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Dominance of transposable element‑related satDNAs results in great complexity of“satDNA library”and invokes the extension towards“repetitive DNA library”

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Marine Life Science & Technology 2024年第2期6卷 236-251页

作者： Monika Tunjić‑Cvitanić daniel García‑Souto Juan J.Pasantes evaŠatović‑Vukšić Division of Molecular Biology Ruđer BoškovićInstitute10000 ZagrebCroatia Genomes and Disease Centre for Research in Molecular Medicine and Chronic Diseases(CIMUS)Universidade de Santiago de Compostela15706 Santiago de CompostelaSpain Department of Zoology Genetics and Physical AnthropologyUniversidade de Santiago de Compostela15706 Santiago de CompostelaSpain Centro de Investigación Mariña Dpto de BioquímicaXenética e InmunoloxíaUniversidade de Vigo36310 VigoSpain

Research on bivalves is fast-growing,including genome-wide analyses and genome *** characteristics qualify oysters as a valuable model to explore repetitive DNA sequences and their genome *** we char-acterize the satellitomes of five species in the family Ostreidae(Crassostrea angulata,***,***,***,Ostrea edulis),revealing a substantial number of satellite DNAs(satDNAs)per genome(ranging between 33 and 61)and peculiarities in the composition of their *** satDNAs were either associated to or derived from transposable elements,displaying a scarcity of transposable element-unrelated satDNAs in these *** to the non-conventional satellitome constitution and dominance of Helitron-associated satDNAs,comparative satellitomics demanded more in-depth analyses than standardly *** analyses(including ***,the first bivalve species with a defined satellitome)revealed that 13 satDNAs occur in all six oyster genomes,with Cg170/HindIII satDNA being the most abundant in all of *** the“satDNA library model”highlighted the necessity to adjust this term when studying tandem repeat evolution in organisms with such *** repetitive sequences with potential variation in the organizational form and repeat-type affiliation are examined across related species,the introduction of the terms“TE library”and“repetitive DNA library”becomes essential.

关键词： Satellitome Comparative satellitomics Helitron Bivalves “Dark matter of the genome”

Antipredatory reaction of the leopard gecko Eublepharis macularius to snake predators

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Current Zoology 2016年第5期62卷 439-450页

作者： eva landova Veronika MuslLovA Jakub POLAK Kristyna SEDLACKOVA daniel frynta Department of Zoology Faculty of Science Charles University Vinicna 7 128 44 Prague Czech Republic National Institute of Mental Health Topolova 748 250 67 Klecany Czech Republic

Ability to recognize a risk of predation and react with adaptive antipredatory behavior can enhance fitness, but has some costs as well. Animals can either specifically react on the most dangerous predators （threat-sensitive avoidance） or they have safe but costly general wariness avoiding all potential predators. The level of threat may depend on the predator＇s foraging ecology and distri- bution with the prey with sympatric and specialist species being the most dangerous. We used 2 choice trials to investigate antipredatory behavior of captive born and wild-caught leopard geckos confronted with different snake predators from 2 families （Colubridae, Boidae） varying in foraging ecology and sympatric/allopatric distribution with the geckos. Predator-na＇ive subadult individuals have general wariness, explore both chemically and visually, and perform antipredatory postures toward a majority of snake predators regardless of their sympatry/allopatry or food specialization. The most exaggerated antipredatory postures in both subadult and adult geckos were toward 2 sympatric snake species, the spotted whip snake Hemorrhois ravergieri, an active forager, and the red sand boa Eryxjohnii, a subterranean snake with a sit-and-wait strategy. In contrast, also subter- ranean but allopatric the Kenyan sand boa Eryx colubrinus did not elicit any antipredatory reaction. We conclude that the leopard gecko possesses an innate general antipredatory reaction to different species of snake predators, while a specific reaction to 2 particular sympatric species can be observed. Moreover, adult wild caught geckos show lower reactivity compared with the captive born ones, presumably due to an experience of a real predation event that can hardly be simulated under laboratory conditions.

关键词： allopatric antipredation lizard posture sympatric 2 choice trial.

Why not to avoid the smell of danger？ Unexpected behavior of the Cypriot mouse surviving on the island invaded by black rats

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Current Zoology 2015年第4期61卷 781-791页

作者： daniel FRYNT Margareta BALADOVA Barbora ELIASOVA Silvie LISKOVA eva landova Department of Zoology Faculty of Science Charles University Vinicna 7 128 44 Prague 2 Czech Republic National Institut of Mental Health Topolova 748 250 67 Klecany Czech Republic

Mus cypriaeus is a recently discovered endemic species that evolved about half a million years ago on the Cyprus Is- land in an absence of most mammalian predators and competitors. As on other Mediterranean islands, the faunal composition was dramatically changed by the invasion of commensal and domestic species following Holocene colonization by humans. We exa- mined the behavioral responses of the Cypriot mouse to the odors of these new competitors （black and Norway rat, house mouse and spiny-mouse） and predator （domestic cat） as well as controls （Herb-field mouse, guinea pig）. We compared them with those of mainland population of house mouse from Syria with different coexistence history. Surprisingly, the Cypriot mouse failed to avoid the odor of its current main competitor, the black rat. Moreover, the response patterns of both the Cypriot and Syrian house mice to the examined odor sources appeared fairly comparable. There was a clear tendency to prefer odors of other murids over unscented sawdust as well as to avoid the odor of a domestic cat. In conclusion, neither the long-term isolation from predators nor the recent strong competition with black rats affected mice eompetitory and antipredatory responses fundamentally [Current Zoology 61 （4）： 781-791, 2015].

关键词： Competition Cyprus Mus cypriacus Odor preference Rattus rattus

c-Met signaling in the development of tumorigenesis and chemoresistance: Potential applications in pancreatic cancer

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World Journal of Gastroenterology 2014年第26期20卷 8458-8470页

作者： daniel Delitto eva Vertes-George Steven J Hughes Kevin E Behrns Jose G Trevino Department of Surgery University of Florida-Gainesville Department of Pathology University of Florida-Gainesville

Pancreatic ductal adenocarcinoma is the 4th leading cause of cancer deaths in the United States. The majority of patients are candidates only for palliative chemotherapy, which has proven largely ineffective in halting tumor progression. One proposed mechanism of chemoresistance involves signaling via the mesenchymal-epithelial transition factor protein (MET), a previously established pathway critical to cell proliferation and migration. Here, we review the literature to characterize the role of MET in the development of tumorigenesis, metastasis and chemoresistance, highlighting the potential of MET as a therapeutic target in pancreatic cancer. In this review, we characterize the role of c-Met in the development of tumorigenesis, metastasis and chemoresistance, highlighting the potential of c-Met as a therapeutic target in pancreatic cancer.

关键词： Pancreatic adenocarcinoma c-Met Chemoresistance Receptor tyrosine kinase

Making the Genotypic Variation Visible:Hyperspectral Phenotyping in Scots Pine Seedlings

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Plant Phenomics 2023年第4期5卷 790-804页

作者： Jan Stejskal Jaroslav Čepl eva Neuwirthová Olusegun Olaitan Akinyemi Jiří Chuchlík daniel Provazník Markku Keinänen Petya Campbell Jana Albrechtová Milan Lstiburek Zuzana Lhotáková Department of Genetics and Physiology of Forest Trees Faculty of Forestry and Wood SciencesCzech University of Life Sciences PraguePragueCzech Republic Department of Environmental and Biological Sciences University of Eastern FinlandJoensuuFinland Department of Experimental Plant Biology Charles UniversityPragueCzech Republic Center for Photonic Sciences University of Eastern FinlandJoensuuFinland Department of Geography and Environmental Sciences University of Maryland Baltimore CountyBaltimoreMDUSA Biospheric Sciences Laboratory NASA Goddard Space Flight CenterGreenbeltMDUSA

Hyperspectral reflectance contains valuable information about leaf functional traits,which can indicate a plant's physiological ***,using hyperspectral reflectance for high-throughput phenotyping of foliar traits could be a powerful tool for tree breeders and nursery practitioners to distinguish and select seedlings with desired adaptation potential to local *** evaluated the use of 2 nondestructive methods(i.e.,leaf and proximal/canopy)measuring hyperspectral reflectance in the 350-to 2,500-nm range for phenotyping on 1,788 individual Scots pine seedlings belonging to lowland and upland ecotypes of 3 different local populations from the Czech ***-level measurements were collected using a spectroradiometer and a contact probe with an internal light source to measure the biconical reflectance factor of a sample of needles placed on a black background in the contact probe field of *** proximal canopy measurements were collected under natural solar light,using the same spectroradiometer with fiber optical cable to collect data on individual seedlings'hemispherical conical reflectance *** latter method was highly susceptible to changes in incoming *** spectral datasets showed statistically significant differences among Scots pine populations in the whole spectral ***,using random forest and support vector machine learning algorithms,the proximal data obtained from the top of the seedlings offered up to 83%accuracy in predicting 3 different Scots pine *** conclude that both approaches are viable for hyperspectral phenotyping to disentangle the phenotypic and the underlying genetic variation within Scots pine seedlings.

关键词： Scots forest reflectance

Thermoelastic damping in MEMS gyroscopes at high frequencies

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Microsystems & Nanoengineering 2023年第1期9卷 137-148页

作者： daniel Schiwietz eva M.Weig Peter Degenfeld-Schonburg Robert Bosch GmbH Corporate Research71272RenningenGermany Department of Electrical&Computer Engineering Technical University of Munich85748GarchingGermany Munich Center for Quantum Science and Technology(MCQST) 80799MunichGermany TUM Center for Quantum Engineering(ZQE) 85748GarchingGermany

Microelectromechanical systems(MEMS)gyroscopes are widely used,e.g.,in modern automotive and consumer applications,and require signal stability and accuracy in rather harsh environmental *** many use cases,device reliability must be guaranteed under large external loads at high *** sensitivity of the sensor to such external loads depends strongly on the damping,or rather quality factor,of the high-frequency mechanical modes of the *** this paper,we investigate the influence of thermoelastic damping on several high-frequency modes by comparing finite element simulations with measurements of the quality factor in an application-relevant temperature *** measure the quality factors over different temperatures in vacuum,to extract the relevant thermoelastic material parameters of the polycrystalline MEMS *** simulation results show a good agreement with the measured quantities,therefore proving the applicability of our method for predictive purposes in the MEMS design ***,we are able to uniquely identify the thermoelastic effects and show their significance for the damping of the high-frequency modes of an industrial MEMS *** approach is generic and therefore easily applicable to any mechanical structure with many possible applications in nano-and micromechanical systems.

关键词： uniquely generic quantities

Celiac disease markers in patients with liver diseases: A single center large scale screening study

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World Journal of Gastroenterology 2012年第43期18卷 6255-6262页

作者： Pavel Drastich eva Honsová Alena Lodererová Marcela Jaresová Aneta Pekáriková Iva Hoffmanová Ludmila Tuková Helena Tlaskalová-Hogenová Julius piák daniel Sánchez Department of Hepatogastroenterology Institute for Clinical and Experimental Medicine 14021 Prague Czech Republic Department of Clinical and Transplant Pathology Institute for Clinical and Experimental Medicine 14021 Prague Czech Republic Department of Immunology Institute for Clinical and Experimental Medicine 14021 Prague Czech Republic Department of Immunology Institute of Microbiology Academy of Sciences of the Czech Republic 14220 Prague Czech Republic 2nd Department of Internal Medicine 3rd Faculty of Medicine Charles University 10034 Prague Czech Republic

AIM:To study the coincidence of celiac disease, we tested its serological markers in patients with various liver ***:Large-scale screening of serum antibodies against tissue transglutaminase (tTG), and deamidated gliadin using enzyme-linked immunosorbent assay and serum antibodies against endomysium using immunohistochemistry, in patients with various liver diseases (n = 962) and patients who underwent liver transplantation (OLTx, n = 523) was performed. The expression of tTG in liver tissue samples of patients simultaneously suffering from celiac disease and from various liver diseases using immunohistochemistry was carried out. The final diagnosis of celiac disease was confirmed by histological analysis of small-intestinal biopsy. RESULTS:We found that 29 of 962 patients (3%) with liver diseases and 5 of 523 patients (0.8%) who underwent OLTx were seropositive for IgA and IgG anti-tTG antibodies. However, celiac disease was biopsy-diagnosed in 16 patients:4 with autoimmune hepatitis type Ⅰ, 3 with Wilson's disease, 3 with celiac hepatitis, 2 with primary sclerosing cholangitis, 1 with primary biliary cirrhosis, 1 with Budd-Chiari syndrome, 1 with toxic hepatitis, and 1 with non-alcoholic steatohepatitis. Unexpectedly, the highest prevalence of celiac disease was found in patients with Wilson's disease (9.7%), with which it is only rarely associated. On the other hand, no OLTx patients were diagnosed with celiac disease in our study. A pilot study of the expression of tTG in liver tissue using immunohistochemistry documented the overexpression of this molecule in endothelial cells and periportal hepatocytes of patients simultaneously suffering from celiac disease and toxic hepatitis, primary sclerosing cholangitis or autoimmune hepatitis type Ⅰ. CONCLUSION:We suggest that screening for celiac disease may be beneficial not only in patients with associated liver diseases, but also in patients with Wilson's disease.

关键词： Tissue transglutaminase Anti-tissue transglutaminase antibodies Autoimmune liver diseases Wilson's disease Celiac disease Liver transplantation

Lightweight porous silica foams with extreme-low dielectric permittivity and loss for future 6G wireless communication technologies

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Nano Research 2021年第5期14卷 1450-1456页

作者： Petra S.Pálvölgyi daniel Sebők Imre Szenti eva Bozo Henri Ervasti Olli Pitkänen Jari Hannu Heli Jantunen Marko E.Leinonen Sami Myllymäki Akos Kukovecz Krisztian Kordas Microelectronics Research Unit Faculty of Information and Electrical EngineeringUniversity of OuluP.O.Box 4500FI-90570OuluFinland Interdisciplinary Excellence Centre Department of Applied and Environmental ChemistryUniversity of SzegedRerrich Béla tér 1H-6720SzegedHungary Centre for Wireless Communications University of OuluP.O.Box 4500FI-90570OuluFinland

In the next generation wireless communication systems operating at near terahertz frequencies, dielectric substrates with the lowest possible permittivity and loss factor are becoming essential. In this work, highly porous (98.9% ± 0.1%) and lightweight silica foams (0.025 ± 0.005 g/cm3), that have extremely low relative permittivity (εr = 1.018 ± 0.003 at 300 GHz) and corresponding loss factor (tan δ< 3 × 10−4 at 300 GHz) are synthetized by a template-assisted sol-gel method. After dip-coating the slabs of foams with a thin film of cellulose nanofibers, sufficiently smooth surfaces are obtained, on which it is convenient to deposit electrically conductive planar thin films of metals important for applications in electronics and telecommunication devices. Here, micropatterns of Ag thin films are sputtered on the substrates through a shadow mask to demonstrate double split-ring resonator metamaterial structures as radio frequency filters operating in the sub-THz band.

关键词： low-permittivity materials low-loss dielectrics templated sol-gel synthesis silica foams 6G telecommunication

Balanced propofol sedation administered by nonanesthesiologists:The first Italian experience

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World Journal of Gastroenterology 2011年第33期17卷 3818-3823页

作者： Alessandro Repici Nico Pagano Cesare Hassan Alessandra Carlino Giacomo Rando Giuseppe Strangio Fabio Romeo Angelo Zullo Elisa Ferrara eva Vitetta daniel de Paula Pessoa Ferreira Silvio Danese Massimo Arosio Alberto Malesci Department of Gastroenterology IRCCS Istituto Clinico HumanitasVia Manzoni 5620089 RozzanoMilanItaly Department of Anaesthesiology IRCCS Istituto Clinico HumanitasVia Manzoni 5620089 RozzanoMilanItaly

AIM:To assess the efficacy and safety of a balanced approach using midazolam in combination with propofol,administered by nonanesthesiologists,in a large series of diagnostic ***:Consecutive patients undergoing diagnostic colonoscopy were sedated with a single dose of midazolam(0.05 mg/kg)and lowdose propofol(starter bolus of 0.5 mg/kg and repeated boluses of 10 to 20 mg).Induction time and deepest level of sedation,adverse and serious adverse events,as well as recovery times,were prospectively *** intubation and adenoma detection rates were also ***:Overall,1593 eligible patients were *** median dose of propofol administered was 70 mg(range:40120 mg),and the median dose of midazolam was 2.3 mg(range:24 mg).Median induction time of sedation was 3 min(range:14 min),and median recovery time was 23 min(range:1040 min).A moderate level of sedation was achieved in 1561(98%) patients,whilst a deep sedation occurred in 32(2%) *** oxygen desaturation requiring further oxygen supplementation occurred in 8(0.46%;95% CI:0.2%0.8%)*** serious adverse event was *** intubation and adenoma detection rates were 93.5%and 23.4%(27.8%for male and 18.5%for female,subjects),***:A balanced sedation protocol provided a minimalization of the dose of propofol needed to target a moderate sedation for colonoscopy,resulting in a high safety profile for nonanesthesiologist propofol sedation.

关键词： Colonoscopy Propofol Sedation