Associations between interleukin-1 polymorphisms and gastric cancers among three ethnicities

作     者：Jiu-Da Zhao Pai-Li Geng Zhan-Quan Li Sen Cui Jun-Hui Zhao Li-Juan Wang Jin-Zhang Li Fa-Xiang Ji Guo-Yuan Li Guo-Shuang Shen Ming-Zhe Lin Cun-Fang Shen Cheng-Zhu Cao 

作者机构：Internal Medicine-OncologyAffiliated Hospital of Qinghai University High Altitude Medical Research CenterQinghai University 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第47期

页      面：7093-7099页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Grants from the National Natural Science Foun dation of China,No.30860259 the Youth Scientific Re search Foundation of Qinghai University,No.2008-QY-09 

主　　题：Gastric cancer Interleukin-1B Interleukin1RN Polymorphism Risk of gastric cancer 

摘      要：AIM:To investigate the associations between interleukin(IL)-1B and IL-1RN polymorphisms and gastric cancers among the Tibet,Hui and Han ***:Genomic DNA was extracted from peripheral blood of 210,205,and 202 healthy volunteers and from 155,158,and 197 gastric cancer patients from the Tibet,Hui,and Han populations,*** in IL-1B and IL-1RN were analyzed by denaturing high-performance liquid ***:Carriers of the IL-1B-31 CC genotype had an increased risk of intestinal type gastric cancer [odds ratio(OR) = 2.17,P = 0.037] in the Tibet *** of the IL-1B 2/L genotype had an increased risk of both intestinal and diffuse types of gastric cancer(OR = 2.08,2.31,P = 0.007,0.016,respectively) in the Hui *** the Han population,carriers of the IL-1B-31 CC,IL-1B-511CT,TT genotypes had increased risk of intestinal type gastric cancer(OR = 2.51,2.74,5.66,P = 0.005,0.002,0.000,respectively).CONCLUSION:IL-1B and IL-RN genotypes may differentially contribute to gastric cancer among the Tibet,Hui,and Han ethnicities in the Qinghai area of China.