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Correlation Between Crystal Rotation and Redundant Shear Strain in Rolled Single Crystals: A Crystal Plasticity FE Analysis

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Acta Metallurgica Sinica(English Letters) 2019年第4期32卷 452-460页

作者： Hui Wang Cheng Lu Kiet Tieu Yu liu Rui Wang jintao li School of Mechanical Materials and Mechatronic Engineering University of Wollongong

The correlation between crystal rotation and redundant shear strain in rolled single crystals was investigated by using the crystal plasticity finite element(CPFE) model in this paper. The deformation in aluminium single crystals of four representative orientations(rotated-Cube, Goss, Copper, and Brass) after rolling and plain strain compression was simulated, and the predictions have been validated by the experimental observations. In the rotated-Cube and Goss, the redundant shear strain and crystal rotation were in the same pattern, alternating along the thickness, while the relation between them was not obvious for the Copper and Brass due to their asymmetrical distributions of activated slip systems. The relations between slip system activation, crystal rotation, and shear strain were investigated based on the CPFE model, and the correlation between shear strain and crystal rotation has been built.

关键词： Crystal plasticity finite element Single crystal Crystal rotation Shear strain Orientation stability

JNK3 involvement in nerve cell apoptosis and neurofunctional recovery after traumatic brain injury

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Neural Regeneration Research 2013年第16期8卷 1491-1499页

作者： Jiang Long li Cai jintao li Lei Zhang Haiyang Yang Tinghua Wang Department of Neurosurgery First Affiliated Hospital of Kunming Medical University Neuroscience Institute of Kunming Medical University

Increasing evidence has revealed that the activation of the JNK pathway participates In apoptosis o1 nerve cells and neurological function recovery after traumatic brain injury. However, which genes inI the JNK family are activated and their role in traumatic brain injury remain unclear. Therefore, in this study, in situ end labeling, reverse transcription-PCR and neurological function assessment were adopted to investigate the alteration of JNK1, JNK2 and JNK3 gene expression in cerebral injured rats, and their role in celt apoptosis and neurological function restoration. Results showed that JNK3 expression significantly decreased at 1 and 6 hours and 1 and 7 days post injury, but that JNK1 and JNK2 expression remained unchanged. In addition, the number of apoptotic nerve cells surrounding the injured cerebral cortex gradually reduced over time post injury. The Neurological Severity Scores gradually decreased over 1,3, 5, 14 and 28 days post injury. These findings suggested that JNK3 expression was downregulated at early stages of brain injury, which may be associated with apoptosis of nerve cells. Downregulation of JNK3 expression may promote the recovery of neurological function following traumatic brain injury.

关键词： neural regeneration JNK1 JNK2 JNK3 traumatic brain injury TdT-mediated dUTP nick endlabeling reverse transcription-PCR cell apoptosis neurological function recovery neuroregeneration

Directional induction of dopaminergic neurons from neural stem cells using substantia nigra homogenates and basic fibroblast growth factor

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Neural Regeneration Research 2012年第7期7卷 511-516页

作者： jintao li Qi Yan Yiliu Ma Zhongtang Feng Tinghua Wang Institute of Neuroscience Kunming Medical College Kunrning 650031 Yunnan Province China Department of Minimally Invasive Neurosurgery First Hospital of Kunming Medical College Kunming 650032 Yunnan Province China

To date, complex components of available reagents have been used for directional induction of neural stem cells into dopaminergic neurons, resulting in a poor ability to repeat experiments. This study sought to investigate whether a homogenate of the substantia nigra of adult rats and/or basic fibroblast growth factor could directionally induce neural stem cells derived from the subventricular zone of embryonic rats to differentiate into dopaminergic neurons. Tyrosine hydroxylase-positive cells were observed exclusively after induction with the homogenate supernatant of the substantia nigra from adult rats and basic fibroblast growth factor for 48 hours in vitro. However, in the groups treated with homogenate supernatant or basic fibroblast growth factor alone, tyrosine hydroxylase expression was not observed. Moreover, the content of dopamine in the culture medium of subventricular zone neurons was significantly increased at 48 hours after induction with the homogenate supernatant of the substantia nigra from adult rats and basic fibroblast growth factor. Experimental findings indicate that the homogenate supernatant of the substantia nigra from adult rats and basic fibroblast growth factor could directionally induce neural stem cells derived from the subventricular zone of embryonic rats to differentiate into dopaminergic neurons in the substantia nigra with the ability to secrete dopamine.

关键词： directional induction in vitro homogenate of substantia nigra basic fibroblast growth factor subventricular zone neural stem cells dopaminergic neurons

Deacetylation of MTHFD2 by SIRT4 senses stress signal to inhibit cancer cell growth by remodeling folate metabolism

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Journal of Molecular Cell Biology 2022年第4期14卷 39-50页

作者： Fan Zhangi: Di Wangl- intao li Ying Su Suling liu Qun-Ying Lei Miao Yin Fudan University Shanghai Cancer Center Instutes of Biomedical Science&School fasic Medical Sciences CancerlnstesKey Laboratory of Breast Cancer in ShanghaiShanghai Key Laboratory of Radiation OncologyThe Shanghai Key Laboratory of Medical EpigeneticsShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Oncology Shanghai Medical CllegeFudan UniversityShanghai 200032China State Key Laboratory of Medical Neurobiology Fudan UniversityShanghai 20o032China

Folate metabolism plays an essential role in tumor *** cancers display therapeutic response to reagents targeting key enzymes of the folate cycle,but obtain chemoresistance ***,novel targets in folate metabolism are highly *** dehydrogenase/methylenetetrahydrofolate cyclohydrolase 2(MTHFD2)is one of the key enzymes in folate metabolism and its expression is highly increased in mutiple human ***,the underlying mechanism that regulates MTHFD2 expression remains ***,we elucidate that SIRT4 deacetylates the conserved lysine 50(K50)residue in MTHFD2.K50 deacetylation destabilizes MTHFD2 by elevating cullin 3 E3 ligase-mediated proteasomal degradation in response to stressful stimuli of folate deprivation,leading to suppression of nicotinamide adenine dinucleotide phosphate production in tumor cells and accumulation of intracellular reactive oxygen species,which in turn inhibits the growth of breast cancer ***,our study reveals that SIRT4 senses folate availability to control MTHFD2 K50 acetylation and its protein stability,bridging nutrient/folate stress and cellular redox to act on cancer cell growth.

关键词： folate metabolism MTHFD2 CUL3 SIRT4 acetylation breast cancer

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从清末民国时期目录看汉译俄罗斯文学的传播

文献 2022年第4期 137-150页

作者：李金涛首都师范大学外国语学院国家图书馆古籍馆

清末民国时期是中国从近代社会向现代社会转型的重要阶段,中西文化交流汇合之际,大量的俄罗斯文学作品被译介到中国。与此同时,该时期也是我国目录学发展的重要阶段。出于不同的目的和需求,目录学家、作家、翻译家、藏书家、出版机构、... 详细信息

清末民国时期是中国从近代社会向现代社会转型的重要阶段,中西文化交流汇合之际,大量的俄罗斯文学作品被译介到中国。与此同时,该时期也是我国目录学发展的重要阶段。出于不同的目的和需求,目录学家、作家、翻译家、藏书家、出版机构、书店及图书馆等编制了种类繁多的目录。本文考述了清末民国时期编纂的收录汉译俄罗斯文学作品的目录30馀种,将其分为译书书目、综合书目、文学专科目录、俄罗斯文学专题目录和俄罗斯作家作品中译本目录五类,并探讨了这些目录在俄罗斯文学传播过程中的作用。

关键词：清末民国目录汉译俄罗斯文学传播

Sensitivity Improvements for Picosecond Ultrasonic Thickness Measurements in Gold and Tungsten Nanoscale Films

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Nanomanufacturing and Metrology 2024年第2期7卷 1-12页

作者： Jiaqi Dong Chengyuan Yao Yuanhao Zhu Shaojie li Bowen liu jintao Fan Chunguang Hu Youjian Song Minglie Hu Key Laboratory of Opto-Electronic Information Science and Technology of Ministry of Education School of Precision Instruments and Opto-Electronics EngineeringTianjin UniversityTianjin 300072China State Key Laboratory of Precision Measuring Technology and Instruments Tianjin UniversityTianjin 300072China

Picosecond ultrasonics,as a nondestructive and noncontact method,can be employed for nanoscale metallic film thickness *** sensitivity of the system,which determines the measurement precision and practicability of this technique,is often limited by the weak intensity of the ultrasonic *** solve this problem,we investigate the distinct mechanisms involved in picosecond ultrasonic thickness measurement for two types of metals,namely tungsten(W)and gold(Au).For thickness measurement in W films,theory and simulation show that optimizing the pump and probe laser wavelengths,which determine the intensity and shape of the ultrasonic signal,is critical to improving measurement sensitivity,while for Au film measurements,where acoustic-induced beam distortion is dominant,the signal intensity can be optimized by selecting an appropriate aperture size and sample *** above approaches are validated in experiments.A dual-wavelength pump-probe system is constructed based on a passively mode-locked ytterbium-doped fiber *** smoothing method and multipeak Gaussian fitting are employed for the extraction of ultrasonic *** measurement precision is achieved in a series of W and Au films with thicknesses of 43-750 *** work can be applied to various high-precision,noncontact measurements of metal film thickness in the semiconductor industry.

关键词： Picosecond ultrasonics Thickness measurement Optical pump-probe Beam distortion technique

Photo-driven fin field-effect transistors

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Opto-Electronic Science 2024年第5期3卷 12-20页

作者： jintao Fu Chongqian Leng Rui Ma Changbin Nie Feiying Sun Genglin li Xingzhan Wei Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China University of Chinese Academy of Sciences Beijing 100049China Chongqing School University of Chinese Academy of SciencesChongqing 400714China

The integration between infrared detection and modern microelectronics offers unique opportunities for compact and high-resolution infrared ***,silicon,the cornerstone of modern microelectronics,can only detect light within a limited wavelength range(lity in the infrared detection ***,a photo-driven fin field-effect transistor is presented,which breaks the spectral response constraint of conventional silicon detectors while achieving sensitive infrared *** device comprises a fin-shaped silicon channel for charge transport and a lead sulfide film for infrared light *** lead sulfide film wraps the silicon channel to form a“three-dimensional”infrared-sensitive gate,enabling the photovoltage generated at the lead sulfide-silicon junction to effectively modulate the channel *** room temperature,this device realizes a broadband photodetection from visible(635 nm)to short-wave infrared regions(2700 nm),surpassing the working range of the regular indium gallium arsenide and germanium ***,it exhibits low equivalent noise powers of 3.2×10^(-12) W·Hz^(-1/2) and 2.3×10^(-11) W·Hz^(-1/2) under 1550 nm and 2700 nm illumination,*** results highlight the significant potential of photo-driven fin field-effect transistors in advancing uncooled silicon-based infrared detection.

关键词： photodetection silicon-on-insulator lead sulfide heterostructure field-effect transistors

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安德列耶夫作品在清末民国时期的翻译与出版

文艺理论与批评 2022年第3期 134-144页

作者：李金涛首都师范大学外国语学院国家图书馆古籍部

安德列耶夫是俄罗斯“白银时代”著名的小说家、剧作家。清末民国时期,他的作品受到文学界的广泛关注,有一大批作家、翻译家对其进行了译介。然而学界对安德列耶夫早期汉译作品的梳理并不充分。钩沉历史文献资料,系统梳理清末民国时期... 详细信息

安德列耶夫是俄罗斯“白银时代”著名的小说家、剧作家。清末民国时期,他的作品受到文学界的广泛关注,有一大批作家、翻译家对其进行了译介。然而学界对安德列耶夫早期汉译作品的梳理并不充分。钩沉历史文献资料,系统梳理清末民国时期安德列耶夫作品翻译出版过程,总结特点并分析原因,十分必要,特别是新发现的安德列耶夫作品译本为研究安德列耶夫对我国现代文学的影响,以及“白银时代”文学和比较文学提供了新的素材,具有重要的学术价值。

关键词：安德列耶夫清末民国翻译出版

NEURAL STEM CELLS AND SPINAL CORD INJURY

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神经解剖学杂志 2007年第2期23卷 214-220页

作者： li jintao Wang Tinghua Feng Zhongtang The Neuroscienee Institute of Kunming Medical College Kunming 650031

Stem cells are multipotential cells that have the capacity to proliferate in an undifferentiated state, to self-renew, and to give rise to all the cell types of a particular tissue. In the developing embryo, neuroepithelial cells of the neural tube generate a variety of lineage-restricted precursor cells that migrate and differentiate into neurons, astrocytes, and oligodendrocytes. These stem cells could potentially be used to promote neurogenesis following injury and disease.

关键词：神经干细胞神经损伤治疗