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In search of a pan-coronavirus vaccine:next-generation vaccine design and immune mechanisms

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Cel.ular & Molecular Immunology 2024年第2期21卷 103-118页

作者： S.Cankat M.u.Demael l.Swadling Division of Infection and Immunity Institute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK

Members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent *** this review,we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus *** will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2,MERS-CoV and the four seasonal coronaviruses(HCoV-OC43,Nl63,HKu1 and 229E)in humans and the potential for future zoonotic *** will highlight how first-generation SARS-CoV-2 vaccines and natural history studies have greatly increased our understanding of effective antiviral immunity to coronaviruses and have informed next-generation vaccine *** will then consider the ideal properties of a pan-coronavirus vaccine and propose a blueprint for the type of immunity that may offer ***,we will describe a subset of the diverse technologies and novel approaches being pursued with the goal of developing broadly or universally protective vaccines for coronaviruses.

关键词： Vaccine Coronavirus Cross-reactive immunity Cross-protection universal

Exact solutions for magnetohydrodynamic nanofluids flow and heat transfer over a permeable axisymmetric radially stretching/shrinking sheet

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Chinese Physics B 2024年第2期33卷 108-114页

作者： u.S.Mahabaleshwar G.P.Vanitha l.M.Pérez Emad H.Aly I.Pop Department of Studies in Mathematics Davangere UniversityShivagangothriDavangereIndia Departamento de F´ısica FACIUniversidad de Tarapac´aCasilla 7DAricaChile Department of Mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt Department of Mathematics Babes-Bolyai University400084 Cluj-NapocaRomania

We report on the magnetohydrodynamic impact on the axisymmetric flow of Al_(2)O_(3)/Cu nanoparticles suspended in H_(2)O past a stretched/shrinked *** the use of partial differential equations and the corresponding thermophysical characteristics of nanoparticles,the physical flow process is *** resultant nonlinear system of partial differential equations is converted into a system of ordinary differential equations using the suitable similarity *** transformed differential equations are solved *** of the magnetic parameter,solid volume fraction and stretching/shrinking parameter on momentum and temperature distribution have been analyzed and interpreted *** skin friction and Nusselt number were also *** addition,existence of dual solution was deduced for the shrinking sheet and unique solution for the stretching ***,Al_(2)O_(3)/H_(2)O nanofluid flow has better thermal conductivity on comparing with Cu/H_(2)O ***,it was found that the first solutions of the stream are stable and physically realizable,whereas those of the second ones are unstable.

关键词： magnetohydrodynamic nanofluid stretching/shrinking sheet axisymmetric flow analytical solution suction/injection

Identification, pathogenicity, and fungicide sensitivity of Eutiarosporella dactylidis associated with leaf blight on maize in China

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Journal of Integrative Agricul.ure 2024年第3期23卷 888-900页

作者： Cheng Guo Xiaojie Zhang Baobao Wang Zhihuan Yang jiping li Shengjun Xu Chunming Wang Zhijie Guo Tianwang Zhou l.u Hong Xiaoming Wang Canxing Duan Institute of Plant Protection Gansu Academy of Agricultural SciencesLanzhou 730070China Pratacul.ural College Gansu Agricultural UniversityLanzhou 730070China Shijiazhuang Academy of Agricul.ure and Forestry Sciences Shijiazhuang 050050China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBejing 100081China

Maize(Zea mays l.) is an economically vital grain crop that is cultivated worldwide. In 2011, a maize foliar disease was detected in lingtai and lintao counties in Gansu Province, China. The characteristic signs and symptoms of this disease include irregular chlorotic lesions on the tips and edges of infected leaves and black punctate fruiting bodies in dead leaf tissues. Given favourable environmental conditions, this disease spread to areas surrounding Gansu. In this study, infected leaves were collected from Gansu and Ningxia Hui Autonomous Region between 2018and 2020 to identify the disease-causing pathogen. Based on morphological features, pathogenicity tests, and multilocus phylogenetic analysis involving internal transcribed spacer(ITS), 18S small subunit rDNA(SSu), 28S large subunit rDNA(l.u), translation elongation factor 1-alpha(TEF), and β-tubulin(TuB) sequences, Eutiarosporella dactylidis was identified as the causative pathogen of this newly discovered leaf blight. Furthermore, an in vitro bioassay was conducted on representative strains using six fungicides, and both fludioxonil and carbendazim were found to significantly inhibit the mycelial growth of E. dactylidis. The results of this study provide a reference for the detection and management of Eutiarosporella leaf blight.

关键词： maize leaf blight morphology molecular phylogeny Eutiarosporella dactylidis fungicide sensitivity

Polar-coordinate line-projection light-curing continuous 3D printing for tubular structures

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International Journal of Extreme Manufacturing 2024年第4期6卷 247-260页

作者： Huiyuan Wang Siqin l.u Xincheng Yin Mingming Huang Yanzhe Fu Xun Chen Chao Wang Jingyong Sun Xin Yan Jianmin Han jiping Yang Zhijian Wang lizhen Wang Yubo Fan Jiebo li Key laboratory of Biomechanics and Mechanobiology(Beihang university) Ministry of EducationInstitute of Medical PhotonicsBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191People's Republic of China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191People's Republic of China Peking university School and Hospital of Stomatology Beijing 100081People's Republic of China School of Materials Science and Engineering Beihang UniversityBeijing 100191People's Republic of China

3D printing techniques offer an effective method in fabricating complex radially multi-material ***,it is challenging for complex and delicate radially multi-material model geometries without supporting structures,such as tissue vessels and tubular graft,among *** this work,we tackle these challenges by developing a polar digital light processing technique which uses a rod as the printing *** 3D model fabrication is accomplished through line *** rotation and translation of the rod are synchronized to project and il.uminate the photosensitive material *** controlling the distance between the rod and the printing window,we achieved the printing of tubular structures with a minimum wall thickness as thin as 50 *** controlling the width of fine slits at the printing window,we achieved the printing of structures with a minimum feature size of 10 *** process accomplished the fabrication of thin-walled tubular graft structure with a thickness of only 100 micrometers and lengths of several centimeters within a timeframe of just 100 ***,it enables the printing of axial multi-material structures,thereby achieving adjustable mechanical *** method is conducive to rapid customization of tubular grafts and the manufacturing of tubular components in fields such as dentistry,aerospace,and more.

关键词： 3D printing polar coordinate line projection light-curing tubular structure radially multi-material structures

Noncoding RNAs：＇our turn＇ to join the p53 networ

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Journal of Molecular Cell Biology 2014年第3期8卷 179-180页

作者： Yong li Hua l.u Department of Biochemistry and Molecular Biology School of Medicine University of Louisville 319 Abraham Flexner Way Louisville KY40202 USA E-mail: yong.ti@louisviUe.edu Department of Biochemistry& Molecular Biology andTulane Cancer Center TulaneUniversity School ofMedicine New Orleans LA70112 USA

The p53 tumor suppressor is the guardian of the rrr- o human genome. Since ,ts discovery in pS3 has been the most studied molecule in the field of cancer. Recently, its role has also been extended to other biological and pathological processes, p53 functions primarily as a transcription factor to regulate target genes that encode proteins crucial for promot- ing apoptotic cell death, cell cycle arrest, senescence, and so on in response to diverse upstream stressors. Interestingly, some of the p53 targets are noncoding RNAs. Noncoding RNAs can be functional without being translated into proteins and are often independent RNA molecules or noncoding parts of messenger RNAs. The past decade has witnessed bur- geoning intensive investigation on the interplay of noncoding RNAs with p53, its regulators, and effectors during the development of cancer and/or other dis- eases. This issue of Journal of Molecular Cell Biology presents five essays to review the rapid progress in this area from five different angles and to offer new insight into the role of noncoding RNAs in the p53 signaling web with updated information.

关键词：非编码RNA BP网络分子细胞生物学 P53 编码蛋白质细胞周期阻滞 p53 人类基因组

Childhood malaria in the Niger delta area of Nigeria:mothers/care givers'perception,definition and treatment practices

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Asian Pacific Journal of Tropical Medicine 2009年第3期2卷 52-58页

作者： Idogun E.Sylvester Airauhi l.u Department of Chemical Pathology University of Benin Teaching HospitalBenin City Department of Medical Microbiology Biology University of Benin Teaching HospitalBenin City

Objective:The objective of the study was to evaluate mothers/care givers perception of malaria,their treatment practices and the effects on the outcome of ***:Four hundred and sixty children were enrolled and their mothers/care givers *** children were screened for malaria parasitaemia and there after,blood specimens were obtained for biochemical and haematological evaluation from those children who met the criteria and tested positive to *** *** cell volume,electrolytes,urea, creatinine,plasma glucose,and serum bilirubin were ***:A total of 460 children were studied, 233(50.7%) males and 227(49.3%) *** malaria cases were 112(24.3%) and severe malaria 348(75.7%).Those who presented early 106(23.0%) and those who presented late 354(77.0%).Perception and definition of malaria as well as the treatment seeking behaviors vary significantly with the level of education of the mothers and care *** without formal education 68(51.9%) wrongly perceived that the etiology of malaria can only be diagnosed by native doctors compared to those with primary six education 61 (26.5%) and junior secondary education 10(10.1%).Only 43(9.3%) gave the correct dose of chloroquine syrup to their sick children,while 32(7.0%) gave at sub optimal ***:Wrong perception of malaria especially the complicated malaria and wrong treatment practices are major contributory factors to the high mortality and morbidity of malaria in *** is therefore a need for health education to correct the wrong ideas about the cause and treatment practices of malaria as part of malaria control programme.

关键词： Childhood malaria Mothers/Caregivers Perception and treatment practices Nigeria

Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-lobato Mariam Masmudi-Martín Manuel F.lópez-Aranda Juan F.lópez-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar u.Khan laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

基于EST-SSR标记的朱顶红种质资源鉴定

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分子植物育种 2024年第4期22卷 1123-1132页

作者：吕文涛娄文睿娄晓鸣宣继萍苏州农业职业技术学院园艺科技学院苏州215008 江苏省科技资源(农业种质)统筹服务平台球根花卉种质资源库(苏州农业职业技术学院) 苏州215008 江苏省中国科学院植物研究所南京210014

以历年引进的朱顶红种质资源为试验材料,将其按照近似花品种和同名品种进行分组,其中近似花品种包括12个组合45个品种,同名品种包括12个组合31个品种,从已开发的EST-SSR标记中筛选多态性引物,对这些引进的朱顶红种质资源进行鉴定。结果... 详细信息

以历年引进的朱顶红种质资源为试验材料,将其按照近似花品种和同名品种进行分组,其中近似花品种包括12个组合45个品种,同名品种包括12个组合31个品种,从已开发的EST-SSR标记中筛选多态性引物,对这些引进的朱顶红种质资源进行鉴定。结果表明:从朱顶红转录组开发的7对SSR标记中利用其中5对进行本次试验,通过近似花组合聚类结果分析得出,12个组合中,5个组合部分品种遗传相似系数较高,大部分组合及品种呈现错综复杂的亲缘关系;同名组合聚类结果为12个组合中有9个组合大部分品种聚在一起;‘橙色君主’、‘苹果花’和‘帆船’3个组合遗传背景复杂。部分组合亲缘关系可以看出,多组白色单瓣和红白条纹单瓣组合的遗传相似系数较高,多组重瓣和单瓣品种聚在一起。朱顶红具有丰富的遗传多样性,本研究为研究朱顶红品种间的亲缘关系,进行朱顶红种质资源鉴定提供参考。

关键词：朱顶红 EST-SSR标记聚类分析资源鉴定

多学科营养支持小组对肺癌化疗患者营养状况及生命质量的影响

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中国实用护理杂志 2024年第1期40卷 27-33页

作者：杨鑫王吉平邬丽红复旦大学附属金山医院肿瘤科上海201508 复旦大学护理学院上海200032 复旦大学附属金山医院预防保健科上海201508

目的探讨多学科营养支持小组对肺癌化疗患者营养状况及生命质量的影响,为肺癌化疗患者营养干预方案的制订提供参考。方法采用类实验研究方法,便利抽样选取2021年2月至2022年7月就诊于复旦大学附属金山医院的74例肺癌化疗患者为研究对象... 详细信息

目的探讨多学科营养支持小组对肺癌化疗患者营养状况及生命质量的影响,为肺癌化疗患者营养干预方案的制订提供参考。方法采用类实验研究方法,便利抽样选取2021年2月至2022年7月就诊于复旦大学附属金山医院的74例肺癌化疗患者为研究对象。按照入院时间将2021年2—8月收治的37例患者设为对照组,给予常规护理干预;将2021年9月至2022年7月收治的37例患者设为观察组,给予多学科营养支持小组模式干预。干预时间为3个化疗周期,比较2组患者干预前后血清营养学指标及生命质量变化的差异。结果对照组男27例,女10例,年龄(68.14±6.82)岁;观察组男30例,女7例,年龄(65.92±9.17)岁。2组患者干预前血清营养学指标及生命质量比较差异均无统计学意义(均P>0.05)。观察组患者干预后血清总蛋白、白蛋白、前白蛋白含量分别为(69.41±5.87)、(38.11±4.04)g/l和(243.57±67.58)mg/l,高于对照组的(65.54±8.33)、(35.78±5.39)g/l和(200.84±60.84)mg/l,差异均有统计学意义(t=-2.31、-2.10、-2.86,均P<0.05)。观察组患者干预后情绪功能、整体健康/生命质量的评分分别为(88.29±16.72)、(60.36±13.24)分,高于对照组的(76.80±17.58)、(46.40±16.38)分;疲倦、恶心呕吐、失眠、食欲丧失症状领域的评分分别为(34.53±22.19)、(11.26±8.83)、(20.72±16.39)、(24.32±18.67)分,低于对照组的(45.65±22.95)、(25.68±18.67)、(36.94±23.29)、(40.54±22.41)分,差异均有统计学意义(t值为-4.03~4.24,均P<0.05)。结论在肺癌患者化疗期间,实施多学科营养支持小组可以显著改善患者的营养状况,提高患者生命质量。

关键词：肺肿瘤生活质量化疗营养支持小组营养状况