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World Journal of Clinical Cases 2021年第34期9卷 10392-10399页

作者： Ling Bai Wang Yang Lei Qian jiu-wei cui Cancer Center The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

The outbreak of coronavirus disease 2019(COVID-19)is a significant challenge for clinicians,especially for immunocompromised cancer *** analyzing the impact of COVID-19 on the immune microenvironment of colorectal cancer(CRC)patients at the tissue level and single-cell level,we found that CRC patients are more easily infected by severe acute respiratory syndrome coronavirus-2(SARSCoV-2),but promotion of infiltration and differentiation of monocytes makes them more likely to develop severe *** of the continuing activation of nuclear factor(NF)-κB and C-C chemokine receptor type 5(CCR5)signaling pathways in monocytes,imbalance of macrophage polarization can aggravate the cytokine release ***,regulating the infiltration and differentiation of monocytes is helpful for the treatment of COVID-19 in CRC patients.

关键词： COVID-19 SARS-CoV-2 Monocyte Macrophage Colorectal cancer

Diverse and precision therapies open new horizons for patients with advanced pancreatic ductal adenocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 10-24页

作者： Ri-Lan Bai Nan-Ya Wang Ling-Ling Zhao Yong-Fei Zhang jiu-wei cui Cancer Center the First Hospital of Jilin UniversityChangchun 130021China

Pancreatic ductal adenocarcinoma(PDAC)is a common cause of cancer-related death,and most patients are with advanced disease when *** present,despite a variety of treatments have been devel-oped for PDAC,few effective treatment options are available;on the other hand,PDAC shows significant resistance to chemoradiotherapy,targeted therapy,and immunotherapy due to its heterogeneous genetic profile,molecular signaling pathways,and complex tumor immune ***,over the past decades,there have been many new advances in the key theory and understanding of the in-trinsic mechanisms and complexity of molecular biology and molecular immunology in pancreatic can-cer,based on which more and more diverse new means and reasonable combination strategies for PDAC treatment have been developed and preliminary breakthroughs have been *** the continuous ex-ploration,from surgical local treatment to comprehensive medical management,the research-diagnosis-management system of pancreatic cancer is *** review focused on the variety of treatments for advanced PDAC,including traditional chemotherapy,targeted therapy,immunotherapy,microenviron-ment matrix regulation as well as the treatment targeting epigenetics,metabolism and cancer stem *** pointed out the current research bottlenecks and future exploration directions.

关键词： Tumor Pancreatic ductal adenocarcinoma Targeted therapy Immunotherapy Epigenetics Tumor microenvironment

High Incidence of Venous Thromboembolism Due to Immune Checkpoint Inhibitors:an Immunotherapy-related Toxicity

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Journal of Nutritional Oncology 2021年第3期6卷 101-108页

作者： Fang Qi Li jiu wei cui Cancer Center The First Hospital of Jilin UniversityChangchun130021China

The incidence of venous thromboembolism(VTE)in cancer patients is 4-7 times higher than that in the general *** is a common complication in clinical practice,and is the second leading cause of death in cancer patients,severely affects the prognosis of cancer *** chemotherapy can result in higher incidence of VTE in cancer patients,a new class of treatments,immune checkpoint inhibitors(ICIs),can reduce the immune escape of tumors and have greatly improved patient survival,become a hot issue at ***,recent reports of high rate of VTE have raised concerns about these agents,suggests that VTE was a new type of toxicity associated with these *** order to make a preliminary exploration,we analyzed the results of 14 retrospective studies and two phaseⅡclinical trials,and herein discuss the incidence of VTE in patients receiving ICIs,as well as the postulated mechanisms and risk factors for *** also analyzed the effects of these VTE on the prognosis of patients receiving ICIs and evaluated the predictive value of the Khorana score to evaluate the adverse reaction to ICIs.

关键词： Cancer Venous thromboembolism Immunotherapy Immune checkpoint inhibitors Mortality Khorana

The Role of Neutrophils in Cancer Development

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Journal of Nutritional Oncology 2019年第2期4卷 85-90页

作者： Fei Fei Guo jiu wei cui Cancer Center of The First Hospital of Jilin University Changchun Jilin 130021 China

In recent years, the numerous roles of neutrophils have gained increasing attention. Beyond their traditional role in infection control, research on neutrophils has expanded to their roles in tumor regulation. It has been found that neutrophils present in the tumor microenvironment, tumor-associated neutrophils (TANs), exert complex and apparently opposing effects by reducing and promoting tumor growth and progression in response to various factors in the tumor microenvironment. In addition, recent studies have reported the heterogeneity and complex tumor regulation of circulating neutrophils. The present paper provides a summary of the related research progress.

关键词： Tumor microenvironment Circulating neutrophils Tumor-associated neutrophils Cancer therapy

Research Progress on Anti-tumor Therapy Targeting Cholesterol Metabolism

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Journal of Nutritional Oncology 2017年第4期2卷 159-164页

作者： Rilan Bai Ling Bai wei Li jiu wei cui Cancer Center the First Hospital of Jilin UniversityChangchun 130021JilinChina

Recent studies have shown that reprogramming of cholesterol metabolism occurs in both tumor cells and immune *** strategies to inhibit the cholesterol synthesis pathway also interfere with normal metabolic homeostasis and actions of immune ***,it is urgent to develop anti-tumor drugs that maintain a balance between inhibiting tumor cells and maintaining immune cell activity for anti-tumor metabolic *** will focus this review on the interaction between cholesterol and immune cells,effects of cholesterol and its metabolites on the pathogenesis and development of tumors,and strategies for developing antitumor therapies based on cholesterol *** has been shown that leelamine and modulators targeting cholesterol esters,27-hydroxycholesterol,and Dendrogenin A are potential candidates for anti-tumor metabolic ***,the ACAT inhibitor avasimibe,an established target for atherosclerosis,has attracted the attention of clinical researches because of its unique influence on both inhibiting tumor cells and enhancing immune cell function,which are expected to provide new research directions for cancer treatment.

关键词： Cancer Immune Cholesterol Metabolic Reprogramming Avasimibe

A brand new era of cancer immunotherapy: breakthroughs and challenges

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Chinese Medical Journal 2021年第11期134卷 1267-1275页

作者： Ri-Lan Bai Nai-Fei Chen Ling-Yu Li jiu-wei cui Cancer Center The First Hospital of Jilin UniversityChangchun 130021JilinChina.

Immunotherapy has opened a new era in cancer *** represented by immune checkpoint inhibitors have led to important breakthroughs in the treatment of various solid tumors,greatly improving the survival rate of cancer *** types of immunotherapeutic drugs have become widely available;however,their efficacy is variable,and relatively few patients with advanced cancer experience life-altering durable survival,reflecting the complex and highly regulated nature of the immune *** research field of cancer immunotherapy(CIT)still faces many challenges in pursuing the broader social goal of“curing cancer.”Increasing attention has been paid to strengthening the understanding of the molecular or cellular drivers of resistance to immunotherapy,actively exploring more effective therapeutic targets,and developing combination therapy ***,we review the key challenges that have emerged in the era of CIT and the possible solutions or development directions to overcome these difficulties,providing relevant references for basic research and the development of modified clinical treatment regimens.

关键词： Neoplasm Immunotherapy Resistance Combination therapy

Association of Base Excision Repair Gene Polymorphisms with the Response to Chemotherapy in Advanced Non-Small Cell Lung Cancer

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Chinese Medical Journal 2018年第16期131卷 1904-1908页

作者： Jie Dong Xu Wang Yu Yu Xu Yan jiu-wei cui Cancer Center The First Hospital of Jilin University Changchun JUin 130021 China

Background： Base excision repair （BER） plays an important role in the maintenance of genome integrity and anticancer drug resistance. This study aimed to explore the role of BER gene polymorphisms in response to chemotherapy for advanced non-small cell lung cancer （NSCLC） patients treated with platinum-based chemotherapy. Methods： During the period from November 2009 to January 2016, a total of 152 patients diagnosed with NSCLC Stage IIIB and IV in the First Hospital of Jilin University were admitted into this study. The XRCC1 G28152A, MUTYH G972C, HOGG1 C1245G. and PARPI T2444C polymorphisms of all the patients were detected by mass spectrometry. The logistic regression was used for statictical analysis. All tests were bilateral test, and a P 〈 0.05 was considered statistically significant. Results： The logistic regression model showed that the response rate of chemotherapy of the PARP1 T2444C polymorphisms, CC genotype （odds ratio [OR]： 5.216, 95% confidence interval [CI]： 1.568-17.352, P = 0.007）, TC genotype （OR： 2.692, 95% C1：1.007-7.198, P = 0.048）, as well as the genotype of TC together with CC （OR： 3.178, 95% CI： 1.229-8.219, P = 0.017） were significantly higher than those of TT wild type. There was no relationship between the MUTYH G972C, XRCC1 G28152A, and HOGGI C1245G gene polymorphisms and chemosensitivity. Conclusions： The PARPI 2444 mutation allele C might be associated with the decreased sensitivity to platinum-based chemotherapy in advanced NSCLC. These findings may be helpful in designing individualized cancer treatment.

关键词： Base Excision Repair Chemotherapy DNA Repair Genetic Non-Small Cell Lung Cancer Platinum Polymorphism

Multiple pulmonary ground-glass nodules: Challenges and advances

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Journal of Nutritional Oncology 2023年第2期8卷 85-93页

作者： Fei-Fei Guo Jue Huang Fei Chen jiu-wei cui Cancer Center The First Hospital of Jilin UniversityChangchunChina

Multiple pulmonary ground-glass nodules(GGNs),a typical clinical manifestation of multiple primary lung cancers(MPLCs),are of great significance for the early screening,diagnosis,and accurate treatment of lung ***,the recent increase in the detection rate of multiple pulmonary GGNs has attracted much ***,compared with the more widely studied single GGNs,evaluating GGNs is more challenging because of the uncertainty of the etiology,difficult differential diagnosis,and lack of optimal management standards and *** current solutions for multiple GGNs are based on the management experiences and principles of a single ***,it is necessary to obtain better understanding of multiple GGNs and to optimize the diagnostic methods and *** the existing challenges and potential of new methods for diagnosing and treating multiple pulmonary GGNs are reviewed and discussed in this article,with the aim of providing a reference for the clinical management of this highly prevalent condition.

关键词： Multiple pulmonary GGNs MPLC Treatment of lung cancer Guidelines

First-line atezolizumab plus chemotherapy in treatment of extensive small cell lung cancer:a cost-effectiveness analysis from China

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Chinese Medical Journal 2019年第23期132卷 2790-2794页

作者： Ling-Yu Li Hong Wang Xiao Chen Wen-Qian Li jiu-wei cui The Cancer Center of the First Hospital of Jilin University ChangchunJilin 130021China

Background:IMpower 133 trial first confirmed the efficacy and safety of adding atezolizumab or placebo to first-line treatment with chemotherapy in patients with extensive-stage small-cell lung cancer(SCLC).While,overprice limited its broad use in *** aim of this study was to evaluate the cost-effectiveness of atezolizumab plus chemotherapy in treatment of extensive SCLC as first line in ***:A Markov model was established by extracting data from the IMpower 133 trial with untreated extensive SCLC *** values were obtained from published studies,and the costs were acquired from real world and ***,sensitivity analyses based on a willingness-to-pay(WTP)threshold were performed to identify the uncertain parameters of Markov ***:Total costs of atezolizumab group were$48,129,while cost of chemotherapy alone was just$12,920 in placebo *** quality-adjusted life-years(QALYs)in atezolizumab group was just 0.072 higher than that in placebo group(0.858 QALYs vs.0.786 QALYs).The cost-effectiveness ratio between atezolizumab combination with chemotherapy and chemotherapy alone was$489,013/QALY in *** net benefit of placebo group was significantly higher than atezolizumab ***-way sensitivity analyses highlighted that utilities of the progression-free survival(PFS)and progression disease state in placebo group were the most influential ***:Atezolizumab combination therapy was not more cost-effective than chemotherapy alone at a WTP threshold of$25,929/QALY in China.

关键词： Cost-effectiveness Immunotherapy Chemotherapy Small cell lung cancer

Combining the Patient-Generated Subjective Global Assessment (PGSGA) and Objective Nutrition Assessment Parameters Better Predicts Malnutrition in Elderly Patients with Colorectal Cancer

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Journal of Nutritional Oncology 2020年第1期5卷 22-30页

作者： Wen Jun Wang Ting Ting Li Xu Wang wei Li jiu wei cui Cancer Center First Hospital of Jilin UniversityJilin UniversityChangchunJilin130021China

Background Malnutrition is common in colorectal cancer(CRC)patients,especially in elderly *** Patient-Generated Subjective Global Assessment(PG-SGA)is a widely used tool developed to detect *** aim of this study was to compare the value of the PG-SGA and objective nutrition assessment parameters,in order to identify a better predictive index for malnutrition in elderly patients with *** A total of 131 elderly patients(age≥60 years)with CRC were included and were evaluated for their individual nutritional status using the *** and serological indicators were also assayed within 48 h of admission to the *** composition analysis was implemented by bioelectrical impedance analysis(BIA)*** Chi-squared test,univariate and multivariate logistic regression analysis,or Spearman’s rank correlation analysis were used to determine the differences among the above indices and parameters with regard to predicting *** According to the PG-SGA score,the incidence of total malnutrition in elderly patients with CRC was 80.92%(PG-SGA score≥2),which increased with *** was found that 28%of the patients with PG-SGA classification A(PG-SGA score 0-1)had a low fat-free mass index(FFMI).Compared with those with PG-SGA A,patients with PG-SGA C PG-SGA score≥9)showed an increased neutrophil to lymphocyte ratio(NLR)and an increased platelet and lymphocyte ratio(PLR)(median=1.78 VS.2.35,P=0.015 and median=108.8 VS.141.6,P=0.001,respectively).In terms of objective nutrition assessment parameters,severely malnourished CRC patients had significantly lower values of serum albumin(ALB),and retinol conjugated protein(RBP)than those who were well-nourished[(38.35±4.84)g/L VS.(40.56±3.44)g/L,P=0.039 and(30.31±15.83)mg/L VS.(39.01±11.95)mg/L,P=0.033,respectively].The Spearman’s rank correlation analysis showed that the PG-SGA findings had positive correlations with the NLR and PLR;while it had negative correlations with

关键词： Colorectal cancer Elderly patients Malnutrition Bioelectrical impedance analysis Scored patientgenerated subjective global assessment