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Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis

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Science China Life Sciences 2025年

作者： Chuan Ye Xuemei Wang Jun Lin Chenyang Wu Yuhua Gao Chenghao Guo Yunxi Liao Ziyan Rao Shaodong Huang Weixuan Chen Ying Huang jinpeng sun Dongyu Zhao Changtao Jiang Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third Hospital Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University Department of Biomedical Informatics School of Basic Medical SciencesPeking University State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking University State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third Hospital National Clinical Research Center for Obstetrics and Gynecology Peking University Third Hospital Department of Endocrinology and Metabolism Peking University Third Hospital Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong University Department of Immunology School of Basic Medical SciencesPeking University

Adipogenesis is the healthy expansion of white adipose tissue (WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the ***,the identification of novel regulatory molecules in adipogenesis,specifically membrane receptors such as G protein-coupled receptors (GPCRs),holds significant clinical *** receptors can serve as viable targets for pharmaceuticals,offering potential for restoring metabolic homeostasis in individuals with *** utilized trajectory inference methods to analyze three distinct single-nucleus sequencing (sNuc-seq) datasets of adipose tissue and systematically identified GPCRs with the potential to regulate *** verification in primary adipose progenitor cells (APCs) of mice,we discovered that ADGRD1 promoted the differentiation of APCs,while GPR39 inhibits this *** the obese mouse model induced by a high-fat diet(HFD),both gain-of-function and loss-of-function studies validated that ADGRD1 promoted adipogenesis,thereby improving metabolic homeostasis,while GPR39 inhibited adipogenesis,leading to metabolic ***,through the analysis of 2,400 ChIP-seq data and 1,204 bulk RNA-seq data,we found that the transcription factors (TFs) MEF2D and TCF12 regulated the expression of ADGRD1and GPR39,*** study revealed the regulatory role of GPCRs in adipogenesis,providing novel targets for clinical intervention of metabolic dysfunction in obese patients.

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Structural basis of signaling of cannabinoids receptors:paving a way for rational drug design in controling mutiple neurological and immune diseases

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1348-1349页

作者： Shenming Huang Peng Xiao jinpeng sun Department of Biochemistry and Molecular Biology School of Basic Medical SciencesKey Laboratory Experimental Teratology of the Ministry of EducationCheeloo college of MedicineShandong University250012 JinanShandongChina Department of Physiology and Pathophysiology School of Basic Medical SciencesKey Laboratory of Molecular Cardiovascular Science of the Ministry of EducationPeking University100191 BeijingChina

Cannabinoids(CBs),analgesic drugs used for thousands of years,were first found in Cannabis sativa,and the multiple CBs used medicinally,such as tetrahydrocannabinol(THC),cannabidiol(CBD)and dozens more,have complex *** addition to their production by plants,CBs are naturally present in the nerves and immune systems of humans and *** exogenous and endogenous CBs carry out a variety of physiological functions by engaging with two CB receptors,the CB1 and CB2 receptors,in the human endocannabinoid system(ECS).Both CB1 and CB2 are G protein-coupled receptors that share a 7-transmembrane(7TM)***1,known as the central CB receptor,is mainly distributed in the brain,spinal cord,and peripheral nervous ***1 activation in the human body typically promotes the release of neurotransmitters,controls pain and memory learning,and regulates metabolism and the cardiovascular ***,CB1 is a direct drug target for drug addiction,neurodegenerative diseases,pain,epilepsy,and *** the exclusive expression of CB1 in the nervous system,CB2 is mainly distributed in peripheral immune *** CB2 agonists would have therapeutic potential in the treatment of inflammation and pain and avoid side effects caused by currently used clinical *** significant progress has been made in developing agonists toward CB receptors,efficient clinical drugs targeting CB receptors remain lacking due to their complex signaling *** recent structural elucidation of CB receptors has greatly aided our understanding of the activation and signal transduction mechanisms of CB receptors.

关键词： drugs diseases metabolism

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Hierarchical ZSM-11 with intergrowth structures:Synthesis,characterization and catalytic properties

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Journal of Energy Chemistry 2013年第5期22卷 761-768页

作者： Qingjun Yu Chaoyue Cui Qiang Zhang Jing Chen Yang Li jinpeng sun Chunyi Li Qiukai Cui Chaohe Yang Honghong Shan State Key Laboratory of Heavy Oil Processing Department of Chemical Engineering China University of Petroleum (East China) Dagang Petrochemical Company PetroChina Corporation

Hierarchical ZSM-11 microspheres with intercrystalline mesoporous properties and rod-like crystals intergrowth morphology have been synthesized using a spot of tetrabutylammonium as a single ***,FTIR,SEM,TEM and N2 adsorption analysis revealed that each individual particle was composed of nanosized rod crystals inserting each other and the intercrystalline voids existing among rods gave a significant mesopore size *** treatment result demonstrated the excellent hydrothermal stability of *** crystallization modes including constant temperature crystallization (one-stage crystallization) and two-stage temperature-varying crystallization with different 1st stage durations were *** results suggested that the crystallization modes were mainly responsible for the adjustable particle size and textural properties of samples while the small amount of tetrabutylammonium bromide was mainly used to direct the formation of both ZSM-11 framework and its intergrowth ***,the performance of optimal ZSM-11 as an active component for the catalytic pyrolysis of heavy oil was also *** with the commercial pyrolysis catalyst,the hierarchical ZSM-11 catalyst exhibited a high selectivity to desired products(LPG+gasoline+diesel),as well as a much lower dry gas and coke yield,plus a high selectivity and yield of light olefins(C=3 C=4)and very poor selectivity to ***,fully open micropore-mesopore connectivity would make such hierarchically porous ZSM-11 zeolites very attractive for applications in clean petrochemical catalysis field.

关键词： intercrystalline mesopore rod-like crystal single template crystallization modes accessibility hydrothermal stability catalytic pyrolysis

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Phospho-decision mechanism of specific arrestin conformations and functions: The music of the receptor revealed by unnatural amino acid incorporation and 19F-NMR

Phospho-decision mechanism of specific arrestin conformation...

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第五届泛环渤海生物化学与分子生物学会学术交流会

作者： jinpeng sun Fan Yang Xiao Yu Jiangyun Wang

G-protein-coupled receptors(GPCRs)convert extracellular stimuli to intracellular signaling cascades primarily through G proteins or arrestin-mediated pathways 1-4.G proteins transduce signals by regulating the levels of second messengers,whereas arrestins recruit distinct downstream proteins to either desensitise receptors or initiate their own signaling pathways by recognising different GPCR conformations and phosphorylation states *** arrestin conformational changes have been *** example,the crystal

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A Stress response pathway upregulates somatostatin level and transcription in pancreatic delta cells

A Stress response pathway upregulates somatostatin level and...

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者： Wang Hongmei Dong Junhong Li Qing sun jinpeng Yu Xiao Department of Physiology Shandong University School of Medicine Department of Molecular Biology and Biochemistry Shandong University School of Medicine 山东大学医学院 Qilu Hospital Shandong University

Somatostatin secretion from islet delta-cells plays an important role in regulating islet function and is tightly controlled by environmental *** of the adrenergic system promoted somatostatin secretion from islet delta-cells;however,the role of the adrenergic system in regulating somatostatin content and transcription has not been *** imbalance between the somatostatin content and its secretion may cause dysfunctions in the islet *** have investigated the role of the adrenergic system in the modulation of somatostatin content and transcription in pancreatic delta-cells and the detailed underlying mechanisms of this *** we found that epinephrine and isoproterenol increased somatostatin content and transcription through the activation ofβ1AR/β*** parallel signaling pathways,Gs-c AMP-PKA-CREB andβ-arrestin1-ERK-PAX6,cooperatively regulated ISO-induced somatostatin transcription.

关键词： adrenergic receptors pancreatic delta cell somatostatin β-arrestin1 CREB

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转甲状腺素蛋白淀粉样变心肌病经氯苯唑酸治疗6个月1例

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临床心血管病杂志 2024年第3期40卷 244-248页

作者：孙金鹏程敏华中科技大学同济医学院附属协和医院心内科武汉430022 生物靶向治疗研究湖北省重点实验室心血管疾病免疫诊疗湖北省工程研究中心

55岁的女性患者,因“反复胸闷、气促1年余,加重半个月余”入我院,同时伴有低血压及双下肢水肿,超声心动图提示左室壁弥漫性肥厚及心肌颗粒样改变,后经心肌磁共振、放射性核素骨闪烁扫描术、心内膜活检、单克隆免疫球蛋白检测、基因检测... 详细信息

55岁的女性患者,因“反复胸闷、气促1年余,加重半个月余”入我院,同时伴有低血压及双下肢水肿,超声心动图提示左室壁弥漫性肥厚及心肌颗粒样改变,后经心肌磁共振、放射性核素骨闪烁扫描术、心内膜活检、单克隆免疫球蛋白检测、基因检测等检查最终被确诊为突变型转甲状腺素蛋白淀粉样变心肌病。该患者服用抑制甲状腺素蛋白淀粉沉积的特异性药物——氯苯唑酸后6个月,随访影像学检查提示心肌淀粉样蛋白沉积略有减少,实验室检查指标略有好转,但短期内发生慢性心力衰竭急性加重的周期并未明显缩短。^(99)Tc^(m)-PYP SPECT/CT是早期筛查和鉴别转甲状腺素蛋白淀粉样变性的有效工具,氯苯唑酸是目前治疗转甲状腺素蛋白淀粉样变心肌病的特效性药物。早筛查、早诊断、早期启动特异性靶向药物治疗将为转甲状腺素蛋白淀粉样变心肌病患者带来新的治疗前景。

关键词：转甲状腺素蛋白淀粉样变心肌病心力衰竭氯苯唑酸

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Marchantin M:A new inhibitor of proteasome induces autophagic cell death in prostate cancer cells

Marchantin M:A new inhibitor of proteasome induces autophagi...

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华东六省一市生物化学与分子生物学学会-2011年学术交流会

作者： Hanming Jiang jinpeng sun Yongqing Liu Charles YF Young Guangmin Xi Huiqing Yuan Hongxiang Lou Department of Biochemistry and Molecular Biology Shandong UniversitySchool of Medicine Department of Natural Product Chemistry Shandong University School of Pharmaceutical Sciences

We recently reported that marchantin M(Mar M),a cyclic bisbibenzyl compound,was an active agent to induce apoptosis in human prostate cancer,but the molecular mechanisms of action remain largely ***,we demonstrated that Mar M treatment dramatically enhanced LC3B expression and turnover,suggesting that Mar M induced *** cell death was responsible for its cancer cell death-

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刍议我国资本弱化税制及其完善

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市场研究 2009年第7期 58-60页

作者：孙进鹏河南经贸职业学院

资本弱化（Thin Capitalization）在欧共体委员会编辑的税收词典里的解释是：“the capitalization of a company whose equity capital is small in comparison to its loan capital and other borrowings often used as a tax avoidance device , based on the fact that payment of interest are normally deductible in arriving at taxable income while dividends are not。”这个定义包括如下内容：

关键词：资本弱化 capital other often 税制 whose while fact

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基于灰色模型对上海市电力需求预测分析研究

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上海节能 2020年第3期 208-212页

作者：孙金朋华北电力大学

基于大量的数据研究,分析了影响上海市电力需求的主要因素,采用GM(1,1)灰色预测模型,结合2009年~2018年上海市的电力数据,对上海市未来五年的电力需求进行预测,并对预测结果进行分析,为上海市未来的电力市场提供相应的对策。

关键词：影响因素分析 GM(1,1)模型电力需求发展对策

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剑麻/含红土聚乙烯基复合材料制备与性能

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化工进展 2020年第5期39卷 2009-2016页

作者：孙金鹏张靠民李如燕赵焱张兰北华航天工业学院材料工程学院河北廊坊065000 昆明理工大学民航与航空学院云南昆明650500 昆明理工大学固体废弃物资源化国家工程研究中心云南昆明650093

针对废旧地膜资源化利用过程中出现的高成本和低性能问题,本文提出了废旧地膜免清洗和剑麻纤维边角料增强的废旧地膜资源化利用技术。采用挤出造粒和注塑成型工艺,制备了剑麻边角料填充含红土废旧聚乙烯复合材料,分析了红土和剑麻纤维... 详细信息

针对废旧地膜资源化利用过程中出现的高成本和低性能问题,本文提出了废旧地膜免清洗和剑麻纤维边角料增强的废旧地膜资源化利用技术。采用挤出造粒和注塑成型工艺,制备了剑麻边角料填充含红土废旧聚乙烯复合材料,分析了红土和剑麻纤维边角料对废旧地膜的填充作用。结果表明,红土颗粒使废旧地膜注塑试样的拉伸模量、硬度和耐热温度分别提高了34.4%、41.3%、和33.1%。红土颗粒难以和塑料基体形成良好的界面粘结,导致含红土废旧地膜注塑试样的拉伸强度、弯曲性能和冲击强度轻微降低,表明红土颗粒不能对废旧地膜进行增韧增强,但可以提高模量和耐热温度。剑麻纤维边角料对含红土废旧地膜具有明显的增强增韧作用,随着剑麻纤维添加量的增加,剑麻纤维填充的含红土废旧地膜复合材料的力学性能增加。剑麻纤维填充量超过一定值后,会在复合材料中引入气孔,同时会降低剑麻纤维的分散程度,出现剑麻聚集体,导致复合材料的力学性能降低。

关键词：复合材料挤出回收聚合物

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