管理前列腺增生

Defect engineering in transition-metal(Fe,Co,andNi)-based electrocatalysts for water splitting

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Carbon Energy 2024年第6期6卷 165-199页

作者： Kaili Wu Chaojie Lyu Jiarun cheng Weifan Ding jiwen Wu Qian Wang Woon-Ming Lau Jinlong Zheng Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijingChina School of Chemistry and Chemical Engineering Linyi UniversityLinyiChina Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijingChina Shunde Innovation School University of Science and Technology BeijingFoshanChina

Electrocatalytic water splitting seems to be an efficient strategy to deal with increasingly serious environmental problems and energy crises but still suffers from the lack of stable and efficient *** practical electrocatalysts by introducing defect engineering,such as hybrid structure,surface vacancies,functional modification,and structural distortions,is proven to be a dependable solution for fabricating electrocatalysts with high catalytic activities,robust stability,and good *** review is an overview of some relevant reports about the effects of defect engineering on the electrocatalytic water splitting performance of *** detail,the types of defects,the preparation and characterization methods,and catalytic performances of electrocatalysts are presented,emphasizing the effects of the introduced defects on the electronic structures of electrocatalysts and the optimization of the intermediates'adsorption energy throughout the ***,the existing challenges and personal perspectives of possible strategies for enhancing the catalytic performances of electrocatalysts are *** in-depth understanding of the effects of defect engineering on the catalytic performance of electrocatalysts will light the way to design high-efficiency electrocatalysts for water splitting and other possible applications.

关键词： defect engineering electrocatalytic water splitting element doping interfacial engineering vacancy

机器学习模型评估RAS亚家族基因对膀胱癌免疫治疗的作用

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中华腔镜泌尿外科杂志(电子版) 2024年第2期18卷 131-140页

作者：黄艺承梁海祺何其焕韦发烨杨舒博谭舒婷翟高强程继文广西医科大学第一附属医院泌尿外科

目的分析RAS亚家族基因在膀胱癌中的表达，探究RAS亚家族基因对免疫治疗应答的预测作用。方法本研究主要基于癌症基因组图谱（TCGA）数据库的407例膀胱癌和19例癌旁正常组织的m RNA测序数据。首先在转录水平对比35个RAS亚家族基因在... 详细信息

目的分析RAS亚家族基因在膀胱癌中的表达，探究RAS亚家族基因对免疫治疗应答的预测作用。方法本研究主要基于癌症基因组图谱（TCGA）数据库的407例膀胱癌和19例癌旁正常组织的m RNA测序数据。首先在转录水平对比35个RAS亚家族基因在肿瘤和正常组织的表达差异，并在人类蛋白质图谱数据库中使用膀胱癌和癌旁正常组织的免疫组织化学染色图像进行蛋白质水平验证。采用单因素和多因素Cox回归分析评估RNA亚家族基因的预后作用。GSE32894数据集308例膀胱癌作为预后分析的验证集。使用CIBERSORT算法计算TCGA肿瘤样本的肿瘤免疫浸润细胞丰度。基于IMvigor210试验的298例膀胱癌患者免疫治疗应答结果，使用随机森林（RF）模型筛选关键基因，并用逻辑回归（LR）、支持向量机（SVM）、人工神经网络（ANN）模型进行验证。GSE145140数据集的1例膀胱癌单细胞RNA测序数据，评估关键基因在膀胱癌单细胞中的表达情况。结果多数RAS亚家族基因在膀胱癌中表达发生改变，并可作为生存预后的预测因素。RAS亚家族基因与M1巨噬细胞浸润的相关性较强，并与一些免疫检查点分子共表达。RHEBL1,RRAD,GEM,RAP2B,HRAS,RERG,NRAS被RF模型认为是最能预测免疫治疗应答的关键基因。结论本研究初步确认RAS亚家族基因的表达可作为膀胱癌的预后因子，并在肿瘤免疫细胞浸润和免疫治疗应答中发挥作用。

关键词：膀胱癌癌症基因组图谱 RAS亚家族基因人类蛋白质图谱机器学习免疫治疗抗程序性细胞死亡受体/配体免疫检查点

基于“热导拘束+局部变形强化”的铝合金焊轧复合成形方法

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机械工程学报 2020年第8期56卷 85-91页

作者：宋刚程继文刘振夫大连理工大学材料科学与工程学院大连116024

铝合金尤其是热处理强化铝合金焊后不可避免会出现热影响区软化现象,导致焊接接头的力学性能显著下降。基于热导拘束+局部变形强化构想,提出一种铝合金焊轧复合成形方法,系统分析铜垫强制冷却非熔化极惰性气体保护电弧焊(Tungsten inert... 详细信息

铝合金尤其是热处理强化铝合金焊后不可避免会出现热影响区软化现象,导致焊接接头的力学性能显著下降。基于热导拘束+局部变形强化构想,提出一种铝合金焊轧复合成形方法,系统分析铜垫强制冷却非熔化极惰性气体保护电弧焊(Tungsten inert gas,TIG)填丝对接焊及焊后轧制复合工艺对5083-O和6061-T6异种铝合金焊接接头组织和力学性能的影响。结果表明,采用焊轧复合成形方法,能够得到成形良好且无缺陷的铝合金对接接头,通过轧制使焊接接头同时发生了纵向变形和横向变形;焊后轧制可以压实铝合金焊缝组织,有效降低焊接接头部分熔化区的宽度,同时热影响区(包括固溶区和过时效软化区)晶粒发生位向改变甚至转动现象;与自由冷却焊接工艺相比,采用铜垫冷却的焊接接头6061-T6侧软化区硬度升高且向焊缝中心产生明显偏移,焊后轧制使两种冷却方式的焊接接头的整体硬度均得到大幅度提升,其中软化最严重位置硬度值由59.5HV提高到84.4HV,提升幅度为41.8%;两种冷却方式的焊接接头轧制后接头的抗拉强度均大幅度提升,其中铜垫冷却焊轧复合成形与自由冷却焊接接头相比,试样抗拉强度由197.0MPa提升到288.6MPa,提升幅度为46.5%,与5083-O母材的抗拉强度相当,断后伸长率由5.88%提升到8.85%,断裂位置由6061-T6侧热影响区转移至5083-O侧母材。

关键词：铝合金热影响区软化焊接局部变形强化复合成形

Single-cell transcriptomics reveals cell type diversity of human prostate

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Journal of Genetics and Genomics 2022年第11期49卷 1002-1015页

作者： Yang Chen Peng Zhang Jinling Liao jiwen cheng Qin Zhang Tianyu Li Haiying Zhang Yonghua Jiang Fangxing Zhang Yanyu Zeng Linjian Mo Haibiao Yan Deyun Liu Qinyun Zhang Chunlin Zou Gong-Hong Wei Zengnan Mo Center for Genomic and Personalized Medicine Guangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Medical UniversityNanningGuangxi 530021China Department of Urology The First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education&Department of Biochemistry and Molecular Biology School of Basic Medical SciencesFudan University Shanghai Cancer CenterFudan UniversityShanghai 201114China Biocenter Oulu Faculty of Biochemistry and Molecular MedicineUniversity of OuluOuluFinland Key Laboratory of Longevity and Ageing-Related Disease of Chinese Ministry of Education Center for Translational Medicine and School of Preclinical MedicineGuangxi Medical UniversityNanningGuangxi 530021China

Extensive studies have been performed to describe the phenotypic changes occurring during malignant transformation of the ***,the cell types and associated changes that contribute to the development of prostate diseases and cancer remain elusive,largely due to the heterogeneous composition of prostatic ***,we conduct a comprehensive evaluation of four human prostate tissues by singlecell RNA sequencing(sc RNA-seq)to analyze their cellular *** identify 18 clusters of cell types,each with distinct gene expression profiles and unique features;of these,one cluster of epithelial cells(Ep)is found to be associated with immune *** addition,we characterize a special cluster of fibroblasts and aberrant signaling changes associated with prostate cancer(PCa).Moreover,we provide insights into the epithelial changes that occur during the cellular senescence and *** results expand our understanding of the unique functional associations between the diverse prostatic cell types and the contributions of specific cell clusters to the malignant transformation of prostate tissues and PCa development.

关键词： scRNA-seq Human prostate Cell type diversity Immunity Cellular senescence Prostate cancer

Variant rs8400 enhances ALKBH5 expression through disrupting miR-186 binding and promotes neuroblastoma progression

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Chinese Journal of Cancer Research 2023年第2期35卷 140-162页

作者： Qian Guan Huiran Lin Wenfeng Hua Lei Lin Jiabin Liu Linqing Deng Jiao Zhang jiwen cheng Zhonghua Yang Yong Li Jun Bian Haixia Zhou Suhong Li Li Li Lei Miao Huimin Xia Jing He Zhenjian Zhuo School of Medicine South China University of TechnologyGuangzhou 510006China Department of Pediatric Surgery Guangzhou Institute of PediatricsGuangdong Provincial Key Laboratory of Research in Structural Birth Defect DiseaseGuangdong Provincial Clinical Research Center for Child HealthGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Faculty of Medicine Macao University of Science and TechnologyMacao 99078China Research Institute for Maternal and Child Health Guangdong Second Provincial General HospitalGuangzhou 510317China Department of Pediatric Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Pediatric Surgery the Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China Department of Pediatric Surgery Shengjing Hospital of China Medical UniversityShenyang 110004China Department of Pediatric Surgery Hunan Children's HospitalChangsha 410004China Department of General Surgery Xi'an Children's HospitalXi'an Jiaotong University Affliated Children's HospitalXi'an 710003China Department of Hematology The Second Affliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325027China Department of Pathology Children Hospital and Women Health Center of ShanxiTaiyuan 030013China Kunming Key Laboratory of Children Infection and Immunity Yunnan Key Laboratory of Children's Major Disease ResearchYunnan Institute of Pediatrics ResearchYunnan Medical Center for Pediatric DiseasesKunming Children's HospitalKunming 650228China Laboratory Animal Center School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055China

Objective:AlkB homolog 5(ALKBH5)has been proven to be closely related to ***,the role and molecular mechanism of ALKBH5 in neuroblastomas have rarely been ***:The potential functional single-nucleotide polymorphisms(SNPs)in ALKBH5 were identified by National Center for Biotechnology Information(NCBI)dbSNP screening and SNPinfo *** probes were used for genotyping.A multiple logistic regression model was used to evaluate the effects of different SNP loci on the risk of *** expression of ALKBH5 in neuroblastoma was evaluated by Western blotting and immunohistochemistry(IHC).Cell counting kit-8(CCK-8),plate colony formation and 5-ethynyl-2'-deoxyuridine(EdU)incorporation assays were used to evaluate cell *** healing and Transwell assays were used to compare cell migration and *** modelling was performed to predict the ability of miRNAs to bind to ALKBH5 with the rs8400 G/A *** sequencing,N6-methyladenosine(mA)sequencing,mA methylated RNA immunoprecipitation(MeRIP)and a luciferase assay were used to identify the targeting effect of ALKBH5 on ***:ALKBH5 was highly expressed in *** down ALKBH5 inhibited the proliferation,migration and invasion of cancer ***-186-3p negatively regulates the expression of ALKBH5,and this ability is affected by the rs8400 *** the G nucleotide was mutated to A,the ability of miR-186-3p to bind to the 3'-UTR of ALKBH5 decreased,resulting in upregulation of *** is the downstream target gene of the ALKBH5 *** down SPP1 partially restored the inhibitory effect of ALKBH5 downregulation on *** of ALKBH5 can improve the therapeutic efficacy of carboplatin and etoposide in ***:We first found that the rs8400 G>A polymorphism in the m6A demethylase-encoding gene ALKBH5 increases neuroblastoma susceptibility and determines the related mechanism

关键词： Neuroblastoma risk ALKBH5 polymorphism progression

6061-T6铝合金激光诱导电弧焊轧复合成形组织性能

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航空学报 2022年第2期43卷 190-197页

作者：宋刚刘振夫程继文刘黎明大连理工大学材料科学与工程学院大连116024 大连理工大学辽宁省先进焊接技术重点实验室大连116024

针对6061-T6热处理强化铝合金焊后由“接头软化”导致的力学性能严重下降等问题,提出激光诱导电弧填丝焊及焊后局部轧制复合成形工艺,利用焊接接头余高的局部变形辅助强化接头“过时效软化区”。结果表明通过焊轧复合成形方法能得到成... 详细信息

针对6061-T6热处理强化铝合金焊后由“接头软化”导致的力学性能严重下降等问题,提出激光诱导电弧填丝焊及焊后局部轧制复合成形工艺,利用焊接接头余高的局部变形辅助强化接头“过时效软化区”。结果表明通过焊轧复合成形方法能得到成形良好且无缺陷的接头。与焊接接头相比,焊轧复合成形接头硬度整体更加均匀,软化最严重位置的硬度由71.2 HV提升到87.8 HV,提升了23.3%;焊轧复合成形接头的平均抗拉强度由246 MPa提升到284 MPa,相对提升了15.4%,达到母材的91.6%。轧制工艺使焊接接头发生局部强制变形,焊缝区等轴晶晶粒被压实且焊缝变宽。焊缝金属向两侧挤压使热影响区组织发生协同变形,导致位错密度增加,实现“过时效软化区”强化效果。

关键词：铝合金接头软化激光诱导电弧焊轧复合成形局部变形

A unique subseafloor microbiosphere in the Mariana Trench driven by episodic sedimentation

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Marine Life Science & Technology 2024年第1期6卷 168-181页

作者： jiwen Liu Da-Wei Li Xinxin He Ronghua Liu Haojin cheng chenglong Su Mengna Chen Yonghong Wang Zhongsheng Zhao Hanyue Xu Zhangyu cheng Zicheng Wang Nikolai Pedentchouk David J.Lea-Smith Jonathan D.Todd Xiaoshou Liu Meixun Zhao Xiao-Hua Zhang Frontiers Science Center for Deep Ocean Multispheres and Earth System and College of Marine Life SciencesOcean University of ChinaQingdao 266003China Laboratory for Marine Ecology and Environmental Science Laoshan LaboratoryQingdao 266237China Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China Key Lab of Submarine Geosciences and Prospecting Techniques Ministry of Education/College of Marine GeosciencesOcean University of ChinaQingdao 266100China Key Laboratory of Physical Oceanography Ministry of Education/Research Vessel CentreOcean University of ChinaQingdao 266100China School of Environmental Sciences University of East AngliaNorwich NR47TJUK School of Biological Sciences University of East AngliaNorwich NR47TJUK

Hadal trenches are characterized by enhanced and infrequent high-rate episodic sedimentation events that likely introduce not only labile organic carbon and key nutrients but also new microbes that significantly alter the subseafloor ***,the role of high-rate episodic sedimentation in controlling the composition of the hadal subseafloor microbiosphere is ***,analyses of carbon isotope composition in a~750 cm long sediment core from the Challenger Deep revealed noncontinuous deposition,with anomalous ^(14)C ages likely caused by seismically driven mass transport and the funneling effect of trench *** community composition and diverse enzyme activities in the upper~27 cm differed from those at lower depths,probably due to sudden sediment deposition and differences in redox condition and organic matter *** lower depths,microbial population numbers,and composition remained relatively constant,except at some discrete depths with altered enzyme activity and microbial phyla abundance,possibly due to additional sudden sedimentation events of different *** is provided of a unique role for high-rate episodic sedimentation events in controlling the subsurface microbiosphere in Earth’s deepest ocean floor and highlight the need to perform thorough analysis over a large depth range to characterize hadal benthic *** depositional processes are likely crucial in shaping deep-water geochemical environments and thereby the deep subseafloor biosphere.

关键词： Hadal subseafloor Deep water sediment Mariana Trench Radiocarbon Microbial community Redox potential

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间充质干细胞与恶性肿瘤关系的研究进展

微创医学 2015年第2期10卷 183-186,204页

作者：程继文广西医科大学附属肿瘤医院泌尿外科南宁市530021

间充质干细胞(MSCs)在恶性肿瘤发展过程中发挥的作用目前仍存有争议。已知MSCs具有自我更新、多向分化、定向趋化的能力,其在再生医学与组织工程中都占有不可忽视的地位。在一定条件下MSCs可能会促进恶性肿瘤细胞的生长,其原因可能涉及... 详细信息

间充质干细胞(MSCs)在恶性肿瘤发展过程中发挥的作用目前仍存有争议。已知MSCs具有自我更新、多向分化、定向趋化的能力,其在再生医学与组织工程中都占有不可忽视的地位。在一定条件下MSCs可能会促进恶性肿瘤细胞的生长,其原因可能涉及免疫抑制、血管形成、肿瘤炎症微环境的变化等多个方面。本文主要介绍间充质干细胞的生物学性状、其他在恶性肿瘤发生、发展中的作用、控制其生物学行为的方法及其在临床药物开发中的作用等方面的新进展。

关键词：间充质干细胞恶性肿瘤综述