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Splitting and placement of data-intensive applications with machine learning for power system in cloud computing

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Digital Communications and Networks 2022年第4期8卷 476-484页

作者： Zhanyang Xu Dawei Zhu jinhui chen Baohua Yu School of Computer and Software Nanjing University of Information Science and TechnologyNanjingChina College of Information Science and Technology Shihezi UniversityXinjiangChina

Aiming to meet the growing demand for observation and analysis in power systems that based on Internet of Things(IoT),machine learning technology has been adopted to deal with the data-intensive power electronics applications in IoT.By feeding previous power electronic data into the learning model,accurate information is drawn,and the quality of IoT-based power services is improved.Generally,the data-intensive electronic applications with machine learning are split into numerous data/control constrained tasks by workflow technology.The efficient execution of this data-intensive Power Workflow(PW)needs massive computing resources,which are available in the cloud infrastructure.Nevertheless,the execution efficiency of PW decreases due to inappropriate sub-task and data placement.In addition,the power consumption explodes due to massive data acquisition.To address these challenges,a PW placement method named PWP is devised.Specifically,the Non-dominated Sorting Differential Evolution(NSDE)is used to generate placement strategies.The simulation experiments show that PWP achieves the best trade-off among data acquisition time,power consumption,load distribution and privacy preservation,confirming that PWP is effective for the placement problem.

关键词： IoT-based power system Cloud Workflow Machine learning NSDE

Tremella polysaccharide mitigates high fat diet-induced anxiety-like behavior through the microbiota-gut-brain axis

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Food Science and Human Wellness 2024年

作者： Haicui Wu Shuyu chen Wenxiu Zhang Yuqing Lu Jiayi Zheng jinhui Chang Jiachi Chiou Research Institute for Future Food The Hong Kong Polytechnic University Shenzhen Key Lab for Food Biological Safety Control The Hong Kong Polytechnic University Shenzhen Research Institute Bo InnoHealth Biotechnology Company Limited Hong Kong Science Park Department of Food Science and Nutrition The Hong Kong Polytechnic University Department of Neurology The Second Affiliated Hospital of Guangzhou University of Chinese Medicine

High-fat diet (HFD) consumption induces gut microbiota dysbiosis and neuropsychiatric disorders， including anxiety. Previous research found that Tremella polysaccharide (TP) exhibited neuroprotective effects in vitro and in vivo. This study aimed to investigate the beneficial effects of TP on HFD-induced anxiety-like behaviors and elucidate the underlying mechanisms from the point view of the microbiota-gut-brain axis. Two groups of HFD-induced obese mice were orally gavaged with low dose (TPL， 40 mg/kg) and high dose (TPH， 400 mg/kg) of TP. A 12-week administration of TPH could significantly improve anxiety-like behaviors in HFD mice. In the hippocampus， microglia activation， the expression of blood-brain barrier (BBB) markers， and the levels of two neurotransmitters (serotonin and norepinephrine) were countered by TPH in mice consuming HFD. Furthermore， TPH improved the intestinal permeability and immune response of the enterocytes in HFD-fed mice. The gut microbiota dysbiosis induced by HFD was also rebalanced by TP treatments， especially in Proteobacteria and its lower taxa. The correlational analysis also suggested that shifts of some microbial genera were closely associated with body weight and the parameters of behavioral tests. Interestingly， fecal microbiota transplantation (FMT) results indicated that fecal microbiota from TPH-treated obese mice could prevent HFD-induced anxiety-like behaviors， suppressing microglia activation and intestinal permeability. In conclusion， the present study indicated that TP intake is a promising dietary intervention strategy to prevent HFD-induced anxiety via the microbiota-gut-brain axis.

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Rice ferredoxin OsFd4 contributes to oxidative stress tolerance but compromises defense against blight bacteria

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The Crop Journal 2023年第6期11卷 1937-1942页

作者： Minfeng Lu jinhui chen Han Meng Guangling Mo Yunhong Liu Fengping chen Zonghua Wang Mo Wang Fujian Universities Key Laboratory for Plant-Microbe Interaction Ministerial and Provincial Joint Innovation Centre for Safety Production of Cross-Strait CropsCollege of Life ScienceFujian Agriculture and Forestry University Fuzhou 350002FujianChina Fujian Key Laboratory of Plant Virology Institute of Plant VirologyFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fuzhou Institute of Oceanography Minjiang UniversityFuzhou 350108FujianChina State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan Agricultural UniversityKunming 650201YunnanChina

Ferredoxins(Fds)in plastids are the most upstream stromal electron receptors shuttling electrons to downstream metabolic systems and function in various physiological processes of dicots,but their roles in monocots’response to stresses are still unclear.In this study,the functions of OsFd4,the major non-photosynthetic type Fd in rice,were characterized under oxidative stress and Xanthomonas oryzae pv.oryzae(Xoo)infection.OsFd4-knockout mutants displayed no defects in key agronomic traits and blast resistance,but were more sensitive to hydrogen peroxide(H2O2)treatment than the wild type.Transient expression of OsFd4 alleviated H2O2-induced rice cell death,suggesting that OsFd4 contributes to rice tolerance to exogenous oxidative stress.Deletion of OsFd4 enhanced rice immune responses against Xoo.OsFd4 formed a complex in vivo with itself and OsFd1,the major photosynthetic Fd in rice,and OsFd1 transcripts were increased in leaf and root tissues of the OsFd4-knockout mutants.These results indicate that OsFd4 is involved in regulating rice defense against stresses and interplays with OsFd1.

关键词： Ferredoxin Rice OsFd4 Oxidative stress Blight bacteria

Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway

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Science China Life Sciences 2024年

作者： Kumar Ganesan Cong Xu Jianming Wu Bing Du Qingqing Liu Yue Sui Cailu Song jinhui Zhang Hailin Tang Jianping chen School of Chinese Medicine LKS Faculty of Medicine The University of Hong Kong School of Pharmacy Southwest Medical University Education Ministry Key Laboratory of Medical Electrophysiology Sichuan Key Medical Laboratory of New Drug Discovery and Druggability EvaluationLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica Southwest Medical University College of Food Science South China Agricultural University State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat-sen University Cancer Center

The spreading of cancer cells from the primary tumor site to other parts of the body, known as metastasis, is the leading cause of cancer recurrence and mortality in patients with triple-negative breast cancer(TNBC). Overexpression of epidermal growth factor receptor(EGFR)is observed in approximately 70% of TNBC patients. EGFR is crucial for promoting tumor metastasis and associated with poor prognosis.Therefore, it is vital to identify effective therapeutic strategies targeting EGFR inhibition. Ononin, an isoflavonoid found in various plants,such as clover and soybeans, has been shown to have anticancer properties in several cancers. In the present study, we aimed to investigate the effects of ononin on TNBC lung metastasis and the associated molecular pathways. We used various assays, including cell viability,colony formation, Transwell, wound healing, ELISA, Western blotting, and staining techniques, to achieve this objective. The results demonstrated that ononin effectively suppressed cellular proliferation and induced apoptosis, as evidenced by the cell viability assay, colony formation assay, and expression of apoptosis markers, and reduced the metastatic capabilities of TNBC cells. These effects were achieved through the direct suppression of cell adhesion, invasiveness and motility. Furthermore, in TNBC xenograft lung metastatic models, ononin treatment significantly reduced tumor growth and lung metastasis. Additionally, ononin reversed the epithelial-mesenchymal transition(EMT) by downregulating the expression of EMT markers and matrix metalloproteinases, as confirmed by Western blot analysis. Furthermore, ononin treatment reduced EGFR phosphorylation and suppressed the PI3K, Akt, and mTOR signaling pathways, which was further confirmed using EGFR agonists or inhibitors. Importantly, ononin treatment did not exert any toxic effects on liver or kidney function. In conclusion, our findings suggest that ononin is a safe and potentially therapeutic treatment for TNBC metastasis that targets the EGFRmediated

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Overexpression of the LcPIN2 and LtPIN2 Gene in Arabidopsis thaliana Promotes Root Elongation

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Phyton-International Journal of Experimental Botany 2023年第8期92卷 2383-2397页

作者： Zijian Cao Guoxia Xue Lingfeng Hu Haoxian Qu Shuang Liang Jisen Shi jinhui chen Zhaodong Hao Key Laboratory of Forest Genetics&Biotechnology of Ministry of Education Co-Innovation Center for Sustainable Forestry in Southern ChinaNanjing Forestry UniversityNanjing210037China

The auxin polar transporter,PIN-FORMED 2(PIN2)plays an important role in root development.However,it remains unclear whether PIN2 genes form two Liriodendron species,L.chinense(LcPIN2)and L.tulipifera(LtPIN2),are both involved in root development and whether and to what extent these two genes diverge in function.Here,we cloned and overexpressed LcPIN2 and LtPIN2 in Arabidopsis thaliana wild-type(WT)and Atpin2 mutant.Phylogenetic and sequence analysis showed a small degree of differentiation between these two Liriodendron PIN2 genes.Tissue-speciﬁc gene expression analysis indicated that both Liriodendron PIN2 genes were highly expressed in roots,implying a potential role in root development.Finally,heterologous overexpression of LcPIN2 and LtPIN2 in Arabidopsis both signiﬁcantly increased the root length compared to wild-type and empty vector.Furthermore,the root length defect in Atpin2 was complemented both by LcPIN2 and LtPIN2.However,heterologous overexpression of LcPIN2 and LtPIN2 cannot rescue the defect in root gravitropism of Atpin2 mutants.Taken together,ourﬁndings unravel PIN2 genes from the magnoliids plant Liriodendron were functionally conserved with AtPIN2 in the dicotyledonous plant Arabidopsis in regard to the regulation of root length,but not root gravitropism.This study also provides a potential target for genetic improvement of the root system in these valuable forest trees Liriodendron.

关键词： Liriodendron PIN2 auxin polar transport root development

Current advances in neurotrauma research:diagnosis, neuroprotection,and neurorepair

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Neural Regeneration Research 2014年第11期9卷 1093-1095页

作者： jinhui chen Riyi Shi Department of Neurological Surgery Stark Neuroscience Research Institute Department of Anatomy Indiana University School of MedicineIndianapolis IN USA Department of Basic Medical Sciences College of Veterinary Medicine Purdue UniversityWest Lafayette IN USA Weldon School of Biomedical Engineering Purdue UniversityWest Lafayette IN USA

Traumatic brain injury （TBI） and spinal cord injury （SCI） causes significant cell death （Raghupathi et al., 1995; DeKosky et al., 1998; Hall et al., 2005; Farkas and Povlishock, 2007） and tissue lesion in the neocortex （Lighthall et al., 1989; Lyeth et al., 1990）, leaving many patients with substantial motor dis- ability and cognitive impairment （Harem et al., 1992; Scheff et al., 1997）. Unfortunately, at present, there are no clinically demonstrated FDA approved drug therapies for treatment of TBI and SCI patients that reduce the neurological injuries. Thus, TBI and SCI are serious health problems. The devel- opment of therapeutic approaches to prevent neuronal death and enhance neuroregeneration for promoting post-traumat- ic functional recovery would be of enormous clinical, social, and economic benefits. The reviews in this specific issue focus largely on the current progress on diagnosis, neuroprotection, and potential neurorepair with stem cells.

关键词： TBI NSCs neuroprotection,and neurorepair

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分布动载荷时域识别的动标定试验方法

南京航空航天大学学报 2024年第3期56卷 561-570页

作者：陈奥辉姜金辉南京航空航天大学航空航天结构力学及控制全国重点实验室南京210016

在工程应用中,作用于工程结构上的载荷多为分布载荷,因此分布载荷识别技术一直备受关注。动标定技术通过建立载荷与响应之间的关系识别载荷,传统动标定方法根据有限元仿真获得标定矩阵,识别结果受到模型误差影响。基于Gauss-Legendre积... 详细信息

在工程应用中,作用于工程结构上的载荷多为分布载荷,因此分布载荷识别技术一直备受关注。动标定技术通过建立载荷与响应之间的关系识别载荷,传统动标定方法根据有限元仿真获得标定矩阵,识别结果受到模型误差影响。基于Gauss-Legendre积分将无限维的动标定转换为有限维的动标定,通过傅里叶逆变换和卷积积分得到时域标定矩阵,对施加于结构上的分布载荷进行时域识别,并用仿真验证了该方法的有效性和高精度。在响应中加入噪声,考察该方法的抗噪性,并与传统仿真标定方法进行对比,并讨论了不同高斯点总数对识别精度的影响。

关键词：分布载荷识别试验动标定 Gauss-Legendre积分正交多项式时域

Development of the pulse bump magnet in HEPS

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Radiation Detection Technology and Methods 2023年第4期7卷 521-530页

作者： Lihua Huo jinhui chen Guanwen Wang Lei Wang Yuemei Peng Zhe Duan Yuanyuan Guo Guanjian Wu Xinzhe Zhai Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China University of Chinese Academy of Sciences CASBeijing100049China

Purpose In the extraction process from booster to storage ring(BTS)for high energy photon source(HEPS),the implementation of four pulse bump magnets plays a crucial role in creating a localized bump.This serves to effectively reduce the upstream kicker strength and facilitate the extraction procedure.In this paper,the development of four pulse bump magnets is presented,which were meticulously designed and thoroughly discussed,taking into consideration dynamic characteristics of the pulse magnet such as magnetic field,eddy current,induced voltage,and vibration.Methods The magnetic field and eddy currents of the pulse bump magnet were calculated through simulation using OPERA/ELLEKTRA,based on the 3D model.The design of the magnet incorporated the utilization of eddy currents within the vacuum chamber to achieve improved field uniformity.Furthermore,the measurements were performed to validate the magnet's design.Results The central magnetic field,integral magnetic field,effective length,and field uniformity measured for the first magnet meet the design specifications.The temperature measurement of the first magnet indicates that the temperature in the magnet was within acceptable limits.The measurement results for the other three magnets are consistent with those of the first one.Conclusions The magnetic field performances of four pulse bump magnets meet the physical requirements for beam extraction in BTS of HEPS.Additionally,the magnets have demonstrated reliable operation during extended testing periods.

关键词： Pulse bump magnet Magnetic field Eddy current Induced voltage Vibration Measurement

A brief review of recent advances in stem cell biology

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Neural Regeneration Research 2014年第7期9卷 684-687页

作者： jinhui chen Libing Zhou Su-yue Pan Stark Neuroscience Research Institute and Department of Neurological Surgery Indiana University School of Medicine Guangdong-Hongkong-Macao Institute of CNS Regeneration (GHMICR) Jinan University Department of Neurology Nanfang Hospital Southern Medical University

Stem cells have the remarkable potential to develop into many different cell types, essentially with- out limit to replenish other cells as long as the person or animal is still alive, offering immense hope of curing Alzheimer＇s disease, repairing damaged spinal cords, treating kidney, liver and lung diseases and making damaged hearts whole. Until recently, scientists primarily worked with two kinds of stem cells from animals and humans： embryonic stem cells and non-embryonic ＂somatic＂ or ＂adult＂ stem cells. Recent breakthrough make it possible to convert or ＂reprogram＂ specialized adult cells to assume a stem stem-like cells with different technologies. The review will briefly dis- cuss the recent progresses in this area.

关键词： stem cell adult stem cell embryonic stem cell somatic cell nuclear transfer induced plu-ripotent stern cell stimulus-triggered acquisition of pluripotency