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Effects of fulvestrant on biological activity and Wnt expression in rat GH3 cells

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Neural Regeneration Research 2012年第4期7卷 283-289页

作者： jiwei bai Yan Wang Chuzhong Li Yazhuo Zhang Beijing Neurosurgical Institute Capital Medical University Beijing 100050 China Center of Clinical Genetics Affiliated Bayi Children＇s Hospital General Hospital of Beijing Military Command of Chinese PLA Beijing 100700 China

The present study investigated the influence of anti-estrogen treatment （fulvestrant） on pituitary adenoma cell line GH3 biological activity, the estrogen receptor a pathway, the WnT pathway, and mechanisms of decreased Wnt inhibitory factor-1 expression in GH3 cells. Results showed that fulvestrant suppressed GH3 cell proliferation and reduced hormone secretion in a dose-dependent manner. Estrogen receptor a and Wnt4 expression decreased, but Wnt inhibitory factor-1 expression increased in a dose-dependent manner following fulvestrant treatment, and β-catenin expression remained unchanged. Inhibitors of DNA methylation and histone modification upregulated Wnt inhibitory factor-1 expression. Results suggested that fulvestrant suppressed biological activity of GH3 cells via the estrogen receptor a and Wnt pathways. These results suggested that decreased Wnt inhibitory factor-1 expression in GH3 cells played a role in epigenetic mechanisms. Anti-estrogen therapies could provide novel treatments for growth hormone adenomas.

关键词： β-catenin estrogen estrogen receptor a GH3 cell line Wnt inhibitory factor-1 Wnt4

Application of endoscopic endonasal approach in skull base surgeries: summary of 1886 cases in a single center for 10 consecutive years

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Chinese Neurosurgical Journal 2020年第3期6卷 133-140页

作者： Chuzhong Li Haibo Zhu Xuyi Zong Xinsheng Wang Songbai Gui Peng Zhao Chunhui Liu jiwei bai Lei Cao Yazhuo Zhang Beijing Neurosurgical Institute Capital Medical UniversityBeijingChina Department of Neurosurgery Beijing Tiantan Hospital affiliated to Capital Medical UniversityBeijingChina Beijing Institute for Brain Disorders Brain Tumor Center BeijingChina China National Clinical Research Center for Neurological Diseases No.119 South 4th Ring West RoadFengtai DistrictBeijing 100050China

Background:Endonasal endoscopic skull base surgery has undergone rapid technological developments and is now widely performed,but its strengths and weaknesses deserve further investigation and *** study was performed to investigate the surgical indications,complications,and technical advantages and disadvantages of endonasal endoscopic skull base ***:The clinical data of 1886 endoscopic endonasal skull base surgeries performed in our ward at Beijing Tiantan Hospital from June 2006 to June 2016 were retrospectively ***:One thousand ninety-three(73.4%,1490)pituitary adenomas,54(24.9%,217)chordomas,28(80.0%,35)craniopharyngiomas,and 15(83.3%,18)meningiomas underwent total *** patients died postoperatively,both having pituitary *** postoperative complications included olfactory disorders(n=226,11.9%),postoperative cerebrospinal fluid leakage(n=78,4.1%),hypopituitarism(n=74,3.9%),diabetes insipidus(n=64,3.4%),intracranial infection(n=36,1.9%),epistaxis(n=24,1.3%),vascular injury(n=8,0.4%),optic nerve injury(n=8,0.4%),and oculomotor movement impairment(n=4,0.2%).In total,1517(80.4%)patients were followed up for 6 to 126 months(average,42.5 months)postoperatively.A total of 196(13.2%)pituitary adenomas and 13(37.1%)craniopharyngiomas recurred but no meningiomas *** recurred in 97(44.7%)patients,in whom 5-year survival rate was 65%.Conclusion:Endoscopic surgery is an innovative surgical technique and the first choice for most midline extradural lesions such as chordomas,and an excellent choice for pituitary *** probably will be a good technique for many kinds of craniopharyngiomas and a common technique for most of skull base meningiomas,so the surgical indications of these cases should be chosen carefully to make good use of its respective advantages.

关键词： Complication Indication Neuroendoscopy Skull base surgery Endonasal approach

DISCUSSION ON THE REQUIREMENTS OF VNIR HYPERSPECTRAL DATA FOR AGRICULTURAL APPLICATIONS ACCORDING TO PHI DATA AND CSAM MODEL

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DISCUSSION ON THE REQUIREMENTS OF VNIR HYPERSPECTRAL DATA FO...

基于动态离散模型的机场ADS-B攻击威胁影响研究

2001 International Conferences on Info-tech and Info-net

作者： Yongchao ZHAO Qingxi TONG Lanfen ZHENG Bing ZHANG Xia ZHANG jiwei bai Chuanqing WU Tuanjie LIU Laboratory of Remote Sensing Information Sciences The Institute of Remote Sensing ApplicationsChinese Academy of Sciences

According to the application of PHI data on agricultural information extraction both in Changzhou, China and ***,we found that the results closely depend on the HRS data *** the spectral features of vegetation are particular with high shape similarity but with high intensity variation,the quality requirements are *** general factors of pixel size,band combination and noise limit for dilTerent informalion objects are discussed in this *** to the two models of CSAM and *** rice as example,it shows that a pixel size of 1.2meter is suitable in the area such as Changzhou and *** top-priority range of VNIR should be the red edge of 670-780nm and fine-division is necessary with a suggestion of about 40 bands with 3nm *** in belts of 400-670 and *** and less bands are acceptable. According to the application of IARS and the linear properly of rice spectral,it was suggested that S/N in order of×10 is enough for plant recognition,but for species classification for a certain plant, it should be square with an order up to×10-×10

关键词： Hyperspectral imaging Hyperspectral sensors Data mining Plants (biology) Spatial resolution Belts Remote sensing Information technology Signal resolution Signal to noise ratio

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电光与控制 2024年第7期31卷 27-35,52页

作者：白洁王布宏田继伟王振曾乐雅阳勇空军工程大学信息与导航学院西安710000

随着航空业信息技术的发展,空中交通管制系统面临着多种网络攻击的威胁。广播式自动相关监视(ADS-B)系统因其明文广播的数据传输方式,存在着被网络攻击的安全问题。依据“等待降落-降落-停泊-排队起飞-起飞”的航班运行全流程,建立了WL... 详细信息

随着航空业信息技术的发展,空中交通管制系统面临着多种网络攻击的威胁。广播式自动相关监视(ADS-B)系统因其明文广播的数据传输方式,存在着被网络攻击的安全问题。依据“等待降落-降落-停泊-排队起飞-起飞”的航班运行全流程,建立了WLPQD动态离散模型,研究机场流量和航班延误。模型引入了系统冗余能力、处理速率等参数,模拟了攻击场景;通过受影响飞机数量和延误时间等指标研究了机场航班延误的传播影响。模型展示了ADS-B消息注入攻击对降落、起飞航班造成的延误,提出了两种攻击缓解方法。结果表明,延误规模的大小与攻击强度呈现正相关,且攻击对起飞航班的延误影响更大;提升对“幽灵飞机”和合法飞机的处理速率都可提升机场系统的抗毁性,但前者对提升机场系统冗余能力的效果更加显著。所做研究为机场系统抵御网络攻击、增强抗毁性提供了决策分析的参考依据。

关键词： ADS-B 动态离散模型网络安全航班延误

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神经内镜扩大经鼻入路切除鞍结节脑膜瘤的疗效分析

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中华神经外科杂志 2022年第2期38卷 113-116页

作者：马国佛李储忠白吉伟赵澎曹磊王新生张亚卓桂松柏首都医科大学附属北京天坛医院神经外科北京10007 北京大学第三医院神经外科北京100191 首都医科大学北京市神经外科研究所北京100070

目的探讨神经内镜扩大经鼻入路切除鞍结节脑膜瘤的临床疗效。方法回顾性分析2018年10月至2020年12月首都医科大学附属北京天坛医院神经外科采用神经内镜扩大经鼻入路肿瘤切除术治疗的39例鞍结节脑膜瘤患者的临床资料。术后1 d,复查患者... 详细信息

目的探讨神经内镜扩大经鼻入路切除鞍结节脑膜瘤的临床疗效。方法回顾性分析2018年10月至2020年12月首都医科大学附属北京天坛医院神经外科采用神经内镜扩大经鼻入路肿瘤切除术治疗的39例鞍结节脑膜瘤患者的临床资料。术后1 d,复查患者内分泌功能;术后7 d,复查头颅增强MRI和眼科。对所有患者行门诊随访,随访内容包括:复查头颅MRI,判断肿瘤复发情况;复查眼科,判断患者的视力、视野改善情况;复查内分泌功能,判断内分泌异常患者的恢复情况。结果39例患者的手术均成功,术后1例(2.6%)发生脑脊液漏,1例(2.6%)发生中枢神经系统感染,经治疗后均好转出院;无一例出现死亡或昏迷。术后1 d,内分泌功能的检查结果显示,5例(12.8%)患者出现皮质醇水平降低。术后7 d,复查头颅增强MRI的结果显示,37例(94.9%)患者的肿瘤达到SimpsonⅠ级切除,另2例(5.1%)的肿瘤达到SimpsonⅡ级切除。术前存在视力、视野受损的33例患者,术后31例(93.9%)改善,2例(6.1%)未改善。39例患者的中位随访时间为17个月(6~32个月)。随访期间,所有患者均未见肿瘤复发;眼科复查结果同术后;皮质醇水平降低的5例患者,术后3个月或6个月均恢复正常。结论神经内镜扩大经鼻入路切除鞍结节脑膜瘤的术后并发症发生率低,且大多数存在视力、视野缺损的患者术后可得到改善。

关键词：脑膜瘤自然腔道内镜手术治疗结果鞍结节

Application of robotic-assisted endoscopic third ventriculostomy

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Journal of Translational Neuroscience 2018年第1期3卷 32-36页

作者： Peng Zhao Yinyan Wang jiwei bai Bin Li Chuzhong Li Songbai Gui Xinsheng Wang Xuyi Zong Yazhuo Zhang Neurosurgical Department Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Key Laboratory of Central Nervous System Injury Research Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100050 China Beijing Neurosurgical Institute Center of Brain Tumor Beijing Institute for Brain Disorders Capital Medical UniversityBeijing 100050 China

Objective:This case series study explored the application of ROSA(robot of stereotactic assistant)robotic-assisted endoscopic third ventriculostomy(ETV)in the treatment of ***:Three patients(January2016-October2017)diagnosed with hydrocephalus based on preoperative computed tomograph(CT)and magnetic resonance imaging(MRI)scans were *** planning scan was performed before *** robot localization program was used to simulate and analyze the path planning of hydrocephalus ETV and store it in the *** the three patients underwent robotic-assisted *** patients'clinical symptoms,imaging manifestations and related complications were evaluated,and a3-month follow-up survey was *** factors were also ***:ETV under the guidance of ROSA robot was successfully performed on the three ***,MRI and cerebrospinal fluid(CSF)cine showed that the ventricles were narrowed,that the velocity and flow of the stoma were normal,and that the CSF flow was *** discharge,the symptoms of hydrocephalus were significantly *** of the robot and design of the surgical path were key to success of the ***:ROSA robotic-assisted ETV is a feasible *** patients recovered well,and the symptoms *** efforts are needed to optimize artificial intelligence and the application of precision treatment in the nervous system.

关键词： robot hydrocephalus neuroendoscope third ventriculostomy artificial intelligence(AI)

神经内镜经鼻蝶入路切除颅底脊索瘤的临床疗效及其影响因素分析

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中华神经外科杂志 2022年第1期38卷 12-18页

作者：白吉伟李明轩李储忠耿素民赵澎曹磊刘春晖桂松柏张亚卓首都医科大学附属北京天坛医院神经外科 100070 首都医科大学北京市神经外科研究所100070

目的探讨神经内镜经鼻蝶入路切除颅底脊索瘤的手术策略、临床疗效及其影响因素。方法回顾性分析2004年1月至2021年3月首都医科大学附属北京天坛医院神经外科采用神经内镜经鼻蝶入路切除的颅底脊索瘤患者的临床资料,共纳入373例患者(共行... 详细信息

目的探讨神经内镜经鼻蝶入路切除颅底脊索瘤的手术策略、临床疗效及其影响因素。方法回顾性分析2004年1月至2021年3月首都医科大学附属北京天坛医院神经外科采用神经内镜经鼻蝶入路切除的颅底脊索瘤患者的临床资料,共纳入373例患者(共行500例次手术)。其中2004—2019年为早期手术组,采用以肿瘤为中心的手术策略;2020—2021年为近期手术组,依据肿瘤的起源部位及其沿着颅底骨缝、神经和大血管孔道延伸生长的特点进行顺序探查和切除(探查顺序形似"龟背")。比较两种手术策略切除肿瘤程度的差异。随访患者的无进展生存期(PFS)和总生存期(OS),采用Kaplan-Meier法生存分析,采用log-rank检验分析不同临床特征患者间PFS和OS的差异。结果500例次手术中,413例次为早期手术组,肿瘤的全切除率、次全切除率、部分切除率分别为35.1%(145例次)、36.6%(151例次)、28.3%(117例次);87例次为近期手术组,肿瘤的全切除率、次全切除率、部分切除率分别为52.9%(46例次)、37.9%(33例次)、9.2%(8例次),两组肿瘤的切除率差异有统计学意义(P<0.001)。500例次手术,脑脊液漏的发生率为4.6%(23例次)。373例患者中,术后1例(0.3%)死亡,1例(0.3%)发生大面积脑梗死;共325例(87.1%)患者获得完整的随访资料,中位随访时间为31个月(3~193个月)。182例(56.0%)复发,估计总体患者的中位PFS为24个月(95%CI:17.5~30.5);85例(26.2%)死亡,估计总体患者的中位OS为106个月。生存分析显示,与原发性肿瘤、肿瘤体积小、肿瘤全切除、病理学类型为经典型或软骨型肿瘤及术后放疗的患者比较,复发性肿瘤、肿瘤体积大、肿瘤非全切除、病理学类型为去分化或差分化或肉瘤样型肿瘤及术后未行放疗患者的PFS和OS均短,差异均有统计学意义(均P<0.05)。结论依据颅底脊索瘤生长侵袭特点,采用"龟背"形顺序探查、切除肿瘤的手术策略有利于提高肿瘤的切除程度。肿瘤是否原发、体积大小、切除程度、病理学类型、术后是否放疗可能与颅底脊索瘤患者术后的PFS和OS有关。

关键词：脊索瘤颅底自然腔道内镜手术治疗结果

神经内镜经鼻前方外侧入路颈静脉孔区解剖学研究及临床应用体会

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中华神经外科杂志 2022年第2期38卷 133-138页

作者：刘春晖张新李储忠桂松柏耿素民赵澎白吉伟曹磊朱海波张亚卓首都医科大学附属北京天坛医院神经外科北京100070 首都医科大学附属北京博爱医院神经外科北京100068 首都医科大学北京市神经外科研究所北京100070

目的探讨神经内镜经鼻前方外侧入路切除颈静脉孔区肿瘤的解剖学基础、手术技术和临床效果。方法收集干性颅骨、湿性尸头标本各3具,模拟神经内镜经鼻前方外侧入路对湿性尸头标本进行双侧逐层解剖,测量干性、湿性标本的相关解剖数据。回... 详细信息

目的探讨神经内镜经鼻前方外侧入路切除颈静脉孔区肿瘤的解剖学基础、手术技术和临床效果。方法收集干性颅骨、湿性尸头标本各3具,模拟神经内镜经鼻前方外侧入路对湿性尸头标本进行双侧逐层解剖,测量干性、湿性标本的相关解剖数据。回顾性分析2018年11月至2021年2月首都医科大学附属北京天坛医院神经外科收治的13例颈静脉孔区肿瘤患者的临床资料。所有患者均采用神经内镜经鼻前方外侧入路切除肿瘤。根据术后MRI结果评估肿瘤切除程度。通过临床症状和影像学随访结果评估手术效果。结果解剖学研究证实,应用神经内镜经鼻入路可清晰显露颈静脉孔区;舌下神经管下缘至枕髁下缘的距离为(8.36±1.77)mm,舌下神经管至颈静脉结节的距离为(7.08±2.23)mm。13例患者共行手术18例次,其中肿瘤全切除10例次,次全切除6例次,大部切除2例次。病理学结果提示,脊索瘤9例,软骨肉瘤2例,神经鞘瘤2例。13例患者的脑神经功能损害症状在术后均有改善,改善比例如下:声音嘶哑为3/6、饮水呛咳为2/5、耸肩无力为2/3、听力下降为5/9、搏动性耳鸣为5/7、平衡障碍为2/4、伸舌偏斜为2/5、周围性面瘫为4/7。术后并发症包括咽鼓管功能障碍(5例)、一过性硬腭麻木(2例)、脑脊液鼻漏(1例)、脑神经麻痹加重(3例)。13例患者的中位随访时间为16个月(3~30个月)。至末次随访,4例患者肿瘤复发,其余9例患者无复发。结论神经内镜经鼻前方外侧入路可为部分累及颈静脉孔区的肿瘤提供安全的手术入路,其手术效果较好。

关键词：自然腔道内镜手术解剖学经鼻前方外侧入路颈静脉孔区临床应用

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上海市土地有形市场管理信息系统

国土资源信息化 2010年第1期 35-39页

作者：白继伟上海市房屋土地资源信息中心上海200003

本文首先介绍了上海市土地有形市场管理信息系统的建设目标和内容,其次从系统的体系架构、与其他现有系统间的关系、系统功能设计和技术路线等方面详细介绍了系统实现的技术方案,然后总结了系统运行的五个特点,最后介绍了系统的运行情况。

关键词：土地有形市场系统技术方案