检索结果-南通市图书馆

Influence of Vertical Load on Lateral-Loaded Monopiles by Numerical Simulation

Computer Modeling in Engineering & Sciences 2023年第4期135卷 465-481页

作者： Qiang li Pan Chen lihong Gao Dan Meng jinjie Zou Huadong Engineering(Shenzhen)Corporation limited Shenzhen518100China Faculty of Civil Engineering and Geosciences Delft University of TechnologyDelft2628 CNThe Netherlands

Monopiles are the most common foundation form of offshore wind turbines,which bear the vertical load,lateral load and bending moment.It remains uncertain whether the applied vertical load increases the lateral deflection of the pile.This paper investigated the influence of vertical load on the behaviour of monopiles installed in the sand under combined load using three-dimensional numerical methods.The commercial software PLAXIS was used for simulations in this paper.Monopiles were modelled as a structure incorporating linear elastic material behaviour and soil was modelled using the Hardening-Soil(HS)constitutive model.The monopiles under vertical load,lateral load and combined vertical and lateral loads were respectively studied taking into account the sequence of load application and pile slenderness ratio(L/D;L and D are the length and diameter of the pile).Results suggest that the sequence of load application plays a major role in how vertical load affects the deflection behaviour of the pile.Specifically,when L/D ratios obtained by lengthening the pile while keeping its diameter constant are 3,5 and 8,the relationships between lateral load and the deflection behaviour of the pile under the effect of vertical load demonstrate a similar trend.Furthermore,the cause of increased lateral capacity of the pile under the action of applied vertical load in the common practical application case and in the VPL case was analyzed by studying the variation law of soil stress along the pile embedment.Results confirm that the confining effect of vertical load increases means effective stress of the soil around the pile,thus increasing soil stiffness and pile capacity.

关键词： Pile lateral capacity combined load sequence of load application L/D ratio

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

地黄对斜纹夜蛾生长发育的影响

引用

棉花学报 2024年第1期36卷 39-49页

作者：梁怀方王丽朱香镇张开心李东阳崔金杰雒珺瑜陈招荣中国农业科学院棉花研究所/棉花生物育种与综合利用全国重点实验室河南安阳455000 天津农学院天津300384

【目的】斜纹夜蛾是危害棉田的重要害虫,地黄是农田常见杂草,探索并利用地黄防治斜纹夜蛾对于棉花可持续生产具有重要意义。【方法】分别将地黄根或叶干粉混拌于斜纹夜蛾人工饲料(地黄干粉与饲料的质量比分别为1∶3、1∶6、1∶9和1∶18)... 详细信息

【目的】斜纹夜蛾是危害棉田的重要害虫,地黄是农田常见杂草,探索并利用地黄防治斜纹夜蛾对于棉花可持续生产具有重要意义。【方法】分别将地黄根或叶干粉混拌于斜纹夜蛾人工饲料(地黄干粉与饲料的质量比分别为1∶3、1∶6、1∶9和1∶18),初步明确地黄对斜纹夜蛾幼虫的死亡率、发育历期和体重的影响;进一步采用药膜法,研究地黄根或叶干粉的95%乙醇提取液(地黄干粉与提取溶剂的料液比分别为1∶50、1∶30和1∶10)对1~6龄斜纹夜蛾幼虫死亡率的影响。【结果】取食混有地黄根或叶干粉饲料的斜纹夜蛾幼虫生长发育受到一定的影响,随着饲料中地黄根或叶干粉含量的增大,斜纹夜蛾幼虫死亡率升高、发育历期延长、体重降低。地黄根或叶干粉与饲料的质量比为1∶3时,其对斜纹夜蛾幼虫的抑制效果最好。地黄根或叶提取液对低龄斜纹夜蛾幼虫有一定抑制作用,对高龄幼虫的毒杀作用较差,同一测定时间随地黄提取液浓度增大,斜纹夜蛾低龄幼虫的死亡率升高。地黄根或叶干粉与提取溶剂的料液比为1∶10时,对斜纹夜蛾1~6龄幼虫的毒杀作用效果最好。【结论】地黄对斜纹夜蛾有一定的抑制作用,在一定范围内,用量越大其抑制作用越强,研究结果可为有效利用农田杂草资源开发植物源杀虫剂奠定理论基础。

关键词：斜纹夜蛾地黄生长发育死亡率干粉提取液

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

计及需求侧管理与碳排放的综合能源系统光-储设备优化配置方法

引用

电力自动化设备 2024年第7期44卷 189-197页

作者：张靖李勇曹一家林锦杰胡斯佳张志文湖南大学电气与信息工程学院湖南长沙410082

合理调整综合能源系统(IES)的配置结构能够有效提升其低碳经济运行水平,基于此,提出了一种计及需求侧管理与碳排放的IES光-储设备优化配置方法。基于IES典型拓扑及供能设备的工作机理,建立其冷-热-电-气能流模型;根据不同柔性负荷特点,... 详细信息

合理调整综合能源系统(IES)的配置结构能够有效提升其低碳经济运行水平,基于此,提出了一种计及需求侧管理与碳排放的IES光-储设备优化配置方法。基于IES典型拓扑及供能设备的工作机理,建立其冷-热-电-气能流模型;根据不同柔性负荷特点,从不同维度构建用能体验的评价指标,并提出一种考虑用户综合满意度的需求侧能量管理策略;在此基础上,为进一步提升系统的低碳性能,设计了一种计及全寿命周期碳排放的奖惩阶梯型碳交易机制;在同时考虑所提需求侧管理与碳交易机制的前提下,以设备全寿命周期内创造的总收益最大为优化目标,构建了从运行到规划层面的源-网-荷-储多环节协同的光-储设备优化配置模型及运行方案;基于某真实IES开展算例研究,结果验证了所提方法在避免设备冗余配置、减碳与提高经济运行水平方面的有效性。

关键词：综合能源系统光-储设备优化配置需求侧管理奖惩阶梯型碳交易机制低碳经济优化运行

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Micro-Sized Pinhole Inspection with Segmented Time Reversal and High-Order Modes Cluster Lamb Waves Based on EMATs

引用

Chinese Journal of Mechanical Engineering 2023年第1期36卷 224-236页

作者： jinjie Zhou Yang Hu Xiang li Yang Zheng Sanhu Yang Yao liu School of Mechanical Engineering North University of ChinaTaiyuan030051China School of Aeronautics and Astronautics University of Electronic Science and Technology of ChinaChengdu611731China China Special Equipment Inspection and Research Institute Beijing100029China

Pinhole corrosion is difficult to discover through conventional ultrasonic guided waves inspection,particularly for micro-sized pinholes less than 1 mm in diameter.This study proposes a new micro-sized pinhole inspection method based on segmented time reversal(STR)and high-order modes cluster(HOMC)Lamb waves.First,the principle of defect echo enhancement using STR is introduced.Conventional and STR inspection experiments were conducted on aluminum plates with a thickness of 3 mm and defects with different diameters and depths.The parameters of the segment window are discussed in detail.The results indicate that the proposed method had an amplitude four times larger than of conventional ultrasonic guided waves inspection method for pinhole defect detection and could detect micro-sized pinhole defects as small as 0.5 mm in diameter and 0.5 mm in depth.Moreover,the segment window location and width(5-10 times width of the conventional excitation signal)did not affect the detection sensitivity.The combination of low-power and STR is more conducive to detection in different environments,indicating the robustness of the proposed method.Compared with conventional ultrasonic guided wave inspection methods,the proposed method can detect much smaller defect echoes usually obscured by noise that are difficult to detect with a lower excitation power and thus this study would be a good reference for pinhole defect detection.

关键词： Pinhole corrosion High-order modes cluster Lamb waves Segmented time reversal inspection Electromagnetic acoustic transducer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigation on the Folding Mode and Deployment Process of an Inflatable Boarding Platform for the Marine Emergency Evacuation System

引用

Computer Modeling in Engineering & Sciences 2023年第4期135卷 483-510页

关键词： Pile lateral capacity combined load sequence of load application L/D ratio

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

左卡尼汀联合尼可地尔对心力衰竭患者血管内皮功能及TRPC-1、NT-proBNP水平的影响

引用

标记免疫分析与临床 2024年第3期31卷 460-463页

作者：周金婕王晓明李宙童上海交通大学医学院附属第九人民医院黄浦分院心内科上海200011

目的探究左卡尼汀联合尼可地尔对心力衰竭患者血管内皮功能及瞬时受体电位通道1(TRPC-1)、N端前体脑钠肽(NT-proBNP)水平的影响。方法将150例心力衰竭患者随机分为2组。对照组采用尼可地尔治疗,研究组采用左卡尼汀联合尼可地尔治疗,均治... 详细信息

目的探究左卡尼汀联合尼可地尔对心力衰竭患者血管内皮功能及瞬时受体电位通道1(TRPC-1)、N端前体脑钠肽(NT-proBNP)水平的影响。方法将150例心力衰竭患者随机分为2组。对照组采用尼可地尔治疗,研究组采用左卡尼汀联合尼可地尔治疗,均治疗3个月,于治疗后评估疗效,比较血管内皮功能及TRPC1、NT-proBNP水平。结果研究组总有效率高于对照组(P<0.05);治疗后,研究组患者血清内皮素-1(ET-1)、TRPC-1及N端前体脑钠肽(NT-proBNP)水平低于对照组(P<0.05);一氧化氮(NO)、肱动脉内皮依赖性血管舒张功能(FMD)高于对照组(P<0.05)。结论与单用尼可地尔相比,联合左卡尼汀治疗心力衰竭患者可提升疗效,调节患者血清TRPC-1及NT-proBNP水平,减轻患者病情严重程度,改善血管内皮功能。

关键词：左卡尼汀尼可地尔心力衰竭血管内皮功能瞬时受体电位通道1 N端前体脑钠肽

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

胆固醇累积暴露对小鼠升主动脉内中膜厚度的影响

引用

中国超声医学杂志 2024年第2期40卷 211-215页

作者：马群群谢谨捷苏瑞娟杨娅闫有青李嘉璐河北北方学院研究生院北京市丰台中西医结合医院超声科首都医科大学附属北京安贞医院超声科北京市垂杨柳医院超声科

目的探讨低密度脂蛋白胆固醇累积暴露(cumLDL-C)与升主动脉内中膜厚度(IMT)的影响。方法分别将28只20周龄LDL-R-/-小鼠与28只20周龄的C57BL/6小鼠按体质量随机分成4组，两组以常规饲料作为普通组，另外两组饲以高脂饮食作为高脂组，... 详细信息

目的探讨低密度脂蛋白胆固醇累积暴露(cumLDL-C)与升主动脉内中膜厚度(IMT)的影响。方法分别将28只20周龄LDL-R-/-小鼠与28只20周龄的C57BL/6小鼠按体质量随机分成4组，两组以常规饲料作为普通组，另外两组饲以高脂饮食作为高脂组，分别饲养8周和16周后，采用Vevo 770超声成像系统对两种小鼠升主动脉根部内中膜厚度(IMT)进行比较，并在观察结束后对两种小鼠的病理组织学结果和血脂水平、血清炎症因子等相关检查进行比较。且对56只小鼠按cumLDL-C(0、8周)将观察对象分成2组。采用Pearson相关和偏相关分析cumLDL-C与IMT的相关性。绘制受试者工作特征(ROC)曲线评估升主动脉内中膜的正常值，采用多因素Logistic回归模型分析cumLDL-C与异常IMT的关联。结果在纳入统计分析观察的56只小鼠中。cumLDL-C 0、8周组的IMT值分别为(0.113 6±0.019 7)、(0.157 9±0.041 9)mm,相应的异常IMT检出率分别为11.9%、85.7%。ROC曲线分析以获得预测小鼠8周随访期间升主动脉内中膜厚度的最佳截断值，预测升主动脉内中膜的最佳截断值为0.119 9 mm(灵敏度：64.2%,特异度：95.2%)。相关分析显示，cumLDL-C与IMT值呈正相关(r=0.704 9,P<0.000 1)。在多因素Logistic回归分析中，校正其他混杂因素后，发现cumLDL-C 8周组与cumLDL-C 0周组比是异常IMT的危险因素，OR值(95%CI)为9.771(2.78～33.92)。结论 LDL-C累积与IMT呈正相关，LDL-C累积暴露是异常IMT的危险因素。

关键词：低密度脂蛋白胆固醇累积暴露升主动脉内中膜厚度超声生物显微镜技术 LDL-R-/-小鼠

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

GABA信号通路对脓毒症大鼠急性肺损伤内质网应激和线粒体自噬的影响

引用

天津医药 2024年第7期52卷 733-737页

作者：钟敏施震周劲松李晋杰作者单位:1湖北中医药大学第一临床医学院 430000 湖北省中医院(光谷院区)疼痛科

目的探讨γ-氨基丁酸(GABA)信号通路对脓毒症大鼠急性肺损伤(Ali)内质网应激(ERS)和线粒体自噬的影响。方法SD大鼠分为CON组、Model组、GABA信号通路激活剂巴氯芬组(巴氯芬组)、GABA信号通路抑制剂荷包牡丹碱(BIC)组(BIC组),每组6只。... 详细信息

目的探讨γ-氨基丁酸(GABA)信号通路对脓毒症大鼠急性肺损伤(Ali)内质网应激(ERS)和线粒体自噬的影响。方法SD大鼠分为CON组、Model组、GABA信号通路激活剂巴氯芬组(巴氯芬组)、GABA信号通路抑制剂荷包牡丹碱(BIC)组(BIC组),每组6只。巴氯芬组腹腔注射5 mg/kg的巴氯芬,BIC组腹腔注射1 mg/kg BIC,每日1次,连续处理2周。CON组、Model组腹腔注射等量生理盐水。酶联免疫吸附试验检测血清中超氧化物歧化酶(SOD)、丙二醛(MDA)水平及支气管肺泡灌洗液(BALF)中细胞色素C(Cyt.C)、烟酰胺腺嘌呤二核苷酸磷酸(NADPH)水平;透射电子显微镜(TEM)观察肺组织细胞超微形态;HE染色观察肺组织病理形态;TUNEL染色观察肺组织细胞凋亡;Western blot检测肺组织GABAAR、GRP78、CHOP蛋白表达。结果与Model组相比,巴氯芬组肺肿胀、充血、炎性细胞浸润现象改善,肺损伤评分、MDA含量、凋亡指数、Cyt.C和NADPH水平、GRP78和CHOP蛋白水平降低(Pli。

关键词：脓毒症急性肺损伤内质网应激线粒体自噬 γ-氨基丁酸

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Polyphenols Extracted from Enteromorpha clathrata Induce Apoptosis in Hepa1-6 Cell by Activating the Mitochondrial Apoptosis Signaling Pathways

引用

中国海洋大学学报:英文版 2023年第5期22卷 1393-1402页

作者： ZHANG Panxue SUN Bolun TONG Jingjing XIA Geran ZHANG jinjie li Chao YANG Wenge College of Food and Pharmaceutical Sciences Ningbo UniversityNingbo 315211China Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province Ningbo UniversityNingbo 315211China

Green alga Enteromorpha clathrata(E.clathrata)contains a variety of bioactive compounds,including polysaccharides,polyphenols and fat-soluble pigments etc.,among which polyphenols exhibit a wide range of medicinal properties.E.clathrata polyphenols(ECPs)have shown various biological activities such as antioxidant,anti-inflammatory and antidiabetic effects;however,the potential of ECPs as an anti-cancer reagent remains unclear.The aim of this study was to investigate the anti-tumor activity and underlying mechanisms of ECPs on hepatocellular carcinoma.The cytotoxicity of Hepa1-6 cells was determined by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)and lactate dehydrogenase(LDH)assay.Flow cytometry and fluorescence microscope analysis of cell apoptosis after annexin V-fluorescein isothiocyanate(FITC)/propidium iodide(PI)staining.2',7'-dichlorodihydrofluorescein diacetate(DCFH-DA)assay was used for intracellular reactive oxygen species(ROS)detection.caspase-9 activity was determined using cspase-9 colorimetric assay.Mitochondrial transmembrane potential(Δψm)was measured using JC-1.Western blot and quantitative real-time PCR(qPCR)were used to assess the expressions of the apoptosis regulators Bax,Bcl-2,cytochrome c and caspase-3.It was found that ECPs showed a dose-dependent cytotoxicity against Hepa1-6 cells by inducing apoptosis.The apoptosis in ECPs-treated Hepa1-6 cells was accompanied by the loss of mitochondrial membrane potential,elevated ROS generation,increased release of mitochondrial cytochrome c,and up-regulation of caspase-9 and caspase-3.The expressions of Bax(pro-apoptotic molecule)and Bcl-2(apoptosis suppressor)were up-regulated and down-regulated,respectively,at both mRNA and protein levels.These molecular alterations revealed that ECPs caused apoptosis of cells through the mitochondrial pathway,suggesting that ECPs are potential candidates to be developed for liver cancer treatment.

关键词： Enteromorpha clathrate polyphenol anti-cancer activity apoptosis mitochondrial-dependent pathway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Whisker of biphasic calcium phosphate ceramics: Osteoimmunomodulatory behaviors

引用

Nano Research 2022年第10期15卷 9169-9182页

作者： jinjie Wu Cong Feng Menglu Wang Hongfeng Wu Xiangdong Zhu Xiangfeng li Xuening Chen Xingdong Zhang National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengdu 610064China

Immune systems play a critical role in the regulation of bone formation and homeostasis,which arouses a growing interest in the development of biomaterials that can modulate both immune response and osteogenesis.In this study,biphasic calcium phosphate(BCP)ceramics were modified with different whiskered surface,and their effects on macrophage polarization and functional status were investigated.The results showed that compared to BCP-W ceramics with long and solid whiskers,BCPHW ceramics with short and hollow whiskers surface were conducive to protein adsorption and macrophage elongation.Furthermore,BCP-HW ceramics down-regulated the expression of M1 macrophage markers(Il1β,Tnfα,and iNos),promoted the expression of M2 macrophage markers(Il10 and Arg)and growth factors(Tgfβ1 and Bmp2),which might be attributed to the differential integrin expression regulated by different whisker structures.The conditioned medium derived from the supernatant of macrophage/whiskered ceramic co-culture was further used to culture MC3T3-E1 pre-osteoblasts to evaluate the effects of whiskered ceramic-mediated macrophage secretion on osteogenesis in vitro.Compared with BCP-W ones,the secretion pattern induced by BCP-HW ceramics could promote the expression of bone markers in pre-osteoblasts,which might due to the activation of intracellular signaling cascades like BMP/Smad and TGF-β/Smad signaling pathways.A murine intramuscular implantation model suggested that after implantation for 1,2,and 3 weeks,BCP-HW ceramics drove the switch of macrophages to ARG+wound-healing M2 phenotype,while BCP-W ceramics increased the proportion of iNOS+M1 inflammatory macrophages.At 2 months,only BCP-HW could induce ectopic bone formation.Taken together,these results indicated that BCP ceramics with hollow whiskers were capable of creating a proper inflammatory microenvironment to induce bone formation.These whiskered BCP ceramics with good osteo-immunomodulatory capacity hold promise in serving as bone grafts to achieve desired bone repair and regenerat

关键词： whisker macrophage polariztion osteoinduction biphasic calcium phosphate surface structure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：