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Recent advances in smart stimuli-responsive biomaterials for bone therapeutics and regeneration

Bone Research 2022年第1期10卷 46-64页

作者： Hongpu Wei jinjie cui Kaili Lin Jing Xie Xudong Wang Department of Oral&Cranio-Maxillofacial Surgery Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai 200011China State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China

Bone defects combined with tumors, infections, or other bone diseases are challenging in clinical practice. Autologous and allogeneic grafts are two main traditional remedies, but they can cause a series of complications. To address this problem,researchers have constructed various implantable biomaterials. However, the original pathological microenvironment of bone defects, such as residual tumors, severe infection, or other bone diseases, could further affect bone regeneration. Thus, the rational design of versatile biomaterials with integrated bone therapy and regeneration functions is in great demand. Many strategies have been applied to fabricate smart stimuli-responsive materials for bone therapy and regeneration, with stimuli related to external physical triggers or endogenous disease microenvironments or involving multiple integrated strategies. Typical external physical triggers include light irradiation, electric and magnetic fields, ultrasound, and mechanical stimuli. These stimuli can transform the internal atomic packing arrangements of materials and affect cell fate, thus enhancing bone tissue therapy and regeneration. In addition to the external stimuli-responsive strategy, some specific pathological microenvironments, such as excess reactive oxygen species and mild acidity in tumors, specific p H reduction and enzymes secreted by bacteria in severe infection, and electronegative potential in bone defect sites, could be used as biochemical triggers to activate bone disease therapy and bone ***, we summarize and discuss the rational construction of versatile biomaterials with bone therapeutic and regenerative functions. The specific mechanisms, clinical applications, and existing limitations of the newly designed biomaterials are also clarified.

关键词： biomaterials smart rational

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Autophagy mediates osteoporotic bone regeneration induced by micro-/nano-structured modification on hydroxyapatite bioceramics

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Engineered Regeneration 2023年第3期4卷 245-256页

作者： jinjie cui Xinran Zhang Liming Cheng Kaili Lin Department of Oral and Cranio-maxillofacial Surgery College of StomatologyNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200011China Shanghai Engineering Research Center of Tooth Restoration and Regeneration School and Hospital of StomatologyTongji UniversityShanghai 200072China Department of Spine Surgery Tongji HospitalTongji University School of MedicineShanghai 200065China Ministry of Education Key Laboratory of spine and spinal cord injury repair and regeneration(Tongji University)ShanghaiChina

Osteoporosis(OP)is an age-related disease of bone metabolism,characterized by bone mass loss and bone mi-croarchitecture deterioration,the poor osteogenesis microenvironment of OP caused hardly repairing of the bone *** a dynamic process to fuel cellular renovation,autophagy has been proved to play a vital role in regulating cell differentiation and maintaining bone *** bone repairing biomaterials are hardly repairing the bone defects under OP pathological ***,it is essential to develop-ment novel biomaterials to improve osteoporotic *** to biochemical cues,biophysical cues exhibited more advantages in biocompatible and side ***,inspired by the importance of enhanced au-tophagic response in osteoporotic environment,we intend to utilize the micro-/nano-structured hydroxyapatite(mnHA)bioceramics as the mimic structure of natural bone tissue to regulate autophagic activity in ovariectomy bone mesenchymal stem cells(OVX-BMSCs),finally promote to bone regeneration in OP *** results indicated that mnHA bioceramics promoted cell adhesion and osteogenesis of OVX-BMSCs,and enhanced au-tophagy level in *** the calvarial defects of OVX-rats,the mnHA scaffold acquired excellent bone repair *** to the current findings,regulating the level of autophagy could be a promising strategy for improve osteoporotic osteogenesis in the future.

关键词： Osteoporosis Osteogenesis Autophagy Hydroxyapatite Micro-/nano-structured modification

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Remodeling Electrophysiological Microenvironment for Promoting Bone Defect Repair via Electret Hybrid Electrospun Fibrous Mat

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Advanced Fiber Materials 2024年第6期6卷 1855-1873页

作者： jinjie cui Bin Yu Dejian Li Zeyu Fu Xiuyi Yang Lingyong Jiang Xudong Wang Kaili Lin Department of Oral and Cranio‑Maxillofacial Surgery College of StomatologyNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyResearch Unit of Oral and Maxillofacial Regenerative MedicineShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineChinese Academy of Medical SciencesShanghai 200011China State Key Lab for Modification of Chemical Fibers&Polymer Materials College of Material Science&EngineeringDonghua UniversityShanghai 201620China Department of Orthodontics The Affiliated Stomatological Hospital of Soochow UniversitySuzhou Stomatological HospitalSuzhou 215005China

Improving the osteogenic properties of bone grafts plays a critical role in the repair and functional restoration of critical-sized bone *** endogenous electric field,one of the most crucial physiological signals,has been confirmed to maintain physiological function and reconstruct the structure of bone,which is inadequate in bone defect *** for the devel-opment of electroactive osteogenic biomaterials arise to remodel and promote the electrophysiological *** the electroactive materials,electret biomaterials can provide a stable and persistent endogenous electrical stimulation,which better conforms to the physiological microenvironment and has long-term effectiveness in the bone repair ***,an electret hybrid electrospun fibrous mat(EHFM)was developed to mimic the structure of the natural extracellular matrix(ECM)with a suitable and persistent electrophysiological *** EHFM was constructed with a core-shell structure,in which silicon dioxide electrets were loaded in the core-layer to remodel and maintain the electrical microenvironment over the long *** EHFM significantly promoted the osteogenesis of bone mesenchymal stem cells(BMSCs)in vitro and showed remarkable ability in bone repair,which was three times better than that of the control group in a critical-sized rat calvarial defect ***,it was verified that EHFM-derived osteogenesis was related to the activation of the calcium ion-sensing receptor(CaSR),while increasing intracellular calcium ion concentration of *** study puts forward a novel engineering strategy to promote bone defect repair by remodeling a stable and persistent electrophysiological microenvironment,showing potential for clinical applications.

关键词： Electret Electrophysiological microenvironment Osteogenesis Electrospun fibrous mat

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Insights into wing dimorphism in worldwide agricultural pest and hostalternating aphid Aphis gossypii

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Journal of Cotton Research 2021年第1期4卷 38-49页

作者： JI Jichao HUANGFU Ningbo LUO Junyu GAO Xueke NIU Lin ZHANG Shuai cui jinjie State Key Laboratory of Cotton Biology/Institute of Cotton Research(ICR) Chinese Academy of Agricultural Sciences(CAAS)Anyang 455000HenanChina Zhengzhou Research Base of ICR CAAS/State Key Laboratory of Cotton

Background:The worldwide pest Aphis gossypii has three-winged morphs in its life cycle,namely,winged parthenogenetic female(WPF),winged gynopara(GP),and winged male,which are all produced by a wingless parthenogenetic female(WLPF).Most studies on *** have focused on WPF,while few have investigated GP and *** shared molecular mechanism underlying the wing differentiation in the three wing morphs of *** remains *** wing differentiation of WPF was explored in a previous ***,GP and male were induced *** characters of the body,internal genitals,wing veins,and fecundity of GP and male were compared with those of WPF or *** with WLPF,the shared and separate differentially expressed genes(DEGs)were identified in these three-wing ***:Newly-born nymphs reared in short photoperiod condition(8 L:16D,18°C)exclusively produced gynoparae(GPe)and males in adulthood successively,in which the sex ratio was GP biased.A total of 14 GPe and 9 males were produced by one mother *** with WLPF,the three-wing morphs exhibited similar morphology and wing vein patterns but were obviously discriminated in the length of fore-and underwings,reproductive system,and fecundity.A total of 37090 annotated unigenes were obtained from libraries constructed using the four morphs via RNA sequencing(RNA-Seq).In addition,10867 and 19334 DEGs were identified in the pairwise comparison of GP versus WLPF and male versus WLPF,*** with WLPF,the winged morphs demonstrated 2335 shared DEGs(1658 upregulated and 677 downregulated).The 1658 shared upregulated DEGs were enriched in multiple signaling pathways,including insulin,FoxO,MAPK,starch and sucrose metabolism,fatty acid biosynthesis,and degradation,suggesting their key roles in the regulation of wing plasticity in the cotton ***-four genes that spanned the range of differential expression were chosen to validate statistical analysis based on RNA-Seq through the

关键词： Cotton aphid Wing differentiation Wing plasticity Winged parthenogenetic female Gynopara Male

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Impact assessment of genetically modified herbicide-tolerant cotton on arthropod communities

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Journal of Cotton Research 2022年第2期5卷 164-172页

作者： LI Dongyang ZHU Xiangzhen ZHANG Kaixin WANG Li ZHANG Rui LIANG Chengzhen LUO Junyu cui jinjie State Key Laboratory of Cotton Biology Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyangHenan 455000 China Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China.

Background:Cotton(Gossypium spp.)is one of the most important economic crops worldwide,and its production plays an important role in the economy of many *** modified herbicide-tolerant(GMHT)crops,which were developed to minimize the losses caused by weeds,have gradually become the most widely adopted genetically modified crops in the world due to their economic and environmental ***,the potential ecological and environmental risks of GMHT crops have attracted extensive attention and *** communities form a promine nt part of the biodiversity of agroecosystems and are important indicators of environmental *** the effects of GMHT crops on the diversity of arthropod communities is necessary to ensure the safety of GMHT ***:In this 2-year study,we investigated the potential impact of GMHT crops on arthropod *** GMHT cotton variety GGK2 with glyphosate tolerance and its near-isogenic non-GMHT variety K312 were used for the experimental *** Shannon diversity index(H),Simpson diversity index(D),Pielou evenness index(J),and principal co-ordinates analysis(PCoA)of the Bray-Curtis distance were used to evaluate the population dynamics and biodiversity of arthropods in cotton *** significant differences were found between GGK2 and K312 in their total abundance of arthropod communities,and biodiversity indexes on most sampling *** arthropod composition in the GGK2 and K312 plots was *** elates had a significant effect on biodiversity indexes,whereas no clear tendencies related to cotton variety or cotton variety x sampling elates interaction were *** addition,PCoA revealed high similarity between the arthropod communities in the plots of the GMHT cotton variety GGK2 and its near-isogenic variety ***:There was no obvious difference in abundance,diversity indexes of arthropod communities between GMHT cotto n variety GGK2 and its near-isogenic var

关键词： GMHT crops Cotton Arthropod communities Biodiversity Diversity index PCoA

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Development and challenges of cells-and materials-based tooth regeneration

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Engineered Regeneration 2022年第2期3卷 163-181页

作者： Zeyu Fu Yu Zhuang jinjie cui Ruilong Sheng Helena Tomás João Rodrigues Bin Zhao Xudong Wang Kaili Lin Department of Oral and Cranio-Maxillofacial Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyResearch Unit of Oral and Maxillofacial Regenerative MedicineChinese Academy of Medical SciencesShanghai 200011China School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China CQM-Centro de Quimica da Madeira MMRGUniversidade da MadeiraCampus da Penteada9000-390 FunchalMadeiraPortugal School of Materials Science and Engineering Center for Nano Energy MaterialsNorthwestern Polytechnical UniversityXi’an710072China

Tooth defect and loss are common clinical diseases in *** the extension of life expectancy,there is an increasing demand for tooth tissue and whole tooth *** with traditional oral prosthetic treatment,tooth regeneration has unique advantages and has become one of the hotspots towards oral biomedical *** this review,we discussed the development and challenges of tooth regeneration based on cells and materials,including tooth enamel,dentin,dental pulp,cementum,dentin-pulp complex,and the whole tooth regeneration,in order to provide a comprehensive,up-to-date,illustrative overview of tooth regeneration *** mechanisms of the regeneration were also summarized and ***,this review hints the future perspective and research direction of tooth regeneration in the challenging field of regenerative dentistry.

关键词： Tooth regeneration Cells Materials Regenerative dentistry

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Comparative transcriptional analysis provides insights of possible molecular mechanisms of wing polyphenism induced by postnatal crowding in Aphis gossypii

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Journal of Cotton Research 2019年第3期2卷 151-161页

作者： JI Jichao ZHANG Shuai LUO Junyu WANG Li ZHU Xiangzhen ZHANG Kaixin ZHANG Lijuan cui jinjie State Key Laboratory of Cotton Biology Institute of Cott on ResearchChinese Academy of Agricultural SciencesAnyang 455000China Zhengzhou Research Base State Key Laboratory of Cotton BiologyZhengzhou UniversityZhengzhou 450001China Research Base State Key Laboratory of Cott on BiologyAnyang Institute of Tech nologyAnyang 455000China

Background:Aphis gossypii is a worldwide sap-sucking pest with a variety of hosts and a vector of more than 50 plant *** strategy of wing polyphenism,mostly resulting from population density increasing,contributes to the evolutionary success of this ***,the related molecular basis remains ***,we identified the effects of postnatal crowding on wing morph determination in cotton aphid,and examined the transcriptomic differences between wingless and wing ***:Effect of postnatal crowding on wing determination in A gossypii was evaluated *** the density of 5 nymphs·cm-2,no wing aphids *** of wing morphs rised with the increase of density in a certain extent,and peaked to 56.1% at the density of 20 nymphs·cm-2,and reduced ***,transcriptomes of wingless and wing morphs were assembled and annotated separately to identify potentially exclusively or differentially expressed transcripts between these two morphs,in which 3 126 and 3 392 unigenes annotated in Nr(Non-redundant protein sequence) database were found in wingless or wing morphs ***,3 187 up-and 1 880 down-regulated genes were identified in wing versus wingless *** analysis suggested the involvement of differentially expressed genes in multiple cellular signaling pathways involved in wing morphs determination,including lipid catabolic and metabolism,insulin,ecdysone and juvenile hormone *** expression levels of related genes were validated by the reverse transcription quantitative real time polymerase chain reaction(RT-qPCR) soon ***:The present study identified the effects of postnatal crowding on wing morphs induction and demonstrated that the critical population density for wing morphs formation in A gossypii was 20 nymphs·*** transcriptome analysis provides transcripts potentially expressed exclusively in wingless or wing morph,*** expressed gen

关键词： Cotton aphid Apterous and alate aphids Wing induction Phenotypic plasticity Gene expression profiling

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Dynamics and diversity of symbiotic bacteria in Apolygus lucorum at different developmental stages

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Journal of Cotton Research 2023年第1期6卷 37-47页

作者： XUE Hui ZHU Xiangzhen WANG Li ZHANG Kaixin LI Dongyang JI Jichao NIU Lin GAO Xueke LUO Junyu cui jinjie State Key Laboratory of Cotton Biology/Institute of Cotton Research Chinese Academy of Agricultural SciencesAnyang 455000HenanChina Zhengzhou Research Base State Key Laboratory of Cotton Biology/Zhengzhou UniversityZhengzhou 450001HenanChina Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory/College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070HubeiChina

Background Apolygus lucorum is a worldwide omnivorous pest damaging a range of crops and causing great economic *** bacteria living in insects play a key role in the nutrition,physiology,and behavior of ***,we present an experiment using Illumina HiSeq sequencing targeting the V3–V4 regions of bacteria’s 16S rRNA throughout the entire life cycle of *** The first and second instar nymphs have the largest alpha diversity compared with other life stages of the *** phyla Proteobacteria(72.29%),Firmicutes(15.24%),Actinobacteria(7.76%)exhibit the largest relative abundance in all developmental ***(23.97%)and Lactococcus(10.62%)are the two genera with the high-est relative *** relative abundance of Erwinia in the nymph stage is significantly greater than the adult stage,and the relative abundance of Lactococcus in 6-day-old and 9-day-old adult females is higher compared with adult *** These results reveal that microbial community composition and relative abundance shift dynamically at different life stages,implying that different bacterial phyla and genera may have specific roles in specific life stages such as metabolism,nutrition absorption,detoxification,and *** study reveals for the first time the community composition and ecological dynamics of symbiotic bacteria throughout the life stages of ***,and thus may provide insight to new strategies for pest control.

关键词： Symbiotic bacteria Apolygus lucorum Life cycle Pest control Community composition Relative abundance Community richness

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Efficiency of cotton bollworm (Helicoverpa armigera Hübner) control of different Bt cotton varieties in North China

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Journal of Cotton Research 2018年第1期1卷 27-34页

作者： Lü Limin LUO Junyu ZHANG Shuai YU Qianlin MA Ligang LIU Xiaofeng WANG Chunyi MA Xiaoyan MA Yan cui jinjie Institute of Cotton Research Chinese Academy of Agricultural Sciences (CAAS)State Key Laboratory of Cotton Biology Cotton Technological Guidance Station of Shandong Province Cash Crops Technological Guidance Station of Hebei Province Cash Crops Extension Station of Henan Province

Background： The cotton bollworm （Helicoverpa armigera） is one of cotton＇s most destructive insect pests in terms of yield and quality. Since 1997, China has grown commercially available transgenic Bacillus thuringiensis （Bt） cotton. We aimed to investigate the variation in resistance of transgenic Bt cotton varieties to cotton bollworm in North China. Methods： Populations of cotton bollworm were monitored from 2008 to 2015 in environments where Bt cotton was planted adjacent to other non Bt crops. The study included 197 Bt cotton varieties planted in 42 counties/locations in three provinces （Hebei, Shandong and Henan） of North China, which were evaluated through field investigations, bioassays, and enzyme linked immunosorbent assays （ELISA）. Results： The average number of cotton bollworms never exceeded the action threshold （10 larvae per 100 cotton plants）, however, their number reached 19.55 per 100 cotton plants in 2011. The ratios of damaged plants to total Bt cotton stem tips, buds, and bolls was low except in 2010, when the ratios reached 1.82%, 2.09%, and 10.63%, respectively. The results of bioassay showed that the corrected mortality were higher at the second generation cotton bollworm stage than the third and fourth germination stages. Totally, Bt protein content declined sharply at the seedling stage from 2008 to 2015. Conclusions： This study indicated that almost all Bt cotton varieties were capable to effectively control the populations of cotton bollworm in North China.

关键词： Upland cotton North China Bt cotton varieties Cotton bollworm Efficiency evaluation

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Comparative transcriptional analysis and identification of hub genes associated with wing differentiation of male in Aphis gossypii

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Journal of Cotton Research 2022年第3期5卷 243-260页

作者： HUANGFU Ningbo SHI Qingyu CHEN Lulu MA Xiaoyan ZHANG Kaixin LI Dongyang WANG Li ZHU Xiangzhen JI Jichao LUO Junyu cui jinjie Zhengzhou Research Base State Key Laboratory of Cotton BiologyZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Cotton Biology Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyangHenan 455000China College of Agronomy Xinjiang Agricultural UniversityUrumqi 830052China.

Background:Aphis gossypii Glover(Hemiptera:Aphididae),a worldwide polyphagous phloem-feeding agricultural pest,has three wing morphs(winged parthenogenetic female,gynopara,and male)in the life *** exclusive males could fly from summer hosts to winter hosts,which are essential for gene exchanges of cotton aphid populations from different hosts or ***,the molecular mechanism of wing differentiation of male in *** remains ***:Morphological observation of male *** showed that there is no distinct difference in the external morphologies of the 1st and 2nd instar *** obvious differentiation of wing buds started in the 3rd instar nymph and was visible via naked eyes in the 4th instar nymphal stage,then adult male emerged with full *** to morphological dynamic changes,the development of wings in males were divided into four stages:preliminary stage(the 1st instar to 2nd instar),prophase(the 3rd instar),metaphase(the 4th instar),anaphase(the 5th instar).Results of feeding behavior monitoring via EPG(electrical penetration graph)technology indicated that although the male cotton aphids had strong desire to feed(longer duration of C 55.24%,F 5.05%and Pd waves 2.56%),its feeding efficiency to summer host cotton was low(shorter E13.56%and E2 waves 2.63%).Dynamic transcriptome analysis of male aphid at 5 different developmental periods showed that in the 3rd instar nymph,the number of up-regulated DEGs was significant increased,and time-course gene transcriptional pattern analyses results also showed that numerous genes categorized in clusters 3,5,and 8 had the highest expressed levels,which were consistent with morphological changes of wing *** results indicate that the 3rd instar nymph is the critical stage of wing bud differentiation in ***,through pathway enrichment analysis of DEGs and WGCNA,it revealed that the neuroactive ligand-receptor interaction,Ras signaling pathway,dopaminergic synaps

关键词： Aphis gossypii EPG Wing bud differentiation Dynamic transcriptome WGCNA

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