检索结果-南通市图书馆

Transmission restriction and genomic evolution co-shape the genetic diversity patterns of influenza A virus

Virologica Sinica 2024年第4期39卷 525-536页

作者： Xiao Ding jingze liu Taijiao Jiang Aiping Wu State Key Laboratory of Common Mechanism Research for Major Diseases Suzhou Institute of Systems MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeSuzhou215123China Key Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical College) Ministry of EducationBeijing100730China Guangzhou National Laboratory Guangzhou510006China State Key Laboratory of Respiratory Disease The Key Laboratory of Advanced Interdisciplinary Studies CenterThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510030China

Influenza A virus(IAV)shows an extensive host range and rapid genomic variations,leading to continuous emergence of novel viruses with significant antigenic variations and the potential for cross-species *** causes global pandemics and seasonal flu outbreaks,posing sustained threats ***,studying all IAVs'evolutionary patterns and underlying mechanisms is crucial for effective prevention and *** developed FluTyping to identify IAV genotypes,to explore overall genetic diversity patterns and their restriction *** groups isolates based on genetic distance and phylogenetic relationships using whole genomes,enabling identification of each isolate's *** distinct genetic diversity patterns were observed:one genotype domination pattern comprising only H1N1 and H3N2 seasonal influenza subtypes,multi-genotypes cocirculation pattern including majority avian influenza subtypes and swine influenza H1N2,and hybrid-circulation pattern involving H7N9 and three H5 subtypes of influenza ***,the IAVs in multi-genotypes cocirculation pattern showed region-specific dominant genotypes,implying the restriction of virus transmission is a key factor contributing to distinct genetic diversity patterns,and the genomic evolution underlying different patterns was more influenced by host-specific *** summary,a comprehensive picture of the evolutionary patterns of overall IAVs is provided by the FluTyping's identified genotypes,offering important theoretical foundations for future prevention and control of these viruses.

关键词： Influenza A virus Genetic diversity Transmission Genetic pattern Genotype

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inhibition effect of phosphate on the crystal grain growth of nanosized titania

引用

Rare Metals 2009年第4期28卷 385-390页

作者： FENG Xiaohui liu jingze LI Ping ZHANG Yanfeng WEI Yu College of Chemistry and Material Science Hebei Normal University Shijiazhuang 050016 China College of Life Science Hebei Normal University Shijiazhuang 050016 China

The inhibitory effect of phosphate on the crystal grain growth of nanosized titania during high temperature calcination was investigated. Nanosized titanium dioxide powders prepared by hydrolysis of titanium tetrachloride were soaked in phosphate solutions with different concentrations. The obtained powders calcined at various temperatures were characterized by X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FTIR）, and X-ray photoelectronic spectroscopy （XPS）. The grain size of the samples without phosphate treatment increased quickly when calcined at high temperatures, while the grain size of the samples with phosphate modification increased slowly when calcined at the same temperature. This phenomenon implies that phosphate treatment plays an important role in inhibiting the crystal grain growth of titania. The possible mechanism of the inhibition effect of phosphate on titania is discussed.

关键词： physical chemistry crystal size soaking method nanosized TiO2 phosphate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Azobenzene-based ultrathin peptoid nanoribbons for the potential on highly efficient artificial light-harvesting

引用

Science China Chemistry 2024年第5期67卷 1680-1686页

作者： Zichao Sun Lingrong Zhu jingze liu Fan liu Pengchao Wu Pengliang Sui Haibao Jin Shaoliang Lin Shanghai Key Laboratory of Advance Polymeric Materials Frontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

The development of artificial light-harvesting systems based on long-range ordered ultrathin organic nanomaterials(i.e., below3 nm), which were assembled from stimuli-responsive sequence-controlled biomimetic polymers, remains challenging. Herein,we report the self-assembly of azobenzene-containing amphiphilic ternary alternating peptoids to construct photo-responsive ultrathin peptoids nanoribbons(UTPNRs) with a thickness of ~2.3 nm and the length in several micrometers. The pendants hydrophobic conjugate stacking mechanism explained the formation of one-dimensional ultrathin nanostructures, whose thickness was highly dependent on the length of side groups. The photo-isomerization of azobenzene moiety endowed the aggregates with a reversible morphology transformation from UTPNRs to spherical micelles(46.5 nm), upon the alternative irradiation with ultraviolet and visible light. Donor of 4-(2-hydroxyethylamino)-7-nitro-2,1,3-benzoxadiazole(NBD) and acceptor of rhodamine B(RB) were introduced onto the hydrophobic and hydrophilic regions, respectively, to generate photocontrollable artificial light-harvesting systems. Compared with the spheres-based systems, the obtained NBD-UTPNRs@RB composite proved a higher energy transfer efficiency(90.6%) and a lower requirement of RB acceptors in water. A proof-ofconcept use as fluorescent writable ink demonstrated the potential of UTPNRs on information encryption.

关键词： azobenzene-based peptoid ultrathin nanoribbon photo-responsive light-harvesting information encryption

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Low-density lipoprotein receptor-related protein 1 is a CROPs-associated receptor for Clostridioides infection toxin B

引用

Science China(Life Sciences) 2022年第1期65卷 107-118页

作者： Shengjie Guo Yiou Chen jingze liu Xinyi Zhang Zhiheng liu Zhuo Zhou Wensheng Wei Biomedical Pioneering Innovation Center Beijing Advanced Innovation Center for GenomicsPeking-Tsinghua Center for Life SciencesPeking University Genome Editing Research CenterState Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking UniversityBeijing 100871China

As the leading cause of worldwide hospital-acquired infection,Clostridioides difficile(***)infection has caused heavy economic and hospitalized burden,while its pathogenesis is not fully *** B(Tcd B)is one of the major virulent factors of ***,CSPG4 and FZD2 were reported to be the receptors that mediate Tcd B cellular ***,genetic ablation of genes encoding these receptors failed to completely block Tcd B entry,implicating the existence of alternative receptor(s)for this ***,by employing the CRISPR-Cas9 screen in CSPG4-deficient He La cells,we identified LDL receptor-related protein-1(LRP1)as a novel receptor for Tcd *** of LRP1 in both CSPG4-deficient He La cells and colonic epithelium Caco2 cells conferred cells with increased Tcd B resistance,while LRP1 overexpression sensitized cells to Tcd B at a low ***-immunoprecipitation assay showed that LRP1 interacts with full-length Tcd ***,CROPs domain,which is dispensable for Tcd B’s interaction with CSPG4 and FZD2,is sufficient for binding to *** such,our study provided evidence for a novel mechanism of Tcd B entry and suggested potential therapeutic targets for treating *** infection.

关键词： Clostridioides difficile low-density lipoprotein receptor-related protein 1 Tcd B toxin receptor CRISPR screening

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development of PREDAC-H1pdm to model the antigenic evolution of influenza A/(H1N1)pdm09 viruses

引用

Virologica Sinica 2023年第4期38卷 541-548页

作者： Mi liu jingze liu Wenjun Song Yousong Peng Xiao Ding Lizong Deng Taijiao Jiang Jiangsu Institute of Clinical Immunology The First Affiliated Hospital of Soochow UniversitySuzhou215006China Institute of Systems Medicine Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100005China Suzhou Institute of Systems Medicine Suzhou215123China Guangzhou Laboratory Guangzhou510005China Bioinformatics Center College of BiologyHunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha410082China State Key Laboratory of Respiratory Disease the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou510120China

The Influenza A(H1N1)pdm09 virus caused a global pandemic in 2009 and has circulated seasonally ever *** the continual genetic evolution of hemagglutinin in this virus leads to antigenic drift,rapid identification of antigenic variants and characterization of the antigenic evolution are *** this study,we developed PREDAC-H1pdm,a model to predict antigenic relationships between H1N1pdm viruses and identify antigenic clusters for post-2009 pandemic H1N1 *** model performed well in predicting antigenic variants,which was helpful in influenza *** mapping the antigenic clusters for H1N1pdm,we found that substitutions on the Sa epitope were common for H1N1pdm,whereas for the former seasonal H1N1,substitutions on the Sb epitope were more common in antigenic ***,the localized epidemic pattern of H1N1pdm was more obvious than that of the former seasonal H1N1,which could make vaccine recommendation more ***,the antigenic relationship prediction model we developed provides a rapid determination method for identifying antigenic variants,and the further analysis of evolutionary and epidemic characteristics can facilitate vaccine recommendations and influenza surveillance for H1N1pdm.

关键词： H1N1pdm virus Antigenic relationship prediction Antigenic evolution Vaccine recommendation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

NAS4RRAM: neural network architecture search for inference on RRAM-based accelerators

引用

Science China(Information Sciences) 2021年第6期64卷 89-99页

作者： Zhihang YUAN jingze liu Xingchen LI Longhao YAN Haoxiang CHEN Bingzhe WU Yuchao YANG Guangyu SUN Center for Energy-Efficient Computing and Applications Peking University Department of Micro/nanoelectronics Peking University Center for Brain Inspired Chips Institute for Artificial IntelligencePeking University

The RRAM-based accelerators enable fast and energy-efficient inference for neural ***, there are some requirements to deploy neural networks on RRAM-based accelerators, which are not considered in existing neural networks.(1) Because the noise problem and analog-digital converters/digitalanalog converters(ADC/DAC) affect the prediction accuracy, they should be modeled in networks.(2) Because the weights are mapped to the RRAM cells, they should be quantized, and the number of weights is limited by the number of RRAM cells in the accelerator. These requirements motivate us to customize the hardware-friendly network for the RRAM-based accelerator. We take the idea of network architecture search(NAS) to design networks with high prediction accuracy that meet the requirements. We propose a framework called NAS4RRAM to search for the optimal network on the given RRAM-based accelerator. The experiments demonstrate that NAS4RRAM can apply to different RRAM-based accelerators with different scales. The performance of searched networks outperforms the manually designed ResNet.

关键词： network architecture search (NAS neural networks RRAM-based accelerator hardware noise quantization

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Removal of bromate ion using powdered activated carbon

引用

Journal of Environmental Sciences 2010年第12期22卷 1846-1853页

作者： Lian Wang Jie Zhang jingze liu Hong He Min Yang Jianwei Yu Zichuan Ma Feng Jiang College of Life Science Hebei Normal University Shijiazhuang 050016 China Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China College of Chemistry & Material Science Hebei Normal University Shijiazhuang 050016 China Beijing YADU Indoor Environmental Protection Science and Technology Co. Ltd. Beijing 102206 China

Bromate ion （BrO3-） removal from drinking water by powdered activated carbons （PACs） in bath mode was evaluated under various operational conditions. Six kinds of PACs, including wood-based carbon, fruit-based carbon, coal-based carbon, and these three carbons thermally deoxidized in a nitrogen atmosphere, were selected to investigate their capacity on BrO3- removal. With the highest zeta potential value and being richly mesoporous, coal-based carbon had a high and an excellent BrO3- adsorption efficiency. The removal content of BrO3- by per gram of coal-based carbon was 0.45 mg within 5 hr in 100 μg/L bromate solution. The surface characteristics of PACs and bromide formation revealed that both physical and chemical PACs properties simultaneously affected the adsorptionreduction process. Under acidic conditions, PACs possessed high zeta value and adequate basic groups and exhibited neutral or positive charges, promoting BrO3- adsorption-reduction on the carbon surface. Interestingly, the PACs thermally deoxidized in N2 atmosphere optimized their properties, e.g. increasing their zeta values and decreasing the oxygen content which accelerated the BrO3- removal rate. The maximum adsorption capacity of fruit-based carbon was the highest among all tested carbons （99.6 mg/g）, possibly due to its highest pore volume. Remarkably, the thermal regeneration of PACs in N2 atmosphere could completely recover the adsorption capacity of PACs. The kinetic data obtained from carbons was analyzed using pseudo second-order and intraparticle diffusion models, with results showing that the intraparticle diffusion was the more applicable model to describe adsorption of BrO3- onto PACs.

关键词： bromate powdered activated carbons adsorption-reduction process adsorption capacity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protein regulation mechanism of cold tolerance in Haemaphysalis longicornis

引用

Insect Science 2023年第3期30卷 725-740页

作者： Ningmei Wang Aimeng Ji Abolfazl Masoudi Shuang Li Yuhong Hu Yefei Zhang Zhijun Yu Han Wang Hui Wang jingze liu Ministry of Education Key Laboratory of Molecular and Cellular Biology Hebei Key Laboratory of Animal PhysiologyBiochemistry and Molecular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuangChina Instrumental Analysis Center Hebei Normal UniversityShjiazhuangChina Hebei Xiaowutai Mountain National Nature Reserve Management Center ZhangjiakouHebei ProvinceChina

Ticks are external parasitic arthropods that can transmit a variety of pathogens by sucking ***-temperature tolerance is essential for ticks to survive during the cold *** the protein regulation mechanism of low-temperature tolerance of Haemaphysalis longicornis could help to explain how ticks survive in *** this study,the quantitative proteomics of several tissues of *** exposed to low temperature were studied by data independent acquisition *** of 3699,3422,and 1958 proteins were identified in the salivary gland,midgut,and ovary,*** proteins involved in energy metabolism,cell signal transduction,protein synthesis and repair,and cytoskeleton synthesis changed under low-temperature *** comprehensive analysis of the protein regulation of multiple tissues of female ticks exposed to low temperature showed that maintaining cell homeostasis,maintaining cell viability,and enhancing cell tolerance were the most important means for ticks to maintain vital signs under low *** expression of proteins involved in and regulating the above cell activities was the key to the survival of ticks under low *** the analysis of a large amount of data,we found that the expression levels of arylamine N-acetyltransferase,inositol polyphosphate multikinase,and dual-specificity phosphatase were up-regulated under low *** speculated that they might have important significance in low-temperature ***,we performed RNA interference on the mRNA of these 3 proteins,and the results showed that the ability of female ticks to tolerate low temperatures decreased significantly.

关键词： low-temperature tolerance protein regulation tick survival strategy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

^(13)C稳定同位素在陆地生态系统植物-微生物-土壤碳循环中的应用

引用

林业科学 2024年第7期60卷 175-190页

作者：白雪娟翟国庆刘敬泽河北师范大学生命科学学院河北省动物生理生化与分子生物学实验室河北省生态环境协同创新中心石家庄050024 河北师范大学生态学博士后科研流动站石家庄050024

绿色植物通过光合作用吸收大气中的CO_(2),是陆地生态系统的主要碳(C)源,量化光合C在植物-土壤系统间的分配,对于明确C的周转与存留、预测气候变化背景下植被和土壤C库潜力具有重要意义。^(13)C稳定同位素技术具有准确性和易操作性,在C... 详细信息

绿色植物通过光合作用吸收大气中的CO_(2),是陆地生态系统的主要碳(C)源,量化光合C在植物-土壤系统间的分配,对于明确C的周转与存留、预测气候变化背景下植被和土壤C库潜力具有重要意义。^(13)C稳定同位素技术具有准确性和易操作性,在C循环研究中被广泛应用,为探究植物-土壤系统C分配、土壤微生物群落结构、C利用效率和土壤C矿化为CO_(2)通量变化等特性提供重要技术支撑。本研究首先介绍^(13)C稳定同位素的发展和标记方法,主要有^(13)C脉冲(单次与多次)标记、^(13)C连续标记、借助C_(4)土壤种植C_(3)植物确定^(13)C丰度以及不改变植被条件鉴定自然^(13)C丰度等。其次总结该技术在植物-微生物-土壤系统C循环中的应用:主要包括^(13)C同位素标记在植物-土壤系统C分配,^(13)C自然丰度技术在树木生长轮和植物群落水平C循环、土壤有机C形成与分解过程中的应用;在土壤微生物方面,概述^(13)C稳定同位素在磷脂脂肪酸、氨基糖、芯片-稳定同位素探针、纳米二次离子质谱同位素成像、荧光原位杂交-纳米二次离子质谱技术等微生物标志物上的应用。接着总结^(13)C稳定同位素方法的缺点,即^(13)C样品检测价格昂贵、由于^(13)C分馏作用影响^(13)C丰度检测不准确及^(13)C标记与微生物标志物技术结合对^(13)C标记丰度要求较高等。最后,对未来^(13)C同位素示踪技术研究提出展望:在理论上,需探究^(13)C标记底物在植物-土壤-微生物系统C分配、转化和固持的作用机制和影响机制,构建统计与验证模型;在应用上,应注重交叉学科的运用,将地理信息系统、遥感等地学技术与^(13)C稳定同位素相结合,从更广泛、更全面的角度推进陆地生态系统C循环研究。

关键词： ^(13)C稳定同位素标记技术陆地生态系统碳循环土壤有机碳微生物标志物

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

上海原油期货与国际原油价格联动性问题研究

引用

世界经济研究 2020年第12期 3-18,M0002页

作者：张天顶刘竞择武汉大学经济与管理学院

文章针对上海原油期货与国际原油期货、亚洲地区原油现货间联动性问题,利用静态和动态Copula函数模型设定,从联动效应、联动结构和尾部相依性等方面进行实证研究,考察上海原油期货融入国际原油价格体系的程度以及它与亚洲地区原油现货... 详细信息

文章针对上海原油期货与国际原油期货、亚洲地区原油现货间联动性问题,利用静态和动态Copula函数模型设定,从联动效应、联动结构和尾部相依性等方面进行实证研究,考察上海原油期货融入国际原油价格体系的程度以及它与亚洲地区原油现货间的价格互动程度。研究发现,上海原油期货与国际原油期货间联动效应较低,尚未能完全地融入全球原油价格体系中;上海原油期货与亚洲地区原油现货间价格互动程度较高;上海原油期货与国际原油间联动性及尾部相依性较低,对亚洲地区现货具有一定代表性。因此,基于实证研究文章认为,上海原油期货已初步融入全球原油价格体系;在亚洲地区具有较强的原油价格代表性,上海原油期货更好地发挥价格机制,给市场参与者提供良好的风险管理机会。

关键词：上海原油期货国际原油联动性尾部相依相依函数

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：