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Polyphenol components in black chokeberry(Aronia melanocarpa)as clinically proven diseases control factors——an overview

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Food Science and Human Wellness 2024年第3期13卷 1152-1167页

作者： Ningxuan Gao Chi Shu Yuehua Wang jinlong tian Yuxi Lang Chenyu Jin Xingyue Cui Hanqian Jiang Shi’an Liu Zhiying Li Wei Chen Hao Xu Bin Li Department of Food Science College of FoodShenyang Agricultural UniversityShenyang 110161China Department of Food Science and Nutrition College of Biosystems Engineering and Food ScienceZhejiang UniversityHangzhou 310058China Chaoyang Beihe Food Co. Ltd.Chaoyang 122100China

The black chokeberry is rich in polyphenols,including flavonoids with anthocyanins,flavanols and lavonols as the main components and a variety of phenolic acids represented by chlorogenic acid.Because of these polyphenols,black chokeberry has the effect of preventing and adjuvant therapy diseases.This study summarized the current research results on the types and contents of functional components in black chokeberry,and analyzed their digestion,absorption and metabolism in human body.On this basis,the disease control functions that have been proved effective in clinical research were reviewed and analyzed.These studies showed that black chokeberry have good prevention and adjuvant therapy effects on hyperlipidemia,hypertension,diabetes and inflammation.Because there are different functional components in black chokeberry,its prevention and treatment of the same disease can come from multiple pathways,which provides a more reliable effectiveness for the disease control of different populations.

关键词： Black chokeberry Hyperlipidemia Hypertension Diabetes Inflammation

The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities

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Food Science and Human Wellness 2023年第5期12卷 1590-1600页

作者： Ningxuan Gao Xu Si Wenzhong Han Ersheng Gong Chi Shu jinlong tian Yuehua Wang Jiyue Zhang Binxu Li Bin Li Department of Food Science College of FoodShenyang Agricultural UniversityShenyang 110161China National R&D Professional Center For Berry Processing Shenyang 110161China Agriculture and Forest Institute in Arid of Liaoning Chaoyang 122000China

Abundant polyphenols make chokeberry have beneficial antioxidant and antiproliferative activity. In order to explore the contribution of different polyphenols in chokeberry to these activities, this study was conducted to determine polyphenol composition from 7 chokeberry varieties produced in China. Totally, 11 kinds of main polyphenol monomers were identified and quantified by UPLC-Q-TOF-MS and UPLC-PDA. HepG2 cells were used to evaluate their cellular antioxidant and antiproliferative activities. Partial least squares method was utilized to analyze multivariate correlations between proportion of different composition and monomers in total polyphenols with these activities. The results showed that the highest proportion in chokeberry polyphenols was proanthocyanidins. In comparing the bioactivities of 7 varieties of chokeberry, ‘Viking' and purple chokeberry had the strongest antioxidant activity, while 'Fukangyuan 1#' had the strongest antiproliferative activity. In terms of the contribution sources of these bioactivities, the total antioxidant activity of chokeberry mainly depended on the contribution of free polyphenols. As the main source of cellular antioxidant activity, anthocyanins and neochlorogenic acid can provide more contribution. The antiproliferative activity mainly depended on the proportion of free polyphenols and proanthocyanidins in total polyphenols. The results may provide some new possibilities for the comprehensive utilization of polyphenols from chokeberry.

关键词： Chokeberry Anthocyanins Proanthocyanidins Antioxidant Antiproliferation

Lonicera caerulea polyphenols inhibit fat absorption by regulating Nrf2-ARE pathway mediated epithelial barrier dysfunction and special microbiota

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Food Science and Human Wellness 2023年第4期12卷 1309-1322页

作者： Yuehua Wang Ningxuan Gao Andrea Nieto-Veloza Lingxi Zhou Xiyun Sun Xu Si jinlong tian Yang Lin Xinyao Jiao Bin Li College of Food Science Shenyang Agricultural UniversityShenyang 110161China Key Laboratory of Healthy Food Nutrition and Innovative Manufacturing of Liaoning Province Shenyang 110161China Instituto de Ciencia y Tecnología de Alimentos Universidad Nacional de ColombiaBogotá111311Colombia Key Laboratory of Industrial Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China College of Food Science and Technology Zhejiang University of TechnologyHangzhou 310014China

Scope:High-fat diet(HFD)induces imbalance in the small intestine environment,where fat digestion and absorption mainly take place.This study aimed to elucidate the mechanisms by which Lonicera caerulea polyphenols(LCP)might inhibit fat absorption,from the perspective of small intestine microbiota and epithelial barrier integrity.Methods and results:Male Sprague-Dawley rats were given HFD with or without co-administration of LCP for 8 weeks.The results showed that LCP supplementation significantly decreased the levels of serum triglycerides(TG),total cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C),and increased the contents of fecal sterols,in HFD rats.LCP also inhibited the dysfunction of the small intestine epithelial barrier,via alleviating the oxidative stress activated by Nrf2-ARE pathway,and by modulating the expressions of pro-inflammatory factors such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),cyclooxygenase-2(COX-2),nuclear factor kappa-B p65(NF-κB p65)and inducible nitric oxide synthase(iNOS)in the small intestine.Additionally,LCP administration restored the balance in small intestine microbiota and increased the abundance of the specific bacteria,such as Lactobacillus,involved in fat absorption.Conclusion:Our results demonstrated that LCP may be beneficial to inhibit fat absorption.The mechanism seems to be associated with the protection of the epithelial barrier integrity and the modulation of specific bacteria in the small intestine.

关键词： Lonicera caerulea berries Polyphenols Gut microbiota Oxidative stress Intestinal epithelial barrier

Preventive effect of kiwi berry(Actinidia arguta) on loperamide-induced constipation

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Food Science and Human Wellness 2023年

作者： Bin Li Jiyue Zhang Ningxuan Gao Haikun Li Xingyue Cui Hanqian Jiang Siyi Tang Chenyu Jin jinlong tian College of Food Science， Shenyang Agricultural University

Constipation is a common intestinal disease. Kiwi berries can effectively prevent constipation. However， studies have yet to be done to determine how kiwi berries prevent constipation. For two weeks， mice in this study were continually orally gavaged with kiwi berry， loperamide， or a combination of the two. This study found that the Kiwi group’s feces had more water than the constipated mice. In addition， kiwi berries can speed up gastrointestinal transit (GI)， shorten the time it takes to pass the first dark stool， and dramatically enhance body weight gain. In the interstitial cells of Cajal (ICC) cells and colon tissues， alterations in the protein expression of vasoactive intestinal peptide (VIP)， cyclic adenosine monophosphate (cAMP)， protein kinase A (PKA)， and aquaporin-3 (AQP3) were found. At 3， 6， and 12 h of ICC cells and mouse colon， the Kiwi group’s VIP， cAMP， PKA， and AQP3 protein expression levels were lower than those of the constipated mice. The kiwi berry can decrease the Firmicutes to Bacteroidetes ratio and boost the diversity and quantity of gut microbiota. By influencing the gut microbiota and VIP-cAMP-PKA-AQP3 signaling pathway， kiwi berries prevent constipation.

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用于液体火灾的环保泡沫制备方法与关键参数

清华大学学报（自然科学版） 2024年第3期64卷 502-508页

作者：赵金龙李浩源张清元杨钧晖田畅疏学明中国矿业大学(北京)应急管理与安全工程学院北京100083 应急管理部国家安全工程与科学研究院北京100029 清华大学工程物理系北京100084

当发生液体火灾时,常使用泡沫快速扑灭。但传统泡沫存在较多缺陷,如泡沫所含成分全氟辛烷磺酰基化合物(PFOS)难以降解,长期积累会造成环境污染;热稳定性差,灭火后液体火灾易发生复燃。该文通过添加瓜尔豆胶制备了一种适用于液体火灾的... 详细信息

当发生液体火灾时,常使用泡沫快速扑灭。但传统泡沫存在较多缺陷,如泡沫所含成分全氟辛烷磺酰基化合物(PFOS)难以降解,长期积累会造成环境污染;热稳定性差,灭火后液体火灾易发生复燃。该文通过添加瓜尔豆胶制备了一种适用于液体火灾的环保型多糖聚合物泡沫,分析了该环保型多糖聚合物泡沫的发泡性能和稳定性能,明确了发泡剂、稳泡剂的浓度和配比,并与氟蛋白泡沫灭火性能进行了对比。结果表明:当脂肪醇聚氧乙烯醚葡糖苷(AEG)和椰油基糖苷(APG-0810)这2种环保型表面活性剂的质量比为2∶8且质量分数均为0.5%时,泡沫综合值最佳。随后分别添加质量分数为0.3%、 0.4%和0.5%的瓜尔豆胶,发现质量分数为0.4%时,泡沫的灭火效果最好,灭火时间为82 s,比氟蛋白泡沫灭火时间缩短10 s。使用该环保型多糖聚合物泡沫灭火后,25%复燃和90%复燃的对应时间分别为501和638 s,比氟蛋白泡沫延长了96.5%和114.1%,表明该环保型多糖聚合物泡沫具有良好的抗复燃性。该成果可为针对液体火灾的抗复燃泡沫配方研发提供参考。

关键词：液体火灾瓜尔豆胶环保泡沫灭火时间复燃时间

Antihyperuricemic effect of mangiferin aglycon derivative J99745 by inhibiting xanthine oxidase activity and urate transporter 1 expression in mice

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Acta Pharmaceutica Sinica B 2018年第2期8卷 306-315页

作者： Zhizhen Qin Shoubao Wang Yihuang Lin Ying Zhao Shengqian Yang Junke Song Tao Xie jinlong tian Song Wu Guanhua Du Beijing Key Laboratory of Drug Target and Screening Research Department of New Drug R&D Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical College

A mangiferin aglycon derivative J99745 has been identified as a potent xanthine oxidase(XOD) inhibitor by previous in vitro study. This study aimed to evaluate the hypouricemic effects of J99745 in experimental hyperuricemia mice, and explore the underlying mechanisms. Mice were orally administered 600 mg/kg xanthine once daily for 7 days and intraperitoneally injected 250 mg/kg oxonic acid on the 7 th day to induce hyperuricemia. Meanwhile, J99745(3, 10, and 30 mg/kg), allopurinol(20 mg/kg) or benzbromarone(20 mg/kg) were orally administered to mice for 7 days. On the 7 th day,uric acid and creatinine in serum and urine, blood urea nitrogen(BUN), malondialdehyde(MDA) content and XOD activities in serum and liver were determined. Morphological changes in kidney were observed using hematoxylin and eosin(H&E) staining. Hepatic XOD, renal urate transporter 1(URAT1), glucose transporter type 9(GLUT9), organic anion transporter 1(OAT1) and ATP-binding cassette transporter G2(ABCG2) were detected by Western blot and real time polymerase chain reaction(PCR). The results showed that J99745 at doses of 10 and 30 mg/kg significantly reduced serum urate, and enhanced fractional excretion of uric acid(FEUA). H&E staining confirmed that J99745 provided greater nephroprotective effects than allopurinol and benzbromarone. Moreover, serum and hepatic XOD activities and renal URAT1 expression declined in J99745-treated hyperuricemia mice. In consistence with the ability to inhibit XOD, J99745 lowered serum MDA content in hyperuricemia mice. Our resultssuggest that J99745 exerts urate-lowering effect by inhibiting XOD activity and URAT1 expression, thus representing a promising candidate as an anti-hyperuricemia agent.

关键词： Antihyperuricemic effect Mangiferin aglycon Derivative Xanthine oxidase Urate transporter 1

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生物结皮生长发育对黄绵土抗侵蚀性能的影响

水土保持学报 2024年第3期38卷 73-81页

作者：田婧王兵马金龙白洁张智健西北农林科技大学水土保持科学与工程学院陕西杨凌712100 中国科学院水利部水土保持研究所陕西杨凌712100

[目的]黄土高原退耕还林(草)工程驱动的生物结皮发育可显著抑制土壤侵蚀,为探明土壤抗侵蚀性能随生物结皮生长发育的变化特征及其响应机制。[方法]设置藻结皮、藓结皮和自然演替结皮3个处理,培育176天,系统研究生物结皮不同发育阶段及... 详细信息

[目的]黄土高原退耕还林(草)工程驱动的生物结皮发育可显著抑制土壤侵蚀,为探明土壤抗侵蚀性能随生物结皮生长发育的变化特征及其响应机制。[方法]设置藻结皮、藓结皮和自然演替结皮3个处理,培育176天,系统研究生物结皮不同发育阶段及其类型差异对黄绵土抗侵蚀性能的影响。[结果](1)生物结皮盖度、厚度、生物量、叶绿素和粗糙度随生长时间均显著增加,培育初期藓结皮较高,培育末期自然演替结皮反而最高。(2)随生物结皮发育,土壤黏结力呈幂函数增强,较初期增加39.8%~60.3%;质量损失率呈指数函数减小,较初期降低45.6%~57.3%;饱和导水率变化趋势较为复杂,但培育末期均最低(0.08~0.12 mm/min)。(3)土壤黏结力随生物结皮盖度、厚度、叶绿素、生物量和表面粗糙度的增加呈幂函数增长,质量损失率随生物结皮盖度、厚度、叶绿素、生物量和表面粗糙度的增加呈指数函数下降。(4)土壤抗侵蚀综合指数(C_(ser))可表示为盖度(Cov)、厚度(T)和生物量(B)的幂函数(Cser=0.279 Cov^(0.194)T^(0.188)B0.119,R^(2)=0.73,p<0.05)。[结论]黄土高原生物结皮发育可显著提高黄绵土抗侵蚀性能,藓结皮效果最强。

关键词：地表粗糙度土壤黏结力饱和导水率质量损失率黄土高原

中新世气候适宜期构造运动加速全球海洋碳循环

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Science Bulletin 2024年第6期69卷 823-832页

作者：刘丰豪杜金龙黄恩清马文涛马小林 Lucas J.Lourens 田军 State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Department of Earth Sciences Faculty of GeosciencesUtrecht UniversityUtrecht CB 3584Netherlands

Global warming during the Miocene Climate Optimum(MCO,~17-14 million years ago)is associated with massive carbon emissions sourced from the flood basalt volcanism and ocean crustal production.However,the perturbation of tectonic carbon degassing on the interaction between climate change and carbon cycle remains unclear.Here,through time-evolutive phase analysis of new and published high-resolution benthic foraminiferal oxygen(δ^(18)O)and carbon(δ^(13)C)isotope records from the global ocean,we find that variations in the marine carbon cycle lead the climate-cryosphere system(δ^(13)Clead-δ^(18)O)on 405,000-year eccentricity timescales during the MCO.This is in contrast to the previously reported climate-lead-carbon(δ^(18)O-lead-δ^(13)C)scenario during most of the Oligo-Miocene(~34-6 million years ago).Further sensitivity analysis and model simulations suggest that the elevated atmospheric CO_(2) concentrations and the resulting greenhouse effect strengthened the low-latitude hydrological cycle during the MCO,accelerating the response of marine carbon cycle to eccentricity forcing.Tropical climate processes played a more important role in regulating carbon-cycle variations when Earth's climate was in a warm regime,as opposed to the dominant influence of polar ice-sheet dynamics during the PlioPleistocene(after~6 million years ago).

关键词： Global warming Eccentricity cycle Carbon cycle Low-latitude hydrological cycle

The effect of kiwi berry(Actinidia arguta)on preventing and alleviating loperamide-induced constipation

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Food Innovation and Advances 2023年第1期2卷 1-8页

作者： Jiyue Zhang Dongnan Li Qilin tian Yumeng Ding Hanqian Jiang Guang Xin Shunchang Cheng Siyi Tang Chenyu Jin jinlong tian Bin Li College of Food Science Shenyang Agricultural UniversityShenyang 110866LiaoningChina

This research aimed to study the preventive and relieving outcomes of kiwi berry on constipation.The administration of kiwi berries to mice resulted in a significant increase in body weight gain of 148.2%compared to mice that were constipated.The number of stools and the water content of stools both increased by 138.5%and 106.5%,respectively.The gastrointestinal transit rate increased by 45.3%,and the time it took for the first dark stool to form decreased by 57.5%.The levels of the excitability neurotransmitters were found to be higher in the group that had been given kiwi berries in comparison to the group that had been given loperamide.The opposite results were produced by vasoactive intestinal peptide(VIP)and aquaporin-3(AQP3).In addition,kiwi berry consumption may lessen epithelial cell apoptosis and promote colon health.All the results point to kiwi berries as an extremely promising food supplement for the prevention and relief of constipation in the future since they successfully prevent and alleviate constipation brought on by loperamide.

关键词： constipation prevention colon