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Science China(Information Sciences) 2023年第12期66卷 281-282页

作者： Cheng HU Yujia YAN Rui WANG Qi JIANG jiong cai Weidong LI Radar Research Laboratory School of Information and ElectronicsBeijing Institute of Technology

Detection of small low-altitude targets such as drone swarms, migrating insects and birds is crucial for both military and civilian applications [1]. There exist two main challenges which significantly affect the radar detection and tracking performance. Firstly, weak echo signals of small targets will be buried in strong ground clutter and rain clutter [2].

关键词：

Robust Unsupervised Discriminative Dependency Parsing

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Tsinghua Science and Technology 2020年第2期25卷 192-202页

作者： Yong Jiang jiong cai Kewei Tu School of Information Science and Technology Shanghai Tech UniversityShanghai 201210China Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai 200050 University of Chinese Academy of Sciences Beijing 100049China

Discriminative approaches have shown their effectiveness in unsupervised dependency parsing.However,due to their strong representational power,discriminative approaches tend to quickly converge to poor local optima during unsupervised training.In this paper,we tackle this problem by drawing inspiration from robust deep learning techniques.Specifically,we propose robust unsupervised discriminative dependency parsing,a framework that integrates the concepts of denoising autoencoders and conditional random field autoencoders.Within this framework,we propose two types of sentence corruption mechanisms as well as a posterior regularization method for robust training.We tested our methods on eight languages and the results show that our methods lead to significant improvements over previous work.

关键词： unsupervised learning dependency parsing autoencoders

Anti-amyloid beta single-chain Fv ameliorates behavioral impairment in Alzheimer's disease mice via adeno-associated virus delivery

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Neural Regeneration Research 2011年第2期6卷 96-100页

作者： jiong cai Yanwei Zhong Fang Li Shizhen Wang Department of Nuclear Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union MedicalCollege Beijing 100730 China Viral Hepa-titis Research Laboratory Institute of Infectious Diseases the 302 Hospital of Chinese PLA Beijing 100039 China

Intracranial delivery of human Fc-deleted antibody specific to amyloid-β peptide （Aβ, anti-Aβ single-chain Fv, scFv） via adeno-associated virus （AAV） inhibits amyloid deposition in transgenic mice. However, the effects of AAV-mediated Fc-deleted antibody on animal behavior remain unclear. In this study, the anti-Aβ scFv antibody gone, isolated from phage display, was fused to the 5＇ end of the scFv antibody gone for antibody secretion by 2 rounds of polymerase chain reaction amplification. The fused antibody cDNA was cloned into a pSNAV2 plasmid under the control of the cytomegalovirus promoter. The sequence verified expression vector pSNAV2/scFv was transferred to BHK-21 ceils, and stable transfected BHK-21/scFv cells were established by G418 selection and infected with the recombinant herpes simplex virus rHSV/repcap for AAV production. Recombinant AAV was injected into the left quadriceps femoris of PDAPP transgenic mice. After 3 months, Morris water-maze results confirmed significantly improved cognitive function in a mouse model of Alzheimer＇s disease. Key Words： Alzheimer＇s disease; adeno-associated virus; amyloid-β peptide; single-chain antibody; neurodegenerative diseases; neural regeneration

关键词： Alzheimer＇s disease adeno-associated virus amyloid-13 peptide single-chain antibody neurodegenerative diseases neural regeneration

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我国汽车产业ERP系统应用浅议

全国流通经济 2024年第8期 129-132页

作者：蔡炯王志亮北方工业大学经济管理学院北京100144

自1958年新中国第一辆“东风”轿车生产装配试车成功至今,我国汽车产业发展进入新发展阶段,随着我国新能源汽车发展的弯道超车,我国汽车产业无论从市场还是制造都有了未来发展更大的底气。本文从我国汽车产业发展的数字化背景出发,分析... 详细信息

自1958年新中国第一辆“东风”轿车生产装配试车成功至今,我国汽车产业发展进入新发展阶段,随着我国新能源汽车发展的弯道超车,我国汽车产业无论从市场还是制造都有了未来发展更大的底气。本文从我国汽车产业发展的数字化背景出发,分析了我国汽车产业发展中应用ERP系统的必要性,提出我国汽车产业应用ERP系统时“干中学”需要进行调整。在此基础上,本文对我国汽车产业应用ERP系统提出重视产学研合作人才培养、持续关注ERP系统运维、重视ERP系统投入以及重视ERP系统与其他相关信息技术的融合等完善建议。

关键词：汽车产业 ERP系统应用 “干中学”

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DD线圈无线电能传输系统最大效率控制

电力电子技术 2024年第3期58卷 85-87页

作者：吴萱俊蔡炯炯殷猛陈吟威浙江科技大学自动化与电气工程学院浙江杭州310023

DD(双D)型耦合机构的无线电能传输(WPT)系统抗偏移能力强,能降低自动引导小车(AGV)泊车控制精度要求。但双发射(Tx)结构增加了系统复杂性。对此,提出了一种DD型耦合机构的最大传输效率控制方法。首先建立了串联-串联(SS)补偿结构的WPT... 详细信息

DD(双D)型耦合机构的无线电能传输(WPT)系统抗偏移能力强,能降低自动引导小车(AGV)泊车控制精度要求。但双发射(Tx)结构增加了系统复杂性。对此,提出了一种DD型耦合机构的最大传输效率控制方法。首先建立了串联-串联(SS)补偿结构的WPT互感模型,利用中心对齐移相脉宽调制(PSPWM)实现多Tx协调控制;接着,针对互感参数识别问题,提出了一种基于磁场抵消的互感比值识别方法,该方法不涉及复杂计算,也不需要引入接收端(Rx)反馈。实验表明所提方法在AGV泊车不同程度偏移的情况下,均能准确识别互感比值,能量传输效率较无控制情况下明显提高。

关键词：无线电能传输耦合机构移相脉宽调制

成都市冷藏即食预包装熟肉制品中单核细胞增生李斯特菌定量检测及污染风险研究

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中国食品卫生杂志 2024年第4期36卷 426-432页

作者：蔡炯陈潇朱虹霖张彪张熳迪张梦姣王家祺闫韶飞李莹刘丽莎孙宏虎白莉成都市食品检验研究院辐照保藏四川省重点实验室四川成都610045 国家食品安全风险评估中心北京100021

目的为探明了解冷藏即食预包装熟肉制品中单核细胞增生李斯特菌(单增李斯特菌)污染情况及潜在风险,本研究针对短保质期的冷藏即食预包装熟肉制品开展单增李斯特菌定量污染风险调查。方法2022年5~8月,从成都市采集样品64份,依据采用传统... 详细信息

目的为探明了解冷藏即食预包装熟肉制品中单核细胞增生李斯特菌(单增李斯特菌)污染情况及潜在风险,本研究针对短保质期的冷藏即食预包装熟肉制品开展单增李斯特菌定量污染风险调查。方法2022年5~8月,从成都市采集样品64份,依据采用传统培养分离鉴定和RT-PCR分子检测方法进行单增李斯特菌的定性和定量检测,分离菌株提取DNA后进行二代全基因组测序并开展相关流行病学特征分析。结果检测结果发现64份即食熟肉样品中,6份样品检出单增李斯特菌,检出份数为6/64。6份阳性样品均由某同一工厂生产,其中5份为卤肉三拼样品。定量检测结果表明,卤肉三拼的单增李斯特菌污染水平为30~200 CFU/g;单增李斯特菌阳性的猪肉样品污染水平为<10 CFU/g。阳性样品中的6株分离菌株经全基因组测序分析鉴定为单增李斯特菌,均含有LIPI-1毒力岛相关基因,多序列位点分型发现主要的序列型(ST)为ST3(n=2)和ST121(n=2),其次是ST8和ST9。单核苷酸多态性(SNP)结果分析发现同一工厂分离到的单增李斯特菌菌株LM22071911和LM22080802之间检测到23个SNP差异,单增李斯特菌株LM22062706和LM22080806之间检测到13个SNP差异,说明在该工厂加工环节存在两种克隆群的单增李斯特菌直接传播的风险。结论成都市部分市售冷藏即食预包装熟肉制品污染多种李斯特菌,需加强源头控制。

关键词：冷藏即食食品预包装食品单核细胞增生李斯特氏菌定量检测食源性致病菌

Expression of secreted human single-chain fragment variable antibody against human amyloid beta peptide in Pichia pastoris

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Neural Regeneration Research 2008年第8期3卷 910-913页

作者： jiong cai Fang Li Shizhen Wang Department of Nuclear Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Hospital Beijing 100730 China

BACKGROUND：Studies have shown that monoclonal or polyclonal antibody injections of amyloid β peptide are effective in removing amyloid β peptide overload in the brain. OBJECTIVE： Based on successful screening of a human single-chain fragment variable antibody specific to amyloidβpeptide, this paper aimed to express recombinant human single-chain variable antibody against amyloid β peptide. DESIGN, TIME AND SETTING： A single sample experiment was performed at the Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Hospital （Beijing, China） from January to July 2006. MATERIALS： Human single-chain fragment variable antibody gene against amyloid β peptide was screened from a human phage-display antibody library. METHODS： Human single-chain fragment variable antibody gene was mutated to eliminate a BamHI restriction site and cloned into a T easy plasmid for pT-scFvAβ construction, which was identified by PCR amplification and endonuclease digestion. Plasmid pT-scFvAβ was cut by EcoRI and NotI endonucleases, and the antibody gene was cloned into pPIC9K plasmid to construct pPIC9K-scFvAβ expression vector, which was confirmed by gene sequencing. Linearized pPIC9K-scFvAβ was used to transform a Pichia pastoris GS115 cell line, and the recombinant was induced by 0.5% methanol to express human single-chain fragment variable antibody specific to amyloid β peptide. MAIN OUTCOME MEASURES： Protein electrophoresis was used to identify PCR products, gene sequencing was used to verify the pPIC9K-scFvA sequence, and SDS-PAGE was used to detect recombinant expression of human single-chain fragment variable antibody specific to amyloid β peptide in Pichia pastoris. RESULTS： Gene sequencing confirmed pPIC9K-scFvAβ orientation. Recombinants were obtained by linearized pPIC9K-scFvAβ transformation. After induction with 0.5% methanol, the recombinant yeast cells secreted proteins of 33-ku size. CONCLUSION： The expression vector pPIC9K-scFvAβ was successfully constr

关键词： Alzheimer＇s disease β amyloid peptide single-chain fragment variable antibody

Combination prediction method of chaotic time series

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Chinese Science Bulletin 2007年第4期52卷 570-573页

作者： ZHAO DongHua RUAN jiong cai ZhiJie Institute of Mathematics and Laboratory of Nonlinear Model and Method Fudan University Shanghai 200433 China

In the present paper, we propose an approach of combination prediction of chaotic time series. The method is based on the adding-weight one-rank local-region method of chaotic time series. The method allows us to define an interval containing a future value with a given probability, which is obtained by studying the prediction error distribution. Its effectiveness is shown with data generated by Logistic map.

关键词：混沌时间序列间隔预测组合预测法误差分布概率

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真空包装粽子中致酸败微生物的分离与鉴定

实验室检测

实验室检测 2024年第1期2卷 52-57页

作者：朱虹霖孙宏虎周浩张熳迪李俊霞朱文斌晋佳琳张倩蔡炯成都市食品检验研究院辐照保藏四川省重点实验室成都611135

目的分离和鉴定引起真空包装粽子酸败的微生物,帮助企业提高产品质量,为食品安全做好把关。方法使用溴甲酚紫葡萄糖肉汤、庖肉培养基对酸败粽子进行培养;使用孟加拉红琼脂、营养琼脂,以划线纯化法进行分离、纯化。根据菌落形态观察、细... 详细信息

目的分离和鉴定引起真空包装粽子酸败的微生物,帮助企业提高产品质量,为食品安全做好把关。方法使用溴甲酚紫葡萄糖肉汤、庖肉培养基对酸败粽子进行培养;使用孟加拉红琼脂、营养琼脂,以划线纯化法进行分离、纯化。根据菌落形态观察、细胞形态观察、16S rRNA序列分析,基质辅助激光解吸电离飞行时间质谱对分离的菌株进行鉴定,将分离菌株分别接种到符合商业无菌的粽子中,验证菌株是否使产品酸败。结果共分离出2株菌,分别为河生莱略特氏菌(Lelliottia amnigena)和异常威克汉姆酵母(Wickerhamomyces anomalus),经反证试验确认可导致粽子酸败。结论河生莱略特氏菌、异常威克汉姆酵母可导致真空包装粽子产生酸败。

关键词：真空包装粽子分离鉴定河生莱略特氏菌异常威克汉姆酵母菌

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基于最小熵的机动目标雷达检测

信号处理 2022年第7期38卷 1416-1423页

作者：蔡炯王锐胡程北京理工大学信息与电子学院北京100081 北京理工大学前沿技术研究院山东济南250300

机动目标速度的不稳定会导致雷达回波产生时变的多普勒调制,即多普勒频率徙动(Doppler frequency migration,DFM)。在相参积累过程中,这将造成信号在多普勒维上散焦,积累增益降低,目标难以被检测。当前针对DFM的补偿研究大多集中于含有... 详细信息

机动目标速度的不稳定会导致雷达回波产生时变的多普勒调制,即多普勒频率徙动(Doppler frequency migration,DFM)。在相参积累过程中,这将造成信号在多普勒维上散焦,积累增益降低,目标难以被检测。当前针对DFM的补偿研究大多集中于含有二阶速度分量的匀加速目标,对于含有三阶以及更高阶运动的补偿算法还需进一步完善。本文以最小熵为代价函数,利用迭代寻优的方式,提出了一种通用的高阶运动补偿算法。该算法通过仿真以及实测数据验证,被证明能够高效准确地估计出机动目标的高阶运动分量,从而有效补偿DFM引发的散焦问题,提高积累增益,完成机动目标的相参积累检测。

关键词：相参积累多普勒徙动最小熵迭代寻优