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The Regulatory Role and Mechanism of Circadian Rhythm in Hemoglobin Co-cultured Neurovascular Unit

Biomedical and Environmental Sciences 2024年第7期37卷 726-738页

作者： Fang Xue Wenchao Chen Xia Lian Guanghui He jingyuan tian Yinghong Liu Gaiqing Wang Department of Neurology The Second Clinical School of MedicineShanxi Medical UniversityTaiyuan 030002ShanxiChina The Second Clinical School of Medicine Shanxi Medical UniversityTaiyuan 030002ShanxiChina Department of Clinical lab The First People’s Hospital of ZhaotongZhaotong 657000YunnanChina Department of Neurology Sanya Central Hospital(Hainan Third People’s Hospital)Hainan Medical UniversitySanya 57200HainanChina

disruption of the blood-brain barrier(BBB),leading to vasogenic edema,plasma protein extravasation,and infiltration of neurotoxic *** clearance capacity of the brain plays a crucial role in maintaining BBB homeostasis and facilitating patient recovery after *** study aimed to investigate the effect of circadian rhythms on BBB function,neuronal damage,and clearance *** The transwell model and hemoglobin were co-cultured to simulate the BBB environment after *** intervention with different light groups,neuronal apoptosis was determined,glial phagocytosis was analyzed,the expression of endogenous clearing-related proteins aquaporin 4(AQP4)and low-density lipoprotein receptor-related protein 1(LRP1)was detected by western blotting and immunofluorescence dual standard method,and the expression of the tight junction protein occludin and melatonin receptor 1A(MTNR1A)was quantitatively *** Circadian rhythms play a key role in maintaining the integrity of the BBB,reducing oxidative stress-induced neuronal damage,and improving microglial ***,the expression of occludin and MTNR1A in neurovascular unit(NVU)co-cultured with hemoglobin improved the expression of AQP4 and LRP1,the key proteins in the NVU’s endogenous brain clearance *** Circadian rhythm(alternating black and white light)protects the NVU BBB function after ICH,promotes the expression of proteins related to the clearance of the hematoma,provides new evidence for the clinical treatment of patients recovering from ICH,and improves the circadian rhythm to promote brain metabolism and hematoma clearance.

关键词： Blood-brain barrier Circadian rhythm Neurovascular unit Melatonin receptor 1A Aquaporin-4

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杨晓晖教授辨证治疗汗证经验举隅

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临床医学研究与实践 2024年第15期9卷 5-8页

作者：田静媛王立强永定路社区卫生服务中心北京100049 北京中医药大学东直门医院通州院区北京101121

多汗症作为一种常见的疾病,虽然不属于危及生命的器质性病变,但对患者生活质量、心理健康造成了严重的影响。无论是西医药物或手术治疗,均存在一定副作用或并发症等危险因素,且费用高昂,难以根治;其次,目前西医尚无公认针对多汗症的标... 详细信息

多汗症作为一种常见的疾病,虽然不属于危及生命的器质性病变,但对患者生活质量、心理健康造成了严重的影响。无论是西医药物或手术治疗,均存在一定副作用或并发症等危险因素,且费用高昂,难以根治;其次,目前西医尚无公认针对多汗症的标准治疗手段。杨晓晖教授从中医辨证论治出发,认为汗证应以辨别虚实为本,同时区分阴阳、气血、脏腑,临床治疗中以调和阴阳、补虚泄实为基本原则,疗效显著,为中医治疗汗症提供了新的思路。

关键词：汗症中医经验辨证论治

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城市综合管理视角下的城市更新着力点研究

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城市管理与科技 2024年第1期25卷 16-19页

作者：秦常清张鹏丁杰田靖源陈光远重庆市停车管理事务中心重庆市城市综合管理工作领导小组办公室重庆市环境卫生事务中心重庆市城市供节水事务中心

党的二十大报告提出,实施城市更新行动,打造宜居、韧性、智慧城市。重庆作为超大山水城市,全市正在努力建设现代化新重庆,城市管理部门正在谋划思考如何把城市综合管理工作积极融入到现代化新重庆建设宏大场景中。为了找准在城市更新国... 详细信息

党的二十大报告提出,实施城市更新行动,打造宜居、韧性、智慧城市。重庆作为超大山水城市,全市正在努力建设现代化新重庆,城市管理部门正在谋划思考如何把城市综合管理工作积极融入到现代化新重庆建设宏大场景中。为了找准在城市更新国家战略中的切入点和着力点,本文从城市更新面临的三个“更加注重”新趋势,梳理了重庆市城市更新现状及问题,结合典型山地城市特色,提出了针对性对策建议。

关键词：城市更新城市综合管理山水城市针对性对策智慧城市城市管理部门宜居着力点

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Optimizing electronic structure of Mo_(2)TiC_(2)T_(x)MXene through Nb doping for enhanced electrochemical performance

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Nano Research 2024年第8期17卷 7174-7181页

作者： jingyuan Zhao Wenzheng Yan Zhaoxi Liu Xiaobin Liu Yapeng tian Xinwei Cui Henan Institute of Advanced Technology College of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450003China College of Physics and Electronic Information Engineering Guilin University of TechnologyGuilin 514004China

MXene is a promising electrode material for both high volumetric capacitance and high-rate performance in ***,the current study has mainly focused on the monometallic element Ti_(3)C_(2)T_(x)MXene until now,while the bimetallic and multimetallic MXene have received comparatively less *** this work,we demonstrate that the electronic structure of the Mo_(2)TiC_(2)T_(x)MXene could be regulated by fine-tuning the content of doped Nb *** enhanced electron cloud density of surface–O termination and the electron spin of the Mo atoms in the Mo_(2)TiC_(2)T_(x)MXene,leads to the boost of electric double-layer capacitor(EDLC)and improvement of *** a consequence,the electrochemical performance of Nb-doped Mo_(2)TiC_(2)T_(x)MXene(Nb-0.3-MXene)demonstrates a capacitance of 398 F·cm^(−3),roughly doubling that of the pristine Mo_(2)TiC_(2)T_(x)MXene electrode at 197 F·cm^(−3)in the 3 M H_(2)SO_(4)*** the same time,the Nb-0.3-MXene could even maintain a capacitance of 82.75%at 200 mV·s−1,with high cyclic stability for 19,000 cycles at 10 A·g−***,Nb-0.3-MXene-based hybrid supercapacitors deliver a remarkable volumetric energy density of 48.1 W·h·L^(−1)at 230.7 W·L^(−1),and 34.4 W·h·L^(−1)at a high power density of 82.6 kW·L^(−1).There exists a balance between the volumetric capacitance and rate performance with different ratios of Nb atoms in the Nb-doped MXene due to the strong interaction between the Nb-doped MXene and the intercalated ***,optimizing the electronic structure of MXene through heteroatom doping is of great potential for enhanced supercapacitor performance.

关键词： niobium doping electronic structure Mo_(2)TiC_(2)T_(x)MXene electron spin rate performance volumetric capacitance

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Celastrol regulates the oligomeric state and chaperone activity of αB-crystallin linked with protein homeostasis in the lens

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Fundamental Research 2024年第2期4卷 394-400页

作者： Huaxia Wang Qing tian Ying Zhang Yibo Xi Lidan Hu Ke Yao jingyuan Li Xiangjun Chen Eye Center of the Second Affiliated Hospital Zhejiang University School of Medicine88 Jiefang RoadHangzhou 310009China Institute of Translational Medicine Zhejiang University School of Medicine268 Kaixuan RoadHangzhou 310020China. State Key Laboratory of Membrane Biology School of Life SciencesTsinghua UniversityBeijing 100084China The Children’s Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Zhejiang Province Key Laboratory of Quantum Technology and Device Department of PhysicsZhejiang UniversityZheda Road 38Hangzhou 310027China

Protein misfolding and aggregation are crucial pathogenic factors for cataracts,which are the leading cause of visual impairment worldwide.α-crystallin,as a small molecular chaperone,is involved in preventing protein misfolding and maintaining lens *** chaperone activity of α-crystallin depends on its oligomeric *** previous work identified a natural compound,celastrol,which could regulate the oligomeric state of α*** this work,based on the UNcle and SEC analysis,we found that celastrol induced𝛼αB-crystallin to form large *** oligomer formation enhanced the chaperone activity of αB-crystallin and prevented aggregation of the cataract-causing mutant α*** interactions between𝛼αB-crystallin and celastrol were detected by the FRET(Fluorescence Resonance Energy Transfer)technique,and verified by molecular *** least 9 binding patterns were recognized,and some binding sites covered the groove structure of α***,αB-R120G,a cataract-causing mutation located at the groove structure,and celastrol can decrease the aggregates of α***,our results suggested celastrol not only promoted the formation of large αB-crystallin oligomers,which enhanced its chaperone activity,but also bound to the groove structure of its α-crystallin domain to maintain its structural *** might serve as a chemical and pharmacological chaperone for cataract treatment.

关键词： αB-crystallin Celastrol Interactions Oligomeric state Chaperone activity Structural stability

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Effects of nitrogen and phosphorus additions on soil nematode community of soybean farmland

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Soil Ecology Letters 2024年第2期6卷 45-55页

作者： Huiying Zhang Mengyang tian Meiguang Jiang jingyuan Yang Qi Xu Ying Zhang Minglu Ji Yuteng Yao Cancan Zhao Yuan Miao International Joint Research Laboratory for Global Change Ecology School of Life SciencesHenan UniversityKaifeng475004China Henan Dabieshan National Field Observation and Research Station of Forest Ecosystem Xinyang Academy of Ecological ResearchXinyang464000China

The nitrogen(N)and phosphorus(P)addition promotes the abundance of soybean soil *** addition of nitrogen can alleviate the suppression of phosphorus on *** addition affects nematode abundance by ammonium nitrogen.

关键词： soil nematodes nitrogen addition phosphorus addition soil food web soybean

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Crocus genome reveals the evolutionary origin of crocin biosynthesis

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1878-1891页

作者： Zhichao Xu Shanshan Chen Yalin Wang Ya tian Xiaotong Wang tianyi Xin Zishan Li Xin Hua Shengnan Tan Wei Sun Xiangdong Pu Hui Yao Ranran Gao jingyuan Song Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People's Republic of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China State Key Laboratory of Basis and New Drug Development of Natural and Nuclear Drugs Engineering Research Center of Chinese Medicine ResourceMinistry of EducationBeijing 100193China College of Life Science Northeast Forestry UniversityHarbin 150040China Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine China Academy of Chinese Medical SciencesInstitute of Chinese Materia MedicaBeijing 100700China Analysis and Testing Center of Northeast Forestry University Harbin 150040China School of Pharmacy Anhui Medical UniversityInflammation and Immune Mediated Diseases Laboratory of Anhui ProvinceHefei 230032China

Crocus sativus (saffron) is a globally autumn-flowering plant, and its stigmas are the most expensive spice and valuable herb medicine. Crocus specialized metabolites, crocins, are biosynthesized in distant species, Gardenia (eudicot) and Crocus (monocot), and the evolution of crocin biosynthesis remains poorly understood. With the chromosome-level Crocus genome assembly, we revealed that two rounds of lineage-specific whole genome triplication occurred, contributing important roles in the production of carotenoids and apocarotenoids. According to the kingdom-wide identification, phylogenetic analysis, and functional assays of carotenoid cleavage dioxygenases (CCDs), we deduced that the duplication, site positive selection, and neofunctionalization of Crocus-specific CCD2 from CCD1 members are responsible for the crocin biosynthesis. In addition, site mutation of CsCCD2 revealed the key amino acids, including I143, L146, R161, E181, T259, and S292 related to the catalytic activity of zeaxanthin cleavage. Our study provides important insights into the origin and evolution of plant specialized metabolites, which are derived by duplication events of biosynthetic genes.

关键词： Crocus sativus WGT Crocin biosynthesis Carotenoids Apocarotenoids CCDs

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Current Perspectives on Histone Demethylases

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Acta Biochimica et Biophysica Sinica 2007年第2期39卷 81-88页

作者： Xiaoqing tian and jingyuan FANG Shanghai Jiaotong University School of Medicine,Renji Hospital,shanghai Instituteof Digestive Disease,Shanghai 200001,China Shanghai Jiaotong University School of Medicine Renji Hospital Shanghai Institute of Digestive DiseaseShanghai 200001 China

The posttranslational modification of histones plays an important role in chromatin *** methylation influences constitutive heterochromatin,genomic imprinting,X-chromosome inactivationand gene *** demethylase catalyzes the removal of methyl groups on lysine or arginineresidues of *** kinds of histone lysine demethylases have been identified, including lysine specificdemethylase 1 and Jumonji C (JmjC) domain family *** histone demethylases are involved in theregulation of gene *** modification is a dynamic process,and the imbalance of histonemethylation has been linked to ***,histone demethylases may represent a new target foranti-cancer therapy.

关键词： epigenetic modification histone methylation demethylase lysine specific demethylase 1 Jumonji C(JmjC)protein

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Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2119-2136页

作者： Li Peng Yanyi Jiang Hengxing Chen Yongqiang Wang Qiusheng Lan Shuiqin Chen Zhanwang Huang jingyuan Zhang Duanqing tian Yuntan Qiu Diankui Cai Jiangyun Peng Daning Lu Xiaoqing Yuan Xianzhu Yang Dong Yin Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Medical Research Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Hefei Institutes of Physical Science Chinese Academy of SciencesHefei 230031China Department of Gastrointestinal Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Hepatobiliary Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China

Transcriptional dysregulation of genes is a hallmark of tumors and can serve as targets for cancer drug ***,it is extremely challenging to develop small-molecule inhibitors to target abnormally expressed transcription factors(TFs)except for the nuclear receptor family of *** is known about the interaction between TFs and transcription cofactors in gastroesophageal adenocarcinoma(GEA)or the therapeutic effects of targeting TF and transcription cofactor *** this study,we found that ETS homologous factor(EHF)expression is promoted by a core transcriptional regulatory circuitry(CRC),specifically ELF3-KLF5-GATA6,and interference with its expression suppressed the malignant biological behavior of GEA ***,we identified Ajuba LIM protein(AJUBA)as a new coactivator of EHF that cooperatively orchestrates transcriptional network activity in ***,we identified KRAS signaling as a common pathway downstream of EHF and ***,dual targeting of EHF and AJUBA by lipid nanoparticles cooperatively attenuated the malignant biological behaviors of GEA in vitro and in *** conclusion,EHF is upregulated by the CRC and promotes GEA malignancy by interacting with AJUBA through the KRAS *** of both EHF and its coactivator AJUBA through lipid nanoparticles is a novel potential therapeutic strategy.

关键词： EHF AJUBA KRAS pathway Enhancer Core transcriptional regulatory circuitry Gastroesophageal adenocarcinoma Gastric adenocarcinoma Esophageal adenocarcinoma Transcription factor Coactivator Lipid nanoparticles

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Raman Scattering Activities for Uniaxially Oriented Molecules

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Chemical Research in Chinese Universities 1990年第3期6卷 203-209页

作者： Wang jingyuan, tian Yongchi and Liang Yingqiu (Institute of Theoretical Chemistry, Jilin University, Changchun)

Raman scattering activities were derived for uniaxially oriented molecules. The unique axis of the molecules is assumed to rotate around one of the axes of space-fixed coordinate in a fixed orientation angle with respect to the axis, while the other two principal axes of the molecules are randomly oriented. Expressions for Raman scattering activities in terms of the elements of derived polarizability tensor are given as the function of orientation angle and are tabulated for various symmetries of point groups.

关键词： Raman scattering activities Uniaxially oriented molecules Molecular orientation

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