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Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease

Signal Transduction and Targeted Therapy 2024年第4期9卷 1730-1744页

作者： Zhenzhen Fang Gang Shen Yina wang Fuyan Hong Xiumei Tang Yongcheng Zeng Ting Zhang Huanyi Liu Yanmei Li jinhong wang Jing Zhang Anton Gao Weiwei Qi Xia Yang Ti Zhou Guoquan Gao Department of Biochemistry Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China Department of VIP Medical Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Physical Examination Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Clinical Laboratory Guangzhou First People's HospitalGuangzhou 510080China Guangdong Key Laboratory of Liver Disease Research the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 51008China Department of Health Sciences College of Health SolutionsArizona State UniversityTempeUSA Guangdong Engineering&Technology Research Center for Gene Manipulation and Biomacromolecular Products Sun Yat-Sen UniversityGuangzhou 510080China Guangdong Province Key Laboratory of Diabetology Guangzhou 510o80China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide,and the development of nonalcoholic steatohepatitis(NASH)might cause irreversible hepatic ***(HLP)is the leading risk factor for *** study aims to illuminate the causative contributor and potential mechanism of Kallistatin(KAL)mediating HLP to NAFLD.221 healthy control and 253 HLP subjects,62 healthy control and 44 NAFLD subjects were *** plasma KAL was significantly elevated in HLP subjects,especially in hypertriglyceridemia(HTG)subjects,and positively correlated with liver ***,KAL levels of NAFLD patients were significantly *** transgenic mice induced hepatic steatosis,inflammation,and fibrosis with time and accelerated inflammation development in high-fat diet(HFD)*** contrast,KAL knockout ameliorated steatosis and inflammation in high-fructose diet(HFruD)and methionine and choline-deficient(MCD)diet-induced NAFLD ***,KAL induced hepatic steatosis and NASH by down-regulating adipose triglyceride lipase(ATGL)and comparative gene identification 58(CGl-58)by LRP6/Gas/PKA/GSK3βpathway through down-regulating peroxisome proliferator-activated receptor(PPARy)and up-regulating kruppel-like factor four(KLF4),***-58 is bound to NF-kB p65 in the cytoplasm,and diminishing CGl-58 facilitated p65 nuclear translocation and TNFa ***,hepatic CGl-58-overexpress reverses NASH in KAL transgenic ***,free fatty acids up-regulated KAL against thyroid hormone in ***,Fenofibrate,one triglyceride-lowering drug,could reverse hepatic steatosis by down-regulating *** results demonstrate that elevated KAL plays a crucial role in the development of HLP to NAFLD and may be served as a potential preventive and therapeutic target.

关键词： GSK3β inflammation elevated

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Workspace optimization of parallel robot by using multi-objective genetic algorithm

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High Technology Letters 2022年第4期28卷 411-417页

作者： wang jinhong LEI Jingtao School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444P.R.China Shanghai Key Laboratory of Intelligent Manufacturing and Robotics Shanghai 200444P.R.China

For the narrow workspace problem of the universal-prismatic-universal(UPU)parallel robotwith fixed orientation,a kind of multi-objective genetic algorithm is studied to optimize the robot’*** concept of the effective workspace and its solution method are *** effectiveworkspace height(EWH)and global condition number index(GCI)of Jacobi matrix are selected asthe optimized objective *** the robot in two different orientations,the geometric pa-rameters are optimized by the multi-objective genetic algorithm named non-dominated sorting geneticalgorithm II(NSGA-II),and a set of structural parameters is *** optimization results areverified by four indicators with the robot’s moving platform at different *** resultsshow that,after optimization,the fixed-orientation workspace volume,the effective workspace heightand the effective workspace volume increase by 32.4%,17.8%and 72.9%on average,*** decreases by 6.8%on average.

关键词： parallel robot multi-objective genetic algorithm workspace optimization

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双剪切复乳化喷雾干燥精氨酸微胶囊制备与性能评价

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现代食品科技 2024年第8期40卷 89-97页

作者：张家乐刘小如王锦红邓泽元王远义钟瑞敏南昌大学食品科学与资源挖掘全国重点实验室江西南昌330001 韶关学院广东省粤北食药资源利用与保护重点实验室广东韶关512005 邦世迪(广东)医用食品股份有限公司广东韶关512048

精氨酸是医药、特医食品和饲料行业广泛应用的组成分或营养添加剂。该文采用二次剪切复乳化形成精氨酸微胶囊乳液,通过喷雾干燥制备固体微胶囊。通过光学显微镜、电镜、质谱成像、电子鼻、电子舌、热重分析、体外模拟消化等系列表征和... 详细信息

精氨酸是医药、特医食品和饲料行业广泛应用的组成分或营养添加剂。该文采用二次剪切复乳化形成精氨酸微胶囊乳液,通过喷雾干燥制备固体微胶囊。通过光学显微镜、电镜、质谱成像、电子鼻、电子舌、热重分析、体外模拟消化等系列表征和检测方法,系统分析了精氨酸微胶囊的形态、性状和消化特性,并通过稳定性试验测试了其贮藏稳定性。研究结果表明双剪切乳化可形成稳定的W/O/W型精氨酸微胶囊乳液,喷雾干燥制备的微胶囊为圆球形,平均粒径41.36μm,精氨酸负载量12.16 wt.%,主要分布于胶囊内部,包埋率为95.51%;外层水溶性壁材对精氨酸的氨味和苦涩味具有良好的掩味效果,且在模拟胃液30 min消化中较易崩解,使精氨酸缓释率达到93.14%;精氨酸微胶囊具有良好的稳定性,在室温条件下贮藏90 d精氨酸保留率达到93.82%。该研究可为精氨酸微胶囊在实际的商业应用提供理论依据。

关键词：精氨酸复乳化微胶囊掩味效果缓释稳定性

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端面泵浦渐变浓度Nd∶YAG温度场数值仿真研究

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光学学报 2024年第7期44卷 125-130页

作者：阮芳芳唐方颖王锦红吕彦飞李家伟王鑫欣闫育辉苏良碧郑丽和杭州医学院医学影像学院浙江杭州310053 云南大学物理与天文学院云南省高校光电子器件工程重点实验室云南昆明650500 中国科学院上海硅酸盐研究所人工晶体研究中心上海201899

采用高功率半导体激光端面泵浦技术,在均一浓度Nd∶YAG中心轴沿泵浦光通光方向可产生温度梯度,引起热透镜效应,降低激光输出功率与光束质量。本文结合静态热场数值仿真,建立Nd∶YAG在方形平顶光泵浦条件下的热源方程,研究渐变浓度Nd∶YA... 详细信息

采用高功率半导体激光端面泵浦技术,在均一浓度Nd∶YAG中心轴沿泵浦光通光方向可产生温度梯度,引起热透镜效应,降低激光输出功率与光束质量。本文结合静态热场数值仿真,建立Nd∶YAG在方形平顶光泵浦条件下的热源方程,研究渐变浓度Nd∶YAG在高功率激光泵浦下的温度分布。当初始泵浦功率为1000 W、泵浦脉宽时间为46μs、重复频率为1 kHz时,均一浓度Nd∶YAG的吸收系数为5.8 cm-1,其中心轴沿通光方向的温度由185℃逐次下降到2、4、6、8 mm处的106、51、29、26℃;相应地,每经过2 mm,温度下降率分别为39.5、27.5、11.0、1.5℃/mm。与此相对应,本文构建出一款渐变浓度Nd∶YAG整体式结构,每段厚度均为1 mm,总长度为4 mm。将4段Nd∶YAG的吸收系数依次调控为1.5、2.1、3.3、9.7 cm-1,则沿泵浦光通光方向的中心轴温度基本维持在86.5℃,在渐变浓度Nd∶YAG中实现沿泵浦光传输方向的温度均匀分布。

关键词：均一浓度Nd∶YAG 渐变浓度Nd∶YAG 数值仿真温度分布

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Waveform digitization utilizing switched-capacitor arrays

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Nuclear Science and Techniques 2012年第2期23卷 109-113页

作者： wang jinhong ZHAO Lei FENG Changqing LIU Shubin AN Qi State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Anhui Key Laboratory of Physical Electronics Department of Modern PhysicsUniversity of Science and Technology of ChinaHefei 230026China

Compared with traditional waveform digitization with flash-ADCs, waveform digitization with switched-capacitor arrays (SCAs) is able to achieve the sampling speed above 1 GS/s without degrading the analog to digital conversion precision significantly. In this paper, we present the implementation of a fast waveform digitization system with the use of SCAs, and evaluate its performance of waveform digitization and the waveform timing. At about 5 GS/s, the dynamic input range of the digitizer is about 66 dB, and its timing precision is about 20 ps (RMS).

关键词：波形数字化开关电容阵列数字化系统数字化波形数字转换器转换精度采样速度执行情况

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不同产地菟丝子基源考证及含总黄酮量测定

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哈尔滨商业大学学报（自然科学版） 2024年第5期40卷 515-522页

作者：王会会王昊王金宏宗政陈鲁宁杨智惠胡扬哈尔滨商业大学药学院哈尔滨150076

对不同产地的菟丝子药材进行基源考证,并对其含总黄酮量进行测定.通过性状、显微以及薄层色谱鉴定法,对10个产地菟丝子药材进行真伪鉴别和基源考证;利用紫外分光光度法测定10个产地菟丝子药材中含总黄酮的量.结果表明,10个产地菟丝子药... 详细信息

对不同产地的菟丝子药材进行基源考证,并对其含总黄酮量进行测定.通过性状、显微以及薄层色谱鉴定法,对10个产地菟丝子药材进行真伪鉴别和基源考证;利用紫外分光光度法测定10个产地菟丝子药材中含总黄酮的量.结果表明,10个产地菟丝子药材均为正品,其中产地黑龙江萝北、内蒙古锡盟、内蒙古阿拉善的基源为菟丝子,产地河南焦作、山东济宁、安徽六安、安徽霍山、广西南宁、陕西宝鸡、云南文山的基源为南方菟丝子;10个产地菟丝子药材含总黄酮的量差异不大,其中河南焦作菟丝子含总黄酮量最高,为18.50 mg·g^(-1),云南文山菟丝子含总黄酮量最低,为16.98 mg·g^(-1).本研究为后续菟丝子药材质量标准的制定及开发利用提供了参考.

关键词：菟丝子南方菟丝子显微鉴定薄层色谱鉴定含量测定

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一种判定初烤烟叶部位的方法

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农产品加工 2024年第1期 55-56,62页

作者：李平钟莉王发勇王金宏杜永红李惠红云红河烟草(集团)有限责任公司云南昆明650000

为了解决目前初烤烟叶收购、分选、加工时存在混部位的问题,研究了不同部位初烤烟叶叶尖夹角、开片度的差异,并对数据进行统计分析。结果表明,随着部位的升高,烟叶叶尖夹角的平均值逐渐减小,符合烟叶生长特性,随着烟叶着生部位的上升,... 详细信息

为了解决目前初烤烟叶收购、分选、加工时存在混部位的问题,研究了不同部位初烤烟叶叶尖夹角、开片度的差异,并对数据进行统计分析。结果表明,随着部位的升高,烟叶叶尖夹角的平均值逐渐减小,符合烟叶生长特性,随着烟叶着生部位的上升,叶形趋于尖锐。提供一种判定初烤烟叶部位的方法,通过对初烤烟叶样品预先做平衡处理,相对湿度恒定,取点更加具有参考性,通过编辑试样信息、选择测试方案、编辑控制方案,初烤烟叶样品部位的方法的准确度具有安全、简便、准确及精确的优点,测定的烟叶样品指标能够表征烤烟样品的物理特性。

关键词：初烤烟叶部位叶尖夹角开片度

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Seasonal Variation of Hearing Sensitivity in the Red-eared Slider(Trachemys scripta elegans)

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Asian Herpetological Research 2024年第2期15卷 82-89页

作者： Tongliang wang Jinxia YANG Handong LI jinhong LEI Haitao SHI Jichao wang Ministry of Education Key Laboratory for Ecology of Tropical Islands Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikou 571158HainanChina

Seasonal variation of hearing sensitivity has been observed in many vertebrate groups with obvious vocal *** hormones,conspecific calling signals,and temperature are potential factors that drive these plasticity *** have a hearing range that appears to be limited to under 1.5 kHz and are often thought to be non-vocal;thus,they are commonly neglected in vocal communication *** this study,we aimed to determine whether the auditory phenotype exhibits seasonal variation in sensitivity and to analyze the potential factors driving such variation patterns in *** measured hearing sensitivity and sex hormone levels in female(estradiol)and male(testosterone and dihydrotestosterone)Red-eared sliders(Trachemys scripta elegans)during spring and *** results showed that auditory brainstem response(ABR)thresholds were significantly lower in spring than in winter at a frequency range of 0.5-0.9 *** hearing-sensitivity bandwidth was wider,and the ABR latency was significantly shorter in spring than in *** significant differences were found in estradiol,testosterone,and dihydrotestosterone levels in *** elegans between spring and *** study is the first to reveal the seasonal variation of peripheral hearing sensitivity in turtles,a special animal group with limited hearing range and less *** variations may be used to explain these seasonal effects,but further research is required to confirm our findings.

关键词： auditory plasticity seasonal variation temperature turtles

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Lung adeno-squamous carcinoma modeling using oncogenic KRAS activation in human embryonic stem cell-derived alveolar organoids

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Genes & Diseases 2023年第1期10卷 33-36页

作者： Jianqi Feng Lian Li Zhihong Tan Shanshan Zhao Xin Zhang jinhong wang Yaping Ye Ying Lin Zhili Rong Cancer Research Institute School of Basic Medical SciencesState Key Laboratory of Organ Failure ResearchNational Clinical Research Center of Kidney DiseaseKey Laboratory of Organ Failure Research(Ministry of Education)Southern Medical UniversityGuangzhouGuangdong 510515China Dermatology Hospital Southern Medical UniversityGuangzhouGuangdong 510091China Department of Respiration The Third Affiliated Hospital of Southern Medical UniversityGuangzhouGuangdong 510630China Department of Pathology Nanfang Hospital and School of Basic Medical ScienceSouthern Medical UniversityGuangzhouGuangdong 510515China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong 510005China Experimental Education/Administration Center School of Basic Medical ScienceSouthern Medical UniversityGuangzhouGuangdong 510515China

Mutant KRAs is a common driver in lung ***,the occurrence of human lung cancer and its subsequent development after activation of oncogenic KRAS in epithelial cells remain poorly *** are embedded in three-dimensional Matrigel in which tissue-derived human adult stem cells can efficiently grow for a long time,maintaining genetic and phenotypic stability."But until now,the use of organoids to simulate human non-small cell lung cancer has not been reported.

关键词： lung KRAS Lung

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TEPG:a traffic engineering based power-aware greedy routing algorithm in backbone networks with bundled links

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Frontiers of Computer Science 2024年第1期18卷 243-245页

作者： jinhong ZHANG Xingwei wang Ruixia LI Bo YI Min HUANG Dongxing SHUI School of Electronic and Information Engineering West Anhui UniversityLu’an 237012China State Key Laboratory of Synthetical Automation for Process Industries Northeastern UniversityShenyang 110819China School of Computer Science and Engineering Northeastern UniversityShenyang 110169China School of Information Science and Engineering Northeastern UniversityShenyang 110819China

1 Introduction and main contributions Various power-aware solutions have been proposed to address the alarming energy waste and consequent serious environmental issues since Gupta and Singh initiated the seminal study on green networking problem in *** of the researches concentrated their efforts on power-aware networking under the non-bundled link scenarios by leveraging the dynamic power management based Low Power Idle(LPI)policy which was defined and standardized in the IEEE 802.3az ***,in modern backbone networks,pairs of routers are typically connected,for each traffic direction,by multiple physical links that form one logical bundled link,which is the link aggregation technique defined and standardized in IEEE 802.1AX.

关键词： power bundle backbone

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