Remodeling Electrophysiological Microenvironment for Promoting Bone Defect Repair via Electret Hybrid Electrospun Fibrous Mat

作     者：Jinjie Cui Bin Yu Dejian Li Zeyu Fu Xiuyi Yang Lingyong Jiang Xudong Wang Kaili Lin 

作者机构：Department of Oral and Cranio‑Maxillofacial SurgeryCollege of StomatologyNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyResearch Unit of Oral and Maxillofacial Regenerative MedicineShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineChinese Academy of Medical SciencesShanghai 200011China State Key Lab for Modification of Chemical Fibers&Polymer MaterialsCollege of Material Science&EngineeringDonghua UniversityShanghai 201620China Department of OrthodonticsThe Affiliated Stomatological Hospital of Soochow UniversitySuzhou Stomatological HospitalSuzhou 215005China 

出 版 物：《Advanced Fiber Materials》 (先进纤维材料（英文）)

年 卷 期：2024年第6卷第6期

页      面：1855-1873页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(32271379,82072396,52203309) Science and Technology Commission of Shanghai Municipality(23YF1421500,22YF1400400,21490711700) Cross Disciplinary Research Fund of Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine(JYJC202219) Shanghai's Top Priority Research Center(2022ZZ01017) CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-037) Fund of Department of Oral and Maxillofacial Surgery(Department 2022-04) the Fundamental Research Funds for the Central Universities(2232022D-09) 

主　　题：Electret Electrophysiological microenvironment Osteogenesis Electrospun fibrous mat 

摘      要：Improving the osteogenic properties of bone grafts plays a critical role in the repair and functional restoration of critical-sized bone *** endogenous electric field,one of the most crucial physiological signals,has been confirmed to maintain physiological function and reconstruct the structure of bone,which is inadequate in bone defect *** for the devel-opment of electroactive osteogenic biomaterials arise to remodel and promote the electrophysiological *** the electroactive materials,electret biomaterials can provide a stable and persistent endogenous electrical stimulation,which better conforms to the physiological microenvironment and has long-term effectiveness in the bone repair ***,an electret hybrid electrospun fibrous mat(EHFM)was developed to mimic the structure of the natural extracellular matrix(ECM)with a suitable and persistent electrophysiological *** EHFM was constructed with a core-shell structure,in which silicon dioxide electrets were loaded in the core-layer to remodel and maintain the electrical microenvironment over the long *** EHFM significantly promoted the osteogenesis of bone mesenchymal stem cells(BMSCs)in vitro and showed remarkable ability in bone repair,which was three times better than that of the control group in a critical-sized rat calvarial defect ***,it was verified that EHFM-derived osteogenesis was related to the activation of the calcium ion-sensing receptor(CaSR),while increasing intracellular calcium ion concentration of *** study puts forward a novel engineering strategy to promote bone defect repair by remodeling a stable and persistent electrophysiological microenvironment,showing potential for clinical applications.