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Adjuvant chemotherapy with S-1 plus oxaliplatin improves survival of patients with gastric cancer after D2 gastrectomy: A multicenter propensity score-matched study

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World Journal of Clinical Cases 2018年第10期6卷 373-383页

作者： Deng-Feng Ren Fang-Chao Zheng Jun-Hui zhao Guo-Shuang Shen Raees Ahmad Shui-Sheng Zhang Yu Zhang Jie Kan Li Dong Zi-Yi Wang Fu-Xing zhao jiu-da zhao Department of Medical Oncology Affiliated Hospital of Qinghai University Affiliated Cancer Hospital of Qinghai University Department of Medical Oncology Shouguang Hospital of Traditional Chinese Medicine Department of Surgical Oncology Affiliated Hospital of Qinghai University Affiliated Cancer Hospital of Qinghai University Department of Pancreatic and Gastric Surgery National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Medical Oncology Qinghai Red Cross Hospital Department of Medical Oncology People's Hospital of Qinghai Province Institutes of Biomedical Sciences Shanxi University

AIM To investigate the safety and efficacy of S-1 plus oxaliplatin(SOX) as an adjuvant chemotherapy regimen in gastric cancer(GC) after D2 *** GC Patients who underwent D2 gastrectomy from September 2009 to December 2011 in four Chinese institutions were enrolled. Patients with stage ⅠB-ⅢC GC, who received adjuvant SOX treatment were matched by propensity scores with those who underwent surgery alone and those who conducted capecitabine plus oxaliplatin(XELOX) regimen. Disease-free survival(DFS) and overall survival(OS) were compared among the groups. In addition, adverse events in SOX patients were *** 1944 GC patients who underwent D2 dissection, 867 were included for analysis. One hundred and seventeen patients treated with SOX were matched to 234 patients who conducted surgery alone. Fifty-seven patients treated with SOX were matched to 57 patients who received XELOX. The estimated five-year DFS was 57.5% in the adjuvant SOX group which was higher than that(44.6%) in the surgery alone group(P = 0.001); and the estimated five-year OS was 68.3% which was higher than that(45.8%) of surgery alone group(P 60 years old subgroups(P < 0.001 and P = 0.015, respectively). Compared with XELOX regimen, SOX showed no significant difference in DFS(P = 0.340) and OS(P = 0.361). The most common ≥ 3 grade adverse events of SOX regimen were neutropenia(22.6%), leukopenia(8.9%) and thrombocytopenia(5.6%).CONCLUSION Compared with surgery alone, SOX regimen significantly improves the long-term survival and has acceptable toxicity in patients with stage ⅠB-ⅢC GC after D2 dissection. It may be a novel adjuvant chemotherapy regimen in GC patients.

关键词： Gastric cancer D2 gastrectomy Adjuvant chemotherapy S-1 Oxaliplatin Capecitabine

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Associations between interleukin-1 polymorphisms and gastric cancers among three ethnicities

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World Journal of Gastroenterology 2012年第47期18卷 7093-7099页

作者： jiu-da zhao Pai-Li Geng Zhan-Quan Li Sen Cui Jun-Hui zhao Li-Juan Wang Jin-Zhang Li Fa-Xiang Ji Guo-Yuan Li Guo-Shuang Shen Ming-Zhe Lin Cun-Fang Shen Cheng-Zhu Cao Internal Medicine-Oncology Affiliated Hospital of Qinghai University High Altitude Medical Research Center Qinghai University

AIM:To investigate the associations between interleukin(IL)-1B and IL-1RN polymorphisms and gastric cancers among the Tibet,Hui and Han ***:Genomic DNA was extracted from peripheral blood of 210,205,and 202 healthy volunteers and from 155,158,and 197 gastric cancer patients from the Tibet,Hui,and Han populations,*** in IL-1B and IL-1RN were analyzed by denaturing high-performance liquid ***:Carriers of the IL-1B-31 CC genotype had an increased risk of intestinal type gastric cancer [odds ratio(OR) = 2.17,P = 0.037] in the Tibet *** of the IL-1B 2/L genotype had an increased risk of both intestinal and diffuse types of gastric cancer(OR = 2.08,2.31,P = 0.007,0.016,respectively) in the Hui *** the Han population,carriers of the IL-1B-31 CC,IL-1B-511CT,TT genotypes had increased risk of intestinal type gastric cancer(OR = 2.51,2.74,5.66,P = 0.005,0.002,0.000,respectively).CONCLUSION:IL-1B and IL-RN genotypes may differentially contribute to gastric cancer among the Tibet,Hui,and Han ethnicities in the Qinghai area of China.

关键词： Gastric cancer Interleukin-1B Interleukin1RN Polymorphism Risk of gastric cancer

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Mechanism of Qili Qiangxin Capsule for Heart Failure Based on miR133a-Endoplasmic Reticulum Stress

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Chinese Journal of Integrative Medicine 2024年第5期30卷 398-407页

作者： JI Xiao-di YANG Ding CUI Xi-yuan LOU Li-xia NIE Bo zhao jiu-li zhao Ming-jing WU Ai-ming Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Key Laboratory of Chinese Internal Medicine of Ministry of Education and BeijingBeijing 100700China Department of Traditional Chinese Medicine Fuwai HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100037China

Objective:To investigate the pharmacological mechanism of Qili Qiangxin Capsule(QLQX)improvement of heart failure(HF)based on miR133a-endoplasmic reticulum stress(ERS)***:A left coronary artery ligation-induced HF after myocardial infarction model was used in this *** were randomly assigned to the sham group,the model group,the QLQX group[0.32 g/(kg·d)],and the captopril group[2.25 mg/(kg·d)],15 rats per group,followed by 4 weeks of *** function such as left ventricular ejection fraction(EF),fractional shortening(FS),left ventricular systolic pressure(LVSP),left ventricular end diastolic pressure(LVEDP),the maximal rate of increase of left ventricular pressure(+dp/dt max),and the maximal rate of decrease of left ventricular pressure(–dp/dt max)were monitored by echocardiography and *** and eosin(HE)and Masson stainings were used to visualize pathological changes in myocardial *** m RNA expression of mi R133a,glucose-regulated protein78(GRP78),inositol-requiring enzyme 1(IRE1),activating transcription factor 6(ATF6),X-box binding protein1(XBP1),C/EBP homologous protein(CHOP)and Caspase 12 were detected by *** protein expression of GRP78,p-IRE1/IRE1ratio,cleaved-ATF6,XBP1-s(the spliced form of XBP1),CHOP and Caspase 12 were detected by Western *** T-mediated d UTP nick-end labeling(TUNEL)staining was used to detect the rate of ***:QLQX significantly improved cardiac function as evidenced by increased EF,FS,LVSP,+dp/dt max,-dp/dt max,and decreased LVEDP(Pdamage to some *** staining indicated that QLQX significantly reduced collagen volume fraction in myocardial tissue(P<0.01).Results from RT-PCR and Western blot showed that QLQX significantly increased the expression of mi R133a and inhibited the m RNA expressions of GRP78,IRE1,ATF6 and XBP1,as well as decreased the protein expressions of GRP78,cleave

关键词： heart failure Qili Qiangxin Capsule miR133a endoplasmic reticulum stress apoptosis

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Discovery of Trametinib as an orchestrator for cytoskeletal vimentin remodeling

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Journal of Molecular Cell Biology 2024年第3期16卷 24-34页

作者： Shuangshuang zhao Zhifang Li Qian Zhang Yue Zhang Jiali Zhang Gaofeng Fan Xiaobao Cao Yaming jiu Unit of Cell Biology and Imaging Study of Pathogen Host Interaction The Center for MicrobesDevelopment and HealthKey Laboratory of Molecular Virology and ImmunologyShanghai Institute of Immunity and InfectionChinese Academy of SciencesShanghai 200031China Guangzhou National Laboratory Guangzhou 510005China University of Chinese Academy of Sciences Beĳing 100049China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

The dynamic remodeling of the cytoskeletal network of vimentin intermediate filaments supports various cellular functions,including cell morphology,elasticity,migration,organelle localization,and resistance against mechanical or pathological *** available chemicals targeting vimentin predominantly induce network reorganization and shrinkage around the *** tools for long-term manipulation of vimentin network dispersion in living cells are still lacking,limiting in-depth studies on vimentin function and potential therapeutic ***,we verified that a commercially available small molecule,trametinib,is capable of inducing spatial spreading of the cellular vimentin network without affecting its transcriptional or Translational *** evidence confirmed its low cytotoxicity and similar effects on different cell ***,Trametinib has no impact on the other two cytoskeletal systems,actin filaments and the microtubule ***,Trametinib regulates vimentin network dispersion rapidly and efficiently,with effects persisting for up to 48 h after drug *** also ruled out the possibility that Trametinib directly affects the phosphorylation level of *** summary,we identified an unprecedented regulator Trametinib,which is capable of spreading the vimentin network toward the cell periphery,and thus complemented the existing repertoire of vimentin remodeling drugs in the field of cytoskeletal research.

关键词： vimentin intermediate filaments cytoskeleton small molecule network reorganization

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Crosstalk among Oxidative Stress,Autophagy,and Apoptosis in the Protective Effects of Ginsenoside Rb1 on Brain Microvascular Endothelial Cells:A Mixed Computational and Experimental Study

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Current Medical Science 2024年第3期44卷 578-588页

作者： Yi-miao LUO Shu-sen LIU Ming zhao Wei WEI jiu-xiu YAO Jia-hui SUN Yu CAO Hao LI Department of Geriatrics Peking University Traditional Chinese Medicine Clinical Medical School (Xiyuan)Beijing100901China Department of Integration of Chinese and Western Medicine Peking University Health Science CenterBeijing100191China School of Pharmacy Harbin University of CommerceHarbin150028China Xiyuan Hospital China Academy of Chinese Medical ScienceBeijing100901China Wangjing Hospital China Academy of Chinese Medical ScienceBeijing100102China

Objective Brain microvascular endothelial cells (BMECs) were found to shift from their usually inactive state to an active state in ischemic stroke (IS) and cause neuronal damage. Ginsenoside Rb1 (GRb1),a component derived from medicinal plants,is known for its pharmacological benefits in IS,but its protective effects on BMECs have yet to be explored. This study aimed to investigate the potential protective effects of GRb1 on BMECs. Methods An in vitro oxygen-glucose deprivation/reperfusion (OGD/R) model was established to mimic ischemia-reperfusion (I/R) injury. Bulk RNA-sequencing data were analyzed by using the Human Autophagy database and various bioinformatic tools,including gene set enrichment analysis (GSEA),Gene Ontology (GO) classification and enrichment analysis,Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis,protein-protein interaction network analysis,and molecular docking. Experimental validation was also performed to ensure the reliability of our findings. Results Rb1 had a protective effect on BMECs subjected to OGD/R injury. Specifically,GRb1 was found to modulate the interplay between oxidative stress,apoptosis,and autophagy in BMECs. Key targets such as sequestosome 1 (SQSTM1/p62),autophagy related 5 (ATG5),and hypoxia-inducible factor 1-alpha (HIF-1α) were identified,highlighting their potential roles in mediating the protective effects of GRb1 against IS-induced damage. Conclusion GRbl protects BMECs against OGD/R injury by influencing oxidative stress,apoptosis,and autophagy. The identification of SQSTM1/p62,ATG5,and HIF-1α as promising targets further supports the potential of GRb1 as a therapeutic agent for IS,providing a foundation for future research into its mechanisms and applications in IS treatment.

关键词： ischemic stroke ginsenoside Rb1 brain microvascular endothelial cells oxidative stress autophagy apoptosis bioinformatic analysis

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Babao dan Inhibits Gastric Cancer Progression in vivo Through Multiple Signaling Pathways

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 14-21页

作者： Hai-Xia Shang Yi Fang Bin Guan Jian-Hua Guan Jun Peng Jin-Yan zhao jiu-Mao Lin Institute of Oncology of Academy of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhouFujianChina Key Laboratory of Integrative Medicine of Fujian Province University Fujian University of Traditional Chinese MedicineFuzhouFujianChina Fujian Key Laboratory of Integrative Medicine on Geriatric Fujian University of Traditional Chinese MedicineFuzhouFujianChina Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhouFujianChina Xiamen Traditional Chinese Medicine Co. Ltd.XiamenFujianChina

Objective:The aim of this study was to explore the effects of Babao dan(BBD),a traditional Chinese medicine,on gastric cancer(GC)progression in *** and Methods:A subcutaneous xenograft mouse model of GC was established using MGC80-3 *** terminal deoxynucleotidyl transferase-mediated dUTP:2'-deoxyuridine 5'-triphosphate-biotin nick-end labeling method was adopted to detect cell apoptosis in *** expression levels of proteins associated with proliferation,apoptosis,and angiogenesis were measured by immunohistochemical staining or western blotting(WB).The activation and protein levels of p-c-Jun N-terminal kinase(JNK),p-p38,p-extracellular-regulated kinase 1/2,p-nuclear factor-κB(NF-κB),and p-STAT3 were examined by Bio-plex and ***:BBD significantly inhibited tumor growth in GC mouse models with no adverse effect on body weight or organ *** was also found that BBD significantly suppressed the proliferation of GC tumor cells,induced the apoptosis of tumor cells,and inhibited angiogenesis through inactivating with mitogen-activated protein kinase,NF-κB,and STAT3 ***:BBD exerts suppressive effects on GC tumor growth by regulating multiple pathways in vivo,which may provide a novel treatment option for GC therapy.

关键词： Babao dan gastric cancer multiple signaling pathways proliferation traditional Chinese medicine

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Association of HER2 status with prognosis in gastric cancer patients undergoing R0 resection: A large-scale multicenter study in China

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World Journal of Gastroenterology 2016年第23期22卷 5406-5414页

作者： Guo-Shuang Shen jiu-da zhao Jun-Hui zhao Xin-Fu Ma Feng Du Jie Kan Fa-Xiang Ji Fei Ma Fang-Chao Zheng Zi-Yi Wang Bing-He Xu Affiliated Hospital of Qinghai University High Altitude Medical Research Center Xining 810001 Qinghai Province China Department of Medical Oncology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China People's Hospital of Qinghai Province Xining 810007 Qinghai Province China

AIM: To determine whether the positive status of human epidermal growth receptor 2(HER2) can be regarded as an effective prognostic factor for patients with gastric cancer(GC) undergoing R0 ***: A total of 1562 GC patients treated by R0 resection were recruited. HER2 status was evaluated in surgically resected samples of all the patients using immunohistochemical(IHC) staining. Correlations between HER2 status and clinicopathological characteristics were retrospective analyzed. Hazard ratios(HRs) and 95% confidence intervals(CIs) were estimated using Cox proportional hazard model, stratified by age, gender, tumor location and tumor-nodemetastasis(TNM) stage, with additional adjustment for potential prognostic ***: Among 1562 patients, 548(positive rate = 35.08%, 95%CI: 32.72%-37.45%) were HER2 positive. Positive status of HER2 was significantly correlated with gender(P = 0.004), minority(P < 0.001), tumor location(P = 0.001), pathological grade(P < 0.001), TNM stage(P < 0.001) and adjuvant radiotherapy(74.67% vs 23.53%, P = 0.011). No significant associations were observed between HER2 status and disease free survival(HR = 0.19, 95%CI: 0.96-1.46, P = 0.105) or overall survival(HR = 1.19, 95%CI: 0.96-1.48, P = 0.118) using multivariate analysis, although stratified analyses showed marginally statistically significant associations both in disease free survival and overall survival, especially among patients aged < 60 years or with early TNM stages(Ⅰ and Ⅱ). Categorical age, TNM stage, neural invasion, and adjuvant chemotherapy were, as expected, independent prognostic factors for both disease free survival and overall survival. CONCLUSION: The positive status of HER2 based on IHC staining was not related to the survival in patients with GC among the Chinese population.

关键词： Human epidermal growth receptor 2 Gastric cancer R0 resection Chinese population Prognostic factors

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成纤维细胞生长因子受体2基因rs1219648位点多态性与青海回族女性乳腺癌易感性的关联研究

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中国现代医学杂志 2016年第10期26卷 45-50页

作者：沈国双郑方超赵久达青海大学附属医院乳腺甲状腺外科青海西宁810016

目的探究成纤维细胞生长因子受体2(FGFR2)基因rs1219648位点单核苷酸多态性(SNP)与青海地区回族女性乳腺癌易感性的关系。方法采用病例对照研究,利用Taq Man-MGB探针法对青海地区110例回族女性乳腺癌病例和110例正常回族女性对照进行FG... 详细信息

目的探究成纤维细胞生长因子受体2(FGFR2)基因rs1219648位点单核苷酸多态性(SNP)与青海地区回族女性乳腺癌易感性的关系。方法采用病例对照研究,利用Taq Man-MGB探针法对青海地区110例回族女性乳腺癌病例和110例正常回族女性对照进行FGFR2基因rs1219648位点基因型检测,利用多元Logistic回归分析该位点不同基因型与乳腺癌易感性之间的关系。结果 FGFR2基因rs1219648位点基因型频率在病例组和对照组之间的差异具有统计学意义(P=0.001)。FGFR2基因rs1219648位点A>G改变可以显著的增加青海地区回族女性人群乳腺癌易感性。其中,在校正初潮年龄、是否绝经、乳腺良性疾病史和乳腺癌家族史因素后,该位点A>G的改变仍可以显著增加该地区回族女性人群乳腺癌患病风险(ORAG-GG/AA=2.37,95%CI:1.18,4.73)。结论 FGFR2基因rs1219648位点A>G改变可显著增加青海地区回族女性乳腺癌的患病风险,预期可以作为该地区女性乳腺癌易感性的重要生物标志物。

关键词： FGFR2基因乳腺癌回族单核苷酸多态性生物标志物

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Genomes of Meniocus linifolius and Tetracme quadricornis reveal the ancestral karyotype and genomic features of core Brassicaceae

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Plant Communications 2024年第7期5卷 68-89页

作者： Jie Liu Shi-zhao Zhou Yun-Long Liu Bin-Yan zhao Dongmei Yu Mi-Cai Zhong Xiao-Dong Jiang Wei-Hua Cui jiu-Xia zhao Juan Qiu Liang-Min Liu Zhen-Hua Guo Hong-Tao Li Dun-Yan Tan Jin-Yong Hu De-Zhu Li CAS Key Laboratory for Plant Diversity and Biogeography of East Asia&Yunnan Key Laboratory of Crop Wild Relatives Omics Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Germplasm Bank of Wild Species&Yunnan Key Laboratory for Crop Wild Relatives Omics Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China College of Life Sciences Xinjiang Agricultural UniversityÜrümqi 830052China University of Chinese Academy of Sciences Beijing 100049China These authors contributed equally to this article

Brassicaceae represents an important plant family from both a scientific and economic ***,genomic features related to the early diversification of this family have not been fully characterized,especially upon the uplift of the Tibetan Plateau,which was followed by increasing aridity in the Asian interior,intensifying monsoons in Eastern Asia,and significantly fluctuating daily ***,we reveal the genomic architecture that accompanied early Brassicaceae diversification by analyzing two high-quality chromosome-level genomes for Meniocus linifolius(Arabodae;clade D)and Tetracme quadricornis(Hesperodae;clade E),together with genomes representing all major Brassicaceae clades and the basal *** reconstructed an ancestral core Brassicaceae karyotype(CBK)containing 9 pseudochromosomes with 65 conserved syntenic genomic blocks and identified 9702 conserved genes in *** detected pervasive conflicting phylogenomic signals accompanied by widespread ancient hybridization events,which correlate well with the early divergence of core *** identified a successive Brassicaceae-specific expansion of the class I TREHALOSE-6-PHOSPHATE SYNTHASE 1(TPS1)gene family,which encodes enzymes with essential regulatory roles in flowering time and embryo *** TPS1s were mainly randomly amplified,followed by expression *** results provide fresh insights into historical genomic features coupled with Brassicaceae evolution and offer a potential model for broad-scale studies of adaptive radiation under an ever-changing environment.

关键词： Cruciferae genomic features ancient hybridization core Brassicaceae karyotype CBK TREHALOSE-6-PHOSPHATE SYNTHASE 1 genes TPS1s

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中华民族共同体学何以成为一级学科

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中南民族大学学报（人文社会科学版） 2024年第1期44卷 16-23,181,182页

作者：陈达云赵九霞西南民族大学教育学与心理学学院四川成都610041

中华民族共同体学一级学科的建设,是新时代党的民族工作高质量发展的客观需要,是中华民族共同体学学科发展的内在要求,是加快构建中国特色哲学社会科学体系的应有之义,有利于服务实现中华民族伟大复兴。以一级学科建设的学理逻辑和政策... 详细信息

中华民族共同体学一级学科的建设,是新时代党的民族工作高质量发展的客观需要,是中华民族共同体学学科发展的内在要求,是加快构建中国特色哲学社会科学体系的应有之义,有利于服务实现中华民族伟大复兴。以一级学科建设的学理逻辑和政策要求为依据,中华民族共同体学已经初步具备设置为一级学科的五个方面基础条件。在交叉学科门类设置中,中华民族共同体学一级学科不仅必要而且具有可行性。

关键词：中华民族共同体学一级学科学科建设交叉学科

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