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PtZn nanoparticles supported on porous nitrogen-doped carbon nanofibers as highly stable electrocatalysts for oxygen reduction reaction

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纳米材料科学:英文版 2023年第3期5卷 329-334页

作者： Lei Zhao jinxia jiang Shuhao Xiao Zhao Li Junjie Wang Xinxin Wei Qingquan Kong Jun Song Chen Rui Wu School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu611731PR China Chongqing Medical and Pharmaceutical College Chongqing401331PR China Institute for Advanced Study Chengdu UniversityChengdu610106PR China

The oxygen reduction reaction(ORR)electrocatalytic activity of Pt-based catalysts can be significantly improved by supporting Pt and its alloy nanoparticles(NPs)on a porous carbon support with large surface area.However,such catalysts are often obtained by constructing porous carbon support followed by depositing Pt and its alloy NPs inside the pores,in which the migration and agglomeration of Pt NPs are inevitable under harsh operating conditions owing to the relatively weak interaction between NPs and carbon support.Here we develop a facile electrospinning strategy to in-situ prepare small-sized PtZn NPs supported on porous nitrogen-doped carbon nanofibers.Electrochemical results demonstrate that the as-prepared PtZn alloy catalyst exhibits excellent initial ORR activity with a half-wave potential(E_(1/2))of 0.911 V versus reversible hydrogen electrode(vs.RHE)and enhanced durability with only decreasing 11 mV after 30,000 potential cycles,compared to a more significant drop of 24 mV in E_(1/2)of Pt/C catalysts(after 10,000 potential cycling).Such a desirable performance is ascribed to the created triple-phase reaction boundary assisted by the evaporation of Zn and strengthened interaction between nanoparticles and the carbon support,inhibiting the migration and aggregation of NPs during the ORR.

关键词： PtZn alloy Porous nitrogen-doped carbon nanofibers Electrospinning Oxygen reduction reaction

Tailoring the interactions of heterostructured Ni_(4)N/Ni_(3)ZnC_(0.7)for efficient CO_(2)electroreduction

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Journal of Energy Chemistry 2022年第12期75卷 1-7,I0001页

作者： Junjie Wang Zhao Li Zhaozhao Zhu jinxia jiang Yulan Li Jinju Chen Xiaobin Niu Jun Song Chen Rui Wu School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina Institute for Advanced Study Chengdu UniversityChengdu 610106SichuanChina Chongqing Medical and Pharmaceutical College Chongqing 401331China

Electrocatalytic CO_(2)reduction into CO has been regarded as one of the most promising strategies for sustainable carbon cycles at ambient conditions,but still faces challenges to achieve both high product selectivity and large current density.Here,we report a Ni_(4)N/Ni_(3)ZnC_(0.7)heterostructured electrocatalyst embedded in accordion-like N-doped carbon through a simple molten salt annealing strategy.The optimal Ni_(4)N/Ni_(3)ZnC_(0.7)electrocatalyst achieves a high CO Faraday efficiency of 92.3%and a large total current density of-15.8 m A cm^(-2)at-0.8 V versus reversible hydrogen electrode,together with a long-term stability about 30 h.Density functional theory results reveal that the energy barrier for*COOH intermediate formation largely decreased on Ni_(4)N/Ni_(3)ZnC_(0.7)heterostructure compared with Ni_(4)N and Ni_(3)ZnC_(0.7),thus giving rise to enhanced activity and selectivity.A rechargeable Zn-CO_(2)battery is further assembled with Ni_(4)N/Ni_(3)ZnC_(0.7)catalyst as the cathode,which shows a maximum power density of 0.85 mW cm^(-2)and excellent stability.

关键词： Interface engineering Ni_(4)N/Ni_(3)ZnC_(0.7) Accordion-like structure CO_(2)electroreduction

Stabilizing highly active atomically dispersed NiN_(4)Cl sites by Cl-doping for CO_(2)electroreduction

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SusMat 2023年第4期3卷 498-509页

作者： Zhao Li Xueqiang Qi Junjie Wang Zhaozhao Zhu jinxia jiang Xiaobin Niu Andreu Cabot Jun Song Chen Rui Wu Institute for Advanced Study Chengdu UniversityChengduChina School of Materials and Energy University of Electronic Science and Technology of ChinaChengduChina Catalonia Institute for Energy Research(IREC) Sant Adriàde BesòsSpain College of Pharmacy Chongqing Medical and Pharmaceutical CollegeChongqingChina

Nickel-nitrogen-carbon single-atom catalysts have attracted widespread interest for CO_(2)electroreduction but they suffer from poor stability.Herein,we report on the preparation of Cl-and N-doped porous carbon nanosheets with atomically dispersed NiN_(4)Cl active sites(NiN_(4)Cl-ClNC)through a molten-salt-assisted pyrolysis strategy.The optimized NiN_(4)Cl-ClNC catalyst delivers exceptional CO_(2)conversion activity with outstanding stability for over 220 h at−0.7 V versus RHE and a high CO Faradaic efficiency of 98.7%at a CO partial current density of 12.4 mA cm^(−2).Moreover,NiN_(4)Cl-ClNC displays a remarkable CO partial current density of approximately 349.4 mA cm^(−2)in flow-cell,meeting the requirements of industrial applications.Operando attenuated total reflectance surface-enhanced infrared absorption spectroscopy and density functional theory calculations are used to understand the outstanding activity and stability.Results reveal that the introduced axial Ni-Cl bond on the Ni center and Cl─C bond on the carbon support synergetically induce electronic delocalization,which not only stabilizes Ni against leaching but also facilitates the formation of the COOH*intermediate that is found to be the rate-determining step.

关键词： atomically dispersed catalyst chlorine-doped carbon electrocatalytic CO_(2)reduction NiN_(4)Cl sites zinc-CO_(2)battery

HSP70L1-mediated intracellular priming of dendritic cell vaccination induces more potent CTL response against cancer

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Cellular & Molecular Immunology 2018年第2期15卷 135-145页

作者： Shuxun Liu Lin Yi Ma Ling jinxia jiang Lijun Song Juan Liu Xuetao Cao National Key Laboratory of Medical Immunology Institute of ImmunologySecond Military Medical UniversityShanghai200433China Department of Immunology National Key Laboratory of Medical Molecular BiologyChinese Academy of Medical SciencesBeijing100730China

Heat-shock protein(HSP)-based immunotherapy is established on its adjuvant effects when applied via an extracellular approach to pulse and activate dendritic cells(DCs).Our previous studies indicate that DCs pulsed with recombinant fusion proteins of antigenic fragment and HSP70-like protein 1(HSP70L1)are potent in stimulating antigen-specific Th1 responses.We herein evaluated the cytotoxic T cell(CTL)response by an intracellular approach of priming DCs with transfection of recombinant adenovirus-expressing the fusion gene of the 576–699 fragment of carcinoembryonic antigen(CEA)and HSP70L1.As compared with DCs pulsed with extracellular fusion protein,the DCs transfected with recombinant adenovirus expressing the fusion gene displayed equivalent mature phenotypes but less inflammatory appearance.However,the transfected DCs were superior to the pulsed DCs in inducing CEA-specific CTLs.Consistently,immunization of HLA-A2.1/H-2Kb transgene mice with the transfected DCs could induce more quantities of HLA-A2.1-restricted CEA-specific CTLs,protecting nude mice more significantly from human CEA-expressing colon tumor challenge when adoptively transferred.Mechanistic investigation indicated that intracellular expression of the fusion protein empowered the transfected DCs by activation of STAT1 possibly via inducing IFN-βand ERK pathways.Therefore,the more potent ability to induce anti-CEA CTL responses enables the DCs,which transfected with recombinant adenovirus expressing the fusion gene of antigenic CEA fragment and Th1 adjuvant,as an alternative promising approach for the immunotherapy of CEA-positive tumors.

关键词： CTL dendritic cell HSP70L1 immunotherapy

Correction: HSP70L1-mediated intracellular priming of dendritic cell vaccination induces more potent CTL response against cancer

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Cellular & Molecular Immunology 2020年第1期17卷 108-109页

作者： Shuxun Liu Lin Yi Ling Ma jinxia jiang Lijun Song Juan Liu Xuetao Cao National Key Laboratory of Medical Immunology Institute of Immunology Second Military Medical University Shanghai 200433 China. liusx@***. National Key Laboratory of Medical Immunology Institute of Immunology Second Military Medical University Shanghai 200433 China. Department of Tumor Ningxia People's Hospital Yinchuan China. National Key Laboratory of Medical Immunology Institute of Immunology Second Military Medical University Shanghai 200433 China. caoxt@***. National Key Laboratory of Medical Molecular Biology Department of Immunology Chinese Academy of Medical Sciences Beijing 100730 China. caoxt@***.

In the published version of Fig.3D,the data of the CH and AdCtrl groups in the CFSE-Lovo/Medium panel were mistakenly presented with incorrected images.Figure 3D has now been corrected.The corrected version of Figure 3 is shown below.Although we regret our mistake during figure assembly and would like to apologize for any inconvenience it may have caused,we did not manipulate our data in any way.This unintentional error also has no bearing on the workʼs scientific conclusions.

关键词： HSP70 Figure vaccination

城市地下空间逆向建模方法的研究——以浙江某高校地下室为例

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丽水学院学报 2024年第2期46卷 54-59页

作者：江金霞徐招惺江丽钧丽水职业技术学院建筑与设计学院浙江丽水323000 丽水市城建测绘中心有限公司浙江丽水323000 丽水市建设技术管理中心浙江丽水323000

使用北斗网络RTK(real-time kinematic,实时动态)技术、三维激光扫描技术,获取已建地下空间CGCS2000坐标系下的点云数据,运用3DMAX、Revit软件参考点云逆向建模,采集模型中的距离和坐标数据与地下空间实测数据进行比较,计算模型内部精... 详细信息

使用北斗网络RTK(real-time kinematic,实时动态)技术、三维激光扫描技术,获取已建地下空间CGCS2000坐标系下的点云数据,运用3DMAX、Revit软件参考点云逆向建模,采集模型中的距离和坐标数据与地下空间实测数据进行比较,计算模型内部精度。实验结果表明:在多种新技术的融合应用下,可实现已建地下多场地使用统一坐标系建模,满足CIM(city information mode,城市信息模型)平台建设的需求。

关键词：网络RTK 地下空间控制测量点云逆向建模

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蒋丽霞治疗继发性不孕用药规律及经验总结

江西中医药 2024年第3期55卷 34-36页

作者：黄锦霞蒋丽霞暨南大学附属口腔医院佛山市顺德区大良医院中医科广东佛山528300

蒋丽霞认为肾虚是该病的基本病机,与肝脾两脏密切相关,湿、痰、瘀则是病理关键,证候多为虚实夹杂,治疗时应以补肾为本,兼顾脾胃,疏肝为要,并注意涤痰祛湿、化瘀消癥以通补兼施。临证主张谨慎求因,重视周期疗法以调经助孕,强调男女同调... 详细信息

蒋丽霞认为肾虚是该病的基本病机,与肝脾两脏密切相关,湿、痰、瘀则是病理关键,证候多为虚实夹杂,治疗时应以补肾为本,兼顾脾胃,疏肝为要,并注意涤痰祛湿、化瘀消癥以通补兼施。临证主张谨慎求因,重视周期疗法以调经助孕,强调男女同调以及心理调节,并辅以中医外治法。现将其诊治继发性不孕的学术思想、用药规律进行阐释,并举隅临证案例,以冀为同道中医药治疗继发性不孕提供借鉴。

关键词：蒋丽霞继发性不孕用药规律临床经验

BCL7A在肝细胞癌中的表达及对患者预后、肝癌细胞侵袭、迁移的影响

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中华肝胆外科杂志 2024年第1期30卷 56-61页

作者：姜佳炜黄伟陈婧马韬宣晗颜杨王若淳刘金霞南通大学附属医院消化内科南通226001

目的:分析B细胞淋巴瘤7A(BCL7A)在肝细胞癌中的表达以及与预后的关系,以及BCL7A表达对肝癌细胞侵袭、迁移的影响和机制。方法:前瞻性收集2017年11月至2018年3月于南通大学附属医院肝胆外科行根治性肝切除术的40例肝细胞癌患者的癌组织... 详细信息

目的:分析B细胞淋巴瘤7A(BCL7A)在肝细胞癌中的表达以及与预后的关系,以及BCL7A表达对肝癌细胞侵袭、迁移的影响和机制。方法:前瞻性收集2017年11月至2018年3月于南通大学附属医院肝胆外科行根治性肝切除术的40例肝细胞癌患者的癌组织及癌旁组织用于提取蛋白质,其中男性29例,女性11例,年龄(58.5±10.4)岁。从癌症基因组图谱(TCGA)数据库中下载374例肝细胞癌和50例癌旁组织样本信息,肝癌细胞系Hep3B、SMMC-7721分别转染过表达BCL7A质粒及空载体质粒(阴性对照)。Western印迹和免疫组化检测BCL7A表达,Western印迹检测上皮间质转化相关蛋白表达(神经钙黏素、上皮钙黏素、锌指转录因子)。Transwell以及细胞划痕实验检测细胞侵袭迁移能力。结果:TCGA中50例肝细胞癌患者(癌组织与癌旁组织匹配),与癌旁组织相比,癌组织中BCL7A的mRNA相对表达显著升高,差异具有统计学意义( t=13.38, P<0.001)。依据BCL7A mRNA表达水平的中位数将374例患者分为BCL7A高表达组( n=187)和低表达组( n=187),BCL7A高表达患者术后累积生存率低于低表达组,差异有统计学意义( χ^(2)=6.95, P=0.009)。Western印迹检测肝胆外科切除的手术标本,癌组织中BCL7A蛋白相对表达也高于癌旁组织。显微镜下(×20),与对照组比较,肝癌细胞Hep3B和SMMC-7721的BCL7A过表达组侵袭的细胞数更多(153.7±1.3)个比(63.7±4.7)个、(307.7±25.1)个比(72.3±12.5)个,差异均具有统计学意义( t=7.97、8.38,均 P=0.001)。细胞划痕实验结果与Transwell侵袭检测结果一致。肝癌细胞BCL7A过表达组神经钙黏素、锌指转录因子表达高于对照组,上皮钙黏素低于对照组,差异均有统计学意义(均 P<0.05)。结论:肝细胞癌患者癌组织中BCL7A表达升高,并且与不良预后相关。BCL7A可能通过促进上皮间质转化促进肝癌细胞转移和侵袭能力。

关键词：癌,肝细胞预后上皮间质转化免疫浸润 B细胞淋巴瘤7A

新入职护士抗逆力体验质性研究的meta整合

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职业卫生与应急救援 2024年第2期42卷 232-237页

作者：赵雨晴曾莉姜金霞同济大学附属第十人民医院急诊科上海200072 河南大学护理与健康学院河南开封475000 同济大学附属同济医院上海200072

目的系统评价新入职护士抗逆力体验的质性研究,为提高新入职护士的抗逆力,促进其心理健康以及更好地适应工作提供依据。方法检索PubMed、Embase、Web of Science、Cochrane Library、Ovid、中国知网、中国生物医学文献数据库、万方数... 详细信息

目的系统评价新入职护士抗逆力体验的质性研究,为提高新入职护士的抗逆力,促进其心理健康以及更好地适应工作提供依据。方法检索PubMed、Embase、Web of Science、Cochrane Library、Ovid、中国知网、中国生物医学文献数据库、万方数据库、维普数据库等有关新入职护士抗逆力体验的质性研究文献,检索时限为建库至2023年5月。采用澳大利亚循证卫生保健中心(JBI)质性研究质量评价标准评价文献质量,采用meta整合方法对结果进行整合分析,采用ConQual证据分级方法对整合结果进行证据质量的评级。结果初步检索获得327篇文献,最终纳入8篇文献,且研究质量均为B级,提取67个研究结果,综合成9个新类别,归纳成3个新的整合结果:能力认知的体验、自我成长、社会支持。3个整合结果的质量均为高等级。结论医院与护理管理者应加快完善对新入职护士的规范化培训,注重对新入职护士的心理疏导与支持,提高新入职护士的抗逆力,建立其积极心理,以更快地投入到工作中。

关键词：新入职护士抗逆力体验质性研究 meta整合