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SAHA attenuates Takotsubo-like myocardial injury by targeting an epigenetic Ac/Dc axis

Signal Transduction and Targeted Therapy 2021年第5期6卷 1429-1432页

作者： Ishant Khurana Scott Maxwell Simon Royce Prabhu Mathiyalagan Tom Karagiannis Nadia Mazarakis Jitraporn Vongsvivut Harikrishnan K.N. Jun Okabe Keith Al-Hasani Chrishan Samuel Assam El-Osta Human Epigenetics Program Department of DiabetesCentral Clinical SchoolMonash UniversityMelbourneVICAustralia Cardiovascular Disease Program Monash Biomedicine Discovery Institute and Department of PharmacologyMonash UniversityClaytonVICAustralia Infrared Microspectroscopy Beamline ANSTO-Australian SynchrotronClaytonVICAustralia Department of Medicine and Therapeutics The Chinese University of Hong Kong(CUHK)Hong Kong SARHong Kong Institute of Diabetes and ObesityCUHKHong Kong SARPrince of Wales HospitalLi Ka Shing Institute of Health SciencesCUHKShatinHong KongChina University College Copenhagen Faculty of HealthDepartment of TechnologyBiomedical Laboratory ScienceCopenhagenDenmark

Dear Editor,Takotsubo syndrome(TS)is a stress-induced non-ischaemic cardiomyopathy that is more common in women,but is associated with higher morbidity and mortality in males.Also known as broken-heart syndrome,TS is characterised by transient left ventricular(LV)dysfunction independent of obstructive coronary artery disease.TS is a polygenic condition and nowhere is this more evident than the use of positive inotropes,such as isoprenaline(ISO)in pre-clinical models.1 There is no standard therapy for broken-heart syndrome because the mechanisms underlying the condition remain unknown.Furthermore,there is no consensus on predisposition for Takotsubo2 and our goal was to better understand the regulatory mechanism as a first step towards improved treatment plans.Suberanilohydroxamic acid or SAHA,a drug approved for cancer treatment by the US Food and Drug Administration has previously been shown to improve cardiopulmonary function.3 We tested the hypothesis that the cardioprotective benefit of SAHA in a pre-clinical model of Takotsubo is conferred by an epigenetic acetylation/deacetylation(Ac/Dc)axis.

关键词： SAHA Takotsubo protective

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Single-shot mid-infrared incoherent holography using Lucy-Richardson-Rosen algorithm

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Opto-Electronic Science 2022年第3期1卷 1-8,I0001页

作者： Vijayakumar Anand Molong Han Jovan Maksimovic Soon Hock Ng Tomas Katkus Annaleise Klein Keith Bambery Mark J.Tobin Jitraporn Vongsvivut Saulius Juodkazis Optical Sciences Center and ARC Training Centre in Surface Engineering for Advanced Materials(SEAM) School of ScienceComputing and Engineering TechnologiesOptical Sciences CenterSwinburne University of TechnologyHawthornMelbourneVictoria 3122Australia Institute of Physics University of Tartu50411 TartuEstonia Infrared Microspectroscopy(IRM)Beamline ANSTO-Australian SynchrotronClaytonVictoria 3168Australia Tokyo Tech World Research Hub Initiative(WRHI) School of Materials and Chemical TechnologyTokyo Institute of Technology2-12-1OokayamaMeguro-kuTokyo 152-8550Japan

In recent years,there has been a significant transformation in the field of incoherent imaging with new possibilities of compressing three-dimensional(3D)information into a two-dimensional intensity distribution without two-beam interference(TBI).Most of the incoherent 3D imagers without TBI are based on scattering by a random phase mask exhibiting sharp autocorrelation and low cross-correlation along the depth.Consequently,during reconstruction,high lateral and axial resolutions are obtained.Imaging based on scattering requires an astronomical photon budget and is therefore precluded in many power-sensitive applications.In this study,a proof-of-concept 3D imaging method without TBI using deterministic fields has been demonstrated.A new reconstruction method called the Lucy-Richardson-Rosen algorithm has been developed for this imaging concept.We believe that the proposed approach will cause a paradigm-shift in the current state-of-the-art incoherent imaging,fluorescence microscopy,mid-infrared fingerprinting,astronomical imaging,and fast object recognition applications.

关键词： imaging holography mid-infrared spectroscopy incoherent optics computational optics mid-infrared imaging

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