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Selenomethionine alleviates chronic heat stress-induced breast muscle injury and poor meat quality in broilers via relieving mitochondrial dysfunction and endoplasmic reticulum stress

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Animal Nutrition 2024年第1期16卷 363-375页

作者： jinzhong jing Jiayi Wang Xiaoyu Xiang Shenggang Yin Jiayong Tang Longqiong Wang Gang Jia Guangmang Liu Xiaoling Chen Gang Tian jingyi Cai Bo Kang Lianqiang Che Hua Zhao Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education of China Ministry of Agriculture and Rural Affairsof Sichuan ProvinceAnimal Nutrition InstituteSichuan Agricultural University College of Animal Science and Technology Sichuan Agricultural University

In the present study,the chronic heat stress （CHS） broiler model was developed to investigate the potential protection mechanism of organic selenium （selenomethionine,SeMet） on CHS-induced skeletal muscle growth retardation and poor meat *** hundred Arbor Acres male broilers （680±70 g,21 d old） were grouped into 5 treatments with 8 replicates of 10 broilers per *** in the control group were raised in a thermoneutral environment （22±2°C） and fed with a basal *** other four treatments were exposed to hyperthermic conditions （33±2°C,24 h in each day） and fed on the basal diet supplied with SeMet at 0.0,0.2,0.4,and 0.6 mg Se/kg,respectively,for 21 *** showed that CHS reduced （P<0.05） the growth performance,decreased （P<0.05） the breast muscle weight and impaired the meat quality of breast muscle in *** induced protein metabolic disorder in breast muscle,which increased （P<0.05） the expression of caspase 3,caspase 8,caspase 9 and ubiquitin proteasome system related genes,while decreased the protein expression of *** also decreased the antioxidant capacity and induced mitochondrial stress and endoplasmic reticulum （ER） stress in breast muscle,which increased （P<0.05） the ROS levels,decreased the concentration of ATP,increased the protein expression of HSP60 and CLPX,and increased （P<0.05） the expression of ER stress *** SeMet supplementation linearly increased （P<0.05） breast muscle Se concentration and exhibited protective effects via up-regulating the expression of the selenotranscriptome and several key selenoproteins,which increased （P<0.05） body weight,improved meat quality,enhanced antioxidant capacity and mitigated mitochondrial stress and ER ***'s more,SeMet suppressed protein degradation and improved protein biosynthesis though inhibiting the caspase and ubiquitin proteasome system and promoting the mTOR-4EBP1 *** conclusion,dietary SeMet supplementation increases the expression of

关键词： Broiler Chronic heat stress Skeletal muscle Meat quality Mitochondrial dysfunction Endoplasmic reticulum stress

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A self-powered solar-blind UV-enhanced Bi_(2)Se_(3)/a-Ga_(2)O_(3)/p-Si heterojunction photodetector for full spectral photoresponse and imaging

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Nano Research 2024年第4期17卷 2960-2970页

作者： Yajie Han Shujie Jiao Jiangcheng jing Lei Chen Ping Rong Shuai Ren Dongbo Wang Shiyong Gao jinzhong Wang School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China

Self-powered full-spectrum photodetectors(PDs)offer numerous advantages,such as broad application fields,high precision,efficiency,and multi-functionality,which represent a highly promising and potentially valuable class of detectors for future ***,insensitive response to solar-blind ultraviolet(UV)and complex and expensive preparation processes greatly limit their performance and practical *** this study,a self-powered full-spectrum Bi_(2)Se_(3)/a-Ga_(2)O_(3)/p-Si heterojunction PD with high sensitivity for solar-blind UV band prepared by a simple and low-cost two-step synthesis method is *** results reveal that the developed PD has an excellent performance,such as high sensitivity from 200 to 850 nm,and a responsivity of 1.38 mA/W as well as a detectivity of 3.22×10^(10) Jones under 254 nm light at zero ***,the unencapsulated device displays exceptional stability and imaging *** is expected that Bi_(2)Se_(3)/a-Ga_(2)O_(3)/p-Si heterojunction PD with a simple and low-cost synthesis method has great potential for self-powered full-spectrum photodetectors.

关键词： Bi_(2)Se_(3)/a-Ga_(2)O_(3)/p-Si self-powered photodetector full spectral photoresponse imaging

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Selenoproteins synergistically protect porcine skeletal muscle from oxidative damage via relieving mitochondrial dysfunction and endoplasmic reticulum stress

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畜牧与生物技术杂志:英文版 2023年第5期14卷 2180-2196页

作者： jinzhong jing Ying He Yan Liu Jiayong Tang Longqiong Wang Gang Jia Guangmang Liu Xiaoling Chen Gang Tian jingyi Cai Lianqiang Che Bo Kang Hua Zhao Key Laboratory for Animal Disease‑Resistance Nutrition of Ministry of Education of China Ministry of Agriculture and Rural Affairsof Sichuan ProvinceAnimal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130SichuanChina College of Animal Science and Technology Sichuan Agricultural UniversityChengdu 611130SichuanChina

Background The skeletal muscle of pigs is vulnerable to oxidative damage,resulting in growth *** are important components of antioxidant systems for animals,which are generally regulated by dietary selenium(Se)***,we developed the dietary oxidative stress(DOS)-inducing pig model to investigate the protective effects of selenoproteins on DOS-induced skeletal muscle growth *** Dietary oxidative stress caused porcine skeletal muscle oxidative damage and growth retardation,which is accompanied by mitochondrial dysfunction,endoplasmic reticulum(ER)stress,and protein and lipid metabolism *** with Se(0.3,0.6 or 0.9 mg Se/kg)in form of hydroxy selenomethionine(OH-SeMet)linearly increased muscular Se deposition and exhibited protective effects via regulating the expression of selenotranscriptome and key selenoproteins,which was mainly reflected in lower ROS levels and higher antioxidant capacity in skeletal muscle,and the mitigation of mitochondrial dysfunction and ER ***’s more,selenoproteins inhibited DOS induced protein and lipid degradation and improved protein and lipid biosynthesis via regulating AKT/mTOR/S6K1 and AMPK/SREBP-1 signalling pathways in skeletal ***,several parameters such as the activity of GSH-Px and T-SOD,the protein abundance of JNK2,CLPP,SELENOS and SELENOF did not show dose-dependent ***,several key selenoproteins such as MSRB1,SELENOW,SELENOM,SELENON and SELENOS play the unique roles during this *** Increased expression of selenoproteins by dietary OH-SeMet could synergistically alleviate mitochondrial dysfunction and ER stress,recover protein and lipid biosynthesis,thus alleviate skeletal muscle growth *** study provides preventive measure for OS-dependent skeletal muscle retardation in livestock husbandry.

关键词： Dietary oxidative stress Endoplasmic reticulum stress Growth retardation Mitochondrial dysfunction Selenoproteins Skeletal muscle

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祛魅与返魅:太极拳技击的理性审视

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成都体育学院学报 2024年第2期50卷 67-74页

作者：刘金钟米靖黄康辉北京体育大学北京100084 中国人民公安大学北京100038

太极拳技击的发展演进是太极拳技击形象从祛魅走向返魅的逻辑进程。以马克斯·韦伯的祛魅理论为切入点,运用文献资料、历史研究、逻辑推理等研究方法,理性审视传统太极拳技击的祛魅历程及其所引发的危机,进而提出现代太极拳技击形象的... 详细信息

太极拳技击的发展演进是太极拳技击形象从祛魅走向返魅的逻辑进程。以马克斯·韦伯的祛魅理论为切入点,运用文献资料、历史研究、逻辑推理等研究方法,理性审视传统太极拳技击的祛魅历程及其所引发的危机,进而提出现代太极拳技击形象的返魅路径。研究认为:(1)“克力斯玛”光环加持、操化传习与对抗的“缺席”以及技击的“求巧”指向使得传统太极拳技击的祛魅化发展成为历史的必然选择。(2)学术祛魅与实践祛魅共同构成了两条太极拳技击的演进脉络,并引发了对太极拳技击的信任崩塌、技击技术至上主义盛行等危机。(3)现代太极拳技击形象的返魅理路应以太极推手项目为抓手,彰显太极拳技击之门内形象;以综合格斗竞技场、警务实战为应用平台,重塑太极拳技击之门外形象。

关键词：祛魅返魅太极拳技击太极推手综合格斗警务实战

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细胞外囊泡中miRNA的分泌机制

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生命的化学 2024年第3期44卷 477-487页

作者：叶扬扬席金忠李菁南京警察学院刑事科学技术学院南京210023 南京大学生命科学学院南京大学生命科学高等研究院江苏省小核酸生物学和生物技术工程研究中心医药生物技术国家重点实验室南京210023

细胞外囊泡(extracellular vesicles,EVs)是一类在生理和病理条件下所有细胞均可分泌的双层膜囊泡。EVs可以包裹很多供体细胞来源的分子物质(蛋白质、脂类、核酸和代谢产物等),并将所携带的分子物质释放到受体细胞内,从而调节受体细胞... 详细信息

细胞外囊泡(extracellular vesicles,EVs)是一类在生理和病理条件下所有细胞均可分泌的双层膜囊泡。EVs可以包裹很多供体细胞来源的分子物质(蛋白质、脂类、核酸和代谢产物等),并将所携带的分子物质释放到受体细胞内,从而调节受体细胞的生物学功能。在EVs携带的分子物质中,microRNA(miRNA)是被广泛研究的一类包含物。EVs中miRNA(EV-miRNAs)作为信号分子介导细胞间通讯,调控受体细胞的基因表达,在诸多生理和病理过程中发挥着重要的作用。由于EVs的miRNA表达谱与亲本细胞的miRNA表达谱不同,表明EV-miRNAs并非随机释放而是选择性地被包装到EVs中。该综述主要对EVs生成、转运以及EVs中miRNA的分泌机制进行介绍,这些机制包括RNA结合蛋白、miRNA序列特征、miRNA介导的沉默复合体、参与EVs生物生成的膜蛋白等。此外,某些生理病理状态也影响EV-miRNAs分泌,揭示了选择性分泌机制在疾病进程中的潜在作用。同时,本综述讨论了EV-miRNAs作为生物标志物在疾病诊疗中的应用价值。

关键词：细胞外囊泡选择性分泌 miRNA分泌机制 RNA结合蛋白表达调控

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Effect on serum metabolomics of rats with premature ovarian insufficiency by Zhibian(BL54) through Shuidao(ST28) acupuncture

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Journal of Traditional Chinese Medicine 2024年第4期44卷 722-733页

作者： YAN jing FENG Huimin QIU Fang WANG Haijun YIN Luyun JIN Xiaofei ZHAO Jiyu WANG Hongyang YAN Xiaoqin Second Clinical College of Shanxi University of Traditional Chinese Medicine Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese Medicine Department of Cervical and Lumbar Vertebral Diseases Jinzhong Hospital Affiliated to Shanxi University of Traditional Chinese Medicine

OBJECTIVE: To analyze the serum metabolic targets of the "Zhibian(BL54) through Shuidao(ST28)" acupuncture technique in cyclophosphamide(CTX)-induced premature ovarian insufficiency(POI) model rats and to elucidate the potential molecular mechanism of acupuncture in improving POI. METHODS: We used an intraperitoneal injection of CTX to establish the POI rat model(POI group) and compared serum hormone levels and ovarian histopathological changes to evaluate the effect of the Zhibian(BL54) through Shuidao(ST28) technique(ZS + POI group) on ovarian function. Then, nontargeted metabolomics was performed using rat serum by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF/MS). RESULTS: After acupuncture intervention, the serum hormone levels and ovarian pathological morphology of POI rats were effectively improved. Moreover, UPLC-Q-TOF/MS results showed that the ZS+POI group showed a significant reversal of the levels of 6 differential metabolites. Among them, the levels of four serum metabolic markers, divanillyltetrahydrofuran ferulate, trans-ferulic acid, tryptamine, and neuraminic acid, increased significantly. Further analysis of biological effects showed that all metabolites were involved in the regulation of reproductive hormone levels and antioxidant and antiapoptotic effects. CONCLUSIONS: The "Zhibian(BL54) through Shuidao(ST28)" acupuncture method may improve the ovarian function of POI rats by regulating serum metabolite markers to exert antioxidant and antiapoptotic effects, which provides a theoretical basis for the clinical application of acupuncture in the treatment of POI.

关键词： Zhibian (BL54) through Shuidao (ST28) acupuncture metabolomics premature ovarian insufficiency ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry

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An inulin-type fructan CP-A from Codonopsis pilosula attenuates experimental colitis in mice by promoting autophagy-mediated inactivation of NLRP3 inflammasome

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Chinese Journal of Natural Medicines 2024年第3期22卷 249-264页

作者： ZHOU Jiangtao WANG Jun WANG Jiajing LI Deyun HOU jing LI Jiankuan BAI Yun’e GAO Jianping School of Pharmaceutical Science Shanxi Medical UniversityJinzhong 030600China

Inulin-type fructan CP-A,a predominant polysaccharide in Codonopsis pilosula,demonstrates regulatory effects on immune activity and *** efficacy of CP-A in treating ulcerative colitis(UC)is,however,not *** study employed an in vitro lipopolysaccharide(LPS)-induced colonic epithelial cell model(NCM460)and an in vivo dextran sulfate sodium(DSS)-induced colitis mouse model to explore CP-A’s protective effects against experimental colitis and its underlying *** monitored the clinical symptoms in mice using various parameters:body weight,disease activity index(DAI),colon length,spleen weight,and histopathological ***,molecular markers were assessed through enzyme-linked immunosorbent assay(ELISA),quantitative real-time polymerase chain reaction(qRT-PCR),immunofluorescence(IF),immunohistochemistry(IHC),and Western blotting *** showed that CP-A significantly reduced reactive oxygen species(ROS),tumor necrosis factor-alpha(TNF-α),and interleukins(IL-6,IL-1β,IL-18)in LPS-induced cells while increasing IL-4 and IL-10 levels and enhancing the expression of Claudin-1,ZO-1,and occludin proteins in NCM460 ***,in vivo findings revealed that CPA administration markedly improved DAI,reduced colon shortening,and decreased the production of myeloperoxidase(MPO),malondialdehyde(MDA),ROS,IL-1β,IL-18,and NOD-like receptor protein 3(NLRP3)inflammasome-associated genes/proteins in UC ***-A treatment also elevated glutathione(GSH)and superoxide dismutase(SOD)levels,stimulated autophagy(LC3B,P62,Beclin-1,and ATG5),and reinforced Claudin-1 and ZO-1 expression,thereby aiding in intestinal epithelial barrier repair in colitis ***,the inhibition of autophagy via chloroquine(CQ)diminished CP-A’s protective impact against colitis in *** findings elucidate that CP-A’s therapeutic effect on experimental colitis possibly involves mitigating intestinal inflammation through autophagymediated N

关键词： Inulin-type fructan CP-A Codonopsis pilosula Ulcerative colitis NLRP3 inflammasome Autophagy

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大慧宗杲研究的新推进——任静伟《大慧宗杲思想研究》读后

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安康学院学报 2024年第4期36卷 107-109页

作者：米进忠东华理工大学文法与艺术学院江西南昌330013

任静伟的《大慧宗杲思想研究》一书,无论是选题还是内容结构,均体现出一定的创新性,具有较高学术价值,从而在已有学术研究的基础上推进了关于大慧宗杲的研究,对中国思想史研究走向精细化也进行了一定的探索。然而,该书也存在诸多不足,... 详细信息

任静伟的《大慧宗杲思想研究》一书,无论是选题还是内容结构,均体现出一定的创新性,具有较高学术价值,从而在已有学术研究的基础上推进了关于大慧宗杲的研究,对中国思想史研究走向精细化也进行了一定的探索。然而,该书也存在诸多不足,有进一步完善的空间。具体来说,该书对大慧宗杲的禅法思想缺乏深刻的体悟与理解,对一些具体问题的论述存在疏误,在脚注及参考文献的运用上也出现了许多错漏。

关键词：《大慧宗杲思想研究》大慧宗杲禅学

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西藏自治区建材类非金属矿山与社会经济的相关性分析

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自然资源遥感 2024年第3期36卷 233-239页

作者：王昊刘采陈理杨金中温静孙娅琴安娜周英杰邵治涛中国自然资源航空物探遥感中心北京100083

该文以西藏自治区为研究对象,利用卫星遥感技术取得的调查监测成果,探索性地将市级行政单元的建材类非金属矿山压占损毁土地情况、矿山环境恢复治理情况、采场挖损规模与地区生产总值、人口、区划面积、人口密度等社会经济典型要素进行... 详细信息

该文以西藏自治区为研究对象,利用卫星遥感技术取得的调查监测成果,探索性地将市级行政单元的建材类非金属矿山压占损毁土地情况、矿山环境恢复治理情况、采场挖损规模与地区生产总值、人口、区划面积、人口密度等社会经济典型要素进行相关统计分析。结果显示,地区生产总值或人口密度越高的地区,建材类非金属矿产资源开采规模越大,该结论为在我国西部省份预测一定区域内建材类非金属矿山开采规模及今后实现建材类非金属矿山地质环境与社会经济建设和谐发展提供了研究基础。

关键词：西藏自治区建材类非金属矿山社会经济相关性分析

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多尺度特征融合与交叉指导的小样本语义分割

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中国图象图形学报 2024年第5期29卷 1265-1276页

作者：郭婧王飞晋中职业技术学院电子信息系晋中030600 英国布莱顿大学智能和可用系统中心英国布莱顿BN24AT

目的构建支持分支和查询分支间的信息交互对于提升小样本语义分割的性能具有重要作用,提出一种多尺度特征融合与交叉指导的小样本语义分割算法。方法利用一组共享权重的主干网络将双分支输入图像映射到深度特征空间,并将输出的低层、中... 详细信息

目的构建支持分支和查询分支间的信息交互对于提升小样本语义分割的性能具有重要作用,提出一种多尺度特征融合与交叉指导的小样本语义分割算法。方法利用一组共享权重的主干网络将双分支输入图像映射到深度特征空间,并将输出的低层、中间层和高层特征进行尺度融合,构造多尺度特征;借助支持分支的掩码将支持特征分解成目标前景和背景特征图;设计了一种特征交互模块,在支持分支的目标前景和整个查询分支的特征图上建立信息交互,增强任务相关特征的表达能力,并利用掩码平均池化策略生成目标前景和背景区域的原型集;利用无参数的度量方法分别计算支持特征和原型集、查询特征与原型集之间的余弦相似度值,并根据相似度值给出对应图像的掩码。结果通过在PASCAL-5^(i)(pattern analysis,statistical modeling and computational learning)和COCO-20^(i)(common objects in context)开源数据集上进行实验,结果表明,利用VGG-16(Visual Geometry Group)、ResNet-50(residual neural network)和ResNet-101作为主干网络时,所提模型在1-way 1-shot任务中,分别获得50.2%、53.2%、57.1%和23.9%、35.1%、36.4%的平均交并比(meanintersectionoverunion,mIoU),68.3%、69.4%、72.3%/和60.1%、62.4%、64.1%的前景背景二分类交并比(foreground and background intersection over union,FB-IoU);在1-way 5-shot任务上,分别获得52.9%、55.7%、59.7%和32.5%、37.3%、38.3%的mIoU,69.7%、72.5%、74.6%和64.2%、66.2%、66.7%的FB-IoU。结论相比当前主流的小样本语义分割模型,所提模型在1-way 1-shot和1-way5-shot任务中可以获得更高的mIoU和FB-IoU,综合性能提升效果显著。

关键词：小样本语义分割多尺度特征融合跨分支交叉指导特征交互掩码平均池化

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