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Sulforaphane Attenuates CD36-mediated Platelet Hyperreactivity through Modulating cAMP/PKA/NOX2 Signaling in Hyperlipidemic Conditions

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Food Science and Human Wellness 2024年

作者： Weiqi Li Chunting Wu Xinyu Zhou Xinhui Huang Chunmei Zhang Yongjie ma jinqiu Hu Xiaoyan Bi Junyu ma Mengyao Li Dong Lu Liang Hu Jiahua Fan Fuli Ya Department of Nutrition School of Public Health Dali University Department of Laboratory Teaching Center School of Public Health Dali University Department of Health management Gem Flower Xi'an Changqing Staff Hospital Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine School of Integrative Medicine Shanghai University of Traditional Chinese Medicine School of Public Health Sun Yat-sen University Institute of Translational Medicine for Metabolic Diseases Dali University

Hyperlipidemia is a risk factor for clinically significant thrombotic events in cardiovascular diseases. Platelet reactivity in hyperlipidemic conditions is enhanced when platelet scavenger receptor CD36 recognizes oxidized lipids in oxidized low-density lipoprotein (ox-LDL) particles， a process that induces atherothrombosis. Sulforaphane (SFN) is a dietary isothiocyanate enriched in cruciferous vegetables and exerts multiple biological activities. The current study sought to investigate the efficacy of SFN on platelet hyperreactivity under hyperlipidemic conditions in vitro and in vivo. Using a series of platelet functional assays in human platelets in vitro， we demonstrated that SFN attenuated ox-LDL-increased platelet aggregation and activation (surface CD62P expression). Mechanistically， studies using pharmacological inhibitors clarified that these inhibitory effects of SFN were mainly modulated by down-regulating CD36-mediated activation of Src kinases， leading to enhanced activation of cAMP/PKA signaling， and resultant inhibition of NAD phosphate oxidase 2 (NOX2)-dependent generation of reactive oxygen species (ROS). Moreover， 12-week supplementation of SFN-enriched broccoli sprout extract (BSE， 0.06% diet) in hyperlipidemic C57BL/6J mice also decreased platelet hyperreactivity. Studies using pharmacological inhibitors of CD36， PKA and NOX2 showed that the efficacy of BSE supplementation was mainly through modulating CD36-mediated the cAMP/PKA/NOX2 signaling. Thus， through modulating the cAMP/PKA/NOX2 pathway and attenuating CD36-mediated platelet hyperreactivity， SFN may play important protective roles in atherothrombosis under hyperlipidemic conditions.

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Intranasal temperature-sensitive hydrogels of cannabidiol inclusion complex for the treatment of post-traumatic stress disorder

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Acta Pharmaceutica Sinica B 2021年第7期11卷 2031-2047页

作者： Lulu Pang Siqing Zhu jinqiu ma Lin Zhu Yijing Liu Ge Ou Ruiteng Li Yaxin Wang Yi Liang Xu Jin Lina Du Yiguang Jin Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China College of Pharmacy Anhui Medical UniversityHefei 230001China Pharmacy Department Chinese PLA General HospitalBeijing 100853China Department of Anesthesiology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

Post-traumatic stress disorder(PTSD)is a psychiatric disease that seriously affects brain function.Currently,selective serotonin reuptake inhibitors(SSRIs)are used to treat PTSD clinically but have decreased efficiency and increased side effects.In this study,nasal cannabidiol inclusion complex temperature-sensitive hydrogels(CBD TSGs)were prepared and evaluated to treat PTSD.Mice model of PTSD was established with conditional fear box.CBD TSGs could significantly improve the spontaneous behavior,exploratory spirit and alleviate tension in open field box,relieve anxiety and tension in elevated plus maze,and reduce the freezing time.Hematoxylin and eosin and c-FOS immunohistochemistry slides showed that the main injured brain areas in PTSD were the prefrontal cortex,amygdala,and hippocampus CA1.CBD TSGs could reduce the level of tumor necrosis factor-a caused by PTSD.Western blot analysis showed that CBD TSGs increased the expression of the 5-HT1 A receptor.Intranasal administration of CBD TSGs was more efficient and had more obvious brain targeting effects than oral administration,as evidenced by the pharmacokinetics and brain tissue distribution of CBD TSGs.Overall,nasal CBD TSGs are safe and effective and have controlled release.There are a novel promising option for the clinical treatment of PTSD.

关键词： Post-traumatic stress disorder Cannabidiol Hydroxypropyl-β-cyclodextrin Inclusion complex Hydrogels Brain targeting Blood-brain barrier Intranasal administration

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管道清扫机器人的研究及在粮油行业中的应用

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现代食品 2024年第7期30卷 5-9页

作者：马宏燕朱金秋中机智慧(河南)科技研究有限公司河南郑州450000 河南机建建设工程有限公司河南郑州450000

针对现有管道清扫机器人的工作原理、结构、特点、存在的问题,对其结构进行新的设计。新设计的自动行走、粉尘防爆、长度定位和多模式操作,具有结构简便、电气粉尘防爆的优点,该新设计的多模式操作适用于多种集尘环境的清扫工作,同时拓... 详细信息

针对现有管道清扫机器人的工作原理、结构、特点、存在的问题,对其结构进行新的设计。新设计的自动行走、粉尘防爆、长度定位和多模式操作,具有结构简便、电气粉尘防爆的优点,该新设计的多模式操作适用于多种集尘环境的清扫工作,同时拓展了粉尘防爆场合的应用。最后阐述了该新设计的优点、特点及其使用前景。

关键词：管道清扫粉尘防爆牵引机防静电刷头长度定位

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Emissions of automobiles fueled with alternative fuels based on engine technology:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2018年第4期5卷 318-334页

作者： Yisong Chen jinqiu ma Bin Han Peng Zhang Haining Hua Hao Chen Xin Su School of Automobile Chang'an University

Diversification of alternative fuels for automobiles is not only an actual situation, but also a development trend. Whether the alternative fuels are clean is an important issue. Emis- sions of automobiles fueled with natural gas （NG）, methanol, ethanol, biodiesel, dimethyl ether （DME） and polyoxymethylene dimethyl ethers （PODEn） are investigated and reviewed based on engine technology and fuel properties. Compared to gasoline, NG/gasoline bi-fuel and NG automobiles have higher brake thermal efficiencies （BTE） and produce less HC, CO and PM emissions, while more NOx emission. Compared to diesel, NG/diesel dual fuel automobiles have lower BTE and emit lower soot and NOx emissions, but higher HC and CO emissions. Methanol and ethanol blending in gasoline can obviously reduce the HC, CO and PM emissions of spark ignition （SI） automobiles. Methanol or ethanol blending in diesel may prolong the ignition delay, shorten the combustion duration and improve the BTE, resulting in lower soot emissions. However, the HC, CO and NOx emissions of methanol or ethanol diesel blend fuels are uncertain due to low cetane number, high latent heat of vaporization. Most biodiesel has higher viscosity, distillation temperature, cetane number and oxygen content than diesel. Soot emission of biodiesel is lower than that of diesel, while NOx emission is higher. Both DME and PODEn do not contain C-C bonds and their blend with diesel can prohibit the formation of soot. PODEn has high cetane number and low viscosity, resulting in better ignitability and spray quality respectively. PODEn blending shortens both the ignition delay and the combustion duration, improves the BTE, and in- creases the temperature in the diffusion combustion phase, leading to a higher NOx emission.

关键词： Natural gas Methanol Ethanol Biodiesel PODE_n Emission

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基于CCD图像处理的智能车系统设计

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山西电子技术 2024年第3期 37-40页

作者：马谡双孙金秋冯冲大连民族大学信息与通信工程学院辽宁大连116600

随着科技革命和产业变革的蓬勃发展,汽车智能化成为一种发展趋势。其中,道路自动识别是汽车智能化的重要特征,是当前的研究热点。基于此,以TSL1401型CCD和STC16F40K128单片机为目标系统,将图像数据处理技术应用于四轮小车的寻迹行驶,并... 详细信息

随着科技革命和产业变革的蓬勃发展,汽车智能化成为一种发展趋势。其中,道路自动识别是汽车智能化的重要特征,是当前的研究热点。基于此,以TSL1401型CCD和STC16F40K128单片机为目标系统,将图像数据处理技术应用于四轮小车的寻迹行驶,并以一套模拟道路验证系统的道路自动识别和轨迹引导功能。实验结果表明,四轮小车能够识别环岛、十字路口、三角路口等情况,识别结果能够引导小车快速运行。

关键词： CCD传感器自动识别循迹

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基于文献计量学分析的草地植被灌丛化研究现状

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中国草地学报 2024年第2期46卷 121-133页

作者：刘金秋张东马文明王长庭邓增卓玛张婷马祥丽母先润西南民族大学青藏高原研究院四川成都610065

灌丛化会改变草本植物的分布格局,影响生态系统结构和功能。为了解“灌丛化”相关领域的发展现状、研究热点及前沿趋势,理清该领域研究的知识结构。本研究依托中国知网数据库(CNKI)及Web of Science(WOS)核心合集数据库,以1982~2023年... 详细信息

灌丛化会改变草本植物的分布格局,影响生态系统结构和功能。为了解“灌丛化”相关领域的发展现状、研究热点及前沿趋势,理清该领域研究的知识结构。本研究依托中国知网数据库(CNKI)及Web of Science(WOS)核心合集数据库,以1982~2023年“灌丛化”相关领域已发表的4114篇文献为数据源,利用VOSviewer和CiteSpace可视化软件对“灌丛化”相关研究领域发文情况(数量、趋势、被引频次)、合作关系(团队、机构、国家)和关键词等进行可视化分析。结果显示:(1)国内国际相关研究总体呈稳步增长趋势,外文研究的热度大于中文研究,且高被引论文均发表在国内外影响力较高的期刊上,表明“灌丛化”相关研究成果在该领域认可度较高,具有较高学术价值;(2)“灌丛化”相关研究国际合作关系(团队、机构、国家)较国内更为密切,且美国、中国、南非、澳大利亚及德国是“灌丛化”相关领域研究的中坚力量。(3)目前“灌丛化”相关领域的研究内容主要包括灌丛化形成机制及生物多样性对灌丛化的响应,草、灌木之间的竞争关系和土壤性质对灌丛化的响应等。研究指出:我国“灌丛化”相关研究尚处于起步阶段,且前人对灌丛化的研究多针对具体研究区域,相对分散,且合作较少;同时在全球尺度上的研究及大数据整合分析相对较少,仍需进一步研究。随着“灌丛化”研究的深入发展,灌丛化对微生物群落组成的影响、灌丛化对干旱胁迫等环境因子的响应及控制灌丛化有效措施等相关研究将在未来一段时间持续热门。

关键词：灌丛化文献计量土壤碳库 VOSviewer CiteSpace

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Hyaluronic acid-based dual-responsive nanomicelles mediated mutually synergistic photothermal and molecular targeting therapies

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Nano Research 2022年第7期15卷 6361-6371页

作者： Liangliang Cai Ronghua Ni Xiaofei ma Rongrong Huang Zhiyuan Tang jinqiu Xu Yong Han Yuehua Guo Zhifeng Gu Department of Pharmacy Affiliated Hospital of Nantong UniversityNantong 226001China Department of Radiation Oncology Affiliated Hospital of Nantong UniversityNantong 226001China Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantong 226001China Department of Rheumatology Affiliated Hospital of Nantong UniversityNantong 226001China

Precise clinical treatment of triple-negative breast cancer(TNBC)is an obstacle in clinic.Nanotechnology-assisted photothermal therapy(PTT)is a superior treatment modality for TNBC in terms of precision.However,thermoresistance arising from PTT and insufficient drug release from nanocarriers decrease the efficacy of PTT.AT13387 is a novel HSP90 inhibitor that can weaken thermoresistance and undergoing clinic II phase study,showing satisfactory antitumour activity through molecularly targeted therapy(MTT).Whereas,it has poor solubility.Hence hyaluronic acid and stearic acid were connected by hydrazone bonds and disulfide bonds,forming an amphipathic copolymer that could self-assembled into nanomicelles,followed by encapsulating Cypate and AT13387.These nanomicelles exhibited great features,including achieving mutually synergistic PTT/MTT for overcoming thermoresistance and promoting translocation of drugs,increasing the solubility of Cypate and AT13387,showing a pH/redox dual response that contributes to drug release,and having the ability of active targeting.Thus,the nanomicelles developed in this study may be a promising strategy for the precise treatment of TNBC.

关键词： hyaluronic acid nanomicelles dual responsive photothermal therapy molecular targeting therapy

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直肠癌患者临时性回肠造口术后心理弹性变化及影响因素的纵向质性研究

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中国初级卫生保健 2024年第4期38卷 85-88页

作者：孙丹丹张焱马慧王瑾吴金球复旦大学附属华东医院上海200040 复旦大学护理学院上海200032 上海交通大学附属新华医院上海200082

目的:探究直肠癌患者临时性回肠造口术后的心理弹性及其影响因素的纵向变化特点。方法:采取纵向的质性研究方法,对某医院收治的13例临时性回肠造口术后的直肠癌患者进行半结构化的深入访谈,利用NVivo 11.0软件以及Colaizzi 7步分析法对... 详细信息

目的:探究直肠癌患者临时性回肠造口术后的心理弹性及其影响因素的纵向变化特点。方法:采取纵向的质性研究方法,对某医院收治的13例临时性回肠造口术后的直肠癌患者进行半结构化的深入访谈,利用NVivo 11.0软件以及Colaizzi 7步分析法对访谈资料进行整理与分析。结果:共发现4种不同的心理弹性变化方式,即“持续存在”“先消失后出现”“先出现后消失”“持续消失”。从心理弹性影响因素的纵向变化中提炼出4大主题,即“外界支持的稳定与减退”“认知的双向强化与转化”“保护性能力的形成与流失”“自尊的剥夺与重建”。结论:在接受临时性回肠造口术后,直肠癌患者的心理弹性及其影响因素会随时间发生变化,持续稳定的社会支持、不断强化的正向认知、保护性能力的维护和自尊的建立均有助于心理弹性的产生与维持。

关键词：直肠癌临时性回肠造口心理弹性纵向质性研究

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细砂及粉煤灰基泡沫轻质土应力与应变特性试验研究

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江苏建筑 2024年第1期 138-140,144页

作者：金瑾秋马千越康星亮时亮张悦张晨江苏省交通工程建设局江苏南京210004 中交第一公路勘察设计研究院有限公司陕西西安710075 中交第二公路勘察设计研究院有限公司湖北武汉430056 东南大学交通学院江苏南京211189

为了探究细砂及粉煤灰基泡沫轻质土(FLS)的应力与应变特性,文章以水泥、粉煤灰、细砂、水和泡沫为原材料制备试样,进行了无侧限抗压强度试验。试验结果表明,FLS的应力与应变曲线呈软化型,其轴向应力随应变的增加先增加后减少。当湿密度... 详细信息

为了探究细砂及粉煤灰基泡沫轻质土(FLS)的应力与应变特性,文章以水泥、粉煤灰、细砂、水和泡沫为原材料制备试样,进行了无侧限抗压强度试验。试验结果表明,FLS的应力与应变曲线呈软化型,其轴向应力随应变的增加先增加后减少。当湿密度、水胶比和细砂含量分别为600 kg/m3、0.60和20%时,FLS的28 d无侧限抗压强度为0.84 MPa。FLS的无侧限抗压强度与细砂含量呈负线性相关。提出的复合正弦-指数模型(CSE)可以有效地表征FLS的应力与应变特性,可为FLS的工程设计及理论分析提供依据。

关键词：细砂粉煤灰泡沫轻质土应力与应变特性复合正弦-指数模型无侧限抗压强度试验

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3D printing-based drug-loaded implanted prosthesis to prevent breast cancer recurrence post-conserving surgery

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Asian Journal of Pharmaceutical Sciences 2021年第1期16卷 86-96页

作者： Wenyan Hao Zengjuan Zheng Lin Zhu Lulu Pang jinqiuma Siqing Zhu Lina Du Yiguang Jin Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Weifang Medical University Weifang 261000China Shandong University of Traditional Chinese Medicine Jinan 250355China Anhui Medical University Hefei 230032China

Systemic chemotherapy of breast cancer is commonly delivered as a large dose and has toxic side effects.Local chemotherapy would overcome the shortcomings of systemic reconstruction and could play an important role in breast cancer surgery according to personalized demand.The application of three-dimensional(3D)printing technology makes personalized customization possible.We designed and prepared a prosthesis containing paclitaxel(PTX)and doxorubicin(DOX)microspheres(PPDM)based on 3D printing to prevent tumor recurrence and metastasis after breast conserving surgery.Polydimethysiloxane has good biocompatibility and was used as a drug carrier in this study.The average particle size of the PTX and DOX microspheres were approximately 3.1μm and 2.2μm,respectively.The drug loading of PTX and DOX microspheres was 4.2% and 2.1%,respectively.In vitro drug release studies demonstrated that the 3D-printed prosthesis loaded with PTX and DOXmicrospheres could release the drugs continuously for more than 3 weeks and thereby suppress cancer recurrence with reduced side effects.The PTX and DOX microspheres not only exerted a synergistic effect,but also achieved a good sustained release effect.In vivo evaluation showed that the PPDM could effectively inhibit breast cancer recurrence andmetastasis inmice with breast cancer.PPDM are expected to achieve postoperative chemotherapy for breast cancer and be highly efficient to prevent local breast cancer recurrence and metastasis.

关键词： Prosthesis Breast cancer Microspheres Paclitaxel Doxorubicin Metastasis

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