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Hypoxia inducible factor-1alpha mediates protection of DL-3-n-butylphthalide in brain microvascular endothelial cells against oxygen glucose deprivation-induced injury

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Neural Regeneration Research 2012年第12期7卷 948-954页

作者： Weihong Yang Ling Li Ruxun Huang Zhong Pei Songjie Liao jinsheng zeng Department of Neurology First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina

Studies have demonstrated that DL-3-n-butylphthalide can significantly alleviate oxygen glucose deprivation-induced injury of human umbilical vein endothelial cells at least partly associated with its enhancement on oxygen glucose deprivation-induced hypoxia inducible factor-1α *** this study,we hypothesized that DL-3-n-butylphthalide can protect against oxygen glucose deprivation-induced injury of newborn rat brain microvascular endothelial cells by means of upregulating hypoxia inducible factor-1α *** assay and Hoechst staining results showed that DL-3-n-butylphthalide protected brain microvascular endothelial cells against oxygen glucose deprivation-induced injury in a dose-dependent *** blot and immunofluorescent staining results further confirmed that the protective effect was related to upregulation of hypoxia inducible factor-1α.Real-time RT-PCR reaction results showed that DL-3-n-butylphthalide reduced apoptosis by inhibiting downregulation of pro-apoptotic gene caspase-3 mRNA expression and upregulation of apoptosis-executive protease bcl-2 mRNA expression;however,DL-3-n-butylphthalide had no protective effects on brain microvascular endothelial cells after knockdown of hypoxia inducible factor-1α by small interfering *** findings suggest that DL-3-n-butylphthalide can protect brain microvascular endothelial cells against oxygen glucose deprivation-induced injury by upregulating bcl-2 expression and downregulating caspase-3 expression though hypoxia inducible factor-1α pathway.

关键词： DL-3-n-butylphthalide apoptosis brain microvascular endothelial cells hypoxia inducible factor-1α

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Mechanisms of secondary damage to the thalamic nucleus and substantia nigra in an adult hypertensive rat model following middle cerebral artery occlusion

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Neural Regeneration Research 2010年第11期5卷 853-858页

作者： Li Xiong Jian Yu Songjie Liao Shihui Xing Zhan Zhao jinsheng zeng Stroke Center and Department of Neurology First Affiliated Hospital Sun Yat-Sen University Guangzhou 510080 Guangdong ProvinceChina

BACKGROUND： Following ischemia, apoptosis is observed at the ipsilateral ventropostenor thalamic nucleus and substantia nigra, which are distant from, but connected to, the ischemic cerebral cortex, in animals with normotension. However, secondary brain damage in hypertension has not been clearly investigated. OBJECTIVE： The present study determined whether neuronal apoptosis is associated with neuronal loss in the ipsilateral ventroposterior thalamic nucleus and substantia nigra following cortical ischemia in adult hypertensive rats. Results should provide options for determining a time window for anti-apoptotic therapy. DESIGN, TIME AND SETTING： All experimental procedures in this randomized, controlled trial were conducted at the Neurological Laboratory of the First Affiliated Hospital of Sun Yat-sen University of China between October 2006 and July 2008. MATERIALS： Monoclonal primary antibodies specific to mouse anti-rat microtubule-associated protein 2 and glial fibrillary acidic protein were respectively purchased from Sigma Chemical, USA and BD Pharmingen, USA. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end-labeling （TUNEL） detection kits were purchased from Roche Applied Science, Switzerland and Upstate, USA, respectively. METHODS： A total of 64 male, Sprague Dawiey rats, aged 60-90 days, were equally and randomly divided into middle cerebral artery occlusion and sham surgery groups. Renovascular hypertension was established in both groups by renal artery occlusion. Right distal middle cerebral artery occlusion was performed by electrocoagulation in the middle cerebral artery occlusion group. MAIN OUTCOME MEASURES： Microtubule-associated protein 2 and glial fibrillary acidic protein were detected by immunohistochemistry, and apoptotic cells were observed by TUNEL assay. The stainings were separately detected in the ipsilateral ventroposterior thalamic nucleus and substantia nigra. RESULTS： During the 4 weeks followin

关键词： ventroposterior thalamic nucleus substantia nigra apoptosis rats cerebral infarction neural regeneration

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脑梗死累及岛叶预示心源性栓塞性卒中风险

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中国神经精神疾病杂志 2024年第2期50卷 76-81页

作者：黄宝资黎建乐李苹萍曹谡涵陈椿勇蒋自牧曾进胜中山大学附属第一医院神经科广东省重大神经疾病诊治研究重点实验室国家临床重点专科和国家重点学科广州510080 广西医科大学第一附属医院神经内科

目的探讨在大脑中动脉供血区脑梗死患者中,病灶累及岛叶是否与心源性栓塞性卒中存在相关性。方法回顾性纳入2020年10月至2023年3月中山大学附属第一医院和广西医科大学第一附属医院卒中中心收治的发病7 d内的大脑中动脉供血区脑梗死... 详细信息

目的探讨在大脑中动脉供血区脑梗死患者中,病灶累及岛叶是否与心源性栓塞性卒中存在相关性。方法回顾性纳入2020年10月至2023年3月中山大学附属第一医院和广西医科大学第一附属医院卒中中心收治的发病7 d内的大脑中动脉供血区脑梗死患者。卒中病因分型分为心源性栓塞型和非心源性栓塞型。病灶是否累及岛叶主要通过磁共振弥散加权成像(DWI)进行确诊。采用单因素和多因素logistic回归分析探讨累及岛叶的脑梗死与心源性栓塞性卒中之间的相关性。结果共纳入大脑中动脉供血区脑梗死患者1585例,其中心源性栓塞型173例(10.9%)和非心源性栓塞型1412例(89.1%)。脑梗死累及岛叶448例(28.3%),其中心源性栓塞组135例(78.0%)和非心源性栓塞组313例(22.2%)。单因素logistic回归分析提示累及岛叶的脑梗死与心源性栓塞性卒中存在相关性(未调整模型:OR=12.474, 95%CI 8.520~18.263,P<0.001)。在调整潜在混杂因素后,两者间仍存在显著相关性(模型3:OR=6.233, 95%CI 3.688~10.543;P<0.001)。此外,累及左侧(模型3:OR=4.977, 95%CI 2.757~8.987,P<0.001)和右侧岛叶的脑梗死(模型3:OR=4.998,95%CI 2.743~9.107,P<0.001)均与心源性栓塞性卒中存在相关性。结论大脑中动脉供血区脑梗死累及岛叶可作为心源性栓塞性卒中的潜在影像学标志。

关键词：岛叶受累心源性栓塞性卒中大脑中动脉供血区脑梗死影像学标志相关性风险非心源性栓塞性卒中

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Bilateral olfactory ensheathing cell transplantation promotes neurological function in a rat model of cerebral infarction

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Neural Regeneration Research 2011年第13期6卷 983-987页

作者： Zhihua Yang Wenli Sheng Huiyong Shen Qinghua Hou Rui Li jinsheng zeng Ruxun Huang Department of Neurology First Affiliated Hospital Jinan University Guangzhou 510120 Guangdong Province China Department of Neurology First Affiliated Hospital Sun Yat-sen University Guangzhou 510080 Guangdong Province China Department of Orthopedics Second Affifiated Hospital Sun Yat-sen University Guangzhou 510120 Guangdong Province China

In the present study, olfactory ensheathing cells were transplanted into the cortices of infarcted （infarct transplantation group）, normal （normal transplantation group）, and bilateral hemispheres （bilateral transplantation group）. Olfactory ensheathing cells migrated to the infarct focus. The number of growth associated protein 43-positive cells and nerve fibers was slightly increased in the infarct area. These changes were more evident in the bilateral cortical transplantation group. Results demonstrated that transplanted olfactory ensheathing cells can migrate in rats with cerebra infarction. The olfactory ensheathing cells on the normal side can also promote neurological function. Bilateral cortical transplantation exhibited superior effects over unilateral transplantation.

关键词： cerebral infarction cell transplantation olfactory ensheathing cells neural regeneration

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Clopidogrel loading dose versus maintenance dose to treat patients with acute ischaemic stroke in China(CLASS-China):results from a prospective double-blind randomised clinical trial

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Stroke & Vascular Neurology 2017年第3期2卷 118-123页

作者： Ying Zhao Wanyong Yang Zefeng Tan Wenmin Wang Weimin Xiao jinsheng zeng Anding Xu Department of Neurology and Stroke Center The First Affiliated HospitalJinan UniversityGuangzhouChina Department of Neurology The First Affiliated HospitalKunming Medical CollegeKunmingYunnanChina Department of Neurology Dongguan People HospitalDongguanGuangdongChina Department of Neurology and Stroke Center First Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdongChina

Aim The role of clopidogrel in treating patients with acute ischaemic stroke is *** have conducted the clinical trial in order to evaluate the efficacy and safety of clopidogrel with a loading dose in treating patients with non-cardiogenic acute ischaemic *** Clopidogrel loading dose versus maintenance dose to treat patients with acute ischaemic stroke in China(CLASS-China)was a prospective,randomised,double-blind and placebo-controlled clinical trial in *** with acute ischaemic stroke of non-cardiogenic origin within 48 hours of onset were enrolled and those received thrombolysis were *** patients were divided into two treatment groups:loading dose and routine *** primary outcome was the incidence of stroke recurrence or progression within 7 *** safety outcome was measured by life-threatening *** intent-to-treat analysis was used for the statistical *** From March 2008 to March 2010,a total of 303 patients from 16 centres were recruited into this study;six were excluded because of lack of basic *** the enrolment was slow and the study drug expired in March 2010,this clinical trial was stopped earlier than *** significant baseline and demographic differences were seen between the two *** was no difference in primary outcome between the loading dosage group 16.1%(24/149)and control group 14.9%(22/148),respectively(p=0.782).The mortality and disability rate within 90 days in loading dose group(19.6%)was slightly lower than that in controlled group(23.4%),p=*** dose group had two(1.3%)cases of fatal haemorrhage and control group had four(2.7%)within 90 days,p=*** significant difference was detected in other adverse events between the *** In our study stopped early due to slow enrolment,loading dose of clopidogrel does not reduce the risk of recurrent *** trials with sufficient number of patients enrolled are needed to re-e

关键词： patients dosage routine

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肺结节性质与中医体质、证型的相关性研究

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河北中医 2024年第1期46卷 46-50,55页

作者：乜炜成程淼张喆王林洋班承钧曾金生北京中医药大学北京100291 北京中医药大东直门医院呼吸科北京100700

目的观察研究肺结节性质与中医体质、证型的相关性。方法收集2019年7月至2020年12月就诊的肺结节患者271例,对患者肺结节的直径、密度、数量情况进行统计,直径按≤4 mm、4~6 mm、6~8 mm、>8 mm划分为4种,密度分为实性肺结节、纯磨玻璃... 详细信息

目的观察研究肺结节性质与中医体质、证型的相关性。方法收集2019年7月至2020年12月就诊的肺结节患者271例,对患者肺结节的直径、密度、数量情况进行统计,直径按≤4 mm、4~6 mm、6~8 mm、>8 mm划分为4种,密度分为实性肺结节、纯磨玻璃结节、混杂性结节3种,数量分为孤立性结节、多发性结节2种。同时对患者的中医体质、证型进行判断,体质分为平和质、气虚质、阳虚质、阴虚质、痰湿质、湿热质、血瘀质、气郁质、特禀质9种类型,证型分为肺气亏虚证、气阴两虚证、瘀血阻络证、痰热郁肺证、肝郁气滞证5种证型。然后整理统计患者的一般资料信息,并进行肺结节直径、密度、数量与中医体质、证型的相关性分析。结果271例肺结节患者老年(>60岁)患者占比最高(164例,60.5%),肺结节直径4~6 mm者最多(134例,49.5%),密度主要为纯磨玻璃结节(160例,59.0%),数量为多发性结节者居多(198例,73.1%)。271例肺结节患者中,中医体质分布最多的是气虚质(64例,23.6%)、气郁质(60例,22.1%)、湿热质(41例,15.1%),中医证型分布最多的是肺气亏虚证(93例,34.3%)、气阴两虚证(52例,19.2%)、瘀血阻络证(48例,17.7%)等。经相关性检验,肺结节直径与中医体质之间有相关性,气郁质患者临床多见直径≤4 mm的肺结节(P8 mm的肺结节(P<0.05);肺结节密度与中医证型之间有相关性,肝郁气滞证患者多见纯磨玻璃结节(P<0.05);肺结节数量与中医证型之间有相关性,肝郁气滞证患者多见多发性结节(P<0.05),少见孤立性结节(P<0.05)。结论肺结节直径、密度、数量与中医体质、证型分布具有一定的相关性,临床辨治时可基于肺结节性质和中医体质、证型的相关性对肺结节进行更精准的诊治。

关键词：肺结节中医体质中医证型相关性

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A deep trench super-junction LDMOS with double charge compensation layer

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Journal of Semiconductors 2022年第10期43卷 103-108页

作者： Lijuan Wu Shaolian Su Xing Chen jinsheng zeng Haifeng Wu Hunan Provincial Key Laboratory of Flexible Electronic Materials Genome Engineering School of Physics&Electronic ScienceChangsha University of Science&TechnologyChangsha 410114China

A deep trench super-junction LDMOS with double charge compensation layer(DC DT SJ LDMOS)is proposed in this *** to the capacitance effect of the deep trench which is known as silicon-insulator-silicon(SIS)capacitance,the charge balance in the super-junction region of the conventional deep trench SJ LDMOS(*** SJ LDMOS)device will be broken,resulting in breakdown voltage(BV)of the device *** DT SJ LDMOS solves the SIS capacitance effect by adding a vertical variable doped charge compensation layer and a triangular charge compensation layer inside the *** SJ LDMOS ***,the drift region reaches an ideal charge balance state *** electric field is optimized by double charge compensation and gate field plate so that the breakdown voltage of the proposed device is improved sharply,meanwhile the enlarged on-current region reduces its specific *** simulation results show that compared with the *** SJ LD-MOS,the BV of the DC DT SJ LDMOS has been increased from 549.5 to 705.5 V,and the R_(on,sp) decreased to 23.7 mΩ·cm^(2).

关键词： double charge compensation layer super-junction deep trench SIS capacitance

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Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of cerebral venous sinus thrombosis

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Stroke & Vascular Neurology 2020年第2期5卷 152-158页

作者： Yuhua Fan Jian Yu Hongbing Chen Jian Zhang Jiangang Duan Dapeng Mo Wenhao Zhu Bo Wang Fubing Ouyang Yicong Chen Linfang Lan jinsheng zeng Chinese Stroke Association Stroke Council CVST Guideline Writing Committee Department of Neurology The First Affiliated HospitalSun Yat-sen UniversityGuangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological DiseasesNational Key Clinical Department and Key Discipline of NeurologyGuangzhouChina Department of Neurology and Department of Emergency Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Interventional Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina 不详

Aim Cerebral venous sinus thrombosis(CVST)is a less common cerebrovascular disease that predominantly affects young *** incidence of CVST is 2-5/10000000/year,accounting for 0.5%-1%of all *** reduce mortality and morbidity associated with CVST,Chinese Stroke Association commissioned the authors to write the current guideline on the management of *** PubMed(MEDLINE),CNKI and Wanfang database were searched for studies related to CVST from 1 January 1990 to 31 July *** were synthesised by evidence *** recommendation was fully discussed by the writing group members and reviewed by Chinese Stroke Association Stroke Fellow *** of evidence grading algorithm of Chinese Stroke Association was used to grade each *** This guideline mainly focuses on the diagnostic evaluation,therapeutic strategies and secondary prevention of ***/CTV and MRI/MRV are recommended in the initial imaging evaluation of patients with suspected *** therapy with low-molecular weight heparin should be initiated in patients with CVST *** the acute stage,warfarin is recommended for 3-6 months to prevent the recurrence of CVST and other venous thromboembolic *** The guideline summarises the current evidence regarding the management of CVST,and provides references for diagnosis,treatment and secondary prevention of CVST in China.

关键词： prevention tables initiated

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我国各类主要脑血管病诊断要点演变与更新

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中华神经科杂志 2019年第9期52卷 681-683页

作者：曾进胜蒲传强中山大学附属第一医院神经内科广州510080 解放军总医院神经内科北京100853

自1978年以来,我国已更新并发表了4个版本的各类脑血管病诊断要点."中国各类主要脑血管病诊断要点2019"是在前3个版本的基础上,结合我国新版脑血管病分类和国际疾病分类-11,综合主要脑血管病类型的症状、体征和影像学检查结果,制定出的... 详细信息

自1978年以来,我国已更新并发表了4个版本的各类脑血管病诊断要点."中国各类主要脑血管病诊断要点2019"是在前3个版本的基础上,结合我国新版脑血管病分类和国际疾病分类-11,综合主要脑血管病类型的症状、体征和影像学检查结果,制定出的简明诊断要点.该诊断要点强调临床表现的重要性和影像学检查在确诊中的必要性,细化各种脑血管病的病因学诊断依据,是我国历年来最具体而全面的脑血管病诊断要点.

关键词：脑血管病诊断诊断,鉴别

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中国颅内静脉血栓形成诊断和治疗指南2019更新要点解读

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中华神经科杂志 2020年第9期53卷 641-643页

作者：曾进胜蒲传强中山大学附属第一医院神经科广东省重大神经疾病诊治研究重点实验室国家重点学科和国家临床重点专科广州510080 解放军总医院神经内科北京100853

在《中国颅内静脉系统血栓形成诊断和治疗指南2015》的基础上,结合近年国内外相关进展,修订的《中国颅内静脉血栓形成诊断和治疗指南2019》,主要将背景资料更新至2019年12月,推荐意见进行了细化和增补,内容涉及病因与危险因素、临床表... 详细信息

在《中国颅内静脉系统血栓形成诊断和治疗指南2015》的基础上,结合近年国内外相关进展,修订的《中国颅内静脉血栓形成诊断和治疗指南2019》,主要将背景资料更新至2019年12月,推荐意见进行了细化和增补,内容涉及病因与危险因素、临床表现、影像学诊断、治疗和预防各个方面,是指导我国诊断和治疗颅内静脉血栓形成的新依据。

关键词：颅内静脉血栓形成诊断治疗指南

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