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Journal of Intelligent Learning Systems and Applications 2011年第3期3卷 122-130页

作者： Ee-May Kan Meng-Hiot Lim Swee-Ping Yeo jiun-sien ho Zhenhai Shao 不详

This research focuses on trajectory generation algorithms that take into account the stealthiness of autonomous UAVs;generating stealthy paths through a region laden with enemy radars. The algorithm is employed to estimate the risk cost of the navigational space and generate an optimized path based on the user-specified threshold altitude value. Thus the generated path is represented with a set of low-radar risk waypoints being the coordinates of its control points. The radar-aware path planner is then approximated using cubic B-splines by considering the least radar risk to the destination. Simulated results are presented, illustrating the potential benefits of such algorithms.

关键词： Unmanned Aerial Vehicles (UAVs) Radar Path Planning B-Splines

Effects of ethanol on antioxidant capacity in isolated rat hepatocytes

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World Journal of Gastroenterology 2005年第46期11卷 7272-7276页

作者： sien-Sing Yang Chi-Chang Huang jiun-Rong Chen Che-Lin Chiu Ming-Jer Shieh Su-jiun Lin Suh-Ching Yang Liver Unit Cathay General Hospital Taipei106 Taiwan China Graduate Institute of Pharmacy School of Pharmacy Taipei Medical University Taipei 110 Taiwan China School of Nutrition and Health Sciences Taipei Medical University Taipei 110 Taiwan China Graduate Institute of Biology and Environment Science School of Cellular and Molecular Biology University of New Haven CT 06516 United States

AIM： To investigate dose-response and time-course of the effects of ethanol on the cell viability and antioxidant capacity in isolated rat hepatocytes. METhoDS： Hepatocytes were isolated from male adult Wistar rats and seeded into 100-mm dishes. Hepatocytes were treated with ethanol at concentrations between 0 （C）, 10 （E10）, 50 （E50）, and 100 （E100） mmol/L （dose response） for 12, 24, and 36 h （time course）. Then, lactate dehydrogenase （LDH） leakage, malondialdehyde （IDA） concentration, glutathione （GSH） level, and activities of glutathione peroxidase （GPX）, glutathione reductase （GRD）, superoxide dismutase （SOD）, and catalase （CAT） were measured. RESULTS： Our data revealed that LDH leakage was significantly increased by about 30% in group E100 over those in groups C and E10 at 24 and 36 h, The HDA concentration in groups C, E10 and E50 were significantly lower than that in group E100 at 36 h. Furthermore, the concentration of IDA in group E100 at 36 h was significantly higher by 4.5- and 1.7-fold, respectively, than that at 12 and 24 h. On the other hand, the GSH level in group E100 at 24 and 36 h was significantly decreased, by 32% and 28%, respectively, compared to that at 12 h. The activities of GRD and CAT in group E100 at 36 h were significantly less than those in groups C and E10. however, The GPX and SOD activities showed no significant change in each group. CONCLUSION： These results suggest that longtime incubation with higher concentration of ethanol （100 mmol/L） decreased the cell viability by means of reducing GRD and CAT activities and increasing lipid peroxidation.

关键词： Hepatocyte Ethanol Lipid peroxidation Antioxidant capacity

An update on transurethral surgery for benign prostatic obstruction

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Asian Journal of Urology 2017年第3期4卷 195-198页

作者： Jonathan Shunming Teo Yee Mun Lee Henry Sun sien ho Department of Urology Singapore General HospitalSingapore Department of Urology Tan Tock Seng HospitalSingapore

Clinical benign prostatic hyperplasia(BPH)is one of the most common cause of lower urinary tract symptoms and transurethral resection of prostate(TURP)has been the gold standard technique for surgical treatment of benign prostate obstruction(BPO)over the last 2 *** monopolar TURP is considered a safe and effective option for surgical management of BPO,there are some disadvantages,namely bleeding,transurethral resection syndrome,incompleteness of *** review aims to highlight these problems,and describe the advances in technology and techniques that have evolved to minimise such *** the advent of lasers and bipolar technology,as well as enucleative techniques to remove the prostatic adenoma/adenomata,the problems of bleeding,transurethral resection syndrome and incomplete treatment are significantly *** TURPwill likely be replaced by such technology and techniques in the near future such that transurethral surgery of the prostate remain a safe and effective option in alleviating the harmful effects of BPO.

关键词： Transurethral resection of prostate Benign prostatic obstruction Bleeding Prostatectomy

A rare case of isolated castrate resistant bilateral testicular metastases in advanced prostate cancer

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Asian Journal of Urology 2018年第2期5卷 127-130页

作者： Jiarui Su Edwin Jonathan Aslim Hakan Aydin Puay hoon Tan Henry Sun sien ho Department of Urology Singapore General HospitalSingapore Department of Anatomical Pathology Singapore General HospitalSingapore Division of Pathology Singapore General HospitalSingapore

Testicular metastasis is rare with the prostate being the most common site of primary *** report a case of a 72-year-old man with castration-resistant prostate cancer(CRPC)and known metastases to bone and lymph nodes,who developed bilateral painful swollen testes 3 years after the initial diagnosis of prostate *** had first presented with lower urinary tract symptoms(LUTS)with suspicious findings on digital rectal examination of the prostate,and an elevated serum prostate specific antigen(PSA)level of 129 ng/*** prostate biopsy revealed Gleason 4þ5 *** staging showed locally advanced prostate cancer with extensive metastases to bone and pelvic and retroperitoneal lymph *** was given hormonal therapy for over 2 years until progression to *** months later he developed painful bilateral testicular swellings,and serum markers for testicular germ cell cancer were *** orchiectomy was performed,showing metastatic prostate cancer(Gleason 4þ5)on *** month postoperatively his PSA level dropped to 0.1 ng/mL from a presurgery level of 6.24 ng/mL.

关键词： Castration-resistant prostate cancer Metastases Testicular tumor Orchiectomy

Benign prostatic hyperplasia and male lower urinary symptoms:A guide for family physicians

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Asian Journal of Urology 2017年第3期4卷 181-184页

作者： Farhad Fakhrudin Vasanwala Michael Yuet Chen Wong Henry Sun sien ho Keong Tatt Foo Department of Family Medicine Sengkang Hospital at Alexandra HospitalSingHealthSingapore International Urology Fertility and Gynaecology CentreMount Elizabeth Medical CentreSingapore Department of Urology Singapore General HospitalSingHealthSingapore

Male patients with lower urinary tract symptoms(LUTS)and benign prostatic hyperplasia(BPH)are increasingly seen by family physicians worldwide due to ageing demographics.A systematic way to stratify patients who can be managed in the community and those who need to be referred to the urologist is thus very *** history taking,physical examination,targeted blood or urine tests,and knowing the red flags for referral are the mainstay of stratifying these *** selection is always key in clinical practice and in the setting of the family *** best patient to manage is one above 40 years of age,symptomatic with nocturia,slower stream and sensation of incomplete voiding,has a normal prostatespecific antigen level,no palpable bladder,and no haematuria or pyuria on the *** roles of α blockers,5-α reductase inhibitors,and antibiotics in a primary care setting to manage this condition are also discussed.

关键词： Benign prostatic hyperplasia Male lower urinary tract symptoms Guideline Family physicians

Peak stent discomfort occurs early and ureteral stent with distal loop design has less paineA pilot prospective randomised singleblinded trial over 2 weeks

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Asian Journal of Urology 2020年第4期7卷 357-362页

作者： Kheng Sit Lim Zhi Wei Law Marcus Way Lunn Chow Allen Soon Phang Sim Henry Sun sien ho Department of Urology Singapore General HospitalSingapore Department of Urology Tan Tock Seng HospitalSingapore

Objectives:The Polarisloop ureteric stent reduces the severity of stent discomfort by minimising stent material in the *** impact of ureteral stenting on quality of life(QoL)within 1 week remains *** usefulness of the patient-administered ureteral stent symptoms questionnaire(USSQ)during this period of stent insertion was *** this pilot single-blinded prospective randomised study,we investigate 1)the presence of early(within the 1st week)stent discomfort via the visual analog scale(VAS);2)determine the QoL of the loop stent against conventional ***:Forty adults requiring retrograde unilateral ureteral stent placements were *** with single ureteric stone or benign stricture were *** were randomised in 1:1 ratio to the loop and pigtail *** USSQ was administered before placement(baseline),USSQ and VAS were administered on Day 3,7,and ***:There were no significant differences between the USSQ *** pain scores on Day 3 were lower in the loop stent group(2.9 vs.4.0,pZ0.047).There was a significant reduction in pain from Day 3e7(0 vs.1,pZ0.016)in the pigtail ***:Our results suggest that peak stent discomfort occurs but resolves quickly within 1 week of post-stent *** loop stent offers a better pain profile compared with conventional stents at Day 3 but no difference in *** loop stent reduces early pain experience post-stent insertion and may have a role in the care of patients who experience significant stent discomfort previously.

关键词： Quality of life Stent discomfort Ureteral stent symptoms questionnaire Ureteric stents

Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment

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Bioactive Materials 2024年第11期41卷 440-454页

作者： Xiaoting Zhang Boguang Yang Lu Feng Xiayi Xu Chenmin Wang Yuk-wai Lee Ming Wang Xuan Lu Ling Qin sien Lin Liming Bian Gang Li Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyThe Chinese University of Hong KongPrince of Wales HospitalHong KongChina Stem Cells and Regenerative Medicine Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalHong KongChina The CUHK-ACC Space Medicine Centre on Health Maintenance of Musculoskeletal System The Chinese University of Hong Kong Shenzhen Research InstituteShenzhenPR China SH ho Scoliosis Research Laboratory Department of Orthopaedics and TraumatologyThe Chinese University of Hong KongHong KongChina Joint Scoliosis Research Center of the Chinese University of hong Kong and Nanjing University The Chinese University of Hong KongHong KongChina Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongChina School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou511442PR China Department of Orthopaedics and Traumatology The University of Hong KongHong KongChina

Osteoporotic bone defects pose a significant challenge for bone regeneration as they exhibit impaired healing capacity and delayed healing *** address this issue,this study introduces a hydrogel that creates a rejuvenating microenvironment,thereby facilitating efficient bone repair during the initial two weeks following bone defect *** hydrogel,named GelHFS,was created through host-guest polymerization of gelatin and acrylatedβ-*** of the human fetal mesenchymal stem cell secretome(HFS)formed GelHFS hydrogel aimed at mimicking a rejuvenated stem cell *** results demonstrated that GelHFS hydrogel promotes cell stellate spreading and osteogenic differentiation via integrinβ1-induced focal adhesion *** of GelHFS hydrogel in an osteoporotic bone defect rat model recruited endogenous integrinβ1-expressing cells and enhanced new bone formation and bone *** findings reveal that GelHFS hydrogel provides a rejuvenating niche for endogenous MSCs and enhances bone regeneration in osteoporotic bone *** findings highlight the potential of GelHFS hydrogel as an effective therapeutic strategy for addressing challenging bone healing such as osteoporotic bone regeneration.

关键词： Osteoporotic bone defects Bone regeneration Rejuvenating microenvironment Secretome Focal adhesion pathway

Low Input and High Output Impedances Current-Mode First-Order Allpass Filter Employing Grounded Passive Components

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Circuits and Systems 2012年第2期3卷 176-179页

作者： jiun-Wei horng Chun-Li hou Yi-Sing Guo Chih-hou Hsu Dun-Yih Yang Min-Jie ho Department of Electronic Engineering Chung Yuan Christian University Chung-Li Chinese Taipei

A current-mode low input and high output impedances first-order allpass filter using two multiple output second-generation current conveyors (MOCCIIs), one grounded capacitor and one grounded resistor is presented. The suggested filter uses a canonical number of passive components without requiring any component matching condition. The frequency responses simulation results of the proposed filter confirm the theoretical analysis.

关键词： Second-Generation Current Conveyor First-Order Filter Allpass Current-Mode

Multiparametric MRI reporting using Prostate Imaging Reporting and Data System version 2.0 (PI-RADSv2) retains clinical efficacy in a predominantly post-biopsy patient population

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Asian Journal of Urology 2019年第3期6卷 256-263页

作者： Edwin Jonathan Aslim Yan Mee Law Puay hoon Tan John Carson Allen Jr Lionel Tim-Ee Cheng Viswanath Anand Chidambaram Li Yan Khor Benjamin Yongcheng Tan Ernest Wencong Eu Christopher Wai Sam Cheng John Shyi Peng Yuen Henry Sun sien ho Lui Shiong Lee Department of Urology Singapore General HospitalSingapore Department of Diagnostic Radiology Singapore General HospitalSingapore Division of Pathology Singapore General HospitalSingapore Centre of Quantitative Medicine DUKE-NUS Medical SchoolSingapore Department of Anatomical Pathology Singapore General HospitalSingapore

Objective:To evaluate the efficacy of multiparametric magnetic resonance imaging(mp-MRI)using Prostate Imaging Reporting and Data System version 2.0(PI-RADSv2)definitions in detecting organ-confined prostate ***:All patients who underwent radical prostatectomy between January 1,2014 and December 30,2014 were *** underwent mp-MRI within 180 days before *** with prior pelvic irradiation or androgen deprivation therapy were *** embedded,whole-mount histopathology was centrally reviewed and correlated with imaging for tumour location,Gleason score(GS)and ***:There were 39 patients included,of which 35(90%)had mp-MRI done post-biopsy.A total of 93 cancer foci were identified on whole-mount pathology,of which mp-MRI detected 63(68%).Of those detected by mp-MRI,14 were PI-RADS 3(n=6 for GS 6,n=8 for GS 7,no GS≥8)and 49 were PI-RADS 4e5(nZ7 for GS 6,nZ33 for GS 7,and nZ9 for GS≥8).There were 30(32%)cancer foci missed by mp-MRI(n=15 for GS 6,n=13 for GS 7 and n=2 for GS≥8).A lesion classified as PI-RADS 4e5 predicted a higher grade cancer on pathology as compared to PI-RADS 3(for GS 7 lesions,odds ratio[OR]=3.53,95%CI:0.93e13.45,p=0.064).The mp-MRI size detection limit was 20 mm2 and 100 mm2 for 50%and 75%probability of cancer,*** associating with radiological and pathologic stage,the weighted Kappa value was 0.69(phort,mp-MRI using PI-RADSv2 reporting has a reasonably high diagnostic accuracy in detecting clinically significant prostate cancer.

关键词： Gleason score Histopathology Magnetic resonance imaging Prostatectomy Prostatic cancer

Enhancing cartilage repair with optimized supramolecular hydrogel-based scaffold and pulsed electromagnetic field

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Bioactive Materials 2023年第4期22卷 312-324页

作者： Yucong Li Linlong Li Ye Li Lu Feng Bin Wang Ming Wang Haixing Wang Meiling Zhu Yongkang Yang Erik IWaldorff Nianli Zhang Ingmar Viohl sien Lin Liming Bian Wayne Yuk-Wai Lee Gang Li Department of Orthopaedics&Traumatology Stem Cells and Regenerative Medicine LaboratoryLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong Special Administrative Region Research&Clinical Affairs Orthofix Medical Inc.LewisvilleTXUSA Department of Rehabilitation Sciences Hong Kong Polytechnic UniversityHong Kong Special Administrative Region Innovation Centre for Advanced Interdisciplinary Medicine Key Laboratory of Biological Targeting DiagnosisTherapy and Rehabilitation of Guangdong Higher Education InstitutesThe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina The Eighth Affiliated hospital Sun Yat-Sen UniversityShenzhenPR China School of Biomedical Sciences and Engineering National Engineering Research Center for Tissue Restoration and ReconstructionKey Laboratory of Biomedical Materials and Engineering of the Ministry of EducationSouth China University of TechnologyGuangzhouPR China Department of Orthopaedics and Traumatology SH Ho Scoliosis Research LaboratoryJoint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing UniversityThe Chinese University of Hong KongHong Kong Special Administrative Region

Functional tissue engineering strategies provide innovative approach for the repair and regeneration of damaged *** is widely used because it could provide rapid defect filling and proper structure support,and is biocompatible for cell aggregation and matrix *** have been made to seek suitable scaffolds for cartilage tissue *** Alg-DA/Ac-β-CD/gelatin hydrogel was designed with the features of physical and chemical multiple crosslinking and self-healing *** time,swelling ratio,biodegradability and biocompatibility of the hydrogels were systematically characterized,and the injectable self-healing adhesive hydrogel were demonstrated to exhibit ideal properties for cartilage ***,the new hydrogel design introduces a pre-gel state before photo-crosslinking,where increased viscosity and decreased fluidity allow the gel to remain in a semi-solid *** granted multiple administration routes to the hydrogels,which brings hydrogels the ability to adapt to complex clinical *** electromagnetic fields(PEMF)have been recognized as a promising solution to various health problems owing to their noninvasive properties and therapeutic *** treatment offers a better clinical outcome with fewer,if any,side effects,and wildly used in musculoskeletal tissue *** we propose PEMF as an effective biophysical stimulation to be 4th key element in cartilage tissue *** this study,the as-prepared Alg-DA/Ac-β-CD/gelatin hydrogels were utilized in the rat osteochondral defect model,and the potential application of PEMF in cartilage tissue engineering were *** treatment were proven to enhance the quality of engineered chondrogenic constructs in vitro,and facilitate chondrogenesis and cartilage repair in *** of the results suggested that with the injectable self-healing adhesive hydrogel and PEMF treatment,this newly proposed tissue engineering strategy r

关键词： Supramolecular hydrogels Pulsed electromagnetic field Cartilage tissue engineering Mesenchymal stem cells Chondrogenesis